Symbol:
Prkar2a
Name:
protein kinase, cAMP dependent regulatory, type II alpha
Description:
ENCODES a protein that exhibits beta-2 adrenergic receptor binding (ortholog); cAMP binding (ortholog); cAMP-dependent protein kinase inhibitor activity (ortholog); INVOLVED IN modulation of chemical synaptic transmission; negative regulation of cAMP-dependent protein kinase activity (ortholog); protein heterooligomerization (ortholog); PARTICIPATES IN protein kinase A (PKA) signaling pathway; apoptotic cell death pathway; insulin signaling pathway; ASSOCIATED WITH no abnormal phenotype detected; ASSOCIATED WITH congestive heart failure (ortholog); FOUND IN glutamatergic synapse; synapse; axoneme (ortholog); INTERACTS WITH 4-vinylcyclohexene dioxide; arsane; arsenic atom
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
1110061A24Rik; AI317181; AI836829; cAMP-dependent protein kinase type II-alpha regulatory subunit; RII(alpha)
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
PRKAR2A (protein kinase cAMP-dependent type II regulatory subunit alpha) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoMCL, Panther, Treefam
Rattus norvegicus (Norway rat):
Prkar2a (protein kinase cAMP-dependent type II regulatory subunit alpha) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Prkar2a (protein kinase cAMP-dependent type II regulatory subunit alpha) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
PRKAR2A (protein kinase cAMP-dependent type II regulatory subunit alpha) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
PRKAR2A (protein kinase cAMP-dependent type II regulatory subunit alpha) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Prkar2a (protein kinase cAMP-dependent type II regulatory subunit alpha) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
PRKAR2A (protein kinase cAMP-dependent type II regulatory subunit alpha) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
PRKAR2B (protein kinase cAMP-dependent type II regulatory subunit beta) HGNC
OrthoDB
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Prkar2a (protein kinase cAMP-dependent type II regulatory subunit alpha)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
PRKAR2A (protein kinase cAMP-dependent type II regulatory subunit alpha)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
prkar2ab (protein kinase, cAMP-dependent, regulatory, type II, alpha, B)
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER, PhylomeDB, TreeFam, ZFIN)
Danio rerio (zebrafish):
prkar2aa (protein kinase, cAMP-dependent, regulatory, type II, alpha A)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Saccharomyces cerevisiae (baker's yeast):
BCY1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Drosophila melanogaster (fruit fly):
Pka-R2
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 9 108,692,143 - 108,750,444 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 9 108,594,474 - 108,651,843 (+) NCBI GRCm37 mm9 NCBIm37 MGSCv36 9 108,549,547 - 108,606,735 (+) NCBI mm8 Celera 9 108,299,573 - 108,356,490 (+) NCBI Celera Cytogenetic Map 9 F2 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
(RS)-amphetamine affects response to substance ISO RGD:3393 6480464 PRKAR2A protein affects the susceptibility to Amphetamine CTD PMID:16896163 (RS)-amphetamine decreases expression ISO RGD:3393 6480464 Amphetamine results in decreased expression of PRKAR2A mRNA CTD PMID:30779732 (RS)-amphetamine increases expression ISO RGD:3393 6480464 Amphetamine results in increased expression of PRKAR2A mRNA, Amphetamine results in increased expression of PRKAR2A protein CTD PMID:16896163 (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE multiple interactions ISO RGD:3393 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of PRKAR2A mRNA CTD PMID:25729387 (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE decreases expression ISO RGD:3393 6480464 Topotecan results in decreased expression of PRKAR2A mRNA CTD PMID:25729387 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expression ISO RGD:732434 6480464 o, p'-DDT results in increased expression of PRKAR2A mRNA CTD PMID:19371625 17alpha-ethynylestradiol increases expression ISO RGD:3393 6480464 Ethinyl Estradiol results in increased expression of PRKAR2A mRNA CTD PMID:29097150 17beta-estradiol increases expression ISO RGD:732434 6480464 Estradiol results in increased expression of PRKAR2A mRNA CTD PMID:23019147 2-ethoxyethanol increases expression ISO RGD:3393 6480464 2-ethoxyethanol results in increased expression of PRKAR2A mRNA CTD PMID:19643169 2-methoxyethanol increases expression ISO RGD:3393 6480464 methyl cellosolve results in increased expression of PRKAR2A mRNA CTD PMID:19643169 3',5'-cyclic AMP multiple interactions ISO RGD:3393 6480464 Clozapine inhibits the reaction [Cyclic AMP binds to PRKAR2A protein], Haloperidol promotes the reaction [Cyclic AMP binds to PRKAR2A protein] CTD PMID:11907174 3-chloropropane-1,2-diol decreases expression ISO RGD:3393 6480464 alpha-Chlorohydrin analog results in decreased expression of PRKAR2A protein CTD PMID:26072098 3H-1,2-dithiole-3-thione increases expression ISO RGD:3393 6480464 1, 2-dithiol-3-thione results in increased expression of PRKAR2A mRNA CTD PMID:19162173 4-vinylcyclohexene dioxide affects expression EXP 6480464 4-vinyl-1-cyclohexene dioxide affects the expression of PRKAR2A mRNA CTD PMID:20829426 6-propyl-2-thiouracil increases expression ISO RGD:3393 6480464 Propylthiouracil results in increased expression of PRKAR2A mRNA CTD PMID:22504374 acrylamide decreases expression ISO RGD:3393 6480464 Acrylamide results in decreased expression of PRKAR2A mRNA CTD PMID:28959563 arsane decreases expression EXP 6480464 Arsenic results in decreased expression of PRKAR2A mRNA CTD PMID:19654921 arsenic atom decreases expression EXP 6480464 Arsenic results in decreased expression of PRKAR2A mRNA CTD PMID:19654921 arsenic(3+) decreases expression EXP 6480464 Arsenic results in decreased expression of PRKAR2A mRNA CTD PMID:19654921 benzo[a]pyrene increases expression ISO RGD:3393 6480464 Benzo(a)pyrene results in increased expression of PRKAR2A mRNA CTD PMID:21839799 bis(2-chloroethyl) sulfide increases phosphorylation ISO RGD:732434 6480464 Mustard Gas results in increased phosphorylation of PRKAR2A protein CTD PMID:19845377 bisphenol A increases expression ISO RGD:732434 6480464 bisphenol A results in increased expression of PRKAR2A mRNA CTD PMID:19371625 bisphenol A increases expression ISO RGD:3393 6480464 bisphenol A results in increased expression of PRKAR2A mRNA CTD PMID:29097150 bisphenol A decreases expression ISO RGD:3393 6480464 bisphenol A results in decreased expression of PRKAR2A mRNA CTD PMID:25181051 C60 fullerene decreases expression ISO RGD:3393 6480464 fullerene C60 results in decreased expression of PRKAR2A mRNA CTD PMID:19167457 cadmium dichloride increases expression ISO RGD:3393 6480464 Cadmium Chloride results in increased expression of PRKAR2A mRNA CTD PMID:25993096 carbon nanotube increases expression EXP 6480464 Nanotubes, Carbon analog results in increased expression of PRKAR2A mRNA, Nanotubes, Carbon results in increased expression of PRKAR2A mRNA CTD PMID:25554681 choline multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PRKAR2A gene CTD PMID:20938992 clozapine multiple interactions ISO RGD:3393 6480464 Clozapine inhibits the reaction [Cyclic AMP binds to PRKAR2A protein] CTD PMID:11907174 clozapine decreases expression ISO RGD:3393 6480464 Clozapine results in decreased expression of PRKAR2A mRNA, Clozapine results in decreased expression of PRKAR2A protein CTD PMID:11907174 cobalt dichloride decreases expression ISO RGD:732434 6480464 cobaltous chloride results in decreased expression of PRKAR2A mRNA CTD PMID:19320972 Colforsin dapropate hydrochloride increases phosphorylation ISO RGD:732434 6480464 Colforsin results in increased phosphorylation of PRKAR2A protein CTD PMID:25943029 deoxynivalenol increases phosphorylation EXP 6480464 deoxynivalenol results in increased phosphorylation of PRKAR2A protein CTD PMID:23352502 diazinon decreases expression ISO RGD:3393 6480464 Diazinon results in decreased expression of PRKAR2A mRNA CTD PMID:17452286 dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of PRKAR2A mRNA CTD PMID:21266533 dorsomorphin multiple interactions ISO RGD:732434 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKAR2A mRNA CTD PMID:27188386 doxorubicin affects expression ISO RGD:732434 6480464 Doxorubicin affects the expression of PRKAR2A protein CTD PMID:29385562 enzyme inhibitor multiple interactions ISO RGD:732434 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PRKAR2A protein CTD PMID:23301498 ethanol affects splicing EXP 6480464 Ethanol affects the splicing of PRKAR2A mRNA CTD PMID:30319688 folic acid multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PRKAR2A gene CTD PMID:20938992 genistein increases expression ISO RGD:732434 6480464 Genistein results in increased expression of PRKAR2A mRNA CTD PMID:19371625 haloperidol multiple interactions ISO RGD:3393 6480464 Haloperidol promotes the reaction [Cyclic AMP binds to PRKAR2A protein] CTD PMID:11907174 haloperidol increases expression ISO RGD:3393 6480464 Haloperidol results in increased expression of PRKAR2A mRNA, Haloperidol results in increased expression of PRKAR2A protein CTD PMID:11907174 L-methionine multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PRKAR2A gene CTD PMID:20938992 methapyrilene decreases expression ISO RGD:3393 6480464 Methapyrilene results in decreased expression of PRKAR2A mRNA CTD PMID:30467583 methimazole increases expression ISO RGD:3393 6480464 Methimazole results in increased expression of PRKAR2A mRNA CTD PMID:22504374 methoxychlor increases methylation ISO RGD:3393 6480464 Methoxychlor results in increased methylation of PRKAR2A gene CTD PMID:23303685 monocrotaline increases expression EXP 6480464 Monocrotaline results in increased expression of PRKAR2A mRNA CTD PMID:28818515 N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide multiple interactions ISO RGD:732434 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [resveratrol results in increased phosphorylation of PRKAR2A protein] CTD PMID:25943029 N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide decreases phosphorylation ISO RGD:732434 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased phosphorylation of PRKAR2A protein CTD PMID:25943029 N-nitrosodiethylamine multiple interactions ISO RGD:3393 6480464 [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PRKAR2A mRNA CTD PMID:20360939 oxaliplatin decreases expression ISO RGD:3393 6480464 oxaliplatin results in decreased expression of PRKAR2A mRNA CTD PMID:25729387 oxaliplatin multiple interactions ISO RGD:3393 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of PRKAR2A mRNA CTD PMID:25729387 paracetamol decreases expression ISO RGD:732434 6480464 Acetaminophen results in decreased expression of PRKAR2A mRNA CTD PMID:21420995 phenethyl caffeate multiple interactions ISO RGD:3393 6480464 [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PRKAR2A mRNA CTD PMID:20360939 phenylpropanolamine increases expression ISO RGD:3393 6480464 Phenylpropanolamine results in increased expression of PRKAR2A mRNA, Phenylpropanolamine results in increased expression of PRKAR2A protein CTD PMID:17684035 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of PRKAR2A mRNA CTD PMID:17426115 potassium dichromate increases expression EXP 6480464 Potassium Dichromate results in increased expression of PRKAR2A mRNA CTD PMID:23608068 quercetin multiple interactions EXP 6480464 Quercetin inhibits the reaction [POMC protein results in increased phosphorylation of PRKAR2A protein] CTD PMID:21290442 resveratrol increases expression ISO RGD:732434 6480464 resveratrol results in increased expression of PRKAR2A mRNA CTD PMID:19371625 resveratrol multiple interactions ISO RGD:732434 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [resveratrol results in increased phosphorylation of PRKAR2A protein] CTD PMID:25943029 resveratrol increases phosphorylation EXP 6480464 resveratrol results in increased phosphorylation of PRKAR2A protein CTD PMID:25943029 resveratrol increases phosphorylation ISO RGD:732434 6480464 resveratrol results in increased phosphorylation of PRKAR2A protein CTD PMID:25943029 SB 431542 multiple interactions ISO RGD:732434 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKAR2A mRNA CTD PMID:27188386 sodium fluoride increases expression EXP 6480464 Sodium Fluoride results in increased expression of PRKAR2A protein CTD PMID:28918527 Soman increases expression ISO RGD:3393 6480464 Soman results in increased expression of PRKAR2A mRNA CTD PMID:19281266 testosterone enanthate decreases expression ISO RGD:3393 6480464 testosterone enanthate results in decreased expression of PRKAR2A mRNA CTD PMID:25603467 testosterone enanthate affects expression ISO RGD:732434 6480464 testosterone enanthate affects the expression of PRKAR2A mRNA CTD PMID:17440010 tetrachloromethane affects expression EXP 6480464 Carbon Tetrachloride affects the expression of PRKAR2A mRNA CTD PMID:17484886 thioacetamide increases methylation ISO RGD:3393 6480464 Thioacetamide results in increased methylation of PRKAR2A promoter CTD PMID:27914986 topotecan multiple interactions ISO RGD:3393 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of PRKAR2A mRNA CTD PMID:25729387 topotecan decreases expression ISO RGD:3393 6480464 Topotecan results in decreased expression of PRKAR2A mRNA CTD PMID:25729387 triclosan decreases expression ISO RGD:732434 6480464 Triclosan results in decreased expression of PRKAR2A mRNA CTD PMID:30510588 trimellitic anhydride increases expression EXP 6480464 trimellitic anhydride results in increased expression of PRKAR2A mRNA CTD PMID:19042947 valproic acid increases expression ISO RGD:732434 6480464 Valproic Acid results in increased expression of PRKAR2A mRNA CTD PMID:23179753 , PMID:26272509 valproic acid multiple interactions ISO RGD:732434 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKAR2A mRNA CTD PMID:27188386 zearalenone increases expression ISO RGD:732434 6480464 Zearalenone results in increased expression of PRKAR2A mRNA CTD PMID:19371625 
Gene-Chemical Interaction Annotations
