Ppargc1a (peroxisome proliferative activated receptor, gamma, coactivator 1 alpha) - Rat Genome Database

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Gene: Ppargc1a (peroxisome proliferative activated receptor, gamma, coactivator 1 alpha) Mus musculus
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Symbol: Ppargc1a
Name: peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
RGD ID: 1332548
MGI Page MGI
Description: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; nucleic acid binding activity; and transcription coactivator activity. Involved in several processes, including gluconeogenesis; positive regulation of cold-induced thermogenesis; and regulation of gene expression. Acts upstream of or within several processes, including negative regulation of neuron apoptotic process; response to dietary excess; and response to muscle activity. Located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; heart; hindlimb digit mesenchyme; and sensory organ. Used to study Parkinson's disease; age related macular degeneration; cardiomyopathy; and congestive heart failure. Human ortholog(s) of this gene implicated in several diseases, including macular degeneration; malignant fibrous histiocytoma; metabolic dysfunction-associated steatotic liver disease; neurodegenerative disease (multiple); and type 2 diabetes mellitus. Orthologous to human PPARGC1A (PPARG coactivator 1 alpha).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: A830037N07Rik; ENSMUSG00000079510; Gm11133; peroxisome proliferator-activated receptor gamma coactivator 1-alpha; peroxisome proliferator-activated receptor gamma coactivator-1 alpha; Pgc; PGC-1; PGC-1-alpha; Pgc-1alpha; Pgc-1alphaa; PGC-1v; Pgc1; Pgco1; PPAR gamma coactivator variant form; PPAR Gamma Coactivator-1; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha; Ppargc1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39551,611,591 - 52,273,316 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl551,611,592 - 51,725,068 (-)EnsemblGRCm39 Ensembl
GRCm38551,454,249 - 52,115,853 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl551,454,250 - 51,567,726 (-)EnsemblGRCm38mm10GRCm38
MGSCv37551,845,488 - 51,945,160 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36551,745,901 - 51,842,109 (-)NCBIMGSCv36mm8
Celera548,830,811 - 48,929,055 (-)NCBICelera
Cytogenetic Map5C1NCBI
cM Map527.02NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome  (ISO)
acute kidney failure  (IEP,IMP)
age related macular degeneration  (IAGP)
Albuminuria  (ISO)
Alzheimer's disease  (IDA,ISO)
amblyopia  (ISO)
amnestic disorder  (ISO)
amyotrophic lateral sclerosis  (IEP,ISO)
Bowen's Disease  (ISO)
Brain Injuries  (IEP,ISO)
Cardiomegaly  (IMP,ISO)
cardiomyopathy  (IAGP)
cardiovascular system disease  (ISO)
Carotid Artery Injuries  (IMP,ISO)
chronic kidney disease  (IDA)
chronic obstructive pulmonary disease  (ISO)
colitis  (ISO)
congenital hypothyroidism  (ISO)
congestive heart failure  (IAGP,IDA,IEP,ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (ISO)
Diseases of the Aged  (ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Fetal Growth Retardation  (ISO)
glucose intolerance  (IEP)
heart disease  (ISO)
Huntington's disease  (IDA,IEP,IMP,ISO)
hyperglycemia  (IDA,ISO)
hyperthyroidism  (ISO)
Hypertriglyceridemia  (ISO)
Hypoxia  (ISO)
Insulin Resistance  (ISO)
Kearns-Sayre syndrome  (IMP)
kidney cancer  (ISO)
kidney failure  (ISO)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (IEP)
Lewy body dementia  (ISO)
macular degeneration  (ISO)
malignant fibrous histiocytoma  (ISO)
melanoma  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
Muscular Dystrophy, Animal  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (IDA)
nephrotic syndrome  (ISO)
neuronal ceroid lipofuscinosis 1  (ISO)
obesity  (IDA,ISO)
Parkinson's disease  (IAGP,ISO)
Parkinsonism  (IDA,IEP,IMP)
placental insufficiency  (ISO)
Plaque, Atherosclerotic  (IEP)
prediabetes syndrome  (ISO)
primary biliary cholangitis  (ISO)
pulmonary emphysema  (IDA)
renal fibrosis  (ISO)
Right Ventricular Hypertrophy  (ISO)
Sarcopenia  (ISO)
schizophrenia  (IDA)
sciatic neuropathy  (ISO)
Sepsis  (IEP)
Sleep Initiation and Maintenance Disorders  (ISO)
Spinal Cord Injuries  (ISO)
steatotic liver disease  (IDA,ISO)
Takotsubo Cardiomyopathy  (ISO)
type 1 diabetes mellitus  (IEP)
type 2 diabetes mellitus  (IDA,IEP,ISO)
Ventricular Dysfunction, Right  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (ISO)
(+)-catechin  (EXP)
(+)-schisandrin B  (ISO)
(+)-taxifolin  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(1->4)-beta-D-glucan  (EXP)
(20S)-ginsenoside Rg3  (ISO)
(R)-adrenaline  (ISO)
(R)-carnitine  (ISO)
(R)-lipoic acid  (EXP,ISO)
(R)-noradrenaline  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1,4-dithiothreitol  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
1-stearoyl-2-arachidonoyl-sn-glycerol  (ISO)
11-deoxycorticosterone  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
1D-myo-inositol 1-phosphate  (ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (ISO)
1H-pyrazole  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (EXP)
2-chloroethanol  (EXP)
3',5'-cyclic AMP  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4,6-dioxoheptanoic acid  (EXP)
4-hydroxyphenyl retinamide  (EXP)
4-phenylbutyric acid  (EXP,ISO)
5-(2-chloroethyl)-4-methylthiazole  (EXP)
5-aminoimidazole-4-carboxamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
8-bromo-3',5'-cyclic GMP  (ISO)
9-cis-retinoic acid  (EXP,ISO)
acadesine  (ISO)
acarbose  (ISO)
acetamide  (ISO)
acetic acid  (ISO)
acetylsalicylic acid  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
adenosine  (ISO)
adenosine 5'-monophosphate  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
AICA ribonucleotide  (EXP,ISO)
albuterol  (EXP)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (ISO)
all-trans-retinal  (ISO)
all-trans-retinoic acid  (EXP)
all-trans-retinol  (EXP)
alloxan  (ISO)
allyl isothiocyanate  (ISO)
alpha,alpha-trehalose  (EXP)
alpha-D-galactose  (ISO)
alpha-Zearalanol  (ISO)
aminoguanidine  (EXP,ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
angiotensin II  (ISO)
Ankaflavin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antimycin A  (EXP)
arachidonyl-2'-chloroethylamide  (EXP)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (EXP,ISO)
asiatic acid  (ISO)
aspartame  (EXP)
atorvastatin calcium  (EXP,ISO)
ATP  (ISO)
atrazine  (ISO)
benfotiamine  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[ghi]perylene  (EXP)
berberine  (EXP)
beta-D-glucosamine  (ISO)
Betanin  (ISO)
bezafibrate  (EXP)
biotin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
bosentan  (ISO)
bromobenzene  (ISO)
bucladesine  (EXP)
bupivacaine  (EXP)
buta-1,3-diene  (EXP)
butan-1-ol  (ISO)
butan-2-one  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
calycosin  (ISO)
cannabidiol  (EXP)
capsaicin  (EXP,ISO)
captan  (EXP)
carbamazepine  (ISO)
carbon monoxide  (EXP,ISO)
carbon nanotube  (EXP)
carfilzomib  (ISO)
carvedilol  (ISO)
casticin  (EXP)
CGP 52608  (ISO)
chicoric acid  (ISO)
CHIR 99021  (EXP)
chitosan  (ISO)
chlormidazole  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
cholate  (ISO)
choline  (ISO)
chromium(6+)  (EXP,ISO)
ciglitazone  (EXP)
ciguatoxin CTX1B  (EXP)
cisplatin  (EXP,ISO)
clenbuterol  (EXP,ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP,ISO)
cortisol  (ISO)
cortisone  (ISO)
creatine  (ISO)
crocidolite asbestos  (EXP,ISO)
curcumin  (ISO)
cyclosporin A  (EXP,ISO)
cyproconazole  (ISO)
D-glucose  (EXP,ISO)
D-glucurono-6,3-lactone  (ISO)
dapagliflozin  (ISO)
DDE  (ISO)
DDT  (EXP)
decanoic acid  (ISO)
dehydroepiandrosterone  (ISO)
Delta(9)-tetrahydrocannabinolic acid  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Di-n-hexyl phthalate  (ISO)
Di-n-octyl phthalate  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (EXP)
dichloromethane  (EXP)
diclofenac  (EXP,ISO)
diethyl phthalate  (EXP)
diethylstilbestrol  (ISO)
dihydrofolic acid  (ISO)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dioxygen  (EXP,ISO)
disodium selenite  (EXP)
dodecanoic acid  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
edaravone  (ISO)
elemental selenium  (EXP)
ellagic acid  (EXP)
enalapril  (ISO)
endosulfan  (ISO)
enilconazole  (ISO)
epoxiconazole  (EXP,ISO)
Erythropoietin  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
farnesol  (ISO)
fenofibrate  (EXP,ISO)
fenoterol  (EXP)
fenpyroximate  (ISO)
flavonoids  (ISO)
fluoxastrobin  (ISO)
folic acid  (EXP)
folpet  (EXP)
formononetin  (ISO)
FR900359  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
galactose  (ISO)
gamma-hexachlorocyclohexane  (ISO)
Genipin  (EXP)
Geniposide  (EXP)
Gingerenone A  (EXP)
ginsenoside Rg2  (ISO)
glucagon  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
GW 1929  (ISO)
GW 501516  (EXP,ISO)
haloperidol  (EXP)
harmine  (EXP)
hemin  (ISO)
herbicide  (EXP)
hesperidin  (ISO)
hexadecanoic acid  (EXP,ISO)
Honokiol  (EXP)
hydrogen cyanide  (EXP)
hydrogen peroxide  (EXP,ISO)
icariin  (EXP,ISO)
ICI 118551  (EXP)
Ile(5)-angiotensin II  (ISO)
imidacloprid  (EXP)
indole-3-methanol  (ISO)
indometacin  (EXP,ISO)
inositol  (ISO)
inulin  (EXP)
ionomycin  (ISO)
iprodione  (ISO)
isobutanol  (ISO)
isoniazide  (ISO)
isoprenaline  (EXP,ISO)
isoxazoles  (ISO)
kaempferol  (ISO)
ketoconazole  (ISO)
ketotifen  (ISO)
kresoxim-methyl  (ISO)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (ISO)
L-glutamic acid  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
leflunomide  (ISO)
Licarin A  (EXP)
limonene  (EXP)
linagliptin  (EXP,ISO)
linoleic acid  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
liraglutide  (EXP)
loliolide  (EXP)
losartan  (ISO)
lovastatin  (EXP)
luzindole  (ISO)
LY294002  (ISO)
mabuterol  (EXP)
Magnolol  (ISO)
malic acid  (ISO)
malonic acid  (ISO)
malvidin  (EXP,ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (EXP)
MeIQ  (ISO)
MeIQx  (ISO)
melatonin  (EXP,ISO)
meldonium  (EXP,ISO)
mesalamine  (ISO)
metformin  (EXP,ISO)
methamphetamine  (EXP)
methimazole  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylglyoxal  (EXP,ISO)
metoprolol  (ISO)
monascin  (EXP)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monocrotophos  (ISO)
monosodium L-glutamate  (EXP,ISO)
morphine hydrochloride  (ISO)
Morroniside  (EXP)
myo-inositol hexakisphosphate  (EXP)
N(6)-butyryl-cAMP  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
naringin  (ISO)
nebivolol  (EXP)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP)
nickel sulfate  (EXP)
nicotinamide  (EXP,ISO)
nicotine  (EXP,ISO)
nicotinic acid  (ISO)
nitrites  (ISO)
nitrogen dioxide  (ISO)
nitroprusside  (ISO)
NMN zwitterion  (ISO)
nordihydroguaiaretic acid  (ISO)
NSC 23766  (EXP)
O-acetyl-L-carnitine  (ISO)
octadecanoic acid  (ISO)
olanzapine  (ISO)
oleic acid  (EXP)
orientin  (EXP)
oxaloacetic acid  (ISO)
oxidopamine  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (EXP)
pentachlorophenol  (EXP)
perfluorododecanoic acid  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorononanoic acid  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
peroxynitrous acid  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
PhIP  (ISO)
Phytolaccoside E  (ISO)
picloram  (EXP)
picoxystrobin  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
platycodin D  (EXP)
poly(guanylic acid)  (ISO)
poly(vinylpyrrolidone)  (EXP)
potassium chloride  (ISO)
potassium cyanide  (EXP)
potassium dichromate  (ISO)
pramipexole  (ISO)
prazosin  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
prochloraz  (ISO)
progesterone  (ISO)
propiconazole  (EXP)
propionic acid  (ISO)
propranolol  (EXP)
prostaglandin D2  (ISO)
prostaglandin I2  (ISO)
pterostilbene  (ISO)
puerarin  (ISO)
pyridaben  (EXP,ISO)
pyridoxine  (ISO)
pyrroloquinoline quinone  (EXP,ISO)
pyruvic acid  (EXP,ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (ISO)
rebaudioside A  (EXP)
resveratrol  (EXP,ISO)
riboflavin  (ISO)
rifampicin  (ISO)
rosmarinic acid  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-adenosyl-L-homocysteine  (ISO)
Salmeterol xinafoate  (EXP)
Salvianolic acid A  (EXP,ISO)
salvianolic acid B  (ISO)
SB 431542  (ISO)
SB-239063  (ISO)
selenium atom  (EXP)
silicon atom  (EXP)
silicon dioxide  (EXP,ISO)
silver(1+) nitrate  (EXP)
sirolimus  (EXP,ISO)
sirtinol  (EXP,ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP)
sodium hydrogensulfite  (ISO)
splitomicin  (ISO)
staurosporine  (EXP)
steviol  (EXP)
stevioside  (EXP)
streptozocin  (EXP,ISO)
sulfadimethoxine  (ISO)
sulforaphane  (EXP,ISO)
sulfur dioxide  (ISO)
sunitinib  (EXP)
T-2 toxin  (EXP,ISO)
tamoxifen  (ISO)
taurine  (EXP,ISO)
tauroursodeoxycholic acid  (ISO)
telmisartan  (EXP)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
tetradecanoic acid  (ISO)
tetraphene  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trans-ferulic acid  (EXP,ISO)
trichlopyr  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trifloxystrobin  (ISO)
trilobatin  (ISO)
triphenylstannane  (ISO)
Triptolide  (EXP,ISO)
troglitazone  (EXP,ISO)
tunicamycin  (EXP)
UDP-alpha-D-glucuronic acid  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
vincristine  (ISO)
vorinostat  (ISO)
ziram  (ISO)
zoledronic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive thermogenesis  (ISO)
adipose tissue development  (IMP)
androgen metabolic process  (ISO)
autophagy of mitochondrion  (ISO)
cellular response to caffeine  (ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to fatty acid  (ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to fructose stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to interleukin-6  (ISO)
cellular response to ionomycin  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to nitrite  (ISO)
cellular response to oxidative stress  (IMP)
cellular response to potassium ion  (ISO)
cellular response to resveratrol  (ISO)
cellular response to thyroid hormone stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
cerebellum development  (ISO)
circadian regulation of gene expression  (IDA)
energy homeostasis  (IBA,IMP)
fatty acid oxidation  (ISO)
flavone metabolic process  (ISO)
forebrain development  (ISO)
galactose metabolic process  (ISO)
gluconeogenesis  (IDA,ISO)
mitochondrion organization  (IDA,IMP,ISO)
negative regulation of glycolytic process  (ISO)
negative regulation of mitochondrial fission  (ISO)
negative regulation of neuron apoptotic process  (IMP)
negative regulation of protein phosphorylation  (ISO)
negative regulation of signaling receptor activity  (ISO)
negative regulation of smooth muscle cell migration  (ISO)
negative regulation of smooth muscle cell proliferation  (IEA,ISO)
neuron apoptotic process  (IMP)
positive regulation of cold-induced thermogenesis  (IMP)
positive regulation of DNA-binding transcription factor activity  (IDA,ISO)
positive regulation of DNA-templated transcription  (IDA,IMP,ISO)
positive regulation of fatty acid oxidation  (ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of podocyte apoptotic process  (ISO)
positive regulation of progesterone biosynthetic process  (ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IGI,IMP,ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
regulation of circadian rhythm  (IDA)
regulation of DNA-templated transcription  (ISO,ISS)
regulation of NMDA receptor activity  (ISO)
respiratory electron transport chain  (IDA)
response to activity  (ISO)
response to dehydroepiandrosterone  (ISO)
response to dietary excess  (IDA)
response to electrical stimulus  (ISO)
response to electrical stimulus involved in regulation of muscle adaptation  (ISO)
response to epinephrine  (ISO)
response to fructose  (ISO)
response to hypobaric hypoxia  (ISO)
response to hypoxia  (ISO)
response to ischemia  (ISO)
response to L-leucine  (ISO)
response to methionine  (ISO)
response to morphine  (ISO)
response to muscle activity  (IDA,IMP,ISO)
response to norepinephrine  (ISO)
response to nutrient  (ISO)
response to nutrient levels  (ISO)
response to organic cyclic compound  (ISO)
response to reactive oxygen species  (ISO)
response to starvation  (ISO)
response to thyroid hormone  (ISO)
response to xenobiotic stimulus  (ISO)
skeletal muscle atrophy  (ISO)

Cellular Component
apical dendrite  (ISO)
chromatin  (ISO)
cytosol  (IEA,ISO)
cytosolic ribosome  (ISO)
euchromatin  (ISO)
neuronal cell body  (ISO)
nucleoplasm  (ISO,TAS)
nucleus  (IBA,IDA,ISO)
PML body  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal basal ganglion morphology  (IAGP)
abnormal behavioral response to amphetamine  (IAGP)
abnormal blood circulation  (IAGP)
abnormal blood homeostasis  (IAGP)
abnormal body weight  (IAGP)
abnormal brainstem morphology  (IAGP)
abnormal brown adipose tissue morphology  (IAGP)
abnormal brown fat cell morphology  (IAGP)
abnormal Bruch membrane morphology  (IAGP)
abnormal cell physiology  (IAGP)
abnormal cellular respiration  (IAGP)
abnormal cerebellum morphology  (IAGP)
abnormal cerebral cortex morphology  (IAGP)
abnormal choriocapillaris morphology  (IAGP)
abnormal choroid vasculature morphology  (IAGP)
abnormal crypts of Lieberkuhn morphology  (IAGP)
abnormal fat cell morphology  (IAGP)
abnormal gluconeogenesis  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal heart development  (IAGP)
abnormal heart left ventricle morphology  (IAGP)
abnormal hippocampus morphology  (IAGP)
abnormal lipid homeostasis  (IAGP)
abnormal liver physiology  (IAGP)
abnormal locomotor behavior  (IAGP)
abnormal melanosome transport  (IAGP)
abnormal mitochondrial physiology  (IAGP)
abnormal myocardium layer morphology  (IAGP)
abnormal neuron morphology  (IAGP)
abnormal pancreatic beta cell morphology  (IAGP)
abnormal pulmonary alveolus morphology  (IAGP)
abnormal retina pigment epithelium morphology  (IAGP)
abnormal skeletal muscle fiber morphology  (IAGP)
abnormal small intestinal villus morphology  (IAGP)
abnormal striatum morphology  (IAGP)
abnormal substantia nigra morphology  (IAGP)
anhedonia  (IAGP)
bradykinesia  (IAGP)
cachexia  (IAGP)
congestive heart failure  (IAGP)
decreased body fat mass  (IEA)
decreased body length  (IEA)
decreased body weight  (IAGP)
decreased bone mineral content  (IEA)
decreased brown fat cell size  (IAGP)
decreased cardiac output  (IAGP)
decreased circulating cholesterol level  (IEA)
decreased circulating glucose level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased dopamine level  (IAGP)
decreased dopaminergic neuron number  (IAGP)
decreased food intake  (IAGP)
decreased gastrocnemius weight  (IAGP)
decreased grip strength  (IAGP)
decreased heart left ventricle muscle contractility  (IAGP)
decreased heart left ventricle weight  (IAGP)
decreased heart rate  (IAGP)
decreased heart weight  (IAGP)
decreased lean body mass  (IAGP)
decreased liver triglyceride level  (IAGP)
decreased liver weight  (IAGP)
decreased locomotor activity  (IAGP)
decreased mitochondrial DNA content  (IAGP)
decreased mitochondrial size  (IAGP)
decreased nervous system dopamine level  (IAGP)
decreased oxygen consumption  (IAGP)
decreased percent body fat/body weight  (IAGP)
decreased respiratory quotient  (IAGP)
decreased retroperitoneal fat pad weight  (IEA)
decreased skeletal muscle weight  (IAGP)
decreased soleus weight  (IAGP)
decreased susceptibility to diet-induced obesity  (IAGP)
decreased total body fat amount  (IAGP)
decreased triglyceride level  (IAGP)
decreased white fat cell size  (IAGP)
dystonia  (IAGP)
enlarged pancreatic islets  (IAGP)
fatigue  (IAGP)
gliosis  (IAGP)
hepatic steatosis  (IAGP)
hyperactivity  (IAGP)
hyperglycemia  (IAGP)
hypoglycemia  (IAGP)
impaired adaptive thermogenesis  (IAGP)
impaired autophagy  (IAGP)
impaired coordination  (IAGP)
impaired glucose tolerance  (IAGP)
improved glucose tolerance  (IAGP)
increased adrenal gland weight  (IEA)
increased basal metabolism  (IAGP)
increased circulating alkaline phosphatase level  (IEA)
increased circulating glucose level  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased heart weight  (IAGP)
increased incidence of tumors by chemical induction  (IAGP)
increased inflammatory response  (IAGP)
increased insulin sensitivity  (IAGP)
increased interleukin-6 secretion  (IAGP)
increased kidney weight  (IEA)
increased lung weight  (IAGP)
increased muscle fatigability  (IAGP)
increased oxygen consumption  (IAGP)
increased pancreatic beta cell mass  (IAGP)
increased percent body fat/body weight  (IAGP)
increased response of heart to induced stress  (IAGP)
increased startle reflex  (IAGP)
increased susceptibility to induced morbidity/mortality  (IAGP)
increased susceptibility to weight gain  (IAGP)
increased thigmotaxis  (IAGP)
increased thymus weight  (IEA)
increased total body fat amount  (IAGP)
increased tumor growth/size  (IAGP)
insulin resistance  (IAGP)
limb grasping  (IAGP)
lipofuscinosis  (IAGP)
male infertility  (IAGP)
myoclonus  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
neurodegeneration  (IAGP)
neuron degeneration  (IAGP)
oxidative stress  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
preweaning lethality, incomplete penetrance  (IEA)
respiratory distress  (IAGP)
retina macular degeneration  (IAGP)
retina photoreceptor degeneration  (IAGP)
short photoreceptor inner segment  (IAGP)
short photoreceptor outer segment  (IAGP)
small heart  (IAGP)
spongiform encephalopathy  (IAGP)
thrombocytopenia  (IEA)
References

References - curated
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89. Decreased mRNA expression of PGC-1alpha and PGC-1alpha-regulated factors in the SOD1G93A ALS mouse model and in human sporadic ALS. Thau N, etal., J Neuropathol Exp Neurol. 2012 Dec;71(12):1064-74. doi: 10.1097/NEN.0b013e318275df4b.
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PMID:37569637   PMID:37639610   PMID:37640195   PMID:37681410   PMID:37744380   PMID:37813066   PMID:37822967   PMID:37931421   PMID:37934783   PMID:37939221   PMID:38031815   PMID:38181046  
PMID:38196272   PMID:38216792   PMID:38231482   PMID:38245592   PMID:38261146   PMID:38355793   PMID:38492883   PMID:38521055   PMID:38604253   PMID:38697949   PMID:38702076   PMID:38754428  
PMID:38760908   PMID:38761195   PMID:38801840   PMID:38824126   PMID:38885788   PMID:38888503   PMID:38943974   PMID:38972757   PMID:39043630   PMID:39366945  


Genomics

Comparative Map Data
Ppargc1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39551,611,591 - 52,273,316 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl551,611,592 - 51,725,068 (-)EnsemblGRCm39 Ensembl
GRCm38551,454,249 - 52,115,853 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl551,454,250 - 51,567,726 (-)EnsemblGRCm38mm10GRCm38
MGSCv37551,845,488 - 51,945,160 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36551,745,901 - 51,842,109 (-)NCBIMGSCv36mm8
Celera548,830,811 - 48,929,055 (-)NCBICelera
Cytogenetic Map5C1NCBI
cM Map527.02NCBI
PPARGC1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38423,792,021 - 24,472,905 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl423,755,041 - 23,904,089 (-)EnsemblGRCh38hg38GRCh38
GRCh37423,793,644 - 24,474,528 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36423,402,742 - 23,500,798 (-)NCBINCBI36Build 36hg18NCBI36
Build 34423,469,913 - 23,567,969NCBI
Celera424,243,466 - 24,341,439 (-)NCBICelera
Cytogenetic Map4p15.2NCBI
HuRef423,138,364 - 23,236,560 (-)NCBIHuRef
CHM1_1423,791,582 - 23,889,913 (-)NCBICHM1_1
T2T-CHM13v2.0423,773,791 - 24,454,625 (-)NCBIT2T-CHM13v2.0
Ppargc1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81463,073,505 - 63,729,215 (+)NCBIGRCr8
mRatBN7.21458,860,752 - 59,516,525 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1458,861,144 - 59,512,656 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1463,825,757 - 63,916,927 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01465,139,390 - 65,230,573 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01461,536,169 - 61,627,348 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01463,095,291 - 63,190,688 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1463,095,720 - 63,187,009 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01463,182,479 - 63,286,252 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41464,278,115 - 64,370,912 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11464,280,505 - 64,373,303 (+)NCBI
Celera1458,516,257 - 58,607,916 (+)NCBICelera
Cytogenetic Map14q11NCBI
Ppargc1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554801,078,322 - 1,188,435 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955480543,397 - 1,188,376 (+)NCBIChiLan1.0ChiLan1.0
PPARGC1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2324,042,857 - 24,723,457 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1424,239,672 - 24,920,223 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0418,196,431 - 18,876,889 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1423,483,377 - 24,160,574 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl423,483,377 - 23,581,212 (-)Ensemblpanpan1.1panPan2
PPARGC1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1385,645,942 - 86,284,570 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl386,016,140 - 86,281,269 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha388,158,508 - 88,796,824 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0386,620,570 - 87,261,415 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl386,992,463 - 87,261,415 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1385,752,591 - 86,391,823 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0385,858,991 - 86,497,911 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0386,243,892 - 86,883,362 (+)NCBIUU_Cfam_GSD_1.0
Ppargc1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528551,179,331 - 51,786,516 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364775,199,881 - 5,488,226 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364774,881,230 - 5,488,208 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPARGC1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl817,841,844 - 17,946,992 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1817,841,844 - 18,527,953 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pig Cytomap8p2.1-p2.3NCBI
PPARGC1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12725,882,385 - 26,563,530 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2726,465,499 - 26,564,582 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604772,634,061 - 73,114,795 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppargc1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247558,375,596 - 8,465,297 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247557,826,219 - 8,460,746 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2172
Count of miRNA genes:797
Interacting mature miRNAs:1074
Transcripts:ENSMUST00000031059, ENSMUST00000127135, ENSMUST00000132734, ENSMUST00000151104
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140990Lgq6_mlate growth QTL 6 (mouse)Not determined32133234100777931Mouse
10043995Hbnr9_mHeligmosomoides bakeri nematode resistance 9 (mouse)Not determined53348866767488876Mouse
1301776Skts3_mskin tumor susceptibility 3 (mouse)Not determined52166729555667403Mouse
1300951Gbvq1_mgallstone bladder volume QTL 1 (mouse)Not determined53811168172111798Mouse
14746981Manh57_mmandible shape 57 (mouse)54716974281169742Mouse
1301845Lxw4_mlupus BXSB x NZW 4 (mouse)Not determined53569446269694594Mouse
1301524Lmb2_mlupus in MRL and B6 F2 cross (mouse)Not determined537581488112465722Mouse
1301403Alcp9_malcohol preference locus 9 (mouse)Not determined53102427565024480Mouse
1300701Cd8ts1_mCD8 T cell subset 1 (mouse)Not determined52721534861215451Mouse
11353827Hplq1_mhot plate latency 1 (mouse)53157045865570458Mouse
1301698Pcfm4_mperiosteal circumference and femur length 4 (mouse)Not determined54458584378585965Mouse
4141219W10q16_mweight 10 weeks QTL 16 (mouse)Not determined32133234100777931Mouse
1301555Alcp10_malcohol preference locus 10 (mouse)Not determined53102427565024480Mouse
1301170Lith13_mlithogenic gene 13 (mouse)Not determined53649448670494598Mouse
11537367Hmtb11_mhemostasis and thrombosis 11 (mouse)52210082364806579Mouse
11537368Hmtb10_mhemostasis and thrombosis 10 (mouse)52210082354500318Mouse
13207584Mwmlpt4_mMorris water maze latency to platform, training, 4 (mouse)54632260680322606Mouse
1300926Hpi2_mhepatic PMN infiltration 2 (mouse)Not determined53758148864806579Mouse
13207588Mwmlpa4_mMorris water maze latency to platform, all, 4 (mouse)54632260680322606Mouse
1301693Sle6_msystemic lupus erythematosus susceptibility 6 (mouse)Not determined5889069387841837Mouse
4141647Hrvhf1_mheart rate variability, high frequency 1 (mouse)Not determined3643342370433423Mouse
11049561Lmr24e_mleishmaniasis resistance 24e (mouse)53569446269694594Mouse
13464252Ahl10_mage related hearing loss, early onset 10 (mouse)53585456869854714Mouse
1301223Hdlq7_mHDL QTL 7 (mouse)Not determined53585456869854714Mouse
13464245Ahl12_mage related hearing loss, early onset 12 (mouse)53811168172111798Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
13464246Ahl11_mage related hearing loss, early onset 11 (mouse)53764377771643896Mouse
1300719Iba5_minduction of brown adipocytes 5 (mouse)Not determined52068699354687134Mouse
11049558Lmr24b_mleishmaniasis resistance 24b (mouse)53569446269694594Mouse
11049559Lmr24c_mleishmaniasis resistance 24c (mouse)53569446269694594Mouse

Markers in Region
Ppargc1a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5C1UniSTS
cM Map5 UniSTS
MARC_49176-49177:1118326844:1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38551,473,916 - 51,474,400UniSTSGRCm38
MGSCv37551,865,155 - 51,865,639UniSTSGRCm37
Celera548,850,485 - 48,850,969UniSTS
Cytogenetic Map5C1UniSTS
PPARGC1A__5755  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38551,454,240 - 51,455,132UniSTSGRCm38
MGSCv37551,845,479 - 51,846,371UniSTSGRCm37
Celera548,830,802 - 48,831,694UniSTS
Cytogenetic Map5C1UniSTS
Ppargc1a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5C1UniSTS
cM Map5 UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001402987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001402988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001402989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001402990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001402991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_027710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_132764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_175325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_175326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_175327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006503775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017320718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030254205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB061324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB061326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC104540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC107227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC111037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC111039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC116763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC158149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC163408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AEKQ02089460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF049330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK032149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK043827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK082685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK138668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK177938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB853729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS298118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JX866946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JX866947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JX866948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000031059   ⟹   ENSMUSP00000138397
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl551,614,995 - 51,711,213 (-)Ensembl
GRCm38.p6 Ensembl551,457,653 - 51,553,871 (-)Ensembl
Ensembl Acc Id: ENSMUST00000127135   ⟹   ENSMUSP00000115586
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl551,653,122 - 51,725,068 (-)Ensembl
GRCm38.p6 Ensembl551,495,780 - 51,567,726 (-)Ensembl
Ensembl Acc Id: ENSMUST00000132734   ⟹   ENSMUSP00000117040
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl551,611,592 - 51,711,264 (-)Ensembl
GRCm38.p6 Ensembl551,454,250 - 51,553,922 (-)Ensembl
Ensembl Acc Id: ENSMUST00000151104   ⟹   ENSMUSP00000116566
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl551,615,522 - 51,725,046 (-)Ensembl
GRCm38.p6 Ensembl551,458,180 - 51,567,704 (-)Ensembl
Ensembl Acc Id: ENSMUST00000196968   ⟹   ENSMUSP00000143553
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl551,614,997 - 51,711,233 (-)Ensembl
GRCm38.p6 Ensembl551,457,655 - 51,553,891 (-)Ensembl
RefSeq Acc Id: NM_001402987   ⟹   NP_001389916
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39551,611,591 - 52,273,316 (-)NCBI
RefSeq Acc Id: NM_001402988   ⟹   NP_001389917
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39551,611,591 - 52,273,316 (-)NCBI
RefSeq Acc Id: NM_001402989   ⟹   NP_001389918
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39551,611,591 - 51,710,420 (-)NCBI
RefSeq Acc Id: NM_001402990   ⟹   NP_001389919
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39551,611,591 - 51,862,308 (-)NCBI
RefSeq Acc Id: NM_001402991   ⟹   NP_001389920
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39551,611,591 - 51,711,351 (-)NCBI
RefSeq Acc Id: NM_008904   ⟹   NP_032930
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39551,611,591 - 51,711,214 (-)NCBI
GRCm38551,454,249 - 51,553,921 (-)NCBI
MGSCv37551,845,488 - 51,945,160 (-)RGD
Celera548,830,811 - 48,929,055 (-)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_027710
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39551,611,591 - 51,711,214 (-)NCBI
GRCm38551,454,249 - 51,553,921 (-)NCBI
MGSCv37551,845,488 - 51,945,160 (-)RGD
Celera548,830,811 - 48,929,055 (-)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_132764
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39551,611,591 - 51,725,067 (-)NCBI
GRCm38551,454,249 - 51,567,725 (-)NCBI
Sequence:
RefSeq Acc Id: NR_175325
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39551,611,591 - 52,273,316 (-)NCBI
RefSeq Acc Id: NR_175326
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39551,611,591 - 51,710,420 (-)NCBI
RefSeq Acc Id: NR_175327
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39551,611,591 - 51,710,420 (-)NCBI
RefSeq Acc Id: XM_006503775   ⟹   XP_006503838
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39551,611,591 - 51,725,064 (-)NCBI
GRCm38551,454,249 - 51,567,720 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017320718   ⟹   XP_017176207
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39551,611,591 - 51,710,442 (-)NCBI
GRCm38551,454,249 - 51,553,095 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030254205   ⟹   XP_030110065
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39551,611,591 - 51,710,283 (-)NCBI
GRCm38551,454,249 - 51,553,084 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036164894   ⟹   XP_036020787
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39551,611,591 - 51,711,387 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001389916 (Get FASTA)   NCBI Sequence Viewer  
  NP_001389917 (Get FASTA)   NCBI Sequence Viewer  
  NP_001389918 (Get FASTA)   NCBI Sequence Viewer  
  NP_001389919 (Get FASTA)   NCBI Sequence Viewer  
  NP_001389920 (Get FASTA)   NCBI Sequence Viewer  
  NP_032930 (Get FASTA)   NCBI Sequence Viewer  
  XP_006503838 (Get FASTA)   NCBI Sequence Viewer  
  XP_017176207 (Get FASTA)   NCBI Sequence Viewer  
  XP_030110065 (Get FASTA)   NCBI Sequence Viewer  
  XP_036020787 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC13554 (Get FASTA)   NCBI Sequence Viewer  
  AAH66868 (Get FASTA)   NCBI Sequence Viewer  
  AFZ74947 (Get FASTA)   NCBI Sequence Viewer  
  AFZ74948 (Get FASTA)   NCBI Sequence Viewer  
  AFZ74949 (Get FASTA)   NCBI Sequence Viewer  
  BAC27725 (Get FASTA)   NCBI Sequence Viewer  
  BAC31667 (Get FASTA)   NCBI Sequence Viewer  
  BAE23740 (Get FASTA)   NCBI Sequence Viewer  
  BAE25525 (Get FASTA)   NCBI Sequence Viewer  
  BAE46507 (Get FASTA)   NCBI Sequence Viewer  
  BAE46509 (Get FASTA)   NCBI Sequence Viewer  
  BAE46510 (Get FASTA)   NCBI Sequence Viewer  
  CAK22377 (Get FASTA)   NCBI Sequence Viewer  
  EDL37647 (Get FASTA)   NCBI Sequence Viewer  
  EDL37648 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000115586.3
  ENSMUSP00000116566.3
  ENSMUSP00000117040
  ENSMUSP00000117040.2
  ENSMUSP00000138397.2
  ENSMUSP00000143553.2
GenBank Protein O70343 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_032930   ⟸   NM_008904
- Peptide Label: isoform a
- UniProtKB: L0APB0 (UniProtKB/Swiss-Prot),   L0AN96 (UniProtKB/Swiss-Prot),   L0AM20 (UniProtKB/Swiss-Prot),   Q3UP72 (UniProtKB/Swiss-Prot),   O70343 (UniProtKB/Swiss-Prot),   A0A0G2JGG3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006503838   ⟸   XM_006503775
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JGG3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017176207   ⟸   XM_017320718
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_030110065   ⟸   XM_030254205
- Peptide Label: isoform X5
Ensembl Acc Id: ENSMUSP00000138397   ⟸   ENSMUST00000031059
Ensembl Acc Id: ENSMUSP00000117040   ⟸   ENSMUST00000132734
Ensembl Acc Id: ENSMUSP00000115586   ⟸   ENSMUST00000127135
Ensembl Acc Id: ENSMUSP00000116566   ⟸   ENSMUST00000151104
Ensembl Acc Id: ENSMUSP00000143553   ⟸   ENSMUST00000196968
RefSeq Acc Id: XP_036020787   ⟸   XM_036164894
- Peptide Label: isoform X6
RefSeq Acc Id: NP_001389916   ⟸   NM_001402987
- Peptide Label: isoform b
RefSeq Acc Id: NP_001389917   ⟸   NM_001402988
- Peptide Label: isoform c
RefSeq Acc Id: NP_001389919   ⟸   NM_001402990
- Peptide Label: isoform e
RefSeq Acc Id: NP_001389920   ⟸   NM_001402991
- Peptide Label: isoform e
RefSeq Acc Id: NP_001389918   ⟸   NM_001402989
- Peptide Label: isoform d
Protein Domains
RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O70343-F1-model_v2 AlphaFold O70343 1-797 view protein structure

Promoters
RGD ID:6886670
Promoter ID:EPDNEW_M6786
Type:multiple initiation site
Name:Ppargc1a_1
Description:Mus musculus peroxisome proliferative activated receptor, gamma,coactivator 1 alpha , transcript variant 3, non-coding RNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38551,553,872 - 51,553,932EPDNEW
RGD ID:6837035
Promoter ID:MM_KWN:42246
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:UC008XKB.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36551,849,011 - 51,849,511 (-)MPROMDB
RGD ID:6838077
Promoter ID:MM_KWN:42248
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:NR_027710_PPARGC1A,   OTTMUST00000054635
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36551,944,841 - 51,945,341 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1342774 AgrOrtholog
Ensembl Genes ENSMUSG00000029167 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000031059.14 UniProtKB/TrEMBL
  ENSMUST00000127135.3 UniProtKB/TrEMBL
  ENSMUST00000132734 ENTREZGENE
  ENSMUST00000132734.8 UniProtKB/Swiss-Prot
  ENSMUST00000151104.8 UniProtKB/Swiss-Prot
  ENSMUST00000196968.5 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot
  PGC-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPARGC1A_RRM UniProtKB/Swiss-Prot
  RBD_domain_sf UniProtKB/Swiss-Prot
  RRM_dom UniProtKB/Swiss-Prot
KEGG Report mmu:19017 UniProtKB/Swiss-Prot
MGD MGI:1342774 ENTREZGENE
NCBI Gene 19017 ENTREZGENE
PANTHER PTHR15528 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15528:SF10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RRM_1 UniProtKB/Swiss-Prot
PhenoGen Ppargc1a PhenoGen
PROSITE RRM UniProtKB/Swiss-Prot
SMART RRM UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot
UniProt A0A0G2JGG3 ENTREZGENE, UniProtKB/TrEMBL
  D3YZS8_MOUSE UniProtKB/TrEMBL
  L0AM20 ENTREZGENE
  L0AN96 ENTREZGENE
  L0APB0 ENTREZGENE
  O70343 ENTREZGENE, UniProtKB/Swiss-Prot
  Q3LIG2_MOUSE UniProtKB/TrEMBL
  Q3UP72 ENTREZGENE
  Q8BRP2_MOUSE UniProtKB/TrEMBL
  Q8CCT1_MOUSE UniProtKB/TrEMBL
UniProt Secondary L0AM20 UniProtKB/Swiss-Prot
  L0AN96 UniProtKB/Swiss-Prot
  L0APB0 UniProtKB/Swiss-Prot
  Q3UP72 UniProtKB/Swiss-Prot