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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10717
Species: Mus musculus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:28077
Term: rifampicin
Definition: A member of the class of rifamycins that is a a semisynthetic antibiotic derived from Amycolatopsis rifamycinica (previously known as Amycolatopsis mediterranei and Streptomyces mediterranei).
Chemical ID: MESH:D012293
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1multiple interactionsEXP 6480464CTD[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HMOX1 mRNAPMID:21224054
Hmox1increases expressionISOHMOX1 (Homo sapiens)6480464CTDRifampin results in increased expression of HMOX1 mRNA; Rifampin results in increased expression of HMOX1 proteinPMID:22258563 PMID:31678598
Hmox1multiple interactionsISOHmox1 (Rattus norvegicus)6480464CTD[arsenite co-treated with Rifampin] results in increased expression of HMOX1 mRNAPMID:22159698
Hmox1multiple interactionsISOHMOX1 (Homo sapiens)6480464CTDdorsomorphin inhibits the reaction [Rifampin results in increased expression of HMOX1 protein]PMID:31678598
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