Ppargc1a (PPARG coactivator 1 alpha) - Rat Genome Database

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Gene: Ppargc1a (PPARG coactivator 1 alpha) Chinchilla lanigera
Analyze
Symbol: Ppargc1a
Name: PPARG coactivator 1 alpha
RGD ID: 8891795
Description: ENCODES a protein that exhibits alpha-tubulin binding (ortholog); chromatin binding (ortholog); chromatin DNA binding (ortholog); INVOLVED IN adaptive thermogenesis (ortholog); adipose tissue development (ortholog); androgen metabolic process (ortholog); PARTICIPATES IN aldosterone signaling pathway; mTOR signaling pathway; ASSOCIATED WITH abdominal obesity-metabolic syndrome (ortholog); acute kidney failure (ortholog); age related macular degeneration (ortholog); FOUND IN apical dendrite (ortholog); cytosol (ortholog); cytosolic ribosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: peroxisome proliferator-activated receptor gamma coactivator 1-alpha; peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554801,078,322 - 1,188,435 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955480543,397 - 1,188,376 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome  (ISO)
acute kidney failure  (ISO)
age related macular degeneration  (ISO)
Albuminuria  (ISO)
Alzheimer's disease  (ISO)
amblyopia  (ISO)
amyotrophic lateral sclerosis  (ISO)
Bowen's Disease  (ISO)
Brain Injuries  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
cardiovascular system disease  (ISO)
Carotid Artery Injuries  (ISO)
chronic kidney disease  (ISO)
chronic obstructive pulmonary disease  (ISO)
colitis  (ISO)
congenital hypothyroidism  (ISO)
congestive heart failure  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (ISO)
Diseases of the Aged  (ISO)
Experimental Diabetes Mellitus  (ISO)
Fetal Growth Retardation  (ISO)
glucose intolerance  (ISO)
heart disease  (ISO)
Huntington's disease  (ISO)
hyperglycemia  (ISO)
hyperthyroidism  (ISO)
Hypertriglyceridemia  (ISO)
Hypoxia  (ISO)
Insulin Resistance  (ISO)
Kearns-Sayre syndrome  (ISO)
kidney cancer  (ISO)
kidney failure  (ISO)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (ISO)
Lewy body dementia  (ISO)
macular degeneration  (ISO)
malignant fibrous histiocytoma  (ISO)
melanoma  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
Muscular Dystrophy, Animal  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
nephrotic syndrome  (ISO)
neuronal ceroid lipofuscinosis 1  (ISO)
obesity  (ISO)
Parkinson's disease  (ISO)
Parkinsonism  (ISO)
placental insufficiency  (ISO)
Plaque, Atherosclerotic  (ISO)
prediabetes syndrome  (ISO)
primary biliary cholangitis  (ISO)
pulmonary emphysema  (ISO)
renal fibrosis  (ISO)
Right Ventricular Hypertrophy  (ISO)
Sarcopenia  (ISO)
schizophrenia  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
Sleep Initiation and Maintenance Disorders  (ISO)
Spinal Cord Injuries  (ISO)
steatotic liver disease  (ISO)
Takotsubo Cardiomyopathy  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
Ventricular Dysfunction, Right  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive thermogenesis  (ISO)
adipose tissue development  (ISO)
androgen metabolic process  (ISO)
autophagy of mitochondrion  (ISO)
cellular response to caffeine  (ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to fatty acid  (ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to fructose stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to interleukin-6  (ISO)
cellular response to ionomycin  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to nitrite  (ISO)
cellular response to oxidative stress  (ISO)
cellular response to potassium ion  (ISO)
cellular response to resveratrol  (ISO)
cellular response to thyroid hormone stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
cerebellum development  (ISO)
circadian regulation of gene expression  (ISO)
energy homeostasis  (ISO)
fatty acid oxidation  (ISO)
flavone metabolic process  (ISO)
forebrain development  (ISO)
galactose metabolic process  (ISO)
gluconeogenesis  (ISO)
mitochondrion organization  (ISO)
negative regulation of glycolytic process  (ISO)
negative regulation of mitochondrial fission  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of signaling receptor activity  (ISO)
negative regulation of smooth muscle cell migration  (ISO)
negative regulation of smooth muscle cell proliferation  (ISO)
neuron apoptotic process  (ISO)
positive regulation of cold-induced thermogenesis  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of fatty acid oxidation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of podocyte apoptotic process  (ISO)
positive regulation of progesterone biosynthetic process  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
regulation of circadian rhythm  (ISO)
regulation of DNA-templated transcription  (ISO)
regulation of NMDA receptor activity  (ISO)
respiratory electron transport chain  (ISO)
response to activity  (ISO)
response to dehydroepiandrosterone  (ISO)
response to dietary excess  (ISO)
response to electrical stimulus  (ISO)
response to electrical stimulus involved in regulation of muscle adaptation  (ISO)
response to epinephrine  (ISO)
response to fructose  (ISO)
response to hypobaric hypoxia  (ISO)
response to hypoxia  (ISO)
response to ischemia  (ISO)
response to L-leucine  (ISO)
response to methionine  (ISO)
response to muscle activity  (ISO)
response to norepinephrine  (ISO)
response to nutrient  (ISO)
response to nutrient levels  (ISO)
response to organic cyclic compound  (ISO)
response to reactive oxygen species  (ISO)
response to starvation  (ISO)
response to thyroid hormone  (ISO)
response to xenobiotic stimulus  (ISO)
skeletal muscle atrophy  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ppargc1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554801,078,322 - 1,188,435 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955480543,397 - 1,188,376 (+)NCBIChiLan1.0ChiLan1.0
PPARGC1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38423,792,021 - 24,472,905 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl423,755,041 - 23,904,089 (-)EnsemblGRCh38hg38GRCh38
GRCh37423,793,644 - 24,474,528 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36423,402,742 - 23,500,798 (-)NCBINCBI36Build 36hg18NCBI36
Build 34423,469,913 - 23,567,969NCBI
Celera424,243,466 - 24,341,439 (-)NCBICelera
Cytogenetic Map4p15.2NCBI
HuRef423,138,364 - 23,236,560 (-)NCBIHuRef
CHM1_1423,791,582 - 23,889,913 (-)NCBICHM1_1
T2T-CHM13v2.0423,773,791 - 24,454,625 (-)NCBIT2T-CHM13v2.0
Ppargc1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39551,611,591 - 52,273,316 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl551,611,592 - 51,725,068 (-)EnsemblGRCm39 Ensembl
GRCm38551,454,249 - 52,115,853 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl551,454,250 - 51,567,726 (-)EnsemblGRCm38mm10GRCm38
MGSCv37551,845,488 - 51,945,160 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36551,745,901 - 51,842,109 (-)NCBIMGSCv36mm8
Celera548,830,811 - 48,929,055 (-)NCBICelera
Cytogenetic Map5C1NCBI
cM Map527.02NCBI
Ppargc1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81463,073,505 - 63,729,215 (+)NCBIGRCr8
mRatBN7.21458,860,752 - 59,516,525 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1458,861,144 - 59,512,656 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1463,825,757 - 63,916,927 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01465,139,390 - 65,230,573 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01461,536,169 - 61,627,348 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01463,095,291 - 63,190,688 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1463,095,720 - 63,187,009 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01463,182,479 - 63,286,252 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41464,278,115 - 64,370,912 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11464,280,505 - 64,373,303 (+)NCBI
Celera1458,516,257 - 58,607,916 (+)NCBICelera
Cytogenetic Map14q11NCBI
PPARGC1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2324,042,857 - 24,723,457 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1424,239,672 - 24,920,223 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0418,196,431 - 18,876,889 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1423,483,377 - 24,160,574 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl423,483,377 - 23,581,212 (-)Ensemblpanpan1.1panPan2
PPARGC1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1385,645,942 - 86,284,570 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl386,016,140 - 86,281,269 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha388,158,508 - 88,796,824 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0386,620,570 - 87,261,415 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl386,992,463 - 87,261,415 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1385,752,591 - 86,391,823 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0385,858,991 - 86,497,911 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0386,243,892 - 86,883,362 (+)NCBIUU_Cfam_GSD_1.0
Ppargc1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528551,179,331 - 51,786,516 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364775,199,881 - 5,488,226 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364774,881,230 - 5,488,208 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPARGC1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl817,841,844 - 17,946,992 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1817,841,844 - 18,527,953 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pig Cytomap8p2.1-p2.3NCBI
PPARGC1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12725,882,385 - 26,563,530 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2726,465,499 - 26,564,582 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604772,634,061 - 73,114,795 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppargc1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247558,375,596 - 8,465,297 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247557,826,219 - 8,460,746 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005402462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005402463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005402464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013503332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AGCD01056582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01056583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01056584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01056585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01056586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01056587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01056588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01056589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01056590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01056591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01056592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GBCQ01054630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCLAT00000002915   ⟹   ENSCLAP00000002858
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554801,078,322 - 1,188,435 (+)Ensembl
Ensembl Acc Id: ENSCLAT00000002916   ⟹   ENSCLAP00000002859
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554801,090,489 - 1,188,435 (+)Ensembl
Ensembl Acc Id: ENSCLAT00000002917   ⟹   ENSCLAP00000002860
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554801,091,192 - 1,184,606 (+)Ensembl
RefSeq Acc Id: XM_005402462   ⟹   XP_005402519
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554801,091,049 - 1,188,376 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005402463   ⟹   XP_005402520
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554801,078,352 - 1,188,376 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005402464   ⟹   XP_005402521
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955480543,397 - 1,188,376 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013503332   ⟹   XP_013358786
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554801,092,212 - 1,188,376 (+)NCBI
Sequence:
RefSeq Acc Id: XP_005402521   ⟸   XM_005402464
- Peptide Label: isoform X4
- UniProtKB: A0A8C2UPM8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005402520   ⟸   XM_005402463
- Peptide Label: isoform X2
- UniProtKB: A0A8C2UQK1 (UniProtKB/TrEMBL),   A0A8C2UPM8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005402519   ⟸   XM_005402462
- Peptide Label: isoform X1
- UniProtKB: A0A8C2USZ5 (UniProtKB/TrEMBL),   A0A8C2UPM8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013358786   ⟸   XM_013503332
- Peptide Label: isoform X3
- UniProtKB: A0A8C2UPM8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000002858   ⟸   ENSCLAT00000002915
Ensembl Acc Id: ENSCLAP00000002860   ⟸   ENSCLAT00000002917
Ensembl Acc Id: ENSCLAP00000002859   ⟸   ENSCLAT00000002916
Protein Domains
RRM


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000002058 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000002915 ENTREZGENE
  ENSCLAT00000002915.1 UniProtKB/TrEMBL
  ENSCLAT00000002916 ENTREZGENE
  ENSCLAT00000002916.1 UniProtKB/TrEMBL
  ENSCLAT00000002917.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.330 UniProtKB/TrEMBL
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/TrEMBL
  PGC-1 UniProtKB/TrEMBL
  PPARGC1A_RRM UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/TrEMBL
  RRM_dom UniProtKB/TrEMBL
NCBI Gene Ppargc1a ENTREZGENE
PANTHER PTHR15528 UniProtKB/TrEMBL
  PTHR15528:SF10 UniProtKB/TrEMBL
Pfam RRM_1 UniProtKB/TrEMBL
PROSITE RRM UniProtKB/TrEMBL
SMART RRM UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/TrEMBL
UniProt A0A8C2UPM8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2UQK1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2USZ5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Ppargc1a  PPARG coactivator 1 alpha    peroxisome proliferator-activated receptor gamma, coactivator 1 alpha  Symbol and/or name change 5135510 APPROVED