Ppargc1a (PPARG coactivator 1 alpha) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Ppargc1a (PPARG coactivator 1 alpha) Chinchilla lanigera
Analyze
Symbol: Ppargc1a
Name: PPARG coactivator 1 alpha
RGD ID: 8891795
Description: ENCODES a protein that exhibits alpha-tubulin binding (ortholog); chromatin binding (ortholog); chromatin DNA binding (ortholog); INVOLVED IN adaptive thermogenesis (ortholog); adipose tissue development (ortholog); aging (ortholog); PARTICIPATES IN aldosterone signaling pathway; mTOR signaling pathway; ASSOCIATED WITH abdominal obesity-metabolic syndrome (ortholog); acute kidney failure (ortholog); Albuminuria (ortholog); FOUND IN apical dendrite (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: peroxisome proliferator-activated receptor gamma coactivator 1-alpha; peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554801,078,322 - 1,188,435 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955480543,397 - 1,188,376 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome  (ISO)
acute kidney failure  (ISO)
Albuminuria  (ISO)
Alzheimer's disease  (ISO)
amblyopia  (ISO)
amyotrophic lateral sclerosis  (ISO)
Bowen's Disease  (ISO)
Brain Injuries  (ISO)
Cardiomegaly  (ISO)
cardiovascular system disease  (ISO)
Carotid Artery Injuries  (ISO)
chronic kidney disease  (ISO)
chronic obstructive pulmonary disease  (ISO)
colitis  (ISO)
congenital hypothyroidism  (ISO)
congestive heart failure  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (ISO)
Diseases of the Aged  (ISO)
Experimental Diabetes Mellitus  (ISO)
fatty liver disease  (ISO)
Fetal Growth Retardation  (ISO)
glucose intolerance  (ISO)
heart disease  (ISO)
Huntington's disease  (ISO)
hyperglycemia  (ISO)
hyperthyroidism  (ISO)
Insulin Resistance  (ISO)
Kearns-Sayre syndrome  (ISO)
kidney cancer  (ISO)
kidney failure  (ISO)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (ISO)
Lewy body dementia  (ISO)
macular degeneration  (ISO)
malignant fibrous histiocytoma  (ISO)
melanoma  (ISO)
Metabolic Syndrome  (ISO)
Muscular Dystrophy, Animal  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
nephrotic syndrome  (ISO)
neuronal ceroid lipofuscinosis 1  (ISO)
non-alcoholic fatty liver disease  (ISO)
obesity  (ISO)
Parkinson's disease  (ISO)
Parkinsonism  (ISO)
placental insufficiency  (ISO)
prediabetes syndrome  (ISO)
primary biliary cholangitis  (ISO)
pulmonary emphysema  (ISO)
renal fibrosis  (ISO)
Right Ventricular Hypertrophy  (ISO)
Sarcopenia  (ISO)
schizophrenia  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
Sleep Initiation and Maintenance Disorders  (ISO)
Spinal Cord Injuries  (ISO)
Takotsubo Cardiomyopathy  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive thermogenesis  (ISO)
adipose tissue development  (ISO)
aging  (ISO)
androgen metabolic process  (ISO)
autophagy of mitochondrion  (ISO)
cellular response to caffeine  (ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to fatty acid  (ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to fructose stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to interleukin-6  (ISO)
cellular response to ionomycin  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to nitrite  (ISO)
cellular response to oxidative stress  (ISO)
cellular response to potassium ion  (ISO)
cellular response to resveratrol  (ISO)
cellular response to thyroid hormone stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
cerebellum development  (ISO)
circadian regulation of gene expression  (ISO)
energy homeostasis  (ISO)
fatty acid oxidation  (ISO)
flavone metabolic process  (ISO)
forebrain development  (ISO)
galactose metabolic process  (ISO)
gluconeogenesis  (ISO)
mitochondrion organization  (ISO)
negative regulation of glycolytic process  (ISO)
negative regulation of mitochondrial fission  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neuron death  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of signaling receptor activity  (ISO)
negative regulation of smooth muscle cell migration  (ISO)
negative regulation of smooth muscle cell proliferation  (ISO)
positive regulation of ATP biosynthetic process  (ISO)
positive regulation of cellular metabolic process  (ISO)
positive regulation of cellular respiration  (ISO)
positive regulation of cold-induced thermogenesis  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of fatty acid oxidation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glomerular visceral epithelial cell apoptotic process  (ISO)
positive regulation of mitochondrial DNA metabolic process  (ISO)
positive regulation of mitochondrion organization  (ISO)
positive regulation of muscle tissue development  (ISO)
positive regulation of progesterone biosynthetic process  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
regulation of circadian rhythm  (ISO)
regulation of NMDA receptor activity  (ISO)
regulation of transcription, DNA-templated  (ISO)
respiratory electron transport chain  (ISO)
response to activity  (ISO)
response to cold  (ISO)
response to dietary excess  (ISO)
response to electrical stimulus  (ISO)
response to electrical stimulus involved in regulation of muscle adaptation  (ISO)
response to epinephrine  (ISO)
response to fructose  (ISO)
response to hypoxia  (ISO)
response to ischemia  (ISO)
response to leucine  (ISO)
response to metformin  (ISO)
response to methionine  (ISO)
response to muscle activity  (ISO)
response to norepinephrine  (ISO)
response to nutrient levels  (ISO)
response to organic cyclic compound  (ISO)
response to reactive oxygen species  (ISO)
response to starvation  (ISO)
response to thyroid hormone  (ISO)
response to xenobiotic stimulus  (ISO)
skeletal muscle atrophy  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References


Genomics

Comparative Map Data
Ppargc1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554801,078,322 - 1,188,435 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955480543,397 - 1,188,376 (+)NCBIChiLan1.0ChiLan1.0
PPARGC1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl423,755,041 - 23,904,089 (-)EnsemblGRCh38hg38GRCh38
GRCh38423,792,021 - 24,472,905 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37423,793,644 - 24,474,528 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36423,402,742 - 23,500,798 (-)NCBINCBI36hg18NCBI36
Build 34423,469,913 - 23,567,969NCBI
Celera424,243,466 - 24,341,439 (-)NCBI
Cytogenetic Map4p15.2NCBI
HuRef423,138,364 - 23,236,560 (-)NCBIHuRef
CHM1_1423,791,582 - 23,889,913 (-)NCBICHM1_1
Ppargc1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39551,611,591 - 52,273,337 (-)NCBIGRCm39mm39
GRCm39 Ensembl551,611,592 - 51,725,068 (-)Ensembl
GRCm38551,454,249 - 52,115,853 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl551,454,250 - 51,567,726 (-)EnsemblGRCm38mm10GRCm38
MGSCv37551,845,488 - 51,945,160 (-)NCBIGRCm37mm9NCBIm37
MGSCv36551,745,901 - 51,842,109 (-)NCBImm8
Celera548,830,811 - 48,929,055 (-)NCBICelera
Cytogenetic Map5C1NCBI
Ppargc1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21458,860,752 - 59,516,525 (+)NCBI
Rnor_6.0 Ensembl1463,095,720 - 63,187,009 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01463,095,291 - 63,190,688 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01463,182,479 - 63,286,252 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41464,278,115 - 64,370,912 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11464,280,505 - 64,373,303 (+)NCBI
Celera1458,516,257 - 58,607,916 (+)NCBICelera
Cytogenetic Map14q11NCBI
PPARGC1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1423,483,377 - 24,160,574 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl423,483,377 - 23,581,212 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0418,196,431 - 18,876,889 (-)NCBIMhudiblu_PPA_v0panPan3
PPARGC1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1385,645,942 - 86,284,570 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl386,016,140 - 86,281,269 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha388,158,508 - 88,796,824 (+)NCBI
ROS_Cfam_1.0386,620,570 - 87,261,415 (+)NCBI
UMICH_Zoey_3.1385,752,591 - 86,391,823 (+)NCBI
UNSW_CanFamBas_1.0385,858,991 - 86,497,911 (+)NCBI
UU_Cfam_GSD_1.0386,243,892 - 86,883,362 (+)NCBI
Ppargc1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528551,179,331 - 51,786,516 (+)NCBI
SpeTri2.0NW_0049364774,881,230 - 5,488,208 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPARGC1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl817,841,844 - 17,961,909 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1817,841,844 - 18,527,953 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pig Cytomap8p2.1-p2.3NCBI
PPARGC1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12725,882,385 - 26,563,530 (+)NCBI
ChlSab1.1 Ensembl2726,465,499 - 26,564,582 (+)Ensembl
Vero_WHO_p1.0NW_02366604772,634,061 - 73,114,795 (+)NCBI
Ppargc1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247557,826,219 - 8,460,746 (+)NCBI


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005402462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005402463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005402464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013503332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AGCD01056582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01056583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01056584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01056585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01056586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01056587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01056588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01056589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01056590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01056591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01056592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GBCQ01054630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCLAT00000002915   ⟹   ENSCLAP00000002858
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554801,078,322 - 1,188,435 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000002916   ⟹   ENSCLAP00000002859
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554801,090,489 - 1,188,435 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000002917   ⟹   ENSCLAP00000002860
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554801,091,192 - 1,184,606 (+)Ensembl
RefSeq Acc Id: XM_005402462   ⟹   XP_005402519
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554801,091,049 - 1,188,376 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005402463   ⟹   XP_005402520
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554801,078,352 - 1,188,376 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005402464   ⟹   XP_005402521
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955480543,397 - 1,188,376 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013503332   ⟹   XP_013358786
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554801,092,212 - 1,188,376 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005402519 (Get FASTA)   NCBI Sequence Viewer  
  XP_005402520 (Get FASTA)   NCBI Sequence Viewer  
  XP_005402521 (Get FASTA)   NCBI Sequence Viewer  
  XP_013358786 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005402521   ⟸   XM_005402464
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_005402520   ⟸   XM_005402463
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005402519   ⟸   XM_005402462
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013358786   ⟸   XM_013503332
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSCLAP00000002858   ⟸   ENSCLAT00000002915
RefSeq Acc Id: ENSCLAP00000002860   ⟸   ENSCLAT00000002917
RefSeq Acc Id: ENSCLAP00000002859   ⟸   ENSCLAT00000002916


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000002058 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000002858 ENTREZGENE
  ENSCLAP00000002859 ENTREZGENE
Ensembl Transcript ENSCLAT00000002915 ENTREZGENE
  ENSCLAT00000002916 ENTREZGENE
NCBI Gene Ppargc1a ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Ppargc1a  PPARG coactivator 1 alpha    peroxisome proliferator-activated receptor gamma, coactivator 1 alpha  Symbol and/or name change 5135510 APPROVED