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Gene: PPARGC1A (PPARG coactivator 1 alpha) Homo sapiens
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Symbol: PPARGC1A
Name: PPARG coactivator 1 alpha
Description: Exhibits several functions, including nuclear receptor binding activity; nuclear receptor transcription coactivator activity; and ubiquitin protein ligase binding activity. Involved in negative regulation of neuron death; positive regulation of mitochondrion organization; and regulation of transcription, DNA-templated. Localizes to nucleoplasm. Implicated in several diseases, including macular degeneration; malignant fibrous histiocytoma; neurodegenerative disease (multiple); non-alcoholic fatty liver disease; and type 2 diabetes mellitus. Biomarker of several diseases, including chronic obstructive pulmonary disease; melanoma; myocardial infarction; neurodegenerative disease (multiple); and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: L-PGC-1alpha; LEM6; ligand effect modulator 6; ligand effect modulator-6; peroxisome proliferative activated receptor, gamma, coactivator 1, alpha; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-3ext; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-8a; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5-NT; peroxisome proliferator-activated receptor gamma coactivator 1-alpha; peroxisome proliferator-activated receptor gamma, coactivator 1 alpha; PGC-1(alpha); PGC-1-alpha; PGC-1alpha; PGC-1v; PGC1; PGC1A; PPAR gamma coactivator variant form; PPAR gamma coactivator-1; PPAR-gamma coactivator 1-alpha; PPARgamma coactivator 1alpha; PPARGC-1-alpha; PPARGC1
Orthologs:
Mus musculus (house mouse) : Ppargc1a (peroxisome proliferative activated receptor, gamma, coactivator 1 alpha)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ppargc1a (PPARG coactivator 1 alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ppargc1a (PPARG coactivator 1 alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : PPARGC1A (PPARG coactivator 1 alpha)
Canis lupus familiaris (dog) : PPARGC1A (PPARG coactivator 1 alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ppargc1a (PPARG coactivator 1 alpha)
Sus scrofa (pig) : PPARGC1A (PPARG coactivator 1 alpha)
Chlorocebus sabaeus (African green monkey) : PPARGC1A (PPARG coactivator 1 alpha)
Heterocephalus glaber (naked mole-rat) : Ppargc1a (PPARG coactivator 1 alpha)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl423,755,041 - 23,904,089 (-)EnsemblGRCh38hg38GRCh38
GRCh38423,792,021 - 24,472,905 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37423,793,644 - 24,474,394 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36423,402,742 - 23,500,798 (-)NCBINCBI36hg18NCBI36
Build 34423,469,913 - 23,567,969NCBI
Celera424,243,466 - 24,341,439 (-)NCBI
Cytogenetic Map4p15.2NCBI
HuRef423,138,364 - 23,236,560 (-)NCBIHuRef
CHM1_1423,791,582 - 23,889,913 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


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RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences