Hars1 (histidyl-tRNA synthetase 1)

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Gene: Hars1 (histidyl-tRNA synthetase 1) Mus musculus

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Symbol:

Hars1

Name:

histidyl-tRNA synthetase 1

RGD ID:

1617628

MGI Page

MGI

Description:

Predicted to enable several functions, including ATP binding activity; histidine-tRNA ligase activity; and protein homodimerization activity. Predicted to be involved in histidyl-tRNA aminoacylation and mitochondrial translation. Predicted to be located in cytoplasm. Predicted to be active in cytosol and mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease, axonal type 2W and Usher syndrome type 3B. Orthologous to human HARS1 (histidyl-tRNA synthetase 1).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Hars; hisRS; histidine tRNA ligase; histidine--tRNA ligase; histidine--tRNA ligase, cytoplasmic; histidyl-tRNA synthetase, cytoplasmic; MMH; MMHRS

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	HARS1 (histidyl-tRNA synthetase 1)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoMCL, Panther, Treefam
Rattus norvegicus (Norway rat):	Hars1 (histidyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Hars1 (histidyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	HARS1 (histidyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	HARS1 (histidyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Hars1 (histidyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	HARS1 (histidyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	HARS1 (histidyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Hars1 (histidyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	HARS2 (histidyl-tRNA synthetase 2, mitochondrial)	HGNC	OrthoMCL
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Hars1 (histidyl-tRNA synthetase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	HARS1 (histidyl-tRNA synthetase 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	hars (histidyl-tRNA synthetase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Saccharomyces cerevisiae (baker's yeast):	HTS1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	HisRS	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	hars-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	hars2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	hars1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)

Related Pseudogenes:

Gm15826

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	36,899,581 - 36,916,258 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	36,899,581 - 36,916,258 (-)	Ensembl		GRCm39 Ensembl
GRCm38	18	36,766,528 - 36,783,205 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	36,766,528 - 36,783,205 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	36,926,182 - 36,942,859 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	36,892,504 - 36,909,094 (-)	NCBI		MGSCv36	mm8
Celera	18	37,218,592 - 37,235,221 (-)	NCBI		Celera
Cytogenetic Map	18	B2	NCBI
cM Map	18	19.46	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autoimmune disease (ISO)

autosomal dominant intellectual developmental disorder 31 (ISO)

cerebellar ataxia (ISO)

Charcot-Marie-Tooth disease (ISO)

Charcot-Marie-Tooth disease, axonal type 2W (ISO)

distal myopathy (ISO)

Dysarthria (ISO)

familial adenomatous polyposis 1 (ISO)

Flatfoot (ISO)

fundus dystrophy (ISO)

genetic disease (ISO)

Hereditary Neoplastic Syndromes (ISO)

intellectual disability (ISO)

Joint Instability (ISO)

lung disease (ISO)

microcephaly (ISO)

Neurodevelopmental Disorders (ISO)

neuropathy (ISO)

nuclear type mitochondrial complex I deficiency 20 (ISO)

peripheral nervous system disease (ISO)

renal cell carcinoma (ISO)

retinitis pigmentosa-deafness syndrome (ISO)

scoliosis (ISO)

spastic ataxia (ISO)

Talipes Cavus (ISO)

Usher syndrome (ISO)

Usher syndrome type 3 (ISO)

Usher syndrome type 3B (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (ISO)

1,2-dimethylhydrazine (EXP)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

4,4'-sulfonyldiphenol (ISO)

acrolein (ISO)

acrylamide (ISO)

actinomycin D (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

aristolochic acid A (ISO)

arsenous acid (ISO)

azoxystrobin (ISO)

benzatropine (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

Brodifacoum (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (EXP,ISO)

chloropicrin (ISO)

chlorpyrifos (ISO)

chromium(6+) (EXP)

clobetasol (EXP)

clozapine (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

enzyme inhibitor (ISO)

flutamide (ISO)

folic acid (EXP)

glyphosate (ISO)

haloperidol (ISO)

imidacloprid (ISO)

ionomycin (ISO)

ivermectin (ISO)

nefazodone (ISO)

nimesulide (ISO)

Nutlin-3 (ISO)

oxaliplatin (ISO)

ozone (ISO)

paracetamol (EXP)

phorbol 13-acetate 12-myristate (ISO)

pyrogallol (EXP)

pyrrolidine dithiocarbamate (ISO)

selenium atom (ISO)

sodium arsenate (EXP)

sodium arsenite (ISO)

tamoxifen (EXP)

tetrachloromethane (EXP,ISO)

thiabendazole (ISO)

thioacetamide (ISO)

topotecan (ISO)

trimellitic anhydride (EXP)

valproic acid (ISO)

vinclozolin (ISO)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

histidyl-tRNA aminoacylation (IBA,ISO,ISS)

mitochondrial translation (IBA)

Cellular Component

cytoplasm (ISO,ISS)

cytosol (IBA,IEA,ISO)

mitochondrion (IBA)

Molecular Function

ATP binding (ISO,ISS)

histidine-tRNA ligase activity (IBA,ISO,ISS)

identical protein binding (IBA,ISO)

protein homodimerization activity (ISO,ISS)

RNA binding (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

histidine metabolic pathway (ISO)

histidinemia pathway (ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

deafness (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
2.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8889548	PMID:8921907	PMID:10349636	PMID:10922068	PMID:11042159	PMID:11076861	PMID:11217851	PMID:12466851	PMID:12477932	PMID:12520002	PMID:14610273	PMID:14681479
PMID:15782199	PMID:16141072	PMID:16141073	PMID:21267068	PMID:21677750	PMID:21873635	PMID:23842751	PMID:27534441	PMID:32325033	PMID:32554809	PMID:36114006	PMID:36738734

Genomics

Comparative Map Data

Hars1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	36,899,581 - 36,916,258 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	36,899,581 - 36,916,258 (-)	Ensembl		GRCm39 Ensembl
GRCm38	18	36,766,528 - 36,783,205 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	36,766,528 - 36,783,205 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	36,926,182 - 36,942,859 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	36,892,504 - 36,909,094 (-)	NCBI		MGSCv36	mm8
Celera	18	37,218,592 - 37,235,221 (-)	NCBI		Celera
Cytogenetic Map	18	B2	NCBI
cM Map	18	19.46	NCBI

HARS1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	140,673,905 - 140,691,370 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	140,673,035 - 140,691,537 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	140,053,490 - 140,070,955 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	140,033,674 - 140,051,155 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	140,033,674 - 140,051,155	NCBI
Celera	5	136,130,237 - 136,147,719 (-)	NCBI		Celera
Cytogenetic Map	5	q31.3	NCBI
HuRef	5	135,198,731 - 135,216,563 (-)	NCBI		HuRef
CHM1_1	5	139,486,739 - 139,504,562 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	141,199,302 - 141,216,757 (-)	NCBI		T2T-CHM13v2.0

Hars1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	28,655,669 - 28,672,712 (-)	NCBI		GRCr8
mRatBN7.2	18	28,381,649 - 28,398,699 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	28,381,655 - 28,398,740 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	28,508,798 - 28,525,835 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	29,270,872 - 29,287,915 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	28,606,100 - 28,623,139 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	29,611,545 - 29,629,087 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	29,611,547 - 29,629,087 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	29,315,352 - 29,332,458 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	29,467,648 - 29,483,037 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	29,494,295 - 29,509,683 (-)	NCBI
Celera	18	28,102,201 - 28,119,274 (-)	NCBI		Celera
Cytogenetic Map	18	p11	NCBI

Hars1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955418	19,346 - 30,514 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955418	19,346 - 30,514 (+)	NCBI	ChiLan1.0	ChiLan1.0

HARS1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	135,931,745 - 135,949,264 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	134,071,296 - 134,088,814 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	136,038,575 - 136,056,400 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	142,154,552 - 142,172,371 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	142,154,552 - 142,172,371 (-)	Ensembl	panpan1.1		panPan2

HARS1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	35,828,243 - 35,843,615 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	35,828,260 - 35,843,583 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	32,867,230 - 32,882,606 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	36,283,853 - 36,299,236 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	36,283,855 - 36,299,210 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	33,336,188 - 33,351,339 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	34,203,967 - 34,219,341 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	34,956,682 - 34,972,058 (-)	NCBI		UU_Cfam_GSD_1.0

Hars1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	151,986,346 - 152,001,170 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936531	9,610,306 - 9,625,551 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936531	9,610,335 - 9,625,203 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HARS1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	142,385,872 - 142,401,208 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	142,387,563 - 142,401,232 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	148,331,743 - 148,345,418 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HARS1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	43,307,573 - 43,324,140 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	43,307,415 - 43,323,767 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666034	34,533,071 - 34,576,958 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hars1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624743	33,423,342 - 33,435,721 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624743	33,424,705 - 33,435,767 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Hars1
589 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	84
Count of miRNA genes:	76
Interacting mature miRNAs:	80
Transcripts:	ENSMUST00000001416
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1558743	Kcal1_m	kilocalorie 1 (mouse)			Not determined		18	19018874	53018992	Mouse
1302163	Bmd16_m	bone mineral density 16 (mouse)			Not determined		18	29667914	63668060	Mouse
11532716	Sluc41c_m	susceptibility to lung cancer 41c (mouse)					18	22619914	56620127	Mouse
11532715	Sluc41b_m	susceptibility to lung cancer 41b (mouse)					18	22619914	56620127	Mouse
11041903	Lmr27_m	leishmaniasis resistance 27 (mouse)					18	36187567	45109518	Mouse
11532710	Sluc41a_m	susceptibility to lung cancer 41a (mouse)					18	22619914	56620127	Mouse
25823171	Hrsq10_m	host response to SARS QTL 10, D4% weight (mouse)					18	27241115	58827077	Mouse
11532709	Sluc41_m	susceptibility to lung cancer 41 (mouse)					18	20953694	57590708	Mouse
1301400	Lmr13_m	leishmaniasis resistance 13 (mouse)			Not determined		18	28109380	62109518	Mouse
25823174	Hrsq11_m	host response to SARS QTL 11, log titer (mouse)					18	27241115	58827077	Mouse
1300638	Im7_m	immunoregulatory 7 (mouse)			Not determined		18	19018874	53018992	Mouse
1558873	Hrtfm7_m	heart failure modifier 7 (mouse)			Not determined		18	8086964	42087106	Mouse
25823173	Hrsq12_m	host response to SARS QTL 12, hemorrhage (mouse)					18	24895881	78339555	Mouse
1300994	Pvcan3_m	protection against vaginal candidiasis 3 (mouse)			Not determined		18	16199640	50199776	Mouse
1301570	Sluc14_m	susceptibility to lung cancer 14 (mouse)			Not determined		18	22619914	56620127	Mouse
13504732	Cath6_m	carotid atherosclerosis 6 (mouse)					18	13637126	47637126	Mouse
1558849	W3q15_m	weight 3 weeks QTL 15 (mouse)			Not determined		18	5041119	61272643	Mouse
12880412	V125Dq12_m	vitamin D active form serum level QTL 12 (mouse)					18	30233067	64233067	Mouse
1301771	Pcyts6_m	plasmacytoma susceptibility 6 (mouse)			Not determined		18	35658632	69658851	Mouse
1300877	Adip8_m	adiposity 8 (mouse)			Not determined		18	22619914	56620127	Mouse
4141857	Mhysq5_m	male hybrid sterility QTL 5 (mouse)			Not determined			28130604	62130739	Mouse
1300685	Scc5_m	colon tumor susceptibility 5 (mouse)			Not determined		18	31988480	65988629	Mouse
4142366	Chlq10_m	circulating hormone level QTL 10 (mouse)			Not determined		18	36291022	70291180	Mouse
1301307	Phospq1_m	phospholipid QTL 1 (mouse)			Not determined		18	18139704	52139859	Mouse
1357690	Vtbt19_m	vertebral trabecular bone trait 19 (mouse)			Not determined		18	33091043	67091221	Mouse
4142031	Moen1_m	modifier of engrailed QTL 1 (mouse)			Not determined		18	24115560	58115730	Mouse
12904950	Smmq3_m	soleus muscle mass QTL 3 (mouse)					18	26056875	60056875	Mouse
25823167	Hrsq5_m	host response to SARS QTL 5, D3% weight (mouse)					18	27241115	58827077	Mouse
1357603	Mom3_m	modifier of Min 3 (mouse)			Not determined		18	14030023	67098962	Mouse
13463476	Hctq8_m	hematocrit QTL 8 (mouse)					18	21217580	55217727	Mouse
27226723	Tibw9_m	tibia width 9, proximal, 16 week (mouse)					18	3200000	60933072	Mouse

Markers in Region

Hars

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	18	36,766,933 - 36,767,297	UniSTS	GRCm38
MGSCv37	18	36,926,587 - 36,926,951	UniSTS	GRCm37
Celera	18	37,219,000 - 37,219,364	UniSTS
Cytogenetic Map	18	B2	UniSTS
cM Map	UN		UniSTS
cM Map	18		UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_008214	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC027740	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AI849599	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK011685	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK077437	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK088824	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK146922	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK150081	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK152329	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK166826	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK166892	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK185027	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK186917	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK188864	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK200496	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK211613	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC020088	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CA561201	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466557	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EU098100	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U39473	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSMUST00000001416 ⟹ ENSMUSP00000001416

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	18	36,899,581 - 36,916,258 (-)	Ensembl
GRCm38.p6 Ensembl	18	36,766,528 - 36,783,205 (-)	Ensembl

Ensembl Acc Id:

ENSMUST00000235494 ⟹ ENSMUSP00000157507

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	18	36,899,743 - 36,903,280 (-)	Ensembl
GRCm38.p6 Ensembl	18	36,766,690 - 36,770,227 (-)	Ensembl

Ensembl Acc Id:

ENSMUST00000235863 ⟹ ENSMUSP00000158246

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	18	36,906,616 - 36,916,175 (-)	Ensembl
GRCm38.p6 Ensembl	18	36,773,563 - 36,783,122 (-)	Ensembl

Ensembl Acc Id:

ENSMUST00000236395

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	18	36,906,286 - 36,916,173 (-)	Ensembl
GRCm38.p6 Ensembl	18	36,773,233 - 36,783,120 (-)	Ensembl

RefSeq Acc Id:

NM_008214 ⟹ NP_032240

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	18	36,899,581 - 36,916,258 (-)	NCBI
GRCm38	18	36,766,528 - 36,783,205 (-)	ENTREZGENE
MGSCv37	18	36,926,182 - 36,942,859 (-)	RGD
Celera	18	37,218,592 - 37,235,221 (-)	RGD
cM Map	18		ENTREZGENE

Sequence:

show sequence

CTCTAGGCACGAAAGCGGGGACTCGGTAACCGGAAGTCATCCGAACCTAGGCTGAGTCCACCAA
GGCGGGTTTTAGACAGCCGTCAGTTCCTGCTGGCAGGCAGGATGGCAGATCGTGCTGCTCTGGA
GGAGCTGGTACGACTCCAGGGAGCGCATGTGAGGGGCCTTAAGGAGCAGAAAGCGTCCGCTGAG
CAGATCGAGGAGGAGGTGACGAAACTCCTAAAACTGAAGGCACAGCTGGGCCAGGATGAAGGCA
AACAGAAGTTTGTGCTCAAAACCCCCAAGGGCACGAGAGACTATAGTCCCCGGCAGATGGCGGT
CCGGGAAAAGGTGTTTGATGTCATCATCCGCTGTTTCAAACGCCATGGAGCAGAAGTGATTGAT
ACACCTGTGTTTGAACTAAAGGAAACACTGACTGGAAAGTACGGAGAAGACTCAAAGCTTATCT
ATGACTTGAAGGACCAGGGTGGGGAGCTGCTGTCCCTCCGTTATGACCTTACTGTCCCTTTTGC
TCGCTATCTGGCAATGAATAAACTGACCAACATTAAACGCTACCATATAGCAAAGGTGTATCGC
CGGGACAACCCAGCTATGACCCGAGGCCGTTACCGTGAATTCTATCAATGCGATTTTGACATTG
CCGGACAGTTCGACCCCATGATTCCTGATGCAGAGTGCCTAAAGATTATGTGCGAGATCCTGAG
TTCACTTCAGATCGGCAACTTCCTGGTCAAGGTAAACGACAGGCGCATCCTAGATGGGATGTTT
GCTGTCTGTGGTGTTCCTGATAGCAAGTTCCGTACCATCTGCTCCTCGGTGGACAAGCTAGACA
AGGTTTCCTGGGAGGAAGTGAAGAATGAGATGGTGGGAGAGAAGGGCCTTGCACCGGAAGTGGC
TGATCGCATCGGGGACTATGTCCAGCAGCATGGTGGGGTTTCTCTGGTGGAGCAGTTACTGCAG
GATCCTAAACTCTCCCAAAACAAACAGGCTGTAGAGGGCTTGGGAGACCTAAAGCTGCTCTTTG
AGTATCTAATCCTGTTTGGCATTGATGACAAGATCTCCTTTGACCTGAGCCTTGCTCGGGGGCT
AGACTACTATACTGGGGTCATCTATGAGGCAGTGCTGCTACAGATGCCAACCCAAGCTGGGGAA
GAGCCCCTGGGTGTGGGCAGCATAGCTGCTGGAGGGCGCTACGATGGCCTGGTTGGCATGTTTG
ACCCCAAGGGGCGCAAGGTGCCATGCGTTGGGCTCAGTATTGGAGTGGAGCGGATCTTTTCCAT
TGTAGAGCAAAGATTAGAGGCTTCAGAGGAAAAGGTACGGACCACAGAGACGCAGGTGCTTGTG
GCATCTGCACAGAAGAAGCTGCTGGAGGAGAGACTGAAGCTTGTCTCAGAGTTATGGGATGCTG
GGATCAAGGCTGAGCTGCTGTACAAGAAGAACCCGAAGTTACTAAACCAGTTGCAGTACTGTGA
GGAGGCAGGCATCCCACTGGTGGCCATCATTGGTGAGCAGGAACTCAAGGATGGCGTCATCAAG
CTCCGCTCGGTGGCCAGCAGAGAGGAGGTGGATGTCCGAAGAGAAGACCTTGTGGAGGAAATCA
GAAGAAGAACAAATCAGCCCCTCTCCACCTGCTGAGCTGAGCAAACCAGTAGAGGAAACAGGAT
TGATCTTAACTGAACGAAAACAAAACTGCATATGTACTTAAACAGTCTGCATATTTGCCATCCA
GCAGAAGACTGAAGGGTGGTCAGAACAGAGGCTTTTTGTTTTTTGTTTTTTTGTTTTTGTTTTT
ATTATTATGTTATCAGTAATCACTGGCAAAAAAAAAAAAAACAATGGCCAGGTACTACACTGTC
GGGGATTATAGGTGGACTAACCACGTCTCTGCCTCCTAAATTCCTGTATGGACTTGAGATGGCT
TCATTGAAAAACCACACGGCAGATGAACAACCTATGGCCAAAACGTCCAATAAATGTCTCTACC
GCTAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_032240	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC52914	(Get FASTA)	NCBI Sequence Viewer
	AAH20088	(Get FASTA)	NCBI Sequence Viewer
	ABU96465	(Get FASTA)	NCBI Sequence Viewer
	BAB27775	(Get FASTA)	NCBI Sequence Viewer
	BAC40595	(Get FASTA)	NCBI Sequence Viewer
	BAE27533	(Get FASTA)	NCBI Sequence Viewer
	BAE29290	(Get FASTA)	NCBI Sequence Viewer
	BAE31128	(Get FASTA)	NCBI Sequence Viewer
	BAE39050	(Get FASTA)	NCBI Sequence Viewer
	BAE39097	(Get FASTA)	NCBI Sequence Viewer
	EDK97179	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000001416
	ENSMUSP00000001416.7
	ENSMUSP00000157507.2
	ENSMUSP00000158246.2
GenBank Protein	Q61035	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_032240 ⟸ NM_008214

- UniProtKB:

Q3TKU3 (UniProtKB/Swiss-Prot), Q61035 (UniProtKB/Swiss-Prot), Q3U890 (UniProtKB/TrEMBL), Q3UDH1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MADRAALEELVRLQGAHVRGLKEQKASAEQIEEEVTKLLKLKAQLGQDEGKQKFVLKTPKGTRD
YSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLTGKYGEDSKLIYDLKDQGGELLSLR
YDLTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRYREFYQCDFDIAGQFDPMIPDAECL
KIMCEILSSLQIGNFLVKVNDRRILDGMFAVCGVPDSKFRTICSSVDKLDKVSWEEVKNEMVGE
KGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNKQAVEGLGDLKLLFEYLILFGIDDKISF
DLSLARGLDYYTGVIYEAVLLQMPTQAGEEPLGVGSIAAGGRYDGLVGMFDPKGRKVPCVGLSI
GVERIFSIVEQRLEASEEKVRTTETQVLVASAQKKLLEERLKLVSELWDAGIKAELLYKKNPKL
LNQLQYCEEAGIPLVAIIGEQELKDGVIKLRSVASREEVDVRREDLVEEIRRRTNQPLSTC

hide sequence

Ensembl Acc Id:

ENSMUSP00000001416 ⟸ ENSMUST00000001416

Ensembl Acc Id:

ENSMUSP00000158246 ⟸ ENSMUST00000235863

Ensembl Acc Id:

ENSMUSP00000157507 ⟸ ENSMUST00000235494

Protein Domains

Aminoacyl-transfer RNA synthetases class-II family WHEP-TRS

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q61035-F1-model_v2	AlphaFold	Q61035	1-509	view protein structure

Promoters

RGD ID:

13677492

Promoter ID:

EPDNEW_M22895

Type:

initiation region

Name:

Hars_1

Description:

Mus musculus histidyl-tRNA synthetase , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	18	36,783,123 - 36,783,183	EPDNEW

RGD ID:

6829298

Promoter ID:

MM_KWN:24991

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day3, 3T3L1_Day4, BoneMarrow_2Hour, Brain, Kidney, Liver

Transcripts:

NM_008214, UC008EOQ.1

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	18	36,942,536 - 36,943,036 (-)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:108087	AgrOrtholog
Ensembl Genes	ENSMUSG00000001380	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000001416	ENTREZGENE
	ENSMUST00000001416.8	UniProtKB/Swiss-Prot
	ENSMUST00000235494.2	UniProtKB/TrEMBL
	ENSMUST00000235863.2	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.800	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	S15/NS1, RNA-binding	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	aa-tRNA-synth_II	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	aa-tRNA-synth_II/BPL/LPL	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Anticodon-bd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Anticodon-bd_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	His-tRNA-ligase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HisRS-like_core	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HisRS/HisZ	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HisRS_anticodon	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	S15_NS1_RNA-bd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	WHEP-TRS_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:15115	UniProtKB/Swiss-Prot
MGD	MGI:108087	ENTREZGENE
NCBI Gene	15115	ENTREZGENE
PANTHER	HISTIDINE--TRNA LIGASE, CYTOPLASMIC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HISTIDYL-TRNA SYNTHETASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	HGTP_anticodon	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	tRNA-synt_His	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	WHEP-TRS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Hars1	PhenoGen
PIRSF	His-tRNA_synth	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	AA_TRNA_LIGASE_II	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	WHEP_TRS_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	WHEP_TRS_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	WHEP-TRS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Class II aaRS ABD-related	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF47060	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF55681	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A494B9A1_MOUSE	UniProtKB/TrEMBL
	A0A494BAV2_MOUSE	UniProtKB/TrEMBL
	Q3TKU3	ENTREZGENE
	Q3U890	ENTREZGENE, UniProtKB/TrEMBL
	Q3UDH1	ENTREZGENE, UniProtKB/TrEMBL
	Q61035	ENTREZGENE
	Q8C2D1_MOUSE	UniProtKB/TrEMBL
	Q8VDX8_MOUSE	UniProtKB/TrEMBL
	Q9D094_MOUSE	UniProtKB/TrEMBL
	SYHC_MOUSE	UniProtKB/Swiss-Prot
UniProt Secondary	Q3TKU3	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2023-04-17	Hars1	histidyl-tRNA synthetase 1	Hars	histidyl-tRNA synthetase	Symbol and/or name updated	27372883	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

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Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

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