HMOX1 (heme oxygenase 1) - Rat Genome Database

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Gene: HMOX1 (heme oxygenase 1) Sus scrofa
Analyze
Symbol: HMOX1
Name: heme oxygenase 1
RGD ID: 14201932
Description: ENCODES a protein that exhibits heme oxygenase (decyclizing) activity; enzyme binding (ortholog); heme binding (ortholog); INVOLVED IN negative regulation by host of viral transcription; negative regulation of viral life cycle; angiogenesis (ortholog); PARTICIPATES IN acute intermittent porphyria pathway; erythropoietic porphyria pathway; heme degradation pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); acute chest syndrome (ortholog); acute kidney failure (ortholog); FOUND IN caveola (ortholog); cytosol (ortholog); endoplasmic reticulum (ortholog); INTERACTS WITH (-)-epigallocatechin 3-gallate; aldosterone; bis(2-chloroethyl) sulfide
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: heat shock protein 32; heme oxygenase (decycling) 1; HO-1; HSP32
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
acute chest syndrome  (ISO)
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
adrenoleukodystrophy  (ISO)
adult respiratory distress syndrome  (ISO)
Altitude Sickness  (ISO)
Alzheimer's disease  (ISO)
arteriosclerosis  (ISO)
asthma  (ISO)
Behcet's disease  (ISO)
berylliosis  (ISO)
Blast Crisis  (ISO)
blood coagulation disease  (ISO)
Brain Death  (ISO)
brain edema  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
bronchiolitis obliterans  (ISO)
Carbon Monoxide Poisoning  (ISO)
Carbon Tetrachloride Poisoning  (ISO)
Cardiomegaly  (ISO)
carotid artery disease  (ISO)
carotid artery thrombosis  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
Chronic Tubulointerstitial Nephropathy  (ISO)
colitis  (ISO)
congestive heart failure  (ISO)
contact dermatitis  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
coronary restenosis  (ISO)
cystic fibrosis  (ISO)
diabetic angiopathy  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
Dilatation, Pathologic  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
esophageal cancer  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
factor VIII deficiency  (ISO)
Fever  (ISO)
Fibrosis  (ISO)
gastroparesis  (ISO)
Graft Occlusion, Vascular  (ISO)
Growth Disorders  (ISO)
Helicobacter Infections  (ISO)
Heme Oxygenase 1 Deficiency  (ISO)
Hemolysis  (ISO)
hemolytic anemia  (ISO)
Hemorrhagic Shock  (ISO)
Henoch-Schoenlein purpura  (ISO)
hepatic encephalopathy  (ISO)
hepatic veno-occlusive disease  (ISO)
hepatitis  (ISO)
hepatopulmonary syndrome  (ISO)
hepatorenal syndrome  (ISO)
hyperinsulinism  (ISO)
Hyperoxic Lung Injury  (ISO)
Hyperplasia  (ISO)
hypertension  (ISO)
hyperthyroidism  (ISO)
Hypoxia-Ischemia, Brain  (ISO)
ileus  (ISO)
Inflammation  (ISO)
Insulin Resistance  (ISO)
interstitial lung disease  (ISO)
Intestinal Reperfusion Injury  (ISO)
intracranial vasospasm  (ISO)
iron metabolism disease  (ISO)
ischemia  (ISO)
Kawasaki disease  (ISO)
Kidney Reperfusion Injury  (ISO)
learning disability  (ISO)
Limb Ischemia  (ISO)
liver disease  (ISO)
Liver Neoplasms  (ISO)
Liver Reperfusion Injury  (ISO)
lung disease  (ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
Lung Reperfusion Injury  (ISO)
Mammary Neoplasms, Experimental  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neointima  (ISO)
Neonatal Hyperbilirubinemia  (ISO)
Neoplasm Invasiveness  (ISO)
neurodegenerative disease  (ISO)
newborn respiratory distress syndrome  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
pancreas disease  (ISO)
Paraparesis  (ISO)
Parkinson's disease  (ISO)
Parkinsonism  (ISO)
Pathologic Constriction  (ISO)
peptic ulcer disease  (ISO)
Perennial Allergic Rhinitis  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumonia  (ISO)
pneumothorax  (ISO)
portal hypertension  (ISO)
pre-eclampsia  (ISO)
Pregnancy-Induced Hypertension  (ISO)
primary biliary cholangitis  (ISO)
Prostatic Neoplasms  (ISO)
Pulmonary Edema of Mountaineers  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary sarcoidosis  (ISO)
pulmonary venoocclusive disease  (ISO)
Radiation Injuries, Experimental  (ISO)
renal hypertension  (ISO)
Reperfusion Injury  (ISO)
Retina Reperfusion Injury  (ISO)
retinal disease  (ISO)
retinal ischemia  (ISO)
Rhabdomyolysis  (ISO)
Right Ventricular Hypertrophy  (ISO)
sciatic neuropathy  (ISO)
sickle cell anemia  (ISO)
silicosis  (ISO)
Sjogren's syndrome  (ISO)
Spinal Cord Injuries  (ISO)
spinocerebellar ataxia type 17  (ISO)
status epilepticus  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
systemic mastocytosis  (ISO)
Testis Reperfusion Injury  (ISO)
thrombosis  (ISO)
toxic shock syndrome  (ISO)
type 2 diabetes mellitus  (ISO)
varicocele  (ISO)
Vascular System Injuries  (ISO)
Ventricular Fibrillation  (ISO)
viral pneumonia  (ISO)
visceral leishmaniasis  (ISO)
Wounds and Injuries  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
apoptotic process  (IEA)
cellular iron ion homeostasis  (IEA,ISS)
cellular response to arsenic-containing substance  (IEA,ISO,ISS)
cellular response to cadmium ion  (IEA,ISO,ISS)
cellular response to cisplatin  (IEA,ISO)
cellular response to heat  (IEA)
cellular response to hypoxia  (IEA)
cellular response to nutrient  (ISO)
epithelial cell apoptotic process  (IEA,ISO)
erythrocyte homeostasis  (IEA,ISS)
heme catabolic process  (IBA,IEA,ISO,ISS)
heme metabolic process  (IEA,ISO,ISS)
heme oxidation  (IBA,IEA,ISS)
intracellular signal transduction  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
iron ion homeostasis  (IBA,IEA,ISS)
liver regeneration  (ISO)
macroautophagy  (IEA,ISO)
negative regulation by host of viral transcription  (IMP)
negative regulation of cell population proliferation  (ISO)
negative regulation of DNA binding  (ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of epithelial cell apoptotic process  (ISO)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IEA,ISS)
negative regulation of macroautophagy  (IEA,ISO)
negative regulation of mast cell cytokine production  (ISO)
negative regulation of mast cell degranulation  (ISO)
negative regulation of muscle cell apoptotic process  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of smooth muscle cell proliferation  (IEA,ISO,ISS)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
negative regulation of viral life cycle  (IMP)
positive regulation of angiogenesis  (IEA,ISO)
positive regulation of apoptotic process  (IEA)
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (IEA)
positive regulation of cell migration involved in sprouting angiogenesis  (IEA)
positive regulation of epithelial cell apoptotic process  (IEA,ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (ISS)
positive regulation of macroautophagy  (IEA,ISO)
positive regulation of smooth muscle cell proliferation  (IEA,ISS)
regulation of blood pressure  (ISO)
regulation of DNA-binding transcription factor activity  (ISO)
regulation of transcription from RNA polymerase II promoter in response to iron  (IEA,ISO,ISS)
regulation of transcription from RNA polymerase II promoter in response to oxidative stress  (ISO)
response to estrogen  (ISO)
response to hydrogen peroxide  (ISO)
response to hypoxia  (ISO)
response to nicotine  (IEA,ISS)
response to oxidative stress  (IBA,IEA,ISO,ISS)
response to xenobiotic stimulus  (ISO)
small GTPase mediated signal transduction  (ISO)
wound healing involved in inflammatory response  (IEA,ISS)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:1288499   PMID:14681463   PMID:15681702   PMID:16333987   PMID:17145712   PMID:19618599   PMID:19966053   PMID:20580034   PMID:23357296   PMID:23936023   PMID:25086213   PMID:25583855  
PMID:26471299   PMID:27908781  


Genomics

Comparative Map Data
HMOX1
(Sus scrofa - pig)
No map positions available.
HMOX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382235,381,096 - 35,394,207 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2235,380,361 - 35,394,214 (+)EnsemblGRCh38hg38GRCh38
GRCh372235,777,089 - 35,790,200 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362234,107,087 - 34,120,194 (+)NCBINCBI36hg18NCBI36
Build 342234,101,640 - 34,114,748NCBI
Celera2219,579,740 - 19,592,881 (+)NCBI
Cytogenetic Map22q12.3NCBI
HuRef2218,737,577 - 18,750,716 (+)NCBIHuRef
CHM1_12235,735,791 - 35,748,937 (+)NCBICHM1_1
T2T-CHM13v2.02235,839,114 - 35,852,226 (+)NCBI
Hmox1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39875,820,246 - 75,827,221 (+)NCBIGRCm39mm39
GRCm39 Ensembl875,820,249 - 75,827,217 (+)Ensembl
GRCm38875,093,618 - 75,100,593 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl875,093,621 - 75,100,589 (+)EnsemblGRCm38mm10GRCm38
MGSCv37877,617,517 - 77,624,492 (+)NCBIGRCm37mm9NCBIm37
MGSCv36877,989,694 - 77,996,657 (+)NCBImm8
Celera879,400,848 - 79,407,824 (+)NCBICelera
Cytogenetic Map8C1NCBI
cM Map835.59NCBI
Hmox1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21913,466,287 - 13,474,082 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1913,467,244 - 13,474,079 (+)Ensembl
Rnor_6.01914,508,634 - 14,515,455 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1914,508,616 - 14,515,456 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01925,622,556 - 25,629,377 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41913,963,139 - 13,969,960 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11913,967,964 - 13,974,784 (+)NCBI
Celera1913,334,259 - 13,341,080 (+)NCBICelera
Cytogenetic Map19p11NCBI
Hmox1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540543,124,510 - 43,130,979 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540543,124,447 - 43,128,873 (+)NCBIChiLan1.0ChiLan1.0
HMOX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12234,230,825 - 34,244,063 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2234,230,825 - 34,244,063 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02216,388,368 - 16,401,289 (+)NCBIMhudiblu_PPA_v0panPan3
HMOX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11028,744,404 - 28,751,544 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1028,743,795 - 28,751,773 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1028,683,213 - 28,689,972 (-)NCBI
ROS_Cfam_1.01029,531,402 - 29,538,230 (-)NCBI
ROS_Cfam_1.0 Ensembl1029,530,793 - 29,539,227 (-)Ensembl
UMICH_Zoey_3.11029,255,139 - 29,261,959 (-)NCBI
UNSW_CanFamBas_1.01029,565,774 - 29,572,612 (-)NCBI
UU_Cfam_GSD_1.01029,745,379 - 29,752,300 (-)NCBI
Hmox1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494512,031,937 - 12,038,780 (-)NCBI
SpeTri2.0NW_0049364925,042,353 - 5,049,216 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HMOX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11918,144,466 - 18,157,944 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1918,144,545 - 18,157,971 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666045107,791,541 - 107,805,610 (-)NCBIVero_WHO_p1.0
Hmox1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624750342,146 - 345,887 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_004624750341,699 - 346,005 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2 2
Low 9 2 1 3 2 8 2 1 1
Below cutoff 1 2 2 15 2

Sequence


Protein Sequences
Protein RefSeqs NP_001004027 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA43092 (Get FASTA)   NCBI Sequence Viewer  
  P32394 (Get FASTA)   NCBI Sequence Viewer  


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000039745 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025050025 UniProtKB/TrEMBL
  ENSSSCG00040068516 UniProtKB/TrEMBL
  ENSSSCG00045017540 UniProtKB/TrEMBL
  ENSSSCG00050062902 UniProtKB/TrEMBL
  ENSSSCG00055006201 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00060031463 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000048349 ENTREZGENE
  ENSSSCP00000048349.2 UniProtKB/TrEMBL
  ENSSSCP00000066228.1 UniProtKB/TrEMBL
  ENSSSCP00025029345.1 UniProtKB/TrEMBL
  ENSSSCP00025029398.1 UniProtKB/TrEMBL
  ENSSSCP00040041452.1 UniProtKB/TrEMBL
  ENSSSCP00045020710.1 UniProtKB/TrEMBL
  ENSSSCP00045020735.1 UniProtKB/TrEMBL
  ENSSSCP00050036785.1 UniProtKB/TrEMBL
  ENSSSCP00055009499.1 UniProtKB/TrEMBL
  ENSSSCP00055009535 UniProtKB/Swiss-Prot
  ENSSSCP00060018136.1 UniProtKB/TrEMBL
  ENSSSCP00060018139.1 UniProtKB/TrEMBL
  ENSSSCP00060018141.1 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000048279 ENTREZGENE
  ENSSSCT00000048279.2 UniProtKB/TrEMBL
  ENSSSCT00000088920.1 UniProtKB/TrEMBL
  ENSSSCT00025068262.1 UniProtKB/TrEMBL
  ENSSSCT00025068359.1 UniProtKB/TrEMBL
  ENSSSCT00040093871.1 UniProtKB/TrEMBL
  ENSSSCT00045029871.1 UniProtKB/TrEMBL
  ENSSSCT00045029912.1 UniProtKB/TrEMBL
  ENSSSCT00050085674.1 UniProtKB/TrEMBL
  ENSSSCT00055012023.1 UniProtKB/TrEMBL
  ENSSSCT00055012067 UniProtKB/Swiss-Prot
  ENSSSCT00060042578.1 UniProtKB/TrEMBL
  ENSSSCT00060042583.1 UniProtKB/TrEMBL
  ENSSSCT00060042587.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.910.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Haem_Oase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Haem_Oase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Haem_Oase-like_multi-hlx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Haem_oxygenase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:445512 UniProtKB/Swiss-Prot
NCBI Gene HMOX1 ENTREZGENE
PANTHER PTHR10720 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Heme_oxygenase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF Haem_Oase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS HAEMOXYGNASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HEME_OXYGENASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48613 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A287AWS9_PIG UniProtKB/TrEMBL
  A0A8D0SBN5_PIG UniProtKB/TrEMBL
  A0A8D1HME6_PIG UniProtKB/TrEMBL
  A0A8D1HMG7_PIG UniProtKB/TrEMBL
  A0A8D1TWP8_PIG UniProtKB/TrEMBL
  A0A8D1V2A9_PIG UniProtKB/TrEMBL
  A0A8D1V371_PIG UniProtKB/TrEMBL
  HMOX1_PIG UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:98036 ENTREZGENE