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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:carbidopa
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Accession:CHEBI:3395 term browser browse the term
Definition:The hydrate of 3-(3,4-dihydroxyphenyl)propanoic acid in which the hydrogens alpha- to the carboxyl group are substituted by hydrazinyl and methyl groups (S-configuration). Carbidopa is a dopa decarboxylase inhibitor, so prevents conversion of levodopa to dopamine. It has no antiparkinson activity by itself, but is used in the management of Parkinson's disease to reduce peripheral adverse effects of levodopa.
Synonyms:exact_synonym: (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid--water (1/1)
 related_synonym: (-)-L-alpha-hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic acid monohydrate;   (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid hydrate;   (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid monohydrate;   (S)-carbidopa hydrate;   (alphaS)-alpha-hydrazino-3,4-dihydroxy-alpha-methylbenzenepropanoic acid monohydrate;   Formula=C10H16N2O5;   InChI=1S/C10H14N2O4.H2O/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6;/h2-4,12-14H,5,11H2,1H3,(H,15,16);1H2/t10-;/m0./s1;   InChIKey=QTAOMKOIBXZKND-PPHPATTJSA-N;   L-alpha-(3,4-dihydroxybenzyl)-alpha-hydrazinopropionic acid monohydrate;   SMILES=O.C[C@@](Cc1ccc(O)c(O)c1)(NN)C(O)=O;   carbidopa hydrate;   carbidopa monohydrate;   carbidopum monohydricum
 alt_id: CHEBI:212626
 xref: CAS:38821-49-7;   DrugBank:DB00190;   KEGG:D00558
 xref_mesh: MESH:D002230
 xref: PMID:10841799;   Patent:DE2062285;   Patent:DE2062332;   Patent:GB940596;   Patent:US3462536


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carbidopa term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comt catechol-O-methyltransferase increases methylation ISO
EXP
COMT protein results in increased methylation of Carbidopa CTD PMID:11160877 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
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Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      chemical role 19336
        greenhouse gas 10999
          water 693
            hydrate 661
              carbidopa 1
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Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        monocarboxylic acid 17632
                                          carbidopa (anhydrous) 1
                                            carbidopa 1
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