Bche (butyrylcholinesterase) - Rat Genome Database

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Gene: Bche (butyrylcholinesterase) Mus musculus
Analyze
Symbol: Bche
Name: butyrylcholinesterase
RGD ID: 732175
MGI Page MGI
Description: Exhibits acetylcholinesterase activity. Predicted to be involved in several processes, including neuroblast differentiation; response to folic acid; and response to glucocorticoid. Localizes to endoplasmic reticulum and nuclear envelope lumen. Is expressed in several structures, including adrenal gland; alimentary system; ear; liver; and nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease (multiple); diabetes mellitus (multiple); epilepsy; and inherited metabolic disorder. Orthologous to human BCHE (butyrylcholinesterase); PARTICIPATES IN heroin pharmacodynamics pathway; heroin pharmacokinetics pathway; irinotecan pharmacodynamics pathway; INTERACTS WITH (+)-alpha-tocopherol; (2-chloroethyl)phosphonic acid; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: acylcholine acylhydrolase; butyrylcholine esterase; C730038G20Rik; choline esterase II; cholinesterase; MGC107651; pseudocholinesterase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39373,543,138 - 73,615,767 (-)NCBIGRCm39mm39
GRCm39 Ensembl373,543,141 - 73,615,748 (-)Ensembl
GRCm38373,635,805 - 73,708,436 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl373,635,808 - 73,708,415 (-)EnsemblGRCm38mm10GRCm38
MGSCv37373,439,731 - 73,512,337 (-)NCBIGRCm37mm9NCBIm37
MGSCv36373,721,734 - 73,794,168 (-)NCBImm8
Celera373,748,016 - 73,817,761 (-)NCBICelera
Cytogenetic Map3E3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Alzheimer's disease  (ISO)
amnestic disorder  (ISO)
Amyloid Plaques  (IEP)
Apnea  (ISO)
bacterial meningitis  (ISO)
Bamforth-Lazarus syndrome  (ISO)
Breast Neoplasms  (ISO)
Butyrylcholinesterase Deficiency  (ISO)
Butyrylcholinesterase Deficiency, Fluoride-Resistant, Japanese Type  (ISO)
Cardiotoxicity  (ISO)
Cocaine-Related Disorders  (ISO)
cognitive disorder  (ISO)
congenital merosin-deficient muscular dystrophy 1A  (IEP)
coronary artery disease  (ISO)
coronary restenosis  (ISO)
Death  (ISO)
dementia  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
dystonia  (ISO)
Endotoxemia  (ISO)
epilepsy  (ISO)
epilepsy with generalized tonic-clonic seizures  (ISO)
Experimental Diabetes Mellitus  (ISO)
familial hyperlipidemia  (ISO)
Fasciculation  (ISO)
glioblastoma  (ISO)
Huntington's disease  (ISO)
hyperhomocysteinemia  (ISO)
Hyperkinesis  (ISO)
hypertension  (ISO)
Hypertriglyceridemia  (ISO)
inherited metabolic disorder  (ISO)
Insulin Resistance  (ISO)
leptospirosis  (ISO)
Metabolic Syndrome  (ISO)
multiple sclerosis  (ISO)
muscular dystrophy  (ISO)
neuroblastoma  (ISO)
obesity  (ISO)
Organophosphate Poisoning  (ISO)
Paralysis  (ISO)
Paresis  (ISO)
Poisoning  (ISO)
Postoperative Complications  (ISO)
primary progressive multiple sclerosis  (ISO)
renal cell carcinoma  (ISO)
schizophrenia  (ISO)
secondary Parkinson disease  (ISO)
sleep apnea  (ISO)
Stroke  (ISO)
Tachycardia  (ISO)
toxic encephalopathy  (ISO)
Trismus  (ISO)
trypanosomiasis  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
visual epilepsy  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (EXP)
(+)-pilocarpine  (ISO)
(+)-schisandrin B  (ISO)
(2-chloroethyl)phosphonic acid  (EXP,ISO)
(R)-lipoic acid  (EXP,ISO)
(R,R)-tramadol  (ISO)
(S)-naringenin  (ISO)
1,2,3-Trichloropropane  (ISO)
17beta-estradiol  (EXP)
2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinolin-9-amine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5,5-diethylbarbituric acid  (EXP)
6-Acetylmorphine  (ISO)
acephate  (ISO)
acetamide  (ISO)
acetylcholine  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
alpha-linolenic acid  (ISO)
ammonium chloride  (ISO)
amodiaquine  (ISO)
arsenous acid  (ISO)
atropine  (ISO)
Avizafone  (ISO)
bambuterol  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (EXP)
benzoic acid  (EXP,ISO)
bicalutamide  (ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butyrylthiocholine  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbaryl  (ISO)
carbofuran  (EXP,ISO)
carbon nanotube  (EXP)
chlorphenamine  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
chrysene  (EXP)
cinchocaine  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cryptotanshinone  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
decamethonium  (ISO)
demeton-S-methyl  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
Diacetylmonoxime  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP,ISO)
diazoxon  (ISO)
dichlorvos  (EXP,ISO)
diethylstilbestrol  (ISO)
diisopropyl fluorophosphate  (EXP,ISO)
dimenhydrinate  (ISO)
dimethoate  (EXP,ISO)
diphenhydramine  (ISO)
donepezil hydrochloride  (EXP,ISO)
dorsomorphin  (ISO)
ecgonine methyl ester  (EXP,ISO)
ecothiopate iodide  (ISO)
edrophonium  (ISO)
endosulfan  (EXP,ISO)
entinostat  (ISO)
ethyl methanesulfonate  (ISO)
fenthion  (ISO)
ferulic acid  (ISO)
flavonoids  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
formetanate  (ISO)
furan  (ISO)
galanthamine  (ISO)
galanthamine Trifluoroacetic acid  (ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (ISO)
glyphosate  (ISO)
heroin  (ISO)
HLo7  (ISO)
homocysteine  (ISO)
ifosfamide  (ISO)
imidacloprid  (ISO)
Indeno[1,2,3-cd]pyrene  (EXP)
indole-3-butyric acid  (ISO)
indometacin  (ISO)
isoflurane  (EXP)
Isosorbide  (EXP,ISO)
L-ascorbic acid  (EXP)
lead diacetate  (ISO)
linoleic acid  (ISO)
lipoic acid  (EXP,ISO)
lycopene  (ISO)
magnesium sulfate  (ISO)
malachite green cation  (ISO)
malaoxon  (ISO)
malathion  (ISO)
melphalan  (ISO)
mepyramine  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
methamidophos  (EXP,ISO)
methiocarb  (ISO)
methomyl  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
metoclopramide  (ISO)
Mipafox  (ISO)
Mivacurium  (ISO)
monosodium L-glutamate  (ISO)
morin  (ISO)
morphine  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naringin  (ISO)
neostigmine  (ISO)
nickel atom  (ISO)
o-cresol  (ISO)
omethoate  (ISO)
organophosphorus compound  (EXP,ISO)
oxamyl  (ISO)
oxydemeton-methyl  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (ISO)
paraoxon  (EXP,ISO)
Paraoxon-methyl  (ISO)
paraquat  (ISO)
pararosaniline free base  (ISO)
parathion  (EXP,ISO)
parathion-methyl  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (ISO)
Phenelzine  (ISO)
phenobarbital  (EXP)
phenothiazines  (ISO)
phenyl acetate  (ISO)
phenylmercury acetate  (ISO)
phenylmethanesulfonyl fluoride  (ISO)
phorate  (ISO)
phosphoryl trichloride  (EXP,ISO)
physostigmine  (ISO)
pioglitazone  (EXP)
piperidine  (ISO)
pirinixic acid  (EXP,ISO)
pralidoxime  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
profenamine  (EXP,ISO)
profenofos  (EXP)
promazine  (ISO)
promethazine  (ISO)
propidium  (ISO)
Propionylcholine  (EXP)
propoxur  (ISO)
Pyridostigmine bromide  (ISO)
quercetin  (ISO)
quinalphos  (ISO)
ranitidine  (ISO)
resveratrol  (EXP,ISO)
rivastigmine  (ISO)
rotenone  (ISO)
salicyl alcohol  (ISO)
sarin  (ISO)
SB 431542  (ISO)
silicon atom  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (EXP)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
solanidine  (ISO)
solasodine  (ISO)
Soman  (EXP,ISO)
streptozocin  (EXP)
succinylcholine  (ISO)
sulforaphane  (EXP)
sunitinib  (ISO)
tacrine  (EXP,ISO)
tapentadol  (ISO)
testosterone  (ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (ISO)
tetraethylammonium  (ISO)
tetramethylammonium  (ISO)
thiazolidines  (ISO)
Thiotepa  (ISO)
Tiapamil  (ISO)
tomatidine  (ISO)
tramadol  (ISO)
trichlorfon  (ISO)
trichostatin A  (ISO)
Tripelennamine  (ISO)
triptonide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (ISO)
vitamin E  (EXP)
vorinostat  (ISO)
VX nerve agent  (ISO)
zinc oxide  (EXP)
zingerone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
1. Abbott CA, etal., Clin Sci (Lond). 1993 Jul;85(1):77-81.
2. Alcântara VM, etal., Scand J Clin Lab Invest. 2002;62(5):399-404.
3. Basu PS, etal., Clin Chim Acta. 1995 Feb 28;235(1):107-12.
4. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
5. Ben Assayag E, etal., Mol Med. 2010 Jul-Aug;16(7-8):278-86. doi: 10.2119/molmed.2010.00015. Epub 2010 Apr 14.
6. Berg RM, etal., Scand J Clin Lab Invest. 2011 Jul;71(4):350-2. doi: 10.3109/00365513.2011.558107. Epub 2011 Feb 8.
7. da Silva CB, etal., J Med Microbiol. 2012 Feb;61(Pt 2):278-84. doi: 10.1099/jmm.0.035501-0. Epub 2011 Sep 15.
8. Darreh-Shori T, etal., J Alzheimers Dis. 2012;28(2):443-58. doi: 10.3233/JAD-2011-111088.
9. Darreh-Shori T, etal., Neurobiol Dis. 2006 Nov;24(2):326-33. Epub 2006 Sep 14.
10. Darvesh S, etal., Chem Biol Interact. 2010 Sep 6;187(1-3):425-31. doi: 10.1016/j.cbi.2010.01.037. Epub 2010 Feb 1.
11. Darvesh S, etal., J Neuropathol Exp Neurol. 2012 Jan;71(1):2-14. doi: 10.1097/NEN.0b013e31823cc7a6.
12. Dave KR and Katyare SS, J Endocrinol. 2002 Oct;175(1):241-50.
13. Gresner P, etal., Biochim Biophys Acta. 2006 Feb;1760(2):207-15. Epub 2005 Dec 21.
14. Hashim Y, etal., Diabetologia. 2001 Dec;44(12):2227-30.
15. Iwasaki T, etal., Intern Med. 2007;46(19):1633-9. Epub 2007 Oct 1.
16. Kálmán J, etal., Life Sci. 2004 Jul 23;75(10):1195-204.
17. Lepienski LM, etal., Diabetes Obes Metab. 2006 Nov;8(6):709-11.
18. Mabrouk H, etal., Ann Biol Clin (Paris). 2011 Nov-Dec;69(6):647-52. doi: 10.1684/abc.2011.0634.
19. Matté C, etal., Int J Dev Neurosci. 2006 Feb;24(1):3-8. Epub 2006 Jan 25.
20. McGuire MC, etal., Proc Natl Acad Sci U S A. 1989 Feb;86(3):953-7.
21. MGD data from the GO Consortium
22. Moral-Naranjo MT, etal., Neurosci Lett. 2002 Oct 18;331(3):155-8.
23. Ofek K, etal., J Mol Med (Berl). 2007 Nov;85(11):1239-51. Epub 2007 Jul 27.
24. Oguri M, etal., Atherosclerosis. 2007 Oct;194(2):e172-8. Epub 2007 Feb 1.
25. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
26. OMIM Disease Annotation Pipeline
27. Pipeline to import SMPDB annotations from SMPDB into RGD
28. Ramkumar KM, etal., J Basic Clin Physiol Pharmacol. 2005;16(1):17-35.
29. Randell EW, etal., Clin Biochem. 2005 Sep;38(9):799-805.
30. RGD automated import pipeline
31. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
32. RGD automated import pipeline for gene-chemical interactions
33. Ruberg M, etal., J Neurol Neurosurg Psychiatry. 1987 May;50(5):538-43.
34. Sakamoto N, etal., Clin Chim Acta. 1998 Jun 22;274(2):159-66.
35. Sánchez-Chávez G and Salceda R, Neurochem Res. 2001 Feb;26(2):153-9.
36. Vaisi-Raygani A, etal., Scand J Clin Lab Invest. 2008;68(2):123-9. Epub 2007 Nov 21.
37. Wang HX, etal., Regul Pept. 2009 Apr 10;154(1-3):85-90. doi: 10.1016/j.regpep.2009.01.004. Epub 2009 Jan 27.
38. Wolkmer P, etal., Exp Parasitol. 2010 Jul;125(3):251-5. doi: 10.1016/j.exppara.2010.01.024. Epub 2010 Feb 6.
39. Yoo DY, etal., Neurochem Int. 2011 Oct;59(5):722-8. doi: 10.1016/j.neuint.2011.06.021. Epub 2011 Jul 13.
Additional References at PubMed
PMID:2016308   PMID:2400605   PMID:8651510   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11929041   PMID:12477932   PMID:14681479   PMID:15318343  
PMID:16141072   PMID:16141073   PMID:17192674   PMID:17194517   PMID:17212694   PMID:18167304   PMID:19416087   PMID:20805581   PMID:21677750   PMID:21767560   PMID:22935510   PMID:23219600  
PMID:23305761   PMID:23313104   PMID:24952961   PMID:25131634   PMID:25269881   PMID:25646463   PMID:25814464   PMID:25931333   PMID:26138460   PMID:26306824   PMID:27091549   PMID:27300766  
PMID:28118357   PMID:32325033  


Genomics

Comparative Map Data
Bche
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39373,543,138 - 73,615,767 (-)NCBIGRCm39mm39
GRCm39 Ensembl373,543,141 - 73,615,748 (-)Ensembl
GRCm38373,635,805 - 73,708,436 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl373,635,808 - 73,708,415 (-)EnsemblGRCm38mm10GRCm38
MGSCv37373,439,731 - 73,512,337 (-)NCBIGRCm37mm9NCBIm37
MGSCv36373,721,734 - 73,794,168 (-)NCBImm8
Celera373,748,016 - 73,817,761 (-)NCBICelera
Cytogenetic Map3E3NCBI
BCHE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3165,772,904 - 165,837,462 (-)EnsemblGRCh38hg38GRCh38
GRCh383165,772,904 - 165,837,423 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373165,490,692 - 165,555,211 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363166,973,386 - 167,037,947 (-)NCBINCBI36hg18NCBI36
Build 343166,973,394 - 167,037,952NCBI
Celera3163,889,280 - 163,954,027 (-)NCBI
Cytogenetic Map3q26.1NCBI
HuRef3162,859,251 - 162,924,002 (-)NCBIHuRef
CHM1_13165,453,437 - 165,518,145 (-)NCBICHM1_1
Bche
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22158,308,674 - 158,401,148 (-)NCBI
Rnor_6.0 Ensembl2171,100,140 - 171,196,395 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02171,104,476 - 171,196,186 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02190,443,044 - 190,536,106 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42164,329,613 - 164,427,994 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12164,279,575 - 164,377,957 (-)NCBI
Celera2152,547,587 - 152,638,478 (-)NCBICelera
Cytogenetic Map2q32NCBI
Bche
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544815,329,273 - 15,396,970 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544815,327,374 - 15,396,827 (-)NCBIChiLan1.0ChiLan1.0
BCHE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13170,845,494 - 170,910,662 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3170,845,494 - 170,911,481 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03162,794,184 - 162,858,574 (-)NCBIMhudiblu_PPA_v0panPan3
BCHE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13430,912,632 - 30,977,624 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3430,912,632 - 30,977,583 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3439,973,463 - 40,038,402 (-)NCBI
ROS_Cfam_1.03430,973,335 - 31,038,334 (-)NCBI
UMICH_Zoey_3.13430,917,722 - 30,976,598 (-)NCBI
UNSW_CanFamBas_1.03430,878,067 - 30,943,017 (-)NCBI
UU_Cfam_GSD_1.03431,141,049 - 31,206,522 (-)NCBI
Bche
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560297,068,925 - 97,127,830 (-)NCBI
SpeTri2.0NW_0049367071,784,338 - 1,913,401 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BCHE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.113104,946,732 - 105,007,568 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213113,411,303 - 113,471,727 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BCHE
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11523,708,121 - 23,778,027 (+)NCBI
ChlSab1.1 Ensembl1523,708,155 - 23,778,286 (+)Ensembl
Bche
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473043,793,550 - 43,849,169 (-)NCBI

Position Markers
AW554002  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38373,635,945 - 73,636,043UniSTSGRCm38
MGSCv37373,439,867 - 73,439,965UniSTSGRCm37
Celera373,748,152 - 73,748,250UniSTS
Cytogenetic Map3E3UniSTS
Whitehead/MRC_RH3672.29UniSTS
RH127260  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38373,670,863 - 73,671,064UniSTSGRCm38
MGSCv37373,474,785 - 73,474,986UniSTSGRCm37
Cytogenetic Map3E3UniSTS
Bche  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3E3UniSTS
cM Map333.61UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33200000142700000Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7521114102782718Mouse
4141563Lgq3_mlate growth QTL 3 (mouse)Not determined1018416183277639Mouse
1357440Hrtpq1_mheart weight percentage QTL 1 (mouse)Not determined31018416183277639Mouse
1357857Lvrq5_mliver weight QTL 5 (mouse)Not determined31018416183277639Mouse
1357584Splq6_mspleen weight QTL 6 (mouse)Not determined31018416183277639Mouse
4141116Lgaq4_mlate growth adjusted QTL 4 (mouse)Not determined1018416183277639Mouse
4141255W10q3_mweight 10 weeks QTL 3 (mouse)Not determined1018416183277639Mouse
39128206Lwq18_mliver weight QTL 18 (mouse)31018416183277639Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316000000109800000Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316450000130370000Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328900000119100000Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330013439147599053Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337120713143647422Mouse
1301585Cd4ts1_mCD4 T cell subset 1 (mouse)Not determined33979668173796810Mouse
10755516Amzn1_manatomical modifier of Zfp423 1 (mouse)33979668173796810Mouse
11039513Ltpr3a_mLeishmania tropica response 3a (mouse)33979668173796810Mouse
11041901Lmr11b_mleishmaniasis resistance 11b (mouse)33979668173796810Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)341000000116000000Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)344000000101700000Mouse
4141079Ath23_matherosclerosis 23 (mouse)Not determined4945016083450160Mouse
1301824Susp_msuppressor of superoxide production (mouse)Not determined34958758483587697Mouse
1300895Hdl5_mHDL level 5 (mouse)Not determined34958758483587697Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)352000000102400000Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352300000137500000Mouse
1301917Tshp4_mtooth shape 4 (mouse)Not determined35271817686718412Mouse
1357585Manln3_mmandible length 3 (mouse)Not determined35271817686718412Mouse
1300593Skull4_mskull morphology 4 (mouse)Not determined35271817686718412Mouse
13464139Nhdlq17_mnon-HDL QTL 17 (mouse)35301585087015850Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356796681100556821Mouse
12880419V125Dq4_mvitamin D active form serum level QTL 4 (mouse)35900000093000000Mouse
4141294Bmd24_mbone mineral density 24 (mouse)Not determined36183275495832934Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366139351100139488Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)368000000128600000Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369661247103661247Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369718176100747974Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370301597104301735Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372232660106232787Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372232660106232787Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1405
Count of miRNA genes:698
Interacting mature miRNAs:872
Transcripts:ENSMUST00000029367, ENSMUST00000133690, ENSMUST00000138216, ENSMUST00000153917
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000029367   ⟹   ENSMUSP00000029367
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl373,635,808 - 73,708,415 (-)Ensembl
RefSeq Acc Id: ENSMUST00000133690
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl373,648,416 - 73,708,242 (-)Ensembl
RefSeq Acc Id: ENSMUST00000138216   ⟹   ENSMUSP00000141329
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl373,701,568 - 73,708,267 (-)Ensembl
RefSeq Acc Id: ENSMUST00000153917
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl373,704,051 - 73,708,267 (-)Ensembl
RefSeq Acc Id: NM_009738   ⟹   NP_033868
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39373,543,142 - 73,615,748 (-)NCBI
GRCm38373,635,809 - 73,708,415 (-)NCBI
MGSCv37373,439,731 - 73,512,337 (-)RGD
Celera373,748,016 - 73,817,761 (-)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011240000   ⟹   XP_011238302
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39373,543,138 - 73,615,767 (-)NCBI
GRCm38373,635,805 - 73,708,436 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_033868   ⟸   NM_009738
- Peptide Label: precursor
- UniProtKB: Q03311 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011238302   ⟸   XM_011240000
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000141329   ⟸   ENSMUST00000138216
RefSeq Acc Id: ENSMUSP00000029367   ⟸   ENSMUST00000029367
Protein Domains
AChE_tetra   COesterase

Promoters
RGD ID:6833495
Promoter ID:MM_KWN:34602
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell,   Liver
Transcripts:OTTMUST00000065820,   OTTMUST00000065822,   OTTMUST00000065823,   UC008PMX.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36373,511,936 - 73,512,436 (-)MPROMDB
RGD ID:6880892
Promoter ID:EPDNEW_M3897
Type:initiation region
Name:Bche_2
Description:Mus musculus butyrylcholinesterase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M3898  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38373,708,242 - 73,708,302EPDNEW
RGD ID:6880894
Promoter ID:EPDNEW_M3898
Type:initiation region
Name:Bche_1
Description:Mus musculus butyrylcholinesterase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M3897  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38373,708,412 - 73,708,472EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:894278 AgrOrtholog
Ensembl Genes ENSMUSG00000027792 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000029367 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000141329 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000029367 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000138216 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AChE_tetra UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CarbesteraseB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carboxylesterase_B_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carboxylesterase_B_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cholinesterase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12038 UniProtKB/Swiss-Prot
MGD MGI:894278 ENTREZGENE
NCBI Gene 12038 ENTREZGENE
Pfam AChE_tetra UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  COesterase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB BCHE RGD
PhenoGen Bche PhenoGen
PRINTS CHOLNESTRASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CARBOXYLESTERASE_B_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CARBOXYLESTERASE_B_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0A6YVZ5_MOUSE UniProtKB/TrEMBL
  CHLE_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q499C7_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q543J3 UniProtKB/Swiss-Prot