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ONTOLOGY REPORT - ANNOTATIONS


Term:carbidopa
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Accession:CHEBI:3395 term browser browse the term
Definition:The hydrate of 3-(3,4-dihydroxyphenyl)propanoic acid in which the hydrogens alpha- to the carboxyl group are substituted by hydrazinyl and methyl groups (S-configuration). Carbidopa is a dopa decarboxylase inhibitor, so prevents conversion of levodopa to dopamine. It has no antiparkinson activity by itself, but is used in the management of Parkinson's disease to reduce peripheral adverse effects of levodopa.
Synonyms:exact_synonym: (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid--water (1/1)
 related_synonym: (-)-L-alpha-hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic acid monohydrate;   (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid hydrate;   (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid monohydrate;   (S)-carbidopa hydrate;   (alphaS)-alpha-hydrazino-3,4-dihydroxy-alpha-methylbenzenepropanoic acid monohydrate;   Formula=C10H16N2O5;   InChI=1S/C10H14N2O4.H2O/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6;/h2-4,12-14H,5,11H2,1H3,(H,15,16);1H2/t10-;/m0./s1;   InChIKey=QTAOMKOIBXZKND-PPHPATTJSA-N;   L-alpha-(3,4-dihydroxybenzyl)-alpha-hydrazinopropionic acid monohydrate;   SMILES=O.C[C@@](Cc1ccc(O)c(O)c1)(NN)C(O)=O;   carbidopa hydrate;   carbidopa monohydrate;   carbidopum monohydricum
 alt_id: CHEBI:212626
 xref: CAS:38821-49-7 "ChemIDplus";   DrugBank:DB00190;   KEGG:D00558
 xref_mesh: MESH:D002230
 xref: PMID:10841799 "ChEMBL";   Patent:DE2062285;   Patent:DE2062332;   Patent:GB940596;   Patent:US3462536


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carbidopa term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Comt catechol-O-methyltransferase JBrowse link 11 86,715,981 86,735,630 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      chemical role 19128
        greenhouse gas 9810
          water 607
            hydrate 588
              carbidopa 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic acid 17923
                                        monocarboxylic acid 17256
                                          carbidopa (anhydrous) 1
                                            carbidopa 1
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