GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Hmox1 | affects response to substance | EXP | | 6480464 | CTD | HMOX1 protein affects the susceptibility to manganese chloride | PMID:21963524 | Hmox1 | increases expression | EXP | | 6480464 | CTD | manganese chloride results in increased expression of HMOX1 protein | PMID:25288107 | Hmox1 | multiple interactions | EXP | | 6480464 | CTD | HMOX1 protein inhibits the reaction [manganese chloride results in increased abundance of Hydrogen Peroxide]; manganese chloride promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 mRNA]; manganese chloride promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 protein]; Melatonin inhibits the reaction [manganese chloride results in increased expression of HMOX1 protein] | PMID:21963524 PMID:25288107 | Hmox1 | increases expression | ISO | Hmox1 (Rattus norvegicus) | 6480464 | CTD | manganese chloride results in increased expression of HMOX1 mRNA; manganese chloride results in increased expression of HMOX1 protein | PMID:21384399 PMID:22281203 PMID:29054681 PMID:30040983 | Hmox1 | multiple interactions | ISO | Hmox1 (Rattus norvegicus) | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in increased expression of HMOX1 protein]; [Acetylcysteine affects the abundance of Reactive Oxygen Species] inhibits the reaction [manganese chloride promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]]; [Acetylcysteine affects the abundance of Reactive Oxygen Species] inhibits the reaction [manganese chloride results in increased expression of HMOX1 protein]; [manganese chloride results in increased abundance of Manganese] which results in increased expression of HMOX1 protein; anacardic acid promotes the reaction [manganese chloride results in increased expression of HMOX1 mRNA]; GW 506033X promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of HMOX1 protein]; lactacystin promotes the reaction [manganese chloride promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]]; lactacystin promotes the reaction [manganese chloride results in increased expression of HMOX1 protein]; manganese chloride promotes the reaction [[NFE2L2 protein binds to HMOX1 promoter] which results in increased expression of HMOX1 mRNA]; manganese chloride promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]; SB 203580 inhibits the reaction [manganese chloride results in increased expression of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [manganese chloride results in increased expression of HMOX1 protein]; trichostatin A promotes the reaction [manganese chloride results in increased expression of HMOX1 mRNA]; trichostatin A promotes the reaction [manganese chloride results in increased expression of HMOX1 protein] | PMID:21107535 PMID:21384399 PMID:29054681 PMID:30040983 PMID:32574669 | | ||||||||||||||||||||||
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