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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10717
Species: Mus musculus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:34317
Term: 3,3',4,4',5-pentachlorobiphenyl
Definition: A pentachlorobiphenyl in which the chlorines are located at the 3, 4, 5, 3', and 4' positions.
Chemical ID: MESH:C023035
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1decreases expressionEXP 6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of HMOX1 mRNA; 3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of HMOX1 proteinPMID:37598416
Hmox1increases expressionEXP 6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in increased expression of HMOX1 proteinPMID:28163111
Hmox1multiple interactionsEXP 6480464CTD[Methionine deficiency co-treated with Choline deficiency co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of HMOX1 mRNA; Acetylcysteine inhibits the reaction [Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of HMOX1 mRNA]]; Acetylcysteine inhibits the reaction [Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of HMOX1 protein]]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of HMOX1 protein]PMID:28163111 PMID:37598416
Hmox1affects expressionISOHMOX1 (Homo sapiens)6480464CTD3,4,5,3',4'-pentachlorobiphenyl affects the expression of HMOX1 mRNAPMID:21703328
Hmox1increases expressionISOHMOX1 (Homo sapiens)6480464CTD3,4,5,3',4'-pentachlorobiphenyl results in increased expression of HMOX1 mRNAPMID:30768972 PMID:35618242
Hmox1multiple interactionsISOHMOX1 (Homo sapiens)6480464CTD[Lipopolysaccharides co-treated with IFNG protein] promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of HMOX1 mRNA]PMID:30768972
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