Ppargc1a (peroxisome proliferative activated receptor, gamma, coactivator 1 alpha) - Rat Genome Database

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Gene: Ppargc1a (peroxisome proliferative activated receptor, gamma, coactivator 1 alpha) Mus musculus
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Symbol: Ppargc1a
Name: peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
RGD ID: 1332548
MGI Page MGI
Description: Enables several functions, including chromatin DNA binding activity; lncRNA binding activity; and transcription coactivator activity. Involved in several processes, including gluconeogenesis; positive regulation of cold-induced thermogenesis; and regulation of gene expression. Acts upstream of or within several processes, including negative regulation of neuron apoptotic process; response to dietary excess; and response to muscle activity. Located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; heart; hindlimb digit mesenchyme; and sensory organ. Used to study Parkinson's disease; age related macular degeneration; cardiomyopathy; and congestive heart failure. Human ortholog(s) of this gene implicated in several diseases, including macular degeneration; malignant fibrous histiocytoma; metabolic dysfunction-associated steatotic liver disease; neurodegenerative disease (multiple); and type 2 diabetes mellitus. Orthologous to human PPARGC1A (PPARG coactivator 1 alpha).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: A830037N07Rik; ENSMUSG00000079510; Gm11133; peroxisome proliferator-activated receptor gamma coactivator 1-alpha; peroxisome proliferator-activated receptor gamma coactivator-1 alpha; Pgc; PGC-1; PGC-1-alpha; Pgc-1alpha; Pgc-1alphaa; PGC-1v; Pgc1; Pgco1; PPAR gamma coactivator variant form; PPAR Gamma Coactivator-1; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha; Ppargc1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39551,611,591 - 52,273,316 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl551,611,592 - 51,725,068 (-)EnsemblGRCm39 Ensembl
GRCm38551,454,249 - 52,115,853 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl551,454,250 - 51,567,726 (-)EnsemblGRCm38mm10GRCm38
MGSCv37551,845,488 - 51,945,160 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36551,745,901 - 51,842,109 (-)NCBIMGSCv36mm8
Celera548,830,811 - 48,929,055 (-)NCBICelera
Cytogenetic Map5C1NCBI
cM Map527.02NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Ppargc1aMouseabdominal obesity-metabolic syndrome  ISOPpargc1a (Rattus norvegicus)7241841mRNA:increased expression:gastrocnemius muscle (rat)RGD 
Ppargc1aMouseacute kidney failure  IMP 7242026associated with EndotoxemiaRGD 
Ppargc1aMouseacute kidney failure  IEP 7242026associated with Endotoxemia and mRNA:decreased expression:kidney (mouse)RGD 
Ppargc1aMouseAlbuminuria  ISOPPARGC1A (Homo sapiens)7242025associated with Diabetes Mellitus more ...RGD 
Ppargc1aMouseAlzheimer's disease disease_progressionISOPPARGC1A (Homo sapiens)7242017mRNA and protein:decreased expression:hippocampal formation (human)RGD 
Ppargc1aMouseAlzheimer's disease  ISOPpargc1a (Rattus norvegicus)7242180 RGD 
Ppargc1aMouseAlzheimer's disease  IDA 6484260 RGD 
Ppargc1aMouseamblyopia  ISOPpargc1a (Rattus norvegicus)10059668protein:decreased expression:visual cortex (rat)RGD 
Ppargc1aMouseamnestic disorder  ISOPpargc1a (Rattus norvegicus)407571681associated with morphine withdrawal syndrome and mRNA:increased expression:hippocamous (rat)RGD 
Ppargc1aMouseamyotrophic lateral sclerosis  IEP 7242019mRNA:decreased expression:spinal cord and gastrocnemius muscle (mouse)RGD 
Ppargc1aMouseamyotrophic lateral sclerosis  ISOPPARGC1A (Homo sapiens)6484265human gene in mouse modelRGD 
Ppargc1aMouseamyotrophic lateral sclerosis  ISOPPARGC1A (Homo sapiens)7242019mRNA:decreased expression:motor cortex and muscle (human)RGD 
Ppargc1aMouseBrain Injuries treatmentISOPpargc1a (Rattus norvegicus)10059630protein:decreased expression:frontal cortex (rat)RGD 
Ppargc1aMouseBrain Injuries  IEP 6484257 RGD 
Ppargc1aMouseCardiomegaly  ISOPpargc1a (Rattus norvegicus)7242192protein:increased expression:myocardium of left ventricle (rat)RGD 
Ppargc1aMouseCardiomegaly  IMP 10053662 RGD 
Ppargc1aMousecardiovascular system disease susceptibilityISOPPARGC1A (Homo sapiens)7242032DNA:snps:cds more ...RGD 
Ppargc1aMouseCarotid Artery Injuries treatmentIMP 2311405mouse gene in a rat modelRGD 
Ppargc1aMouseCarotid Artery Injuries  ISOPpargc1a (Rattus norvegicus)7242065 RGD 
Ppargc1aMousechronic kidney disease  IDA 7242023 RGD 
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Ppargc1aMouseamyotrophic lateral sclerosis  ISOPPARGC1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22975021
Ppargc1aMouseBowen's Disease  ISOPPARGC1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21514422
Ppargc1aMousecongestive heart failure  ISOPPARGC1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19808358 and PMID:22503866
Ppargc1aMouseExperimental Diabetes Mellitus  ISOPPARGC1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:14563825
Ppargc1aMouseLewy body dementia  ISOPPARGC1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:30236862
Ppargc1aMouseMuscular Dystrophy, Animal  ISOPPARGC1A (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:22795790
Ppargc1aMousemyocardial infarction  ISOPPARGC1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22503866
Ppargc1aMouseneuronal ceroid lipofuscinosis 1  ISOPPARGC1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21224254
Ppargc1aMouseParkinson's disease  ISOPPARGC1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:30236862
Ppargc1aMousetype 2 diabetes mellitus  ISOPPARGC1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15592662 and PMID:17317762
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Ppargc1aMouseage related macular degeneration  IAGP 13592920 MouseDO 
Ppargc1aMousecardiomyopathy  IAGP 13592920 MouseDO 
Ppargc1aMousecongestive heart failure  IAGP 13592920 MouseDO 
Ppargc1aMouseParkinson's disease  IAGP 13592920 MouseDO 

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Original Reference(s)
Ppargc1aMouse(+)-artemisinin multiple interactionsISOPPARGC1A (Homo sapiens)6480464artemisinin inhibits the reaction [PPARGC1A protein results in increased activity of ESRRA protein]CTDPMID:30818834
Ppargc1aMouse(+)-catechin affects expressionEXP 6480464Catechin affects the expression of PPARGC1A mRNACTDPMID:26363153
Ppargc1aMouse(+)-catechin multiple interactionsEXP 6480464Quercetin affects the reaction [Catechin affects the expression of PPARGC1A mRNA]CTDPMID:26363153
Ppargc1aMouse(+)-schisandrin B multiple interactionsISOPpargc1a (Rattus norvegicus)6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARGC1A mRNA]CTDPMID:31150632
Ppargc1aMouse(+)-taxifolin multiple interactionsISOPpargc1a (Rattus norvegicus)6480464taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of PPARGC1A protein]CTDPMID:32525071
Ppargc1aMouse(-)-epigallocatechin 3-gallate multiple interactionsISOPpargc1a (Rattus norvegicus)6480464[1-Methyl-4-phenylpyridinium co-treated with epigallocatechin gallate] results in increased expression of PPARGC1A mRNA and [1-Methyl-4-phenylpyridinium co-treated with epigallocatechin gallate] results in increased expression of PPARGC1A proteinCTDPMID:22742579
Ppargc1aMouse(-)-epigallocatechin 3-gallate decreases expressionEXP 6480464epigallocatechin gallate results in decreased expression of PPARGC1A proteinCTDPMID:29175576
Ppargc1aMouse(1->4)-beta-D-glucan multiple interactionsEXP 6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of PPARGC1A mRNACTDPMID:36331819
Ppargc1aMouse(20S)-ginsenoside Rg3 increases expressionISOPpargc1a (Rattus norvegicus)6480464ginsenoside Rg3 results in increased expression of PPARGC1A mRNACTDPMID:30144466
Ppargc1aMouse(R)-adrenaline increases expressionISOPpargc1a (Rattus norvegicus)6480464Epinephrine results in increased expression of PPARGC1A mRNACTDPMID:22496244
Ppargc1aMouse(R)-carnitine multiple interactionsISOPpargc1a (Rattus norvegicus)6480464Carnitine inhibits the reaction [Methotrexate results in decreased expression of PPARGC1A protein]CTDPMID:37312617
Ppargc1aMouse(R)-lipoic acid multiple interactionsISOPPARGC1A (Homo sapiens)6480464[Acetylcarnitine co-treated with Thioctic Acid] results in increased expression of PPARGC1A proteinCTDPMID:20414966
Ppargc1aMouse(R)-lipoic acid decreases expressionEXP 6480464Thioctic Acid results in decreased expression of PPARGC1A proteinCTDPMID:37739047
Ppargc1aMouse(R)-lipoic acid multiple interactionsEXP 6480464[Thioctic Acid co-treated with Silicon] results in increased expression of PPARGC1A protein and Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of PPARGC1A mRNA]CTDPMID:34252510 and PMID:37739047
Ppargc1aMouse(R)-lipoic acid multiple interactionsISOPpargc1a (Rattus norvegicus)6480464Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1A mRNA]CTDPMID:22464149
Ppargc1aMouse(R)-lipoic acid increases expressionISOPPARGC1A (Homo sapiens)6480464Thioctic Acid results in increased expression of PPARGC1A proteinCTDPMID:20414966
Ppargc1aMouse(R)-noradrenaline multiple interactionsEXP 6480464[Propranolol co-treated with Prazosin] inhibits the reaction [Norepinephrine results in increased expression of PPARGC1A mRNA] and N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Norepinephrine results in increased expression of PPARGC1A mRNA]CTDPMID:16513826
Ppargc1aMouse(R)-noradrenaline multiple interactionsISOPpargc1a (Rattus norvegicus)6480464Norepinephrine inhibits the reaction [Testosterone results in decreased expression of PPARGC1A mRNA]CTDPMID:16954335
Ppargc1aMouse(R)-noradrenaline increases expressionEXP 6480464Norepinephrine results in increased expression of PPARGC1A mRNACTDPMID:16513826
Ppargc1aMouse(S)-nicotine multiple interactionsEXP 6480464[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PPARGC1A mRNA and [BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of PPARGC1A proteinCTDPMID:33091441

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Biological Process
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Original Reference(s)
Ppargc1aMouseadaptive thermogenesis  ISOPpargc1a (Rattus norvegicus)9068941 RGDPMID:20363363 and REF_RGD_ID:10401808
Ppargc1aMouseadipose tissue development involved_inIMP 2290270 PMID:22237023CACAOPMID:22237023
Ppargc1aMouseandrogen metabolic process  ISOPpargc1a (Rattus norvegicus)9068941nandroloneRGDPMID:23338851 and REF_RGD_ID:7241839
Ppargc1aMouseautophagy of mitochondrion  ISOPpargc1a (Rattus norvegicus)9068941 RGDPMID:19783904 and REF_RGD_ID:10059673
Ppargc1aMousecellular response to caffeine  ISOPpargc1a (Rattus norvegicus)9068941 RGDPMID:17516843 and REF_RGD_ID:10059651
Ppargc1aMousecellular response to estradiol stimulus  ISOPpargc1a (Rattus norvegicus)9068941 RGDPMID:19786068 and REF_RGD_ID:10059654
Ppargc1aMousecellular response to fatty acid  ISOPpargc1a (Rattus norvegicus)9068941 RGDPMID:22676303 and REF_RGD_ID:7242169
Ppargc1aMousecellular response to follicle-stimulating hormone stimulus involved_inISOPpargc1a (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Ppargc1aMousecellular response to follicle-stimulating hormone stimulus  ISOPpargc1a (Rattus norvegicus)9068941 RGDPMID:18511507 and REF_RGD_ID:4781450
Ppargc1aMousecellular response to fructose stimulus  ISOPpargc1a (Rattus norvegicus)9068941 RGDPMID:21212096 and REF_RGD_ID:9585757
Ppargc1aMousecellular response to glucose stimulus  ISOPpargc1a (Rattus norvegicus)9068941 RGDPMID:23692924 and REF_RGD_ID:10059632
Ppargc1aMousecellular response to hypoxia  ISOPpargc1a (Rattus norvegicus)9068941 RGDPMID:22527940 and REF_RGD_ID:7242177
Ppargc1aMousecellular response to interleukin-6  ISOPpargc1a (Rattus norvegicus)9068941 RGDPMID:23692924 and REF_RGD_ID:10059632
Ppargc1aMousecellular response to ionomycin  ISOPpargc1a (Rattus norvegicus)9068941 RGDPMID:17516843 and REF_RGD_ID:10059651
Ppargc1aMousecellular response to lipopolysaccharide  ISOPpargc1a (Rattus norvegicus)9068941 RGDPMID:19853624 and REF_RGD_ID:10059687
Ppargc1aMousecellular response to nitrite  ISOPpargc1a (Rattus norvegicus)9068941 RGDPMID:22892143 and REF_RGD_ID:7242065
Ppargc1aMousecellular response to oxidative stress acts_upstream_of_or_withinIMP 2290270 PMID:20566846MGIPMID:20566846
Ppargc1aMousecellular response to potassium ion  ISOPpargc1a (Rattus norvegicus)9068941 RGDPMID:17870059 and REF_RGD_ID:10059655
Ppargc1aMousecellular response to resveratrol  ISOPpargc1a (Rattus norvegicus)9068941 RGDPMID:20438809 and REF_RGD_ID:10059668
Ppargc1aMousecellular response to thyroid hormone stimulus involved_inISOPpargc1a (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
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Cellular Component
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Ppargc1aMouseapical dendrite  ISOPpargc1a (Rattus norvegicus)9068941 RGDPMID:17335037 and REF_RGD_ID:10059646
Ppargc1aMouseapical dendrite located_inISOPpargc1a (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Ppargc1aMousechromatin located_inISOUniProtKB:Q9UBK22290270 PMID:27471003MGIPMID:27471003
Ppargc1aMousecytosol located_inIEAUniProtKB:Q9UBK2 and ensembl:ENSP000002648672290270 EnsemblGO_REF:0000107
Ppargc1aMousecytosol located_inISOUniProtKB:Q9UBK22290270 GO_CentralGO_REF:0000119
Ppargc1aMousecytosolic ribosome located_inISOPpargc1a (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Ppargc1aMousecytosolic ribosome  ISOPpargc1a (Rattus norvegicus)9068941 RGDPMID:17870059 and REF_RGD_ID:10059655
Ppargc1aMouseeuchromatin  ISOPpargc1a (Rattus norvegicus)9068941 RGDPMID:17870059 and REF_RGD_ID:10059655
Ppargc1aMouseeuchromatin located_inISOPpargc1a (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Ppargc1aMouseneuronal cell body located_inISOPpargc1a (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Ppargc1aMouseneuronal cell body  ISOPpargc1a (Rattus norvegicus)9068941 RGDPMID:17335037 and REF_RGD_ID:10059646
Ppargc1aMousenucleoplasm located_inTAS 2290270 ReactomeReactome:R-MMU-1368101 more ...
Ppargc1aMousenucleoplasm located_inISOUniProtKB:Q9UBK22290270 GO_CentralGO_REF:0000119
Ppargc1aMousenucleus located_inISOUniProtKB:Q9UBK22290270 GO_CentralGO_REF:0000119
Ppargc1aMousenucleus located_inIDA 2290270 PMID:17952069MGIPMID:17952069
Ppargc1aMousenucleus is_active_inIBAPANTHER:PTN000399017 more ...2290270 GO_CentralGO_REF:0000033
Ppargc1aMousenucleus is_active_inISOUniProtKB:Q9UBK22290270 GO_CentralGO_REF:0000119
Ppargc1aMousePML body located_inIEAUniProtKB-SubCell:SL-04652290270 UniProtGO_REF:0000044
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Molecular Function
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Ppargc1aMousealpha-tubulin binding enablesISOPpargc1a (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Ppargc1aMousealpha-tubulin binding  ISOPpargc1a (Rattus norvegicus)9068941 RGDPMID:23297307 and REF_RGD_ID:10059660
Ppargc1aMousechromatin binding  ISOPpargc1a (Rattus norvegicus)9068941 RGDPMID:22705949 and REF_RGD_ID:7242168
Ppargc1aMousechromatin binding enablesISOPpargc1a (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Ppargc1aMousechromatin DNA binding enablesIDA 2290270 PMID:17952069MGIPMID:17952069
Ppargc1aMouseDNA binding enablesIDA 2290270 PMID:15681609MGIPMID:15681609
Ppargc1aMouselncRNA binding enablesIPIMGI:21441142290270 PMID:27760051MGIPMID:27760051
Ppargc1aMousenuclear estrogen receptor binding  ISOEsr1 (Rattus norvegicus)9068941 RGDPMID:18511507 and REF_RGD_ID:4781450
Ppargc1aMousenuclear estrogen receptor binding enablesISOPpargc1a (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Ppargc1aMousenuclear receptor binding enablesIEAUniProtKB:Q9UBK2 and ensembl:ENSP000002648672290270 EnsemblGO_REF:0000107
Ppargc1aMousenuclear receptor binding enablesISOUniProtKB:Q9UBK22290270 GO_CentralGO_REF:0000119
Ppargc1aMouseperoxisome proliferator activated receptor binding enablesISOPpargc1a (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Ppargc1aMouseperoxisome proliferator activated receptor binding  ISOPpara (Rattus norvegicus)9068941 RGDPMID:22464285 and REF_RGD_ID:10059644
Ppargc1aMousepromoter-specific chromatin binding  ISOPpargc1a (Rattus norvegicus)9068941 RGDPMID:19948729 and REF_RGD_ID:10059643
Ppargc1aMousepromoter-specific chromatin binding enablesISOPpargc1a (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Ppargc1aMouseprotein binding enablesIPIUniProtKB:Q6PB662290270 PMID:17050673IntActPMID:17050673
Ppargc1aMouseprotein binding enablesIPIUniProtKB:Q60641-1 and UniProtKB:Q60641-22290270 PMID:14729567IntActPMID:14729567
Ppargc1aMouseprotein binding enablesIPIUniProtKB:P51448 and UniProtKB:P514502290270 PMID:17476214UniProtPMID:17476214
Ppargc1aMouseprotein binding enablesIPIUniProtKB:Q923E42290270 PMID:15716268 and PMID:15744310IntActPMID:15716268 and PMID:15744310
Ppargc1aMouseprotein binding enablesIPIPR:P519492290270 PMID:17276355MGIPMID:17276355
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RGD Manual Annotations


  
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Ppargc1aMousealdosterone signaling pathway   ISOPPARGC1A (Homo sapiens)7421504 RGD 

Imported Annotations - KEGG (archival)

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Ppargc1aMouseHuntington's disease pathway   IEA 6907045 KEGGmmu:05016
Ppargc1aMouseinsulin signaling pathway   IEA 6907045 KEGGmmu:04910

Imported Annotations - PID (archival)

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Original Reference(s)
Ppargc1aMousemTOR signaling pathway   ISOPPARGC1A (Homo sapiens)6484113 PIDPID:200096
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Ppargc1aMouseabnormal basal ganglion morphology  IAGP 5509061 MGIPMID:15760270
Ppargc1aMouseabnormal behavioral response to amphetamine  IAGP 5509061 MGIPMID:27622213
Ppargc1aMouseabnormal blood circulation  IAGP 5509061 MGIPMID:18628400
Ppargc1aMouseabnormal blood homeostasis  IAGP 5509061 MGIPMID:16122419
Ppargc1aMouseabnormal body weight  IAGP 5509061 MGIPMID:15760270
Ppargc1aMouseabnormal brainstem morphology  IAGP 5509061 MGIPMID:15760270
Ppargc1aMouseabnormal brown adipose tissue morphology  IAGP 5509061 MGIPMID:15454086
Ppargc1aMouseabnormal brown adipose tissue morphology  IAGP 5509061 MGIPMID:18628400
Ppargc1aMouseabnormal brown fat cell morphology  IAGP 5509061 MGIPMID:22087241
Ppargc1aMouseabnormal Bruch membrane morphology  IAGP 5509061 MGIPMID:29925537
Ppargc1aMouseabnormal cell physiology  IAGP 5509061 MGIPMID:16122419
Ppargc1aMouseabnormal cellular respiration  IAGP 5509061 MGIPMID:15454086
Ppargc1aMouseabnormal cellular respiration  IAGP 5509061 MGIPMID:15760270
Ppargc1aMouseabnormal cerebellum morphology  IAGP 5509061 MGIPMID:15760270
Ppargc1aMouseabnormal cerebral cortex morphology  IAGP 5509061 MGIPMID:15760270
Ppargc1aMouseabnormal choriocapillaris morphology  IAGP 5509061 MGIPMID:29925537
Ppargc1aMouseabnormal choroid vasculature morphology  IAGP 5509061 MGIPMID:29925537
Ppargc1aMouseabnormal crypts of Lieberkuhn morphology  IAGP 5509061 MGIPMID:21467224
Ppargc1aMouseabnormal fat cell morphology  IAGP 5509061 MGIPMID:18628400
Ppargc1aMouseabnormal gluconeogenesis  IAGP 5509061 MGIPMID:15454086
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Reference Title
Reference Citation
1. Fibre type distribution and gene expression levels of both succinate dehydrogenase and peroxisome proliferator-activated receptor-gamma coactivator-1alpha of fibres in the soleus muscle of Zucker diabetic fatty rats. Adachi T, etal., Exp Physiol. 2007 Mar;92(2):449-55. Epub 2006 Dec 7.
2. Coupling energy homeostasis with a mechanism to support plasticity in brain trauma. Agrawal R, etal., Biochim Biophys Acta. 2014 Apr;1842(4):535-46. doi: 10.1016/j.bbadis.2013.12.004. Epub 2013 Dec 15.
3. Hepatic lipid metabolic pathways modified by resveratrol in rats fed an obesogenic diet. Alberdi G, etal., Nutrition. 2013 Mar;29(3):562-7. doi: 10.1016/j.nut.2012.09.011. Epub 2012 Dec 28.
4. Sex differences in the effect of high-fat diet feeding on rat white adipose tissue mitochondrial function and insulin sensitivity. Amengual-Cladera E, etal., Metabolism. 2012 Aug;61(8):1108-17. doi: 10.1016/j.metabol.2011.12.016. Epub 2012 Mar 7.
5. Role of neuropeptide Y and peroxisome proliferator-activated receptor gamma coactivator-1alpha in stress cardiomyopathy. Ananda S, etal., J Huazhong Univ Sci Technolog Med Sci. 2012 Dec;32(6):823-8. doi: 10.1007/s11596-012-1041-3. Epub 2012 Dec 28.
6. Mitochondrial biogenesis fails in secondary biliary cirrhosis in rats leading to mitochondrial DNA depletion and deletions. Arduini A, etal., Am J Physiol Gastrointest Liver Physiol. 2011 Jul;301(1):G119-27. Epub 2011 Mar 17.
7. ERK and p38 inhibitors attenuate memory deficits and increase CREB phosphorylation and PGC-1alpha levels in Abeta-injected rats. Ashabi G, etal., Behav Brain Res. 2012 Jun 15;232(1):165-73. doi: 10.1016/j.bbr.2012.04.006. Epub 2012 Apr 9.
8. No decline in skeletal muscle oxidative capacity with aging in long-term calorically restricted rats: effects are independent of mitochondrial DNA integrity. Baker DJ, etal., J Gerontol A Biol Sci Med Sci. 2006 Jul;61(7):675-84.
9. Thyroid hormone effects on LKB1, MO25, phospho-AMPK, phospho-CREB, and PGC-1alpha in rat muscle. Branvold DJ, etal., J Appl Physiol (1985). 2008 Oct;105(4):1218-27. doi: 10.1152/japplphysiol.00997.2007. Epub 2008 Jul 31.
10. Tissue-specific remodeling of the mitochondrial proteome in type 1 diabetic akita mice. Bugger H, etal., Diabetes. 2009 Sep;58(9):1986-97. doi: 10.2337/db09-0259. Epub 2009 Jun 19.
11. Maternal high-fat intake during pregnancy programs metabolic-syndrome-related phenotypes through liver mitochondrial DNA copy number and transcriptional activity of liver PPARGC1A. Burgueno AL, etal., J Nutr Biochem. 2013 Jan;24(1):6-13. doi: 10.1016/j.jnutbio.2011.12.008. Epub 2012 May 30.
12. Modified high-sucrose diet-induced abdominally obese and normal-weight rats developed high plasma free fatty acid and insulin resistance. Cao L, etal., Oxid Med Cell Longev. 2012;2012:374346. doi: 10.1155/2012/374346. Epub 2012 Dec 25.
13. Effects of exercise on AMPK signaling and downstream components to PI3K in rat with type 2 diabetes. Cao S, etal., PLoS One. 2012;7(12):e51709. doi: 10.1371/journal.pone.0051709. Epub 2012 Dec 13.
14. Localization of sequence variations in PGC-1alpha influence their modifying effect in Huntington disease. Che HV, etal., Mol Neurodegener. 2011 Jan 6;6(1):1. doi: 10.1186/1750-1326-6-1.
15. G(s)alpha deficiency in skeletal muscle leads to reduced muscle mass, fiber-type switching, and glucose intolerance without insulin resistance or deficiency. Chen M, etal., Am J Physiol Cell Physiol. 2009 Apr;296(4):C930-40. doi: 10.1152/ajpcell.00443.2008. Epub 2009 Jan 21.
16. Roles of transcriptional corepressor RIP140 and coactivator PGC-1alpha in energy state of chronically infarcted rat hearts and mitochondrial function of cardiomyocytes. Chen Y, etal., Mol Cell Endocrinol. 2012 Oct 15;362(1-2):11-8. doi: 10.1016/j.mce.2012.03.023. Epub 2012 Apr 5.
17. The dysfunction of hepatic transcriptional factors in mice with Huntington's Disease. Chiang MC, etal., Biochim Biophys Acta. 2011 Sep;1812(9):1111-20. Epub 2011 May 30.
18. High-fat diet-induced renal cell apoptosis and oxidative stress in spontaneously hypertensive rat are ameliorated by fenofibrate through the PPARalpha-FoxO3a-PGC-1alpha pathway. Chung HW, etal., Nephrol Dial Transplant. 2012 Jun;27(6):2213-25. doi: 10.1093/ndt/gfr613. Epub 2011 Nov 9.
19. Training-induced alterations of skeletal muscle mitochondrial biogenesis proteins in non-insulin-dependent type 2 diabetic men. Chung N, etal., Can J Physiol Pharmacol. 2012 Dec;90(12):1634-41. doi: 10.1139/y2012-144. Epub 2012 Nov 29.
20. Sustained expression of PGC-1alpha in the rat nigrostriatal system selectively impairs dopaminergic function. Ciron C, etal., Hum Mol Genet. 2012 Apr 15;21(8):1861-76. Epub 2012 Jan 12.
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1 to 10 of 74 rows
PMID:9529258   PMID:10349636   PMID:10441518   PMID:10585775   PMID:11018072   PMID:11042159   PMID:11076861   PMID:11108270   PMID:11217851   PMID:11544199   PMID:11557984   PMID:11940593  
PMID:12181572   PMID:12416993   PMID:12477932   PMID:12531492   PMID:12578979   PMID:12651943   PMID:12746468   PMID:12754525   PMID:12764228   PMID:12777397   PMID:12805272   PMID:12837957  
PMID:14522988   PMID:14645497   PMID:14722127   PMID:14729567   PMID:14744933   PMID:15100410   PMID:15107844   PMID:15178647   PMID:15199055   PMID:15202934   PMID:15297879   PMID:15322103  
PMID:15454086   PMID:15456881   PMID:15489334   PMID:15545607   PMID:15589691   PMID:15623424   PMID:15680331   PMID:15681609   PMID:15684380   PMID:15687259   PMID:15699338   PMID:15716268  
PMID:15733855   PMID:15744310   PMID:15760270   PMID:15767263   PMID:15782199   PMID:15930144   PMID:16024798   PMID:16025253   PMID:16033648   PMID:16054070   PMID:16122419   PMID:16141072  
PMID:16141073   PMID:16213225   PMID:16271724   PMID:16314495   PMID:16364253   PMID:16492670   PMID:16511594   PMID:16574644   PMID:16670093   PMID:16679291   PMID:16753578   PMID:16775082  
PMID:16825189   PMID:16876797   PMID:16880515   PMID:16891621   PMID:16929032   PMID:16950137   PMID:16980408   PMID:17003343   PMID:17003473   PMID:17030788   PMID:17050673   PMID:17053067  
PMID:17055439   PMID:17086191   PMID:17141629   PMID:17275789   PMID:17276355   PMID:17301033   PMID:17347648   PMID:17403779   PMID:17446185   PMID:17460188   PMID:17464331   PMID:17468099  
PMID:17476214   PMID:17502589   PMID:17554339   PMID:17575086   PMID:17584738   PMID:17593537   PMID:17609368   PMID:17618855   PMID:17636037   PMID:17702743   PMID:17932032   PMID:17932310  
PMID:17932564   PMID:17937892   PMID:17951580   PMID:17952069   PMID:17992259   PMID:18031569   PMID:18046414   PMID:18073319   PMID:18095059   PMID:18204786   PMID:18239076   PMID:18287559  
1 to 10 of 74 rows



Ppargc1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39551,611,591 - 52,273,316 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl551,611,592 - 51,725,068 (-)EnsemblGRCm39 Ensembl
GRCm38551,454,249 - 52,115,853 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl551,454,250 - 51,567,726 (-)EnsemblGRCm38mm10GRCm38
MGSCv37551,845,488 - 51,945,160 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36551,745,901 - 51,842,109 (-)NCBIMGSCv36mm8
Celera548,830,811 - 48,929,055 (-)NCBICelera
Cytogenetic Map5C1NCBI
cM Map527.02NCBI
PPARGC1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38423,792,021 - 24,472,905 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl423,755,041 - 23,904,089 (-)EnsemblGRCh38hg38GRCh38
GRCh37423,793,644 - 24,474,528 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36423,402,742 - 23,500,798 (-)NCBINCBI36Build 36hg18NCBI36
Build 34423,469,913 - 23,567,969NCBI
Celera424,243,466 - 24,341,439 (-)NCBICelera
Cytogenetic Map4p15.2NCBI
HuRef423,138,364 - 23,236,560 (-)NCBIHuRef
CHM1_1423,791,582 - 23,889,913 (-)NCBICHM1_1
T2T-CHM13v2.0423,773,791 - 24,454,625 (-)NCBIT2T-CHM13v2.0
Ppargc1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81463,073,505 - 63,729,215 (+)NCBIGRCr8
mRatBN7.21458,860,752 - 59,516,525 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1458,861,144 - 59,512,656 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1463,825,757 - 63,916,927 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01465,139,390 - 65,230,573 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01461,536,169 - 61,627,348 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01463,095,291 - 63,190,688 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1463,095,720 - 63,187,009 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01463,182,479 - 63,286,252 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41464,278,115 - 64,370,912 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11464,280,505 - 64,373,303 (+)NCBI
Celera1458,516,257 - 58,607,916 (+)NCBICelera
Cytogenetic Map14q11NCBI
Ppargc1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554801,078,322 - 1,188,435 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955480543,397 - 1,188,376 (+)NCBIChiLan1.0ChiLan1.0
PPARGC1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2324,042,857 - 24,723,457 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1424,239,672 - 24,920,223 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0418,196,431 - 18,876,889 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1423,483,377 - 24,160,574 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl423,483,377 - 23,581,212 (-)Ensemblpanpan1.1panPan2
PPARGC1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1385,645,942 - 86,284,570 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl386,016,140 - 86,281,269 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha388,158,508 - 88,796,824 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0386,620,570 - 87,261,415 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl386,992,463 - 87,261,415 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1385,752,591 - 86,391,823 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0385,858,991 - 86,497,911 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0386,243,892 - 86,883,362 (+)NCBIUU_Cfam_GSD_1.0
Ppargc1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528551,179,331 - 51,786,516 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364775,199,881 - 5,488,226 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364774,881,230 - 5,488,208 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPARGC1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl817,841,844 - 17,946,992 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1817,841,844 - 18,527,953 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pig Cytomap8p2.1-p2.3NCBI
PPARGC1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12725,882,385 - 26,563,530 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2726,465,499 - 26,564,582 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604772,634,061 - 73,114,795 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppargc1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247558,375,596 - 8,465,297 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247557,826,219 - 8,460,746 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Ppargc1a
30615 total Variants

Predicted Target Of
Summary Value
Count of predictions:2172
Count of miRNA genes:797
Interacting mature miRNAs:1074
Transcripts:ENSMUST00000031059, ENSMUST00000127135, ENSMUST00000132734, ENSMUST00000151104
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 30 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
4140990Lgq6_mlate growth QTL 6 (mouse)Not determined32133234100777931Mouse
10043995Hbnr9_mHeligmosomoides bakeri nematode resistance 9 (mouse)Not determined53348866767488876Mouse
1301776Skts3_mskin tumor susceptibility 3 (mouse)Not determined52166729555667403Mouse
1300951Gbvq1_mgallstone bladder volume QTL 1 (mouse)Not determined53811168172111798Mouse
14746981Manh57_mmandible shape 57 (mouse)54716974281169742Mouse
1301845Lxw4_mlupus BXSB x NZW 4 (mouse)Not determined53569446269694594Mouse
1301524Lmb2_mlupus in MRL and B6 F2 cross (mouse)Not determined537581488112465722Mouse
1301403Alcp9_malcohol preference locus 9 (mouse)Not determined53102427565024480Mouse
1300701Cd8ts1_mCD8 T cell subset 1 (mouse)Not determined52721534861215451Mouse
11353827Hplq1_mhot plate latency 1 (mouse)53157045865570458Mouse

1 to 10 of 30 rows
Ppargc1a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5C1UniSTS
cM Map5 UniSTS
MARC_49176-49177:1118326844:1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38551,473,916 - 51,474,400UniSTSGRCm38
MGSCv37551,865,155 - 51,865,639UniSTSGRCm37
Celera548,850,485 - 48,850,969UniSTS
Cytogenetic Map5C1UniSTS
PPARGC1A__5755  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38551,454,240 - 51,455,132UniSTSGRCm38
MGSCv37551,845,479 - 51,846,371UniSTSGRCm37
Celera548,830,802 - 48,831,694UniSTS
Cytogenetic Map5C1UniSTS
Ppargc1a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5C1UniSTS
cM Map5 UniSTS






1 to 30 of 40 rows
RefSeq Transcripts NM_001402987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001402988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001402989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001402990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001402991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_027710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_132764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_175325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_175326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_175327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006503775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017320718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030254205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB061324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB061326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC104540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC107227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC111037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC111039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC116763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC158149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC163408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AEKQ02089460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF049330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK032149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK043827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK082685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK138668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 30 of 40 rows

Ensembl Acc Id: ENSMUST00000031059   ⟹   ENSMUSP00000138397
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl551,614,995 - 51,711,213 (-)Ensembl
GRCm38.p6 Ensembl551,457,653 - 51,553,871 (-)Ensembl
Ensembl Acc Id: ENSMUST00000127135   ⟹   ENSMUSP00000115586
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl551,653,122 - 51,725,068 (-)Ensembl
GRCm38.p6 Ensembl551,495,780 - 51,567,726 (-)Ensembl
Ensembl Acc Id: ENSMUST00000132734   ⟹   ENSMUSP00000117040
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl551,611,592 - 51,711,264 (-)Ensembl
GRCm38.p6 Ensembl551,454,250 - 51,553,922 (-)Ensembl
Ensembl Acc Id: ENSMUST00000151104   ⟹   ENSMUSP00000116566
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl551,615,522 - 51,725,046 (-)Ensembl
GRCm38.p6 Ensembl551,458,180 - 51,567,704 (-)Ensembl
Ensembl Acc Id: ENSMUST00000196968   ⟹   ENSMUSP00000143553
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl551,614,997 - 51,711,233 (-)Ensembl
GRCm38.p6 Ensembl551,457,655 - 51,553,891 (-)Ensembl
RefSeq Acc Id: NM_001402987   ⟹   NP_001389916
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39551,611,591 - 52,273,316 (-)NCBI
RefSeq Acc Id: NM_001402988   ⟹   NP_001389917
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39551,611,591 - 52,273,316 (-)NCBI
RefSeq Acc Id: NM_001402989   ⟹   NP_001389918
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39551,611,591 - 51,710,420 (-)NCBI
RefSeq Acc Id: NM_001402990   ⟹   NP_001389919
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39551,611,591 - 51,862,308 (-)NCBI
RefSeq Acc Id: NM_001402991   ⟹   NP_001389920
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39551,611,591 - 51,711,351 (-)NCBI
RefSeq Acc Id: NM_008904   ⟹   NP_032930
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39551,611,591 - 51,711,214 (-)NCBI
GRCm38551,454,249 - 51,553,921 (-)NCBI
MGSCv37551,845,488 - 51,945,160 (-)RGD
Celera548,830,811 - 48,929,055 (-)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_027710
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39551,611,591 - 51,711,214 (-)NCBI
GRCm38551,454,249 - 51,553,921 (-)NCBI
MGSCv37551,845,488 - 51,945,160 (-)RGD
Celera548,830,811 - 48,929,055 (-)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_132764
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39551,611,591 - 51,725,067 (-)NCBI
GRCm38551,454,249 - 51,567,725 (-)NCBI
Sequence:
RefSeq Acc Id: NR_175325
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39551,611,591 - 52,273,316 (-)NCBI
RefSeq Acc Id: NR_175326
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39551,611,591 - 51,710,420 (-)NCBI
RefSeq Acc Id: NR_175327
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39551,611,591 - 51,710,420 (-)NCBI
RefSeq Acc Id: XM_006503775   ⟹   XP_006503838
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39551,611,591 - 51,725,064 (-)NCBI
GRCm38551,454,249 - 51,567,720 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017320718   ⟹   XP_017176207
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39551,611,591 - 51,710,442 (-)NCBI
GRCm38551,454,249 - 51,553,095 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030254205   ⟹   XP_030110065
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39551,611,591 - 51,710,283 (-)NCBI
GRCm38551,454,249 - 51,553,084 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036164894   ⟹   XP_036020787
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39551,611,591 - 51,711,387 (-)NCBI
Sequence:
1 to 29 of 29 rows
Protein RefSeqs NP_001389916 (Get FASTA)   NCBI Sequence Viewer  
  NP_001389917 (Get FASTA)   NCBI Sequence Viewer  
  NP_001389918 (Get FASTA)   NCBI Sequence Viewer  
  NP_001389919 (Get FASTA)   NCBI Sequence Viewer  
  NP_001389920 (Get FASTA)   NCBI Sequence Viewer  
  NP_032930 (Get FASTA)   NCBI Sequence Viewer  
  XP_006503838 (Get FASTA)   NCBI Sequence Viewer  
  XP_017176207 (Get FASTA)   NCBI Sequence Viewer  
  XP_030110065 (Get FASTA)   NCBI Sequence Viewer  
  XP_036020787 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC13554 (Get FASTA)   NCBI Sequence Viewer  
  AAH66868 (Get FASTA)   NCBI Sequence Viewer  
  AFZ74947 (Get FASTA)   NCBI Sequence Viewer  
  AFZ74948 (Get FASTA)   NCBI Sequence Viewer  
  AFZ74949 (Get FASTA)   NCBI Sequence Viewer  
  BAC27725 (Get FASTA)   NCBI Sequence Viewer  
  BAC31667 (Get FASTA)   NCBI Sequence Viewer  
  BAE23740 (Get FASTA)   NCBI Sequence Viewer  
  BAE25525 (Get FASTA)   NCBI Sequence Viewer  
  BAE46507 (Get FASTA)   NCBI Sequence Viewer  
  BAE46509 (Get FASTA)   NCBI Sequence Viewer  
  BAE46510 (Get FASTA)   NCBI Sequence Viewer  
  CAK22377 (Get FASTA)   NCBI Sequence Viewer  
  EDL37647 (Get FASTA)   NCBI Sequence Viewer  
  EDL37648 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000116566.3
  ENSMUSP00000117040
  ENSMUSP00000117040.2
GenBank Protein O70343 (Get FASTA)   NCBI Sequence Viewer  
1 to 29 of 29 rows
1 to 5 of 15 rows
1 to 5 of 15 rows
RefSeq Acc Id: NP_032930   ⟸   NM_008904
- Peptide Label: isoform a
- UniProtKB: L0APB0 (UniProtKB/Swiss-Prot),   L0AN96 (UniProtKB/Swiss-Prot),   L0AM20 (UniProtKB/Swiss-Prot),   Q3UP72 (UniProtKB/Swiss-Prot),   O70343 (UniProtKB/Swiss-Prot),   A0A0G2JGG3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006503838   ⟸   XM_006503775
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JGG3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017176207   ⟸   XM_017320718
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_030110065   ⟸   XM_030254205
- Peptide Label: isoform X5
Ensembl Acc Id: ENSMUSP00000138397   ⟸   ENSMUST00000031059
RRM

Name Modeler Protein Id AA Range Protein Structure
AF-O70343-F1-model_v2 AlphaFold O70343 1-797 view protein structure

RGD ID:6886670
Promoter ID:EPDNEW_M6786
Type:multiple initiation site
Name:Ppargc1a_1
Description:Mus musculus peroxisome proliferative activated receptor, gamma,coactivator 1 alpha , transcript variant 3, non-coding RNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38551,553,872 - 51,553,932EPDNEW
RGD ID:6837035
Promoter ID:MM_KWN:42246
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:UC008XKB.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36551,849,011 - 51,849,511 (-)MPROMDB
RGD ID:6838077
Promoter ID:MM_KWN:42248
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:NR_027710_PPARGC1A,   OTTMUST00000054635
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36551,944,841 - 51,945,341 (-)MPROMDB


1 to 34 of 34 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000029167 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000132734 ENTREZGENE
  ENSMUST00000132734.8 UniProtKB/Swiss-Prot
  ENSMUST00000151104.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot
  PGC-1 UniProtKB/Swiss-Prot
  PPARGC1A_RRM UniProtKB/Swiss-Prot
  RBD_domain_sf UniProtKB/Swiss-Prot
  RRM_dom UniProtKB/Swiss-Prot
KEGG Report mmu:19017 UniProtKB/Swiss-Prot
MGD MGI:1342774 ENTREZGENE
NCBI Gene 19017 ENTREZGENE
PANTHER PTHR15528 UniProtKB/Swiss-Prot
  PTHR15528:SF10 UniProtKB/Swiss-Prot
Pfam RRM_1 UniProtKB/Swiss-Prot
PhenoGen Ppargc1a PhenoGen
PROSITE RRM UniProtKB/Swiss-Prot
SMART RRM UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot
UniProt A0A0G2JGG3 ENTREZGENE, UniProtKB/TrEMBL
  D3YZS8_MOUSE UniProtKB/TrEMBL
  L0AM20 ENTREZGENE
  L0AN96 ENTREZGENE
  L0APB0 ENTREZGENE
  O70343 ENTREZGENE, UniProtKB/Swiss-Prot
  Q3LIG2_MOUSE UniProtKB/TrEMBL
  Q3UP72 ENTREZGENE
  Q8BRP2_MOUSE UniProtKB/TrEMBL
  Q8CCT1_MOUSE UniProtKB/TrEMBL
UniProt Secondary L0AM20 UniProtKB/Swiss-Prot
  L0AN96 UniProtKB/Swiss-Prot
  L0APB0 UniProtKB/Swiss-Prot
  Q3UP72 UniProtKB/Swiss-Prot
1 to 34 of 34 rows