PPARGC1A (PPARG coactivator 1 alpha) - Rat Genome Database

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Gene: PPARGC1A (PPARG coactivator 1 alpha) Pan paniscus
Analyze
Symbol: PPARGC1A
Name: PPARG coactivator 1 alpha
RGD ID: 11863356
Description: ENCODES a protein that exhibits alpha-tubulin binding (ortholog); chromatin binding (ortholog); nuclear estrogen receptor binding (ortholog); INVOLVED IN adaptive thermogenesis (ortholog); androgen metabolic process (ortholog); autophagy of mitochondrion (ortholog); PARTICIPATES IN aldosterone signaling pathway; mTOR signaling pathway; ASSOCIATED WITH abdominal obesity-metabolic syndrome (ortholog); acute kidney failure (ortholog); age related macular degeneration (ortholog); FOUND IN apical dendrite (ortholog); cytosolic ribosome (ortholog); euchromatin (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: peroxisome proliferator-activated receptor gamma coactivator 1-alpha
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2324,042,857 - 24,723,457 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1424,239,672 - 24,920,223 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0418,196,431 - 18,876,889 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1423,483,377 - 24,160,574 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl423,483,377 - 23,581,212 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome  (ISO)
acute kidney failure  (ISO)
age related macular degeneration  (ISO)
Albuminuria  (ISO)
Alzheimer's disease  (ISO)
amblyopia  (ISO)
amnestic disorder  (ISO)
amyotrophic lateral sclerosis  (ISO)
Bowen's Disease  (ISO)
Brain Injuries  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
cardiovascular system disease  (ISO)
Carotid Artery Injuries  (ISO)
chronic kidney disease  (ISO)
chronic obstructive pulmonary disease  (ISO)
colitis  (ISO)
congenital hypothyroidism  (ISO)
congestive heart failure  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (ISO)
Diseases of the Aged  (ISO)
Experimental Diabetes Mellitus  (ISO)
Fetal Growth Retardation  (ISO)
glucose intolerance  (ISO)
heart disease  (ISO)
Huntington's disease  (ISO)
hyperglycemia  (ISO)
hyperthyroidism  (ISO)
Hypertriglyceridemia  (ISO)
Hypoxia  (ISO)
Insulin Resistance  (ISO)
Kearns-Sayre syndrome  (ISO)
kidney cancer  (ISO)
kidney failure  (ISO)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (ISO)
Lewy body dementia  (ISO)
macular degeneration  (ISO)
malignant fibrous histiocytoma  (ISO)
melanoma  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
Muscular Dystrophy, Animal  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
nephrotic syndrome  (ISO)
neuronal ceroid lipofuscinosis 1  (ISO)
obesity  (ISO)
Parkinson's disease  (ISO)
Parkinsonism  (ISO)
placental insufficiency  (ISO)
Plaque, Atherosclerotic  (ISO)
prediabetes syndrome  (ISO)
primary biliary cholangitis  (ISO)
pulmonary emphysema  (ISO)
renal fibrosis  (ISO)
Right Ventricular Hypertrophy  (ISO)
Sarcopenia  (ISO)
schizophrenia  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
Sleep Initiation and Maintenance Disorders  (ISO)
Spinal Cord Injuries  (ISO)
steatotic liver disease  (ISO)
Takotsubo Cardiomyopathy  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
Ventricular Dysfunction, Right  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive thermogenesis  (ISO)
adipose tissue development  (IEA)
androgen metabolic process  (ISO)
autophagy of mitochondrion  (ISO)
cellular response to caffeine  (ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to fatty acid  (ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to fructose stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to interleukin-6  (ISO)
cellular response to ionomycin  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to nitrite  (ISO)
cellular response to oxidative stress  (IEA,ISO)
cellular response to potassium ion  (ISO)
cellular response to resveratrol  (ISO)
cellular response to thyroid hormone stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
cerebellum development  (ISO)
circadian regulation of gene expression  (IEA)
energy homeostasis  (IEA,ISO)
fatty acid oxidation  (ISO)
flavone metabolic process  (ISO)
forebrain development  (ISO)
galactose metabolic process  (ISO)
gluconeogenesis  (IEA,ISO)
mitochondrion organization  (IEA,ISO)
negative regulation of glycolytic process  (ISO)
negative regulation of mitochondrial fission  (ISO)
negative regulation of neuron apoptotic process  (IEA,ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of signaling receptor activity  (ISO)
negative regulation of smooth muscle cell migration  (ISO)
negative regulation of smooth muscle cell proliferation  (IEA,ISO)
neuron apoptotic process  (IEA,ISO)
positive regulation of cold-induced thermogenesis  (IEA)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of fatty acid oxidation  (ISO)
positive regulation of gene expression  (IEA)
positive regulation of podocyte apoptotic process  (ISO)
positive regulation of progesterone biosynthetic process  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
regulation of circadian rhythm  (IEA)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of NMDA receptor activity  (ISO)
respiratory electron transport chain  (IEA,ISO)
response to activity  (ISO)
response to dehydroepiandrosterone  (ISO)
response to dietary excess  (IEA,ISO)
response to electrical stimulus  (ISO)
response to electrical stimulus involved in regulation of muscle adaptation  (ISO)
response to epinephrine  (ISO)
response to fructose  (ISO)
response to hypobaric hypoxia  (ISO)
response to hypoxia  (ISO)
response to ischemia  (ISO)
response to L-leucine  (ISO)
response to methionine  (ISO)
response to morphine  (ISO)
response to muscle activity  (IEA,ISO)
response to norepinephrine  (ISO)
response to nutrient  (ISO)
response to nutrient levels  (ISO)
response to reactive oxygen species  (ISO)
response to starvation  (ISO)
response to thyroid hormone  (ISO)
response to xenobiotic stimulus  (ISO)
rhythmic process  (IEA)
skeletal muscle atrophy  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PPARGC1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2324,042,857 - 24,723,457 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1424,239,672 - 24,920,223 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0418,196,431 - 18,876,889 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1423,483,377 - 24,160,574 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl423,483,377 - 23,581,212 (-)Ensemblpanpan1.1panPan2
PPARGC1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38423,792,021 - 24,472,905 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl423,755,041 - 23,904,089 (-)EnsemblGRCh38hg38GRCh38
GRCh37423,793,644 - 24,474,528 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36423,402,742 - 23,500,798 (-)NCBINCBI36Build 36hg18NCBI36
Build 34423,469,913 - 23,567,969NCBI
Celera424,243,466 - 24,341,439 (-)NCBICelera
Cytogenetic Map4p15.2NCBI
HuRef423,138,364 - 23,236,560 (-)NCBIHuRef
CHM1_1423,791,582 - 23,889,913 (-)NCBICHM1_1
T2T-CHM13v2.0423,773,791 - 24,454,625 (-)NCBIT2T-CHM13v2.0
Ppargc1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39551,611,591 - 52,273,316 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl551,611,592 - 51,725,068 (-)EnsemblGRCm39 Ensembl
GRCm38551,454,249 - 52,115,853 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl551,454,250 - 51,567,726 (-)EnsemblGRCm38mm10GRCm38
MGSCv37551,845,488 - 51,945,160 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36551,745,901 - 51,842,109 (-)NCBIMGSCv36mm8
Celera548,830,811 - 48,929,055 (-)NCBICelera
Cytogenetic Map5C1NCBI
cM Map527.02NCBI
Ppargc1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81463,073,505 - 63,729,215 (+)NCBIGRCr8
mRatBN7.21458,860,752 - 59,516,525 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1458,861,144 - 59,512,656 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1463,825,757 - 63,916,927 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01465,139,390 - 65,230,573 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01461,536,169 - 61,627,348 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01463,095,291 - 63,190,688 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1463,095,720 - 63,187,009 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01463,182,479 - 63,286,252 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41464,278,115 - 64,370,912 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11464,280,505 - 64,373,303 (+)NCBI
Celera1458,516,257 - 58,607,916 (+)NCBICelera
Cytogenetic Map14q11NCBI
Ppargc1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554801,078,322 - 1,188,435 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955480543,397 - 1,188,376 (+)NCBIChiLan1.0ChiLan1.0
PPARGC1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1385,645,942 - 86,284,570 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl386,016,140 - 86,281,269 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha388,158,508 - 88,796,824 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0386,620,570 - 87,261,415 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl386,992,463 - 87,261,415 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1385,752,591 - 86,391,823 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0385,858,991 - 86,497,911 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0386,243,892 - 86,883,362 (+)NCBIUU_Cfam_GSD_1.0
Ppargc1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528551,179,331 - 51,786,516 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364775,199,881 - 5,488,226 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364774,881,230 - 5,488,208 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPARGC1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl817,841,844 - 17,946,992 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1817,841,844 - 18,527,953 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pig Cytomap8p2.1-p2.3NCBI
PPARGC1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12725,882,385 - 26,563,530 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2726,465,499 - 26,564,582 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604772,634,061 - 73,114,795 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppargc1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247558,375,596 - 8,465,297 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247557,826,219 - 8,460,746 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000045862   ⟹   ENSPPAP00000023044
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl423,483,377 - 23,581,212 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000045865   ⟹   ENSPPAP00000023046
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl423,483,377 - 23,572,475 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000045871   ⟹   ENSPPAP00000023052
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl423,486,309 - 23,580,948 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000045891   ⟹   ENSPPAP00000023071
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl423,487,150 - 23,580,948 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000045898   ⟹   ENSPPAP00000023078
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl423,487,150 - 23,519,763 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000045901   ⟹   ENSPPAP00000023081
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl423,487,179 - 23,580,948 (-)Ensembl
RefSeq Acc Id: XM_003826832   ⟹   XP_003826880
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2324,042,857 - 24,155,623 (-)NCBI
NHGRI_mPanPan1424,239,672 - 24,338,120 (-)NCBI
Mhudiblu_PPA_v0418,196,431 - 18,295,328 (-)NCBI
PanPan1.1423,483,377 - 23,581,212 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034958375   ⟹   XP_034814266
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2324,042,857 - 24,343,043 (-)NCBI
NHGRI_mPanPan1424,239,672 - 24,920,223 (-)NCBI
Mhudiblu_PPA_v0418,196,431 - 18,876,889 (-)NCBI
RefSeq Acc Id: XM_063603745   ⟹   XP_063459815
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2324,042,857 - 24,723,457 (-)NCBI
RefSeq Acc Id: XM_063603746   ⟹   XP_063459816
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2324,042,857 - 24,509,269 (-)NCBI
RefSeq Acc Id: XM_063603747   ⟹   XP_063459817
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2324,042,857 - 24,155,623 (-)NCBI
RefSeq Acc Id: XP_003826880   ⟸   XM_003826832
- Peptide Label: isoform X3
- UniProtKB: A0A2R9B1U3 (UniProtKB/TrEMBL),   A0A2R9B6V2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034814266   ⟸   XM_034958375
- Peptide Label: isoform X2
- UniProtKB: A0A2R9B6V2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000023046   ⟸   ENSPPAT00000045865
Ensembl Acc Id: ENSPPAP00000023044   ⟸   ENSPPAT00000045862
Ensembl Acc Id: ENSPPAP00000023052   ⟸   ENSPPAT00000045871
Ensembl Acc Id: ENSPPAP00000023078   ⟸   ENSPPAT00000045898
Ensembl Acc Id: ENSPPAP00000023071   ⟸   ENSPPAT00000045891
Ensembl Acc Id: ENSPPAP00000023081   ⟸   ENSPPAT00000045901
RefSeq Acc Id: XP_063459815   ⟸   XM_063603745
- Peptide Label: isoform X1
- UniProtKB: A0A2R9B6V2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063459816   ⟸   XM_063603746
- Peptide Label: isoform X4
- UniProtKB: A0A2R9B6V2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063459817   ⟸   XM_063603747
- Peptide Label: isoform X5
- UniProtKB: A0A2R9B0J6 (UniProtKB/TrEMBL),   A0A2R9B6V2 (UniProtKB/TrEMBL)
Protein Domains
RRM


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000034694 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000045862.1 UniProtKB/TrEMBL
  ENSPPAT00000045865.1 UniProtKB/TrEMBL
  ENSPPAT00000045871.1 UniProtKB/TrEMBL
  ENSPPAT00000045891.1 UniProtKB/TrEMBL
  ENSPPAT00000045898.1 UniProtKB/TrEMBL
  ENSPPAT00000045901.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.330 UniProtKB/TrEMBL
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/TrEMBL
  PGC-1 UniProtKB/TrEMBL
  PPARGC1A_RRM UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/TrEMBL
  RRM_dom UniProtKB/TrEMBL
KEGG Report pps:100990453 UniProtKB/TrEMBL
NCBI Gene PPARGC1A ENTREZGENE
PANTHER PTHR15528 UniProtKB/TrEMBL
  PTHR15528:SF10 UniProtKB/TrEMBL
Pfam RRM_1 UniProtKB/TrEMBL
PROSITE RRM UniProtKB/TrEMBL
SMART RRM UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/TrEMBL
UniProt A0A2R9B0J6 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9B0M5_PANPA UniProtKB/TrEMBL
  A0A2R9B0N3_PANPA UniProtKB/TrEMBL
  A0A2R9B1U3 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9B4I0_PANPA UniProtKB/TrEMBL
  A0A2R9B6V2 ENTREZGENE, UniProtKB/TrEMBL