GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Hmox1 | increases expression | EXP | | 6480464 | CTD | Diclofenac results in increased expression of HMOX1 mRNA; Diclofenac results in increased expression of HMOX1 protein | PMID:12763371 | Hmox1 | multiple interactions | EXP | | 6480464 | CTD | Acetylcysteine inhibits the reaction [Diclofenac results in increased expression of HMOX1 protein]; Buthionine Sulfoximine promotes the reaction [Diclofenac results in increased expression of HMOX1 protein]; Diclofenac promotes the reaction [Buthionine Sulfoximine results in increased expression of HMOX1 protein] | PMID:12763371 | Hmox1 | affects expression | ISO | HMOX1 (Homo sapiens) | 6480464 | CTD | Diclofenac affects the expression of HMOX1 protein | PMID:19952508 | Hmox1 | increases expression | ISO | Hmox1 (Rattus norvegicus) | 6480464 | CTD | Diclofenac results in increased expression of HMOX1 mRNA | PMID:12763371 PMID:18172885 PMID:19022234 PMID:29027214 | Hmox1 | increases expression | ISO | HMOX1 (Homo sapiens) | 6480464 | CTD | Diclofenac results in increased expression of HMOX1 mRNA | PMID:18227147 PMID:19022234 PMID:27313093 PMID:29027214 | Hmox1 | multiple interactions | ISO | Hmox1 (Rattus norvegicus) | 6480464 | CTD | Acetylcysteine inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; Diclofenac promotes the reaction [Poly I-C results in increased expression of HMOX1 mRNA]; Ketoconazole inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; Sulfaphenazole inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; Tranylcypromine inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA] | PMID:12763371 PMID:23939143 | Hmox1 | multiple interactions | ISO | HMOX1 (Homo sapiens) | 6480464 | CTD | 1-aminobenzotriazole inhibits the reaction [[Diclofenac co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Diclofenac results in increased expression of HMOX1 mRNA] | PMID:18227147 | | ||||||||||||||||||||||
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