Gad2 (glutamic acid decarboxylase 2) - Rat Genome Database

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Gene: Gad2 (glutamic acid decarboxylase 2) Mus musculus
Analyze
Symbol: Gad2
Name: glutamic acid decarboxylase 2
RGD ID: 10616
MGI Page MGI
Description: Predicted to enable glutamate binding activity; glutamate decarboxylase activity; and pyridoxal phosphate binding activity. Predicted to be involved in gamma-aminobutyric acid biosynthetic process and glutamate decarboxylation to succinate. Located in axon; cytoplasm; and synapse. Is expressed in several structures, including central nervous system; genitourinary system; gut; heart; and sensory organ. Used to study epilepsy and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; amphetamine abuse; diabetes mellitus (multiple); drug psychosis; and heroin dependence. Orthologous to human GAD2 (glutamate decarboxylase 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 6330404F12Rik; 65 kDa glutamic acid decarboxylase; GAD(65; GAD(65); Gad-; Gad-2; GAD-65; GAD6; GAD65; glutamate decarboxylase 2; glutamate decarboxylase 65 kDa isoform
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39222,512,262 - 22,583,889 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl222,512,217 - 22,583,886 (+)EnsemblGRCm39 Ensembl
GRCm38222,621,015 - 22,693,877 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl222,622,205 - 22,693,874 (+)EnsemblGRCm38mm10GRCm38
MGSCv37222,477,847 - 22,549,397 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36222,473,967 - 22,542,641 (+)NCBIMGSCv36mm8
Celera222,352,193 - 22,424,544 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map215.15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(aminooxy)acetic acid  (ISO)
(S)-nicotine  (ISO)
17alpha-ethynylestradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-mercaptopropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-aminopyridine  (ISO)
6-propyl-2-thiouracil  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP)
amitraz  (ISO)
ammonium chloride  (ISO)
Aroclor 1254  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
Brodifacoum  (ISO)
bromobenzene  (ISO)
chlorpyrifos  (ISO)
clozapine  (EXP,ISO)
Cyclopamine  (EXP)
dexamethasone  (ISO)
diazepam  (ISO)
diazinon  (ISO)
dichloroacetic acid  (EXP)
diisopropyl fluorophosphate  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
ethanol  (EXP)
ethylparaben  (ISO)
fenamidone  (EXP)
fluoxetine  (ISO)
gamma-aminobutyric acid  (ISO)
glyphosate  (ISO)
haloperidol  (ISO)
hexadecanoic acid  (ISO)
hydrazine  (ISO)
idazoxan  (ISO)
kainic acid  (ISO)
L-glutamic acid  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
malathion  (ISO)
methamphetamine  (ISO)
methylmercury chloride  (EXP)
Mipafox  (ISO)
monosodium L-glutamate  (ISO)
morphine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-ethylmaleimide  (ISO)
nicotine  (ISO)
Nonylphenol  (ISO)
olanzapine  (ISO)
oxidopamine  (ISO)
panobinostat  (ISO)
paraoxon  (ISO)
paraquat  (ISO)
pentetrazol  (EXP)
phencyclidine  (EXP)
phenylmercury acetate  (ISO)
picrotoxin  (EXP,ISO)
pyridoxal 5'-phosphate  (ISO)
sarin  (ISO)
SB 431542  (ISO)
sevoflurane  (EXP)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
tamoxifen  (EXP)
tributylstannane  (ISO)
triphenyl phosphate  (ISO)
triptonide  (EXP)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (ISO)
VX nerve agent  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal associative learning  (IAGP)
abnormal behavior  (IEA)
abnormal CNS synaptic transmission  (IAGP)
abnormal GABAergic neuron physiology  (IAGP)
abnormal inhibitory postsynaptic currents  (IAGP)
abnormal nerve fiber response  (IAGP)
abnormal nervous system electrophysiology  (IAGP)
cleft palate  (IAGP)
decreased aggression towards male mice  (IAGP)
decreased body weight  (IAGP)
decreased exploration in new environment  (IEA)
decreased gamma-aminobutyric acid level  (IAGP)
decreased locomotor activity  (IEA)
decreased prepulse inhibition  (IEA)
decreased respiratory quotient  (IEA)
decreased susceptibility to pharmacologically induced seizures  (IAGP)
impaired ability to fire action potentials  (IAGP)
impaired contextual conditioning behavior  (IAGP)
impaired cued conditioning behavior  (IAGP)
impaired glucose tolerance  (IEA)
increased anxiety-related response  (IAGP)
increased circulating alkaline phosphatase level  (IEA)
increased circulating chloride level  (IEA)
increased circulating glucose level  (IAGP)
increased circulating sodium level  (IEA)
increased coping response  (IAGP)
increased excitatory postsynaptic current amplitude  (IAGP)
increased fasting circulating glucose level  (IEA)
increased thigmotaxis  (IEA)
increased vertical activity  (IEA)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
myoclonus  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IEA)
omphalocele  (IAGP)
pancreas inflammation  (IAGP)
premature death  (IAGP)
primary atelectasis  (IAGP)
respiratory failure  (IAGP)
seizures  (IAGP)
tonic-clonic seizures  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Differential adaptations in GABAergic and glutamatergic systems during ethanol withdrawal in male and female rats. Alele PE and Devaud LL, Alcohol Clin Exp Res. 2005 Jun;29(6):1027-34.
2. Mice lacking the 65 kDa isoform of glutamic acid decarboxylase (GAD65) maintain normal levels of GAD67 and GABA in their brains but are susceptible to seizures. Asada H, etal., Biochem Biophys Res Commun 1996 Dec 24;229(3):891-5.
3. Cleft palate in mice with a targeted mutation in the gamma-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67. Condie BG, etal., Proc Natl Acad Sci U S A 1997 Oct 14;94(21):11451-5.
4. Modulation of diabetes in NOD mice by GAD65-specific monoclonal antibodies is epitope specific and accompanied by anti-idiotypic antibodies. Hall TR, etal., Immunology. 2008 Apr;123(4):547-54. Epub 2007 Nov 14.
5. Induction of anti-whole GAD65 reactivity in vivo results in disease suppression in type 1 diabetes. Kanazawa Y, etal., J Autoimmun. 2009 Mar;32(2):104-9. Epub 2009 Feb 1.
6. Characterization of hydroxyl radical modified GAD65: a potential autoantigen in type 1 diabetes. Khan MW, etal., Autoimmunity. 2009 Feb;42(2):150-8.
7. Mutation screen of the GAD2 gene and association study of alcoholism in three populations. Lappalainen J, etal., Am J Med Genet B Neuropsychiatr Genet. 2007 Mar 5;144B(2):183-92. doi: 10.1002/ajmg.b.30377.
8. Heroin addiction in African Americans: a hypothesis-driven association study. Levran O, etal., Genes Brain Behav. 2009 Jul;8(5):531-40. Epub 2009 Jun 20.
9. Increased GAD expression in the striatum after transient cerebral ischemia. Li Y, etal., Mol Cell Neurosci. 2010 Dec;45(4):370-7. doi: 10.1016/j.mcn.2010.07.010. Epub 2010 Jul 24.
10. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
11. MGDs mouse GO annotations MGD data from the GO Consortium
12. MGD IEA MGD IEA
13. Autoimmunity in gestational diabetes mellitus in Sardinia: a preliminary case-control report. Murgia C, etal., Reprod Biol Endocrinol. 2008 Jun 29;6:24.
14. Increased anxiety-like behaviour and altered GABAergic system in the amygdala and cerebellum of VPA rats - An animal model of autism. Olexová L, etal., Neurosci Lett. 2016 Aug 26;629:9-14. doi: 10.1016/j.neulet.2016.06.035. Epub 2016 Jun 25.
15. Pancreatic Islet Autoantibodies as Predictors of Type 1 Diabetes in the Diabetes Prevention Trial-Type 1 (DPT-1). Orban T, etal., Diabetes Care. 2009 Sep 9.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. Mouse MP Annotation Import Pipeline RGD automated import pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Increased density of GAD65/67 immunoreactive neurons in the posterior subiculum and parahippocampal gyrus in treated patients with chronic schizophrenia. Schreiber S, etal., World J Biol Psychiatry. 2011 Feb;12(1):57-65. Epub 2011 Jan 20.
21. Expression of plasma membrane GABA transporters but not of the vesicular GABA transporter in dentate granule cells after kainic acid seizures. Sperk G, etal., Hippocampus. 2003;13(7):806-15. doi: 10.1002/hipo.10133.
22. Association of polymorphisms in GAD1 and GAD2 genes with methamphetamine dependence. Veerasakul S, etal., Pharmacogenomics. 2017 Jan;18(1):17-22. doi: 10.2217/pgs-2016-0101. Epub 2016 Dec 14.
Additional References at PubMed
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PMID:35512705   PMID:35535852   PMID:35545672   PMID:35589394   PMID:35615067   PMID:35672398   PMID:35687680   PMID:35700056   PMID:35705957   PMID:35716006   PMID:35794483   PMID:35858542  
PMID:35896744   PMID:35910255   PMID:35926459   PMID:35975980   PMID:36030255   PMID:36067316   PMID:36070775   PMID:36130507   PMID:36152627   PMID:36170850   PMID:36260661   PMID:36317965  
PMID:36334588   PMID:36351404   PMID:36371399   PMID:36394958   PMID:36417873   PMID:36610397   PMID:36614104   PMID:36650535   PMID:36670467   PMID:36768252   PMID:36774552   PMID:36801399  
PMID:36875016   PMID:36924980   PMID:37001500   PMID:37086721   PMID:37198238   PMID:37210550   PMID:37216370   PMID:37230180   PMID:37254876   PMID:37298722   PMID:37389991   PMID:37414552  
PMID:37590135   PMID:37624694   PMID:37647395   PMID:37659408   PMID:37704057   PMID:37759737   PMID:37838945   PMID:38089586   PMID:38134920   PMID:38242692   PMID:38388443   PMID:38505753  
PMID:38523779  


Genomics

Comparative Map Data
Gad2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39222,512,262 - 22,583,889 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl222,512,217 - 22,583,886 (+)EnsemblGRCm39 Ensembl
GRCm38222,621,015 - 22,693,877 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl222,622,205 - 22,693,874 (+)EnsemblGRCm38mm10GRCm38
MGSCv37222,477,847 - 22,549,397 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36222,473,967 - 22,542,641 (+)NCBIMGSCv36mm8
Celera222,352,193 - 22,424,544 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map215.15NCBI
GAD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381026,216,372 - 26,304,558 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1026,216,665 - 26,304,558 (+)EnsemblGRCh38hg38GRCh38
GRCh371026,505,301 - 26,593,487 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361026,545,600 - 26,633,493 (+)NCBINCBI36Build 36hg18NCBI36
Build 341026,545,599 - 26,633,493NCBI
Celera1026,216,982 - 26,305,252 (+)NCBICelera
Cytogenetic Map10p12.1NCBI
HuRef1026,164,647 - 26,252,919 (+)NCBIHuRef
CHM1_11026,506,137 - 26,594,390 (+)NCBICHM1_1
T2T-CHM13v2.01026,240,884 - 26,329,300 (+)NCBIT2T-CHM13v2.0
Gad2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81789,671,718 - 89,734,246 (+)NCBIGRCr8
mRatBN7.21784,763,630 - 84,826,155 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1784,763,628 - 84,826,155 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1788,243,822 - 88,306,313 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01792,079,214 - 92,141,706 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01786,096,016 - 86,158,509 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01789,171,576 - 89,234,770 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1789,171,250 - 89,238,040 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01790,851,699 - 90,914,893 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41796,259,430 - 96,321,857 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11796,270,262 - 96,332,686 (+)NCBI
Celera1784,065,137 - 84,127,559 (-)NCBICelera
RH 3.4 Map17841.1RGD
Cytogenetic Map17q12.3NCBI
Gad2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554293,096,453 - 3,169,259 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554293,092,977 - 3,170,128 (-)NCBIChiLan1.0ChiLan1.0
GAD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2838,914,567 - 39,001,884 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11038,919,890 - 39,007,209 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01026,392,877 - 26,481,859 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11026,757,877 - 26,843,647 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1026,759,243 - 26,843,197 (+)Ensemblpanpan1.1panPan2
GAD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.127,365,708 - 7,450,893 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl27,365,283 - 7,450,893 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha26,118,684 - 6,180,324 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.025,562,197 - 5,647,420 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl25,558,766 - 5,648,257 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.124,932,241 - 5,017,384 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.025,011,639 - 5,096,787 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.025,177,275 - 5,262,494 (-)NCBIUU_Cfam_GSD_1.0
Gad2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934425,572,699 - 25,645,221 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364841,737,520 - 1,810,398 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364841,737,806 - 1,810,378 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GAD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1049,313,647 - 49,390,926 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11049,316,682 - 49,391,013 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21054,614,739 - 54,689,368 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GAD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1925,906,047 - 25,993,715 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl925,906,103 - 25,995,489 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605131,891,428 - 31,980,135 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gad2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247962,703,614 - 2,771,555 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247962,700,443 - 2,771,757 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gad2
1223 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1416
Count of miRNA genes:659
Interacting mature miRNAs:847
Transcripts:ENSMUST00000028123, ENSMUST00000156728
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141836Tgq11_mtriglyceride QTL 11 (mouse)Not determined125324559Mouse
4142333Tgq10_mtriglyceride QTL 10 (mouse)Not determined125324559Mouse
1301838Sluc16_msusceptibility to lung cancer 16 (mouse)Not determined2126529589Mouse
12904743Carcdq3_mcardiac collagen deposition QTL 3 (mouse)2323494028179150Mouse
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
1301980Fcsa5_mfemoral cross-sectional area 5 (mouse)Not determined2767911541679261Mouse
1301790Pcfm1_mperiosteal circumference and femur length 1 (mouse)Not determined2823629642236396Mouse
10043876Adip22_madiposity 22 (mouse)Not determined2830805142308240Mouse
1300624Insq7_minsulin QTL 7 (mouse)Not determined2938444643384575Mouse
10755513Amzn4_manatomical modifier of Zfp423 4 (mouse)2938444643384575Mouse
12903993Opfaq1_mopen field activity QTL 1 (mouse)2967669127022642Mouse
8552707Cia23_mcollagen induced arthritis QTL 23 (mouse)Not determined21212953766556453Mouse
1301641Sbmd2_mspinal bone mineral density 2 (mouse)Not determined21421456748214713Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1301376Etohc1_methanol consumption 1 (mouse)Not determined22112972555129871Mouse
4141708Pbwg1.2_mpostnatal body weight growth 1.2 (mouse)Not determined2112972555129871Mouse

Markers in Region
Gad2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37222,545,740 - 22,545,868UniSTSGRCm37
MGSCv37222,547,923 - 22,548,831UniSTSGRCm37
Celera222,420,881 - 22,421,009UniSTS
Celera222,423,064 - 22,423,978UniSTS
Cytogenetic Map2A3UniSTS
cM Map29.0UniSTS
cM Map29.0UniSTS
MARC_35149-35150:1060024542:1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38222,684,968 - 22,685,457UniSTSGRCm38
MGSCv37222,540,488 - 22,540,977UniSTSGRCm37
Celera222,415,541 - 22,416,030UniSTS
Cytogenetic Map2A3UniSTS
cM Map29.0UniSTS
D10Mit157.2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6D1UniSTS
Cytogenetic Map16B4UniSTS
Cytogenetic Map18E2UniSTS
Cytogenetic Map4C3UniSTS
Cytogenetic Map7B2UniSTS
Cytogenetic Map4D2.3UniSTS
Cytogenetic Map11E1UniSTS
Cytogenetic Map14E2.2UniSTS
Cytogenetic Map4C7UniSTS
Cytogenetic Map2H4UniSTS
Cytogenetic Map1FUniSTS
Cytogenetic Map6C3UniSTS
Cytogenetic Map11DUniSTS
Cytogenetic Map3G2UniSTS
Cytogenetic Map17A1UniSTS
Cytogenetic Map9F2UniSTS
Cytogenetic Map12F1UniSTS
Cytogenetic Map19C2UniSTS
Cytogenetic Map3BUniSTS
Cytogenetic Map8C1UniSTS
Cytogenetic Map18A2UniSTS
Cytogenetic Map3F2UniSTS
Cytogenetic Map14C3UniSTS
Cytogenetic Map8E1UniSTS
Cytogenetic Map8E2UniSTS
Cytogenetic Map5B1UniSTS
Cytogenetic Map18B1UniSTS
Cytogenetic Map9CUniSTS
Cytogenetic Map14C2UniSTS
Cytogenetic Map6A1UniSTS
Cytogenetic Map10B4UniSTS
Cytogenetic Map13D2.1UniSTS
Cytogenetic Map5E5UniSTS
Cytogenetic Map11B1.3UniSTS
Cytogenetic Map4D1UniSTS
Cytogenetic Map9A5.2UniSTS
Cytogenetic Map3F1UniSTS
Cytogenetic Map17E3UniSTS
Cytogenetic Map11B3UniSTS
Cytogenetic Map1H4UniSTS
Cytogenetic Map6A3UniSTS
Cytogenetic Map5E4-E5UniSTS
Cytogenetic Map15E1UniSTS
Cytogenetic Map13DUniSTS
Cytogenetic Map14BUniSTS
Cytogenetic Map14D1UniSTS
Cytogenetic Map7B4UniSTS
Cytogenetic Map8D3UniSTS
Cytogenetic MapXDUniSTS
Cytogenetic Map17A3.3UniSTS
Cytogenetic Map7E2UniSTS
Cytogenetic Map1H2.3UniSTS
Cytogenetic Map7A2UniSTS
Cytogenetic Map7F3UniSTS
Cytogenetic Map9F1UniSTS
Cytogenetic Map10C1UniSTS
Cytogenetic Map4E2UniSTS
Cytogenetic Map16A1UniSTS
Cytogenetic Map8B3.3UniSTS
Cytogenetic Map8D2UniSTS
Cytogenetic Map3DUniSTS
Cytogenetic Map15D2UniSTS
Cytogenetic Map17B1UniSTS
Cytogenetic Map7A3UniSTS
Cytogenetic Map15F1UniSTS
Cytogenetic Map16B2UniSTS
Cytogenetic Map7CUniSTS
Cytogenetic Map3F2.1UniSTS
Cytogenetic Map6F3UniSTS
Cytogenetic Map1C4UniSTS
Cytogenetic Map11E2UniSTS
Cytogenetic Map11B5UniSTS
Cytogenetic Map9F3UniSTS
Cytogenetic Map2BUniSTS
Cytogenetic Map13B3UniSTS
Cytogenetic Map9A4UniSTS
Cytogenetic Map5A3UniSTS
Cytogenetic Map2H1UniSTS
Cytogenetic Map16B1UniSTS
Cytogenetic Map1A5UniSTS
Cytogenetic Map11CUniSTS
Cytogenetic Map9E1UniSTS
Cytogenetic Map6G1UniSTS
Cytogenetic MapXA2UniSTS
Cytogenetic Map13B1UniSTS
Cytogenetic Map5E2UniSTS
Cytogenetic Map12C1UniSTS
Cytogenetic Map5FUniSTS
Cytogenetic Map4D3UniSTS
Cytogenetic Map10C2UniSTS
Cytogenetic Map9BUniSTS
Cytogenetic Map5G2UniSTS
Cytogenetic Map7F1UniSTS
Cytogenetic Map12C3UniSTS
Cytogenetic Map10A4UniSTS
Cytogenetic Map8A2UniSTS
Cytogenetic Map18A1UniSTS
Cytogenetic Map12A1.1UniSTS
Cytogenetic Map1C2UniSTS
Cytogenetic Map11B2UniSTS
Cytogenetic Map6E3UniSTS
Cytogenetic Map5C3.3UniSTS
Cytogenetic Map1BUniSTS
Cytogenetic Map17A3.1UniSTS
Cytogenetic Map7A1UniSTS
Cytogenetic Map2E5UniSTS
Cytogenetic Map11A1UniSTS
Cytogenetic Map4B1UniSTS
Cytogenetic Map15A2UniSTS
Cytogenetic Map8C3UniSTS
Cytogenetic Map2A3UniSTS
Cytogenetic Map5G3UniSTS
Cytogenetic Map4A3UniSTS
Cytogenetic Map2H3UniSTS
Cytogenetic Map8A1UniSTS
Cytogenetic Map8A1.1UniSTS
Cytogenetic Map16A3UniSTS
Cytogenetic Map10B1UniSTS
Cytogenetic Map19AUniSTS
Cytogenetic Map10A1UniSTS
Cytogenetic Map13D1UniSTS
Cytogenetic Map4A1UniSTS
Cytogenetic Map9A3UniSTS
Cytogenetic Map17CUniSTS
Cytogenetic Map1DUniSTS
Cytogenetic Map5E3UniSTS
Cytogenetic Map15D3UniSTS
Cytogenetic Map2H2UniSTS
Cytogenetic Map7D3UniSTS
Cytogenetic Map2A1UniSTS
Cytogenetic Map14C1UniSTS
Cytogenetic Map14E5UniSTS
Cytogenetic Map10CUniSTS
Cytogenetic Map18B2UniSTS
Cytogenetic Map2F1UniSTS
Cytogenetic Map10D3UniSTS
Cytogenetic Map17A2UniSTS
Cytogenetic Map2C3UniSTS
Cytogenetic Map1C3UniSTS
Cytogenetic Map17B2UniSTS
Cytogenetic Map5B2UniSTS
Cytogenetic Map5G1UniSTS
Cytogenetic Map4C6UniSTS
Cytogenetic Map13C3UniSTS
Cytogenetic Map2E1UniSTS
Cytogenetic Map17A3.2-A3.3UniSTS
Cytogenetic Map19C3UniSTS
Cytogenetic Map7E3UniSTS
Cytogenetic Map13C1UniSTS
Cytogenetic Map9E3.1UniSTS
Cytogenetic Map15E3UniSTS
Cytogenetic Map6B1UniSTS
Cytogenetic MapXE3UniSTS
Cytogenetic Map4C4UniSTS
Cytogenetic Map3E3UniSTS
Cytogenetic Map11A4UniSTS
Cytogenetic Map4C5UniSTS
Cytogenetic Map18B3UniSTS
Cytogenetic Map9A2UniSTS
Cytogenetic Map7E1UniSTS
Cytogenetic Map5D-E1UniSTS
Cytogenetic Map5B3UniSTS
Cytogenetic Map13A2-A3UniSTS
Cytogenetic Map5A2UniSTS
Cytogenetic Map4B3UniSTS
Cytogenetic Map1E4UniSTS
Cytogenetic Map17E4UniSTS
Cytogenetic Map1G2UniSTS
Cytogenetic Map15B3.1UniSTS
Cytogenetic Map12EUniSTS
Cytogenetic MapXA5UniSTS
Cytogenetic Map6A3.3UniSTS
Cytogenetic Map6G3UniSTS
Cytogenetic Map6F2UniSTS
Cytogenetic Map5C1UniSTS
Cytogenetic Map4D2.1UniSTS
Cytogenetic Map4A5UniSTS
Cytogenetic Map3F2.2UniSTS
Cytogenetic Map1E3-E4UniSTS
Cytogenetic Map9F1-F3UniSTS
Cytogenetic Map1C1.1UniSTS
Cytogenetic Map14D2UniSTS
Cytogenetic Map12A2UniSTS
Cytogenetic Map17A3-BUniSTS
Cytogenetic Map7F5UniSTS
Cytogenetic Map14A3UniSTS
Cytogenetic Map5G1.1UniSTS
Cytogenetic MapXF2-F4UniSTS
Cytogenetic Map7D2UniSTS
Cytogenetic Map2F3UniSTS
Cytogenetic Map10A3UniSTS
Cytogenetic MapXA7.3UniSTS
Cytogenetic Map9F1-F2UniSTS
Cytogenetic Map13A3.2UniSTS
Cytogenetic Map10A2UniSTS
Cytogenetic Map1C1UniSTS
Cytogenetic Map1A1UniSTS
Cytogenetic Map12D3UniSTS
Cytogenetic Map1A3-A5UniSTS
Cytogenetic Map2A2UniSTS
Cytogenetic Map3A1UniSTS
Cytogenetic MapXA3.3UniSTS
Cytogenetic Map16A-B1UniSTS
Cytogenetic Map1D2.3UniSTS
Cytogenetic Map6B2.3UniSTS
Cytogenetic Map2G3UniSTS
Cytogenetic MapXA2-A3.1UniSTS
Cytogenetic Map9A5.3UniSTS
Cytogenetic Map14A2-BUniSTS
Cytogenetic Map8E1-E2UniSTS
Cytogenetic Map8A3UniSTS
Cytogenetic Map1G3-H1UniSTS
Cytogenetic Map8B3-C1UniSTS
Cytogenetic Map19C1UniSTS
Cytogenetic Map8C5UniSTS
Cytogenetic Map8A4UniSTS
Cytogenetic Map15F3UniSTS
Cytogenetic Map14E4UniSTS
Cytogenetic Map4D2.2UniSTS
Cytogenetic MapXF5UniSTS
cM Map1040.0UniSTS
Whitehead Genetic1033.9UniSTS
Gad2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38222,690,220 - 22,690,348UniSTSGRCm38
MGSCv37222,545,740 - 22,545,868UniSTSGRCm37
Celera222,420,881 - 22,421,009UniSTS
Cytogenetic Map2A3UniSTS
cM Map29.0UniSTS
Gad2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2A3UniSTS
Gad2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2A3UniSTS
Gad2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38222,692,403 - 22,693,311UniSTSGRCm38
MGSCv37222,547,923 - 22,548,831UniSTSGRCm37
Celera222,423,064 - 22,423,978UniSTS
Cytogenetic Map2A3UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_008078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011239023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB032757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF326549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF326550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF357434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK018118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK136834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK141473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL928693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC018380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ571205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D42051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC134211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L16980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S67454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000028123   ⟹   ENSMUSP00000028123
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl222,512,217 - 22,583,886 (+)Ensembl
GRCm38.p6 Ensembl222,622,205 - 22,693,874 (+)Ensembl
RefSeq Acc Id: ENSMUST00000156728
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl222,513,316 - 22,520,013 (+)Ensembl
GRCm38.p6 Ensembl222,623,304 - 22,630,001 (+)Ensembl
RefSeq Acc Id: NM_008078   ⟹   NP_032104
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39222,512,339 - 22,583,889 (+)NCBI
GRCm38222,622,327 - 22,693,877 (+)NCBI
MGSCv37222,477,847 - 22,549,397 (+)RGD
Celera222,352,193 - 22,424,544 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011239023   ⟹   XP_011237325
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39222,512,262 - 22,546,286 (+)NCBI
GRCm38222,621,015 - 22,656,274 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_032104   ⟸   NM_008078
- UniProtKB: O35519 (UniProtKB/Swiss-Prot),   P48320 (UniProtKB/Swiss-Prot),   Q548L4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011237325   ⟸   XM_011239023
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000028123   ⟸   ENSMUST00000028123

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P48320-F1-model_v2 AlphaFold P48320 1-585 view protein structure

Promoters
RGD ID:6831416
Promoter ID:MM_KWN:27989
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000026891,   UC008INI.1,   UC008INJ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36222,477,601 - 22,478,101 (+)MPROMDB
RGD ID:6876474
Promoter ID:EPDNEW_M1688
Type:initiation region
Name:Gad2_1
Description:Mus musculus glutamic acid decarboxylase 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M1689  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38222,622,298 - 22,622,358EPDNEW
RGD ID:6876476
Promoter ID:EPDNEW_M1689
Type:initiation region
Name:Gad2_2
Description:Mus musculus glutamic acid decarboxylase 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M1688  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38222,622,628 - 22,622,688EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95634 AgrOrtholog
Ensembl Genes ENSMUSG00000026787 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000028123 ENTREZGENE
  ENSMUST00000028123.4 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.640.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.1150.170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro PyrdxlP-dep_de-COase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_major UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyridoxal-P_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14417 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:95634 ENTREZGENE
NCBI Gene 14417 ENTREZGENE
PANTHER GLUTAMATE DECARBOXYLASE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLUTAMATE DECARBOXYLASE-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pyridoxal_deC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gad2 PhenoGen
PROSITE DDC_GAD_HDC_YDC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53383 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt DCE2_MOUSE UniProtKB/Swiss-Prot
  O35519 ENTREZGENE
  P48320 ENTREZGENE
  Q3URJ3_MOUSE UniProtKB/TrEMBL
  Q548L4 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary O35519 UniProtKB/Swiss-Prot