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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10717
Species: Mus musculus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:33217
Term: 3,3',5,5'-tetrabromobisphenol A
Definition: A bromobisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups and the phenyl rings are substituted by bromo groups at positions 2, 2', 6 and 6'. It is a brominated flame retardant.
Chemical ID: MESH:C020806
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1increases expressionEXP 6480464CTDtetrabromobisphenol A results in increased expression of HMOX1 mRNAPMID:25172293
Hmox1decreases expressionISOHMOX1 (Homo sapiens)6480464CTDtetrabromobisphenol A results in decreased expression of HMOX1 proteinPMID:31675489
Hmox1increases expressionISOHMOX1 (Homo sapiens)6480464CTDtetrabromobisphenol A results in increased expression of HMOX1 mRNA; tetrabromobisphenol A results in increased expression of HMOX1 proteinPMID:25461914 PMID:30951941
Hmox1multiple interactionsISOHMOX1 (Homo sapiens)6480464CTD[tetrabromobisphenol A co-treated with Antigens, Bacterial] results in decreased expression of HMOX1 protein; Acetylcysteine inhibits the reaction [tetrabromobisphenol A results in increased expression of HMOX1 mRNA]PMID:30055667 PMID:30951941
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