Ddx3x (DEAD box helicase 3, X-linked) - Rat Genome Database

Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Ddx3x (DEAD box helicase 3, X-linked) Mus musculus
Analyze
Symbol: Ddx3x
Name: DEAD box helicase 3, X-linked
RGD ID: 1557808
MGI Page MGI
Description: Enables primary miRNA binding activity. Involved in positive regulation of NLRP3 inflammasome complex assembly and stress granule assembly. Acts upstream of or within with a negative effect on primary miRNA processing. Located in cytoplasmic stress granule. Part of NLRP3 inflammasome complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in colorectal cancer and syndromic X-linked intellectual disability. Orthologous to human DDX3X (DEAD-box helicase 3 X-linked).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ATP-dependent RNA helicase DDX3X; D-E-A-D (aspartate-glutamate-alanine-aspartate) box polypeptide 3; D1Pas; D1Pas1-related sequence 2; D1Pas1-rs2; Ddx3; DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 3; DEAD box protein 3, X-chromosomal; DEAD box RNA helicase DEAD3; DEAD-box protein 3 (DEAD-box RNA helicase DEAD3) (mDEAD3) (Embryonic RNA helicase) (D1PAS1 related sequence 2); DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked; embryonic RNA helicase; fibroblast growth factor inducible 14; Fin; Fin14; mDEAD3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X13,147,261 - 13,160,222 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX13,147,209 - 13,160,291 (+)EnsemblGRCm39 Ensembl
GRCm38X13,280,496 - 13,293,988 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX13,280,970 - 13,294,052 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X12,858,148 - 12,871,109 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X12,437,997 - 12,449,573 (+)NCBIMGSCv36mm8
CeleraX10,940,806 - 10,968,272 (+)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX8.17NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,6-dinitrotoluene  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (EXP)
6-bromoindirubin-3'-oxime  (ISO)
acetamide  (ISO)
acetazolamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
aloxistatin  (ISO)
alpha-pinene  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
C60 fullerene  (ISO)
caffeine  (ISO)
carbon nanotube  (EXP)
chloroquine  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
cylindrospermopsin  (ISO)
D-glucose  (ISO)
dibutyl phthalate  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP)
fenvalerate  (ISO)
flutamide  (ISO)
folic acid  (EXP)
fulvestrant  (ISO)
geldanamycin  (ISO)
gentamycin  (ISO)
glucose  (ISO)
hydrogen peroxide  (ISO)
hypochlorous acid  (EXP)
irinotecan  (ISO)
ivermectin  (ISO)
ketorolac  (ISO)
leflunomide  (ISO)
leupeptin  (ISO)
methidathion  (EXP)
methylparaben  (ISO)
ozone  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
phenol  (ISO)
piroxicam  (ISO)
poly(I:C)  (ISO)
pyrogallol  (EXP)
quizartinib  (ISO)
resveratrol  (EXP,ISO)
rimonabant  (EXP)
rottlerin  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP)
temozolomide  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA)
cell differentiation  (IBA)
cellular response to arsenic-containing substance  (ISO)
cellular response to osmotic stress  (ISO)
cellular response to virus  (ISO)
chromosome segregation  (ISO)
cytosolic ribosome assembly  (ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
gamete generation  (IBA)
immune system process  (IEA)
inflammatory response  (IEA)
innate immune response  (ISO)
intracellular signal transduction  (ISO)
intrinsic apoptotic signaling pathway  (ISO)
lipid homeostasis  (ISO)
negative regulation by host of viral genome replication  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
negative regulation of intrinsic apoptotic signaling pathway  (ISO)
negative regulation of NIK/NF-kappaB signaling  (ISO)
negative regulation of protein-containing complex assembly  (ISO)
negative regulation of translation  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of G1/S transition of mitotic cell cycle  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of interferon-alpha production  (ISO)
positive regulation of interferon-beta production  (ISO)
positive regulation of NIK/NF-kappaB signaling  (ISO)
positive regulation of NLRP3 inflammasome complex assembly  (IDA)
positive regulation of protein acetylation  (ISO)
positive regulation of protein autophosphorylation  (ISO)
positive regulation of protein K63-linked ubiquitination  (ISO)
positive regulation of protein serine/threonine kinase activity  (ISO)
positive regulation of toll-like receptor 7 signaling pathway  (ISO)
positive regulation of toll-like receptor 8 signaling pathway  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of translation  (ISO)
positive regulation of translation in response to endoplasmic reticulum stress  (ISO)
positive regulation of translational initiation  (ISO)
positive regulation of type I interferon production  (ISO)
positive regulation of viral genome replication  (ISO)
primary miRNA processing  (IDA,IMP)
protein localization to cytoplasmic stress granule  (ISO)
regulation of translation  (IEA)
response to virus  (ISO)
response to virus  (ISO)
ribosome biogenesis  (IEA)
RNA secondary structure unwinding  (ISO)
stress granule assembly  (IMP,ISO)
translational initiation  (ISO)
Wnt signaling pathway  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. DNA Damage, Liver Injury, and Tumorigenesis: Consequences of DDX3X Loss. Chan CH, etal., Mol Cancer Res. 2019 Feb;17(2):555-566. doi: 10.1158/1541-7786.MCR-18-0551. Epub 2018 Oct 8.
2. DDX3, a DEAD box RNA helicase, is deregulated in hepatitis virus-associated hepatocellular carcinoma and is involved in cell growth control. Chang PC, etal., Oncogene. 2006 Mar 30;25(14):1991-2003. doi: 10.1038/sj.onc.1209239.
3. Avenanthramide A triggers potent ROS-mediated anti-tumor effects in colorectal cancer by directly targeting DDX3. Fu R, etal., Cell Death Dis. 2019 Aug 7;10(8):593. doi: 10.1038/s41419-019-1825-5.
4. DDX3 promotes tumor invasion in colorectal cancer via the CK1ε/Dvl2 axis. He TY, etal., Sci Rep. 2016 Feb 19;6:21483. doi: 10.1038/srep21483.
5. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Ketorolac salt is a newly discovered DDX3 inhibitor to treat oral cancer. Samal SK, etal., Sci Rep. 2015 Apr 28;5:9982. doi: 10.1038/srep09982.
13. DDX3 as a strongest prognosis marker and its downregulation promotes metastasis in colorectal cancer. Su CY, etal., Oncotarget. 2015 Jul 30;6(21):18602-12.
14. Rottlerin upregulates DDX3 expression in hepatocellular carcinoma. Wang Z, etal., Biochem Biophys Res Commun. 2018 Jan 1;495(1):1503-1509. doi: 10.1016/j.bbrc.2017.11.198. Epub 2017 Dec 2.
15. DDX3 enhances oncogenic KRAS‑induced tumor invasion in colorectal cancer via the β‑catenin/ZEB1 axis. Wu DW, etal., Oncotarget. 2016 Apr 19;7(16):22687-99. doi: 10.18632/oncotarget.8143.
Additional References at PubMed
PMID:8144024   PMID:8649829   PMID:8661741   PMID:8948440   PMID:9021147   PMID:9693046   PMID:10349636   PMID:10859333   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12023983  
PMID:12477932   PMID:12904583   PMID:14681479   PMID:14729942   PMID:15782199   PMID:16107646   PMID:16141072   PMID:16141073   PMID:16728723   PMID:18307411   PMID:18495661   PMID:18583960  
PMID:19571810   PMID:21267068   PMID:21471155   PMID:21873635   PMID:22566683   PMID:22573614   PMID:22794259   PMID:24457600   PMID:26041499   PMID:26265008   PMID:26296893   PMID:26336360  
PMID:26370502   PMID:27179789   PMID:27656019   PMID:28671696   PMID:28784777   PMID:28819115   PMID:28855249   PMID:29530978   PMID:30475900   PMID:30531905   PMID:30613052   PMID:31330130  
PMID:31511697   PMID:32098917   PMID:32135084   PMID:32325033   PMID:32553121   PMID:32554809   PMID:33268895   PMID:33766561   PMID:34133714   PMID:34158847   PMID:34344536   PMID:34387860  
PMID:35451177   PMID:35460172   PMID:35762573   PMID:35815807   PMID:35920200   PMID:36242920  


Genomics

Comparative Map Data
Ddx3x
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X13,147,261 - 13,160,222 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX13,147,209 - 13,160,291 (+)EnsemblGRCm39 Ensembl
GRCm38X13,280,496 - 13,293,988 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX13,280,970 - 13,294,052 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X12,858,148 - 12,871,109 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X12,437,997 - 12,449,573 (+)NCBIMGSCv36mm8
CeleraX10,940,806 - 10,968,272 (+)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX8.17NCBI
DDX3X
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X41,333,308 - 41,364,472 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX41,333,348 - 41,364,472 (+)EnsemblGRCh38hg38GRCh38
GRCh37X41,192,561 - 41,223,725 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X41,077,595 - 41,094,471 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X40,948,904 - 40,979,978NCBI
CeleraX45,333,407 - 45,350,283 (+)NCBICelera
Cytogenetic MapXp11.4NCBI
HuRefX38,924,970 - 38,941,587 (+)NCBIHuRef
CHM1_1X41,225,367 - 41,242,242 (+)NCBICHM1_1
T2T-CHM13v2.0X40,735,393 - 40,766,556 (+)NCBIT2T-CHM13v2.0
Ddx3x
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X9,479,532 - 9,493,455 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX9,479,532 - 9,493,168 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX9,663,528 - 9,677,065 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X13,160,667 - 13,174,198 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X9,425,314 - 9,438,972 (-)NCBIRnor_WKY
Rnor_6.0X10,400,363 - 10,414,010 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX10,400,366 - 10,413,995 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X11,198,745 - 11,212,383 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X21,495,072 - 21,508,690 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX10,011,280 - 10,024,898 (-)NCBICelera
Cytogenetic MapXq12NCBI
Ddx3x
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555651,386,973 - 1,404,220 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555651,387,043 - 1,403,624 (-)NCBIChiLan1.0ChiLan1.0
DDX3X
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X41,474,515 - 41,491,479 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX41,475,116 - 41,505,837 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X33,780,381 - 33,796,829 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
DDX3X
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X35,759,367 - 35,789,759 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX35,759,416 - 35,789,774 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX23,107,814 - 23,138,223 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X35,809,592 - 35,840,330 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX35,809,593 - 35,840,343 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X35,887,325 - 35,918,053 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X35,859,851 - 35,889,927 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X35,902,946 - 35,933,679 (+)NCBIUU_Cfam_GSD_1.0
Ddx3x
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X27,967,669 - 27,979,844 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365027,804,824 - 7,820,569 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365027,770,896 - 7,820,555 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DDX3X
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX36,988,031 - 37,018,202 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X36,988,031 - 37,005,496 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X41,162,232 - 41,177,756 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DDX3X
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X38,513,251 - 38,539,982 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660763,696,930 - 3,714,667 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ddx3x
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476214,290,267 - 14,305,633 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476214,290,267 - 14,305,437 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1557
Count of miRNA genes:688
Interacting mature miRNAs:916
Transcripts:ENSMUST00000000804, ENSMUST00000123096, ENSMUST00000149639, ENSMUST00000153611, ENSMUST00000153851
Prediction methods:Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302195Pbwg10_mpostnatal body weight growth 10 (mouse)Not determinedX126202173Mouse
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse
1301551Spha1_msperm head anomaly 1 (mouse)Not determinedX1026622539921652Mouse
13208553Wght11_mweight 11 (mouse)X1186623959045360Mouse
13208557Lgth13_mbody length 13 (mouse)X1186623959045360Mouse

Markers in Region
RH127853  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X13,293,753 - 13,293,938UniSTSGRCm38
GRCm386102,936,289 - 102,936,474UniSTSGRCm38
MGSCv376102,886,283 - 102,886,468UniSTSGRCm37
MGSCv37X12,870,879 - 12,871,064UniSTSGRCm37
Celera6104,806,565 - 104,806,750UniSTS
CeleraX10,968,042 - 10,968,227UniSTS
Cytogenetic MapXA1.1UniSTS
L25126  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X13,291,566 - 13,291,668UniSTSGRCm38
MGSCv37X12,868,692 - 12,868,794UniSTSGRCm37
CeleraX10,965,855 - 10,965,957UniSTS
Cytogenetic MapXA1.1UniSTS
Whitehead_YACX UniSTS
Ddx3x  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X13,291,630 - 13,292,537UniSTSGRCm38
MGSCv37X12,868,756 - 12,869,663UniSTSGRCm37
CeleraX10,965,919 - 10,966,826UniSTS
Cytogenetic MapXA1.1UniSTS
U42386  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386102,937,032 - 102,937,182UniSTSGRCm38
GRCm38X13,293,045 - 13,293,195UniSTSGRCm38
MGSCv376102,887,026 - 102,887,176UniSTSGRCm37
MGSCv37X12,870,171 - 12,870,321UniSTSGRCm37
Celera6104,807,308 - 104,807,458UniSTS
CeleraX10,967,334 - 10,967,484UniSTS
Cytogenetic MapXA1.1UniSTS
Whitehead_YACX UniSTS
Ddx3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X13,293,719 - 13,293,898UniSTSGRCm38
MGSCv37X12,870,845 - 12,871,024UniSTSGRCm37
CeleraX10,968,008 - 10,968,187UniSTS
Cytogenetic MapXA1.1UniSTS
cM MapX UniSTS
cM Map17.0UniSTS
cM MapX UniSTS
DBX  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X13,293,649 - 13,293,736UniSTSGRCm38
GRCm386102,936,491 - 102,936,578UniSTSGRCm38
MGSCv376102,886,485 - 102,886,572UniSTSGRCm37
MGSCv37X12,870,775 - 12,870,862UniSTSGRCm37
Celera6104,806,767 - 104,806,854UniSTS
CeleraX10,967,938 - 10,968,025UniSTS
Cytogenetic MapXA1.1UniSTS
Fin14  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXA1.1UniSTS
cM Map642.0UniSTS
Ddx3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38127,991,957 - 27,992,232UniSTSGRCm38
GRCm38X13,291,664 - 13,291,936UniSTSGRCm38
MGSCv37128,048,802 - 28,049,077UniSTSGRCm37
MGSCv37X12,868,790 - 12,869,062UniSTSGRCm37
CeleraX10,965,953 - 10,966,225UniSTS
Celera127,768,749 - 27,769,024UniSTS
Cytogenetic MapXA1.1UniSTS
cM Map17.0UniSTS
Ddx3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X13,287,308 - 13,288,907UniSTSGRCm38
MGSCv37X12,864,434 - 12,866,033UniSTSGRCm37
Cytogenetic MapXA1.1UniSTS
cM MapX UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_010028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK002917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK013335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK140990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK176969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK182672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK188456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL833805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB854842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC067210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC083059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC150862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC172016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ858457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ858458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ858459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L25126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U42386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z38117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000000804   ⟹   ENSMUSP00000000804
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX13,147,209 - 13,160,291 (+)Ensembl
GRCm38.p6 EnsemblX13,280,970 - 13,294,052 (+)Ensembl
RefSeq Acc Id: ENSMUST00000123096
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX13,153,523 - 13,155,091 (+)Ensembl
GRCm38.p6 EnsemblX13,287,284 - 13,288,852 (+)Ensembl
RefSeq Acc Id: ENSMUST00000149639
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX13,154,024 - 13,156,154 (+)Ensembl
GRCm38.p6 EnsemblX13,287,785 - 13,289,915 (+)Ensembl
RefSeq Acc Id: ENSMUST00000153611
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX13,147,271 - 13,154,111 (+)Ensembl
GRCm38.p6 EnsemblX13,281,032 - 13,287,872 (+)Ensembl
RefSeq Acc Id: ENSMUST00000153851
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX13,147,261 - 13,158,261 (+)Ensembl
GRCm38.p6 EnsemblX13,281,022 - 13,292,022 (+)Ensembl
RefSeq Acc Id: NM_010028   ⟹   NP_034158
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X13,147,261 - 13,160,222 (+)NCBI
GRCm38X13,281,022 - 13,293,983 (+)NCBI
MGSCv37X12,858,148 - 12,871,109 (+)RGD
CeleraX10,940,806 - 10,968,272 (+)RGD
cM MapX ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034158   ⟸   NM_010028
- UniProtKB: O09143 (UniProtKB/Swiss-Prot),   Q62167 (UniProtKB/Swiss-Prot),   Q3TQX5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000000804   ⟸   ENSMUST00000000804
Protein Domains
DEAD-box RNA helicase Q   Helicase ATP-binding   Helicase C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62167-F1-model_v2 AlphaFold Q62167 1-662 view protein structure

Promoters
RGD ID:6845597
Promoter ID:MM_KWN:59636
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000041354,   OTTMUST00000041355,   OTTMUST00000041356
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X12,857,421 - 12,858,237 (+)MPROMDB
RGD ID:6848518
Promoter ID:MM_ACW:52763
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day6,   Kidney
Transcripts:DDX3X.JSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X12,861,541 - 12,862,522 (+)MPROMDB
RGD ID:6845598
Promoter ID:MM_KWN:59637
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   MEF_B6
Transcripts:OTTMUST00000041357,   OTTMUST00000041358
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X12,863,586 - 12,864,972 (+)MPROMDB
RGD ID:6845599
Promoter ID:MM_KWN:59638
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   Brain,   Kidney,   Liver,   Lung,   MEF_B6
Transcripts:UC009SRM.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X12,868,771 - 12,871,102 (+)MPROMDB
RGD ID:13680128
Promoter ID:EPDNEW_M24213
Type:multiple initiation site
Name:Ddx3x_1
Description:Mus musculus DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3,X-linked , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X13,281,022 - 13,281,082EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:103064 AgrOrtholog
Ensembl Genes ENSMUSG00000000787 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000000804 ENTREZGENE
  ENSMUSP00000000804.7 UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000000804 ENTREZGENE
  ENSMUST00000000804.7 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DEAD/DEAH_box_helicase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helicase_ATP-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helicase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNA-helicase_DEAD-box_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNA_helicase_DEAD_Q_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13205 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:103064 ENTREZGENE
NCBI Gene 13205 ENTREZGENE
PANTHER ATP-DEPENDENT RNA HELICASE DBP3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP-DEPENDENT RNA HELICASE DDX3X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DEAD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helicase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ddx3x PhenoGen
PROSITE DEAD_ATP_HELICASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HELICASE_ATP_BIND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HELICASE_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Q_MOTIF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DEXDc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HELICc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B7ZWF1_MOUSE UniProtKB/TrEMBL
  B9EKE9_MOUSE UniProtKB/TrEMBL
  DDX3X_MOUSE UniProtKB/Swiss-Prot
  O09143 ENTREZGENE
  Q3TQX5 ENTREZGENE, UniProtKB/TrEMBL
  Q62167 ENTREZGENE
UniProt Secondary O09060 UniProtKB/Swiss-Prot
  O09143 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-03-31 Ddx3x  DEAD box helicase 3, X-linked  Ddx3x  DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked  Symbol and/or name change 5135510 APPROVED