PPARGC1A (PPARG coactivator 1 alpha) - Rat Genome Database

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Gene: PPARGC1A (PPARG coactivator 1 alpha) Homo sapiens
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Symbol: PPARGC1A
Name: PPARG coactivator 1 alpha
RGD ID: 1342674
HGNC Page HGNC
Description: Enables several functions, including nuclear receptor binding activity; nuclear receptor coactivator activity; and ubiquitin protein ligase binding activity. Involved in negative regulation of neuron death; positive regulation of mitochondrion organization; and regulation of gene expression. Acts upstream of or within regulation of transcription, DNA-templated. Located in nucleoplasm. Implicated in several diseases, including macular degeneration; malignant fibrous histiocytoma; neurodegenerative disease (multiple); non-alcoholic fatty liver disease; and type 2 diabetes mellitus. Biomarker of several diseases, including chronic obstructive pulmonary disease; kidney cancer; myocardial infarction; neurodegenerative disease (multiple); and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: L-PGC-1alpha; LEM6; ligand effect modulator 6; ligand effect modulator-6; peroxisome proliferative activated receptor, gamma, coactivator 1, alpha; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-3ext; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-8a; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5-NT; peroxisome proliferator-activated receptor gamma coactivator 1-alpha; peroxisome proliferator-activated receptor gamma, coactivator 1 alpha; PGC-1(alpha); PGC-1-alpha; PGC-1alpha; PGC-1v; PGC1; PGC1A; PPAR gamma coactivator variant form; PPAR gamma coactivator-1; PPAR-gamma coactivator 1-alpha; PPARgamma coactivator 1alpha; PPARGC-1-alpha; PPARGC1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl423,755,041 - 23,904,089 (-)EnsemblGRCh38hg38GRCh38
GRCh38423,792,021 - 24,472,905 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37423,793,644 - 24,474,528 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36423,402,742 - 23,500,798 (-)NCBINCBI36hg18NCBI36
Build 34423,469,913 - 23,567,969NCBI
Celera424,243,466 - 24,341,439 (-)NCBI
Cytogenetic Map4p15.2NCBI
HuRef423,138,364 - 23,236,560 (-)NCBIHuRef
CHM1_1423,791,582 - 23,889,913 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome  (ISO)
acute kidney failure  (ISO)
age related macular degeneration  (ISS)
Albuminuria  (IAGP)
Alzheimer's disease  (IEP,ISO)
amblyopia  (ISO)
amyotrophic lateral sclerosis  (EXP,IEP,IMP,ISO)
Bowen's Disease  (EXP)
Brain Injuries  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISS)
cardiovascular system disease  (IAGP)
Carotid Artery Injuries  (ISO)
chronic kidney disease  (ISO)
chronic obstructive pulmonary disease  (IEP)
colitis  (ISO)
congenital hypothyroidism  (ISO)
congestive heart failure  (EXP,ISO)
Diabetic Nephropathies  (IAGP,IEP)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (ISO)
Diseases of the Aged  (ISO)
Experimental Diabetes Mellitus  (EXP,ISO)
fatty liver disease  (ISO)
Fetal Growth Retardation  (ISO)
glucose intolerance  (ISO)
heart disease  (ISO)
Huntington's disease  (IAGP,IEP,ISO)
hyperglycemia  (ISO)
hyperthyroidism  (ISO)
Insulin Resistance  (IAGP,ISO)
Kearns-Sayre syndrome  (ISO)
kidney cancer  (IEP)
kidney failure  (ISO)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (ISO)
Lewy body dementia  (EXP)
macular degeneration  (IAGP)
malignant fibrous histiocytoma  (IDA)
melanoma  (IEP)
Metabolic Syndrome  (ISO)
Muscular Dystrophy, Animal  (EXP)
myocardial infarction  (EXP,IEP,ISO)
Myocardial Reperfusion Injury  (ISO)
nephrotic syndrome  (ISO)
neuronal ceroid lipofuscinosis 1  (EXP)
non-alcoholic fatty liver disease  (IAGP,ISO)
obesity  (ISO)
Parkinson's disease  (EXP,IAGP,IEP)
Parkinsonism  (ISO)
placental insufficiency  (ISO)
prediabetes syndrome  (ISO)
primary biliary cholangitis  (ISO)
pulmonary emphysema  (ISO)
renal fibrosis  (ISO)
Right Ventricular Hypertrophy  (ISO)
Sarcopenia  (ISO)
schizophrenia  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
Sleep Initiation and Maintenance Disorders  (IAGP)
Spinal Cord Injuries  (ISO)
Takotsubo Cardiomyopathy  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (EXP,IAGP,IEP,ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (EXP)
(+)-catechin  (ISO)
(+)-schisandrin B  (ISO)
(+)-taxifolin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(R)-adrenaline  (ISO)
(R)-lipoic acid  (EXP,ISO)
(R)-noradrenaline  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-stearoyl-2-arachidonoyl-sn-glycerol  (EXP)
11-deoxycorticosterone  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
1D-myo-inositol 1-phosphate  (EXP)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (EXP,ISO)
1H-pyrazole  (ISO)
2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-butoxyethanol  (ISO)
2-chloroethanol  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4,6-dioxoheptanoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (EXP,ISO)
5-(2-chloroethyl)-4-methylthiazole  (ISO)
5-aminoimidazole-4-carboxamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-propyl-2-thiouracil  (ISO)
8-bromo-3',5'-cyclic GMP  (EXP)
9-cis-retinoic acid  (EXP,ISO)
acadesine  (EXP,ISO)
acarbose  (EXP)
acetamide  (ISO)
acrylamide  (EXP)
adenosine  (EXP)
adenosine 5'-monophosphate  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (EXP)
aflatoxin B2  (EXP)
AICA ribonucleotide  (EXP,ISO)
albuterol  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (ISO)
all-trans-retinal  (EXP)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
alloxan  (ISO)
allyl isothiocyanate  (EXP)
alpha,alpha-trehalose  (ISO)
alpha-D-galactose  (ISO)
aminoguanidine  (ISO)
amiodarone  (EXP)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aristolochic acid  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP,ISO)
asiatic acid  (EXP)
aspartame  (ISO)
atorvastatin calcium  (ISO)
atrazine  (EXP,ISO)
benfotiamine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
Benzo[ghi]perylene  (ISO)
berberine  (ISO)
beta-D-glucosamine  (EXP,ISO)
Betanin  (ISO)
bezafibrate  (ISO)
biotin  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (EXP)
bosentan  (EXP)
bromobenzene  (ISO)
bucladesine  (ISO)
buta-1,3-diene  (ISO)
butan-1-ol  (EXP)
butan-2-one  (EXP)
butanal  (EXP)
Butylbenzyl phthalate  (EXP,ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (EXP,ISO)
capsaicin  (ISO)
captan  (ISO)
carbamazepine  (EXP)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
carfilzomib  (EXP)
carvedilol  (ISO)
casticin  (ISO)
Chicoric acid  (ISO)
CHIR 99021  (ISO)
chlormidazole  (EXP)
chloroprene  (ISO)
chlorpyrifos  (EXP,ISO)
cholate  (ISO)
choline  (EXP)
chromium(6+)  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clenbuterol  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
cortisol  (EXP)
cortisone  (EXP)
creatine  (EXP)
crocidolite asbestos  (EXP,ISO)
curcumin  (ISO)
cyclosporin A  (EXP,ISO)
cyproconazole  (ISO)
D-glucose  (EXP,ISO)
D-glucurono-6,3-lactone  (EXP)
dapagliflozin  (ISO)
DDE  (EXP)
DDT  (ISO)
decanoic acid  (EXP)
dehydroepiandrosterone  (ISO)
Delta(9)-tetrahydrocannabinolic acid  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Di-n-hexyl phthalate  (ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
diclofenac  (EXP,ISO)
diethylstilbestrol  (EXP)
dihydrofolic acid  (EXP)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
dodecanoic acid  (EXP)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
edaravone  (ISO)
elemental selenium  (ISO)
ellagic acid  (ISO)
enalapril  (ISO)
endosulfan  (ISO)
enilconazole  (EXP)
epoxiconazole  (ISO)
Erythropoietin  (EXP)
ethanol  (ISO)
etoposide  (EXP)
farnesol  (ISO)
fenofibrate  (EXP,ISO)
fenpyroximate  (EXP)
ferulic acid  (ISO)
flavonoids  (EXP)
fluoxastrobin  (EXP)
folic acid  (ISO)
folpet  (ISO)
fructose  (EXP,ISO)
fulvestrant  (EXP,ISO)
galactose  (ISO)
gamma-hexachlorocyclohexane  (EXP)
Genipin  (ISO)
ginsenoside Rg2  (EXP)
glucagon  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP)
GW 1929  (EXP)
GW 501516  (EXP,ISO)
harmine  (ISO)
hemin  (ISO)
herbicide  (ISO)
hesperidin  (ISO)
hexadecanoic acid  (EXP,ISO)
Honokiol  (ISO)
hydrogen peroxide  (ISO)
icariin  (ISO)
ICI 118551  (ISO)
imidacloprid  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP,ISO)
ionomycin  (ISO)
iprodione  (ISO)
isobutanol  (EXP)
isoniazide  (EXP)
isoprenaline  (ISO)
isoxazoles  (EXP)
kaempferol  (EXP)
ketotifen  (EXP)
kresoxim-methyl  (EXP)
L-1,4-dithiothreitol  (EXP)
L-ascorbic acid  (EXP)
L-glutamic acid  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP)
Licarin A  (ISO)
limonene  (ISO)
linagliptin  (ISO)
linoleic acid  (EXP,ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (ISO)
liraglutide  (ISO)
losartan  (ISO)
lovastatin  (ISO)
luzindole  (EXP)
LY294002  (EXP,ISO)
Magnolol  (ISO)
malic acid  (EXP)
malonic acid  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mangiferin  (ISO)
melatonin  (EXP,ISO)
meldonium  (ISO)
metformin  (EXP,ISO)
methamphetamine  (ISO)
methyl methanesulfonate  (EXP)
methylglyoxal  (ISO)
metoprolol  (ISO)
monascin  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monosodium L-glutamate  (ISO)
myo-inositol hexakisphosphate  (ISO)
N(6)-butyryl-cAMP  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
naringin  (ISO)
nebivolol  (ISO)
nickel atom  (EXP)
nickel sulfate  (ISO)
nicotinamide  (EXP,ISO)
nicotine  (ISO)
nicotinic acid  (EXP)
nitrites  (ISO)
nitrogen dioxide  (EXP)
nitroprusside  (EXP)
NSC 23766  (ISO)
O-acetyl-L-carnitine  (EXP)
octadecanoic acid  (EXP)
olanzapine  (ISO)
oleic acid  (ISO)
orientin  (ISO)
oxaloacetic acid  (EXP)
oxidopamine  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
perfluorododecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
peroxynitrous acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (EXP)
picloram  (ISO)
picoxystrobin  (EXP)
pioglitazone  (EXP,ISO)
pirinixic acid  (EXP,ISO)
platycodin D  (ISO)
potassium chloride  (ISO)
potassium dichromate  (EXP,ISO)
prazosin  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
prochloraz  (ISO)
progesterone  (EXP,ISO)
propiconazole  (ISO)
propionic acid  (EXP)
propranolol  (ISO)
prostaglandin D2  (EXP)
prostaglandin I2  (EXP)
pterostilbene  (EXP)
puerarin  (ISO)
pyridaben  (EXP,ISO)
pyridoxine  (EXP,ISO)
pyrroloquinoline quinone  (EXP,ISO)
pyruvic acid  (EXP,ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (ISO)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
riboflavin  (EXP)
rifampicin  (EXP)
rotenone  (EXP,ISO)
S-adenosyl-L-homocysteine  (EXP)
Salmeterol xinafoate  (ISO)
Salvianolic acid A  (ISO)
salvianolic acid B  (ISO)
SB 431542  (EXP)
SB-239063  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP,ISO)
sirolimus  (ISO)
sirtinol  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium hydrogensulfite  (ISO)
splitomicin  (ISO)
staurosporine  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (ISO)
sulforaphane  (EXP,ISO)
sulfur dioxide  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (EXP)
taurine  (ISO)
tauroursodeoxycholic acid  (EXP,ISO)
telmisartan  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
tetradecanoic acid  (EXP)
tetraphene  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichlopyr  (ISO)
trichostatin A  (EXP)
triclosan  (EXP)
trifloxystrobin  (EXP)
trilobatin  (ISO)
triphenylstannane  (EXP,ISO)
Triptolide  (ISO)
troglitazone  (EXP,ISO)
tunicamycin  (ISO)
UDP-alpha-D-glucuronic acid  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vorinostat  (EXP)
ziram  (ISO)
zoledronic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive thermogenesis  (IEA,ISO)
adipose tissue development  (IEA)
aging  (IEA,ISO)
androgen metabolic process  (IEA,ISO)
autophagy of mitochondrion  (IEA,ISO)
brown fat cell differentiation  (TAS)
cellular glucose homeostasis  (NAS)
cellular respiration  (TAS)
cellular response to caffeine  (IEA,ISO)
cellular response to estradiol stimulus  (IEA,ISO)
cellular response to fatty acid  (ISO)
cellular response to follicle-stimulating hormone stimulus  (IEA,ISO)
cellular response to fructose stimulus  (IEA,ISO)
cellular response to glucose stimulus  (IEA,ISO)
cellular response to hypoxia  (IEA,ISO)
cellular response to interleukin-6  (IEA,ISO)
cellular response to ionomycin  (IEA,ISO)
cellular response to lipopolysaccharide  (IEA,ISO)
cellular response to nitrite  (IEA,ISO)
cellular response to oxidative stress  (ISO,ISS)
cellular response to potassium ion  (IEA,ISO)
cellular response to resveratrol  (IEA,ISO)
cellular response to thyroid hormone stimulus  (IEA,ISO)
cellular response to transforming growth factor beta stimulus  (IEA,ISO)
cellular response to tumor necrosis factor  (IEA,ISO)
cerebellum development  (IEA,ISO)
circadian regulation of gene expression  (ISS)
digestion  (TAS)
energy homeostasis  (ISS)
fatty acid oxidation  (ISO,NAS)
flavone metabolic process  (IEA,ISO)
forebrain development  (IEA,ISO)
galactose metabolic process  (IEA,ISO)
gluconeogenesis  (ISO,NAS)
mitochondrion organization  (IEA,ISO,NAS)
mRNA processing  (TAS)
negative regulation of glycolytic process  (IEA,ISO)
negative regulation of mitochondrial fission  (IEA,ISO)
negative regulation of neuron apoptotic process  (ISO,ISS)
negative regulation of neuron death  (IGI)
negative regulation of protein phosphorylation  (IEA,ISO)
negative regulation of signaling receptor activity  (IEA,ISO)
negative regulation of smooth muscle cell migration  (IEA,ISO)
negative regulation of smooth muscle cell proliferation  (IMP,ISO)
positive regulation of ATP biosynthetic process  (ISS)
positive regulation of cellular respiration  (IEA)
positive regulation of cold-induced thermogenesis  (ISS)
positive regulation of DNA-binding transcription factor activity  (IBA,IDA)
positive regulation of fatty acid oxidation  (ISO,TAS)
positive regulation of gene expression  (IDA,IMP)
positive regulation of glomerular visceral epithelial cell apoptotic process  (IEA,ISO)
positive regulation of gluconeogenesis  (TAS)
positive regulation of histone acetylation  (TAS)
positive regulation of mitochondrial DNA metabolic process  (IEA)
positive regulation of mitochondrion organization  (IMP,ISS)
positive regulation of muscle tissue development  (IEA)
positive regulation of progesterone biosynthetic process  (IEA,ISO)
positive regulation of smooth muscle cell proliferation  (IEA)
positive regulation of transcription by RNA polymerase II  (IBA,IDA,ISO,ISS)
positive regulation of transcription, DNA-templated  (IDA,ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
protein stabilization  (TAS)
protein-containing complex assembly  (TAS)
regulation of circadian rhythm  (ISS)
regulation of NMDA receptor activity  (IEA,ISO)
regulation of transcription, DNA-templated  (IDA,IEA)
respiratory electron transport chain  (ISO,ISS)
response to activity  (ISO)
response to cold  (IEA,ISO)
response to dietary excess  (IEA,ISO)
response to electrical stimulus  (ISO)
response to electrical stimulus involved in regulation of muscle adaptation  (IEA,ISO)
response to epinephrine  (IEA,ISO)
response to fructose  (ISO)
response to hypoxia  (ISO)
response to ischemia  (IEA,ISO)
response to leucine  (IEA,ISO)
response to metformin  (IEA,ISO)
response to methionine  (IEA,ISO)
response to muscle activity  (ISO,ISS)
response to norepinephrine  (IEA,ISO)
response to nutrient levels  (ISO)
response to organic cyclic compound  (ISO)
response to reactive oxygen species  (IEA,ISO)
response to starvation  (ISO,NAS)
response to thyroid hormone  (ISO)
response to xenobiotic stimulus  (IEA,ISO)
RNA splicing  (TAS)
skeletal muscle atrophy  (IEA,ISO)
temperature homeostasis  (TAS)
transcription initiation from RNA polymerase II promoter  (TAS)

Cellular Component
apical dendrite  (IEA,ISO)
chromatin  (IC)
cytoplasm  (ISO)
cytosol  (ISO)
cytosolic ribosome  (IEA,ISO)
euchromatin  (IEA,ISO)
intracellular membrane-bounded organelle  (IDA)
mitochondrion  (IEA,ISO)
neuronal cell body  (IEA,ISO)
nucleoplasm  (IDA,TAS)
nucleus  (IBA,IDA,IEA,ISO,ISS,TAS)
PML body  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Adachi T, etal., Exp Physiol. 2007 Mar;92(2):449-55. Epub 2006 Dec 7.
2. Agrawal R, etal., Biochim Biophys Acta. 2014 Apr;1842(4):535-46. doi: 10.1016/j.bbadis.2013.12.004. Epub 2013 Dec 15.
3. Alberdi G, etal., Nutrition. 2013 Mar;29(3):562-7. doi: 10.1016/j.nut.2012.09.011. Epub 2012 Dec 28.
4. Amengual-Cladera E, etal., Metabolism. 2012 Aug;61(8):1108-17. doi: 10.1016/j.metabol.2011.12.016. Epub 2012 Mar 7.
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PMID:27974213   PMID:27984584   PMID:27998274   PMID:28051997   PMID:28053050   PMID:28074493   PMID:28076790   PMID:28177701   PMID:28239025   PMID:28281651   PMID:28363985   PMID:28364603  
PMID:28381162   PMID:28398573   PMID:28400503   PMID:28418876   PMID:28433632   PMID:28452072   PMID:28453464   PMID:28483651   PMID:28488691   PMID:28546467   PMID:28550474   PMID:28591028  
PMID:28591759   PMID:28596418   PMID:28607951   PMID:28768874   PMID:28795454   PMID:28801652   PMID:28803067   PMID:28819135   PMID:28824327   PMID:28947843   PMID:28973039   PMID:28978464  
PMID:28978917   PMID:28988825   PMID:28991225   PMID:29030253   PMID:29063962   PMID:29126696   PMID:29130104   PMID:29140431   PMID:29182484   PMID:29186342   PMID:29192176   PMID:29233908  
PMID:29258108   PMID:29261667   PMID:29268263   PMID:29269047   PMID:29383885   PMID:29388552   PMID:29413962   PMID:29429541   PMID:29472690   PMID:29496354   PMID:29507755   PMID:29537859  
PMID:29566941   PMID:29630901   PMID:29658071   PMID:29663401   PMID:29678181   PMID:29680477   PMID:29700317   PMID:29709472   PMID:29730292   PMID:29749474   PMID:29753744   PMID:29762540  
PMID:29782967   PMID:29879371   PMID:29888964   PMID:29930100   PMID:30017591   PMID:30021884   PMID:30030137   PMID:30041843   PMID:30087287   PMID:30201263   PMID:30207204   PMID:30233161  
PMID:30236862   PMID:30259075   PMID:30291832   PMID:30324415   PMID:30348778   PMID:30406665   PMID:30419515   PMID:30556158   PMID:30578297   PMID:30595551   PMID:30625151   PMID:30648791  
PMID:30651555   PMID:30684287   PMID:30759490   PMID:30829051   PMID:30880247   PMID:30920960   PMID:30944665   PMID:30945396   PMID:30959809   PMID:30993568   PMID:31055583   PMID:31064849  
PMID:31066170   PMID:31119261   PMID:31161726   PMID:31182654   PMID:31190345   PMID:31217429   PMID:31283791   PMID:31290617   PMID:31313501   PMID:31313989   PMID:31351089   PMID:31390852  
PMID:31469445   PMID:31471878   PMID:31480724   PMID:31519589   PMID:31555811   PMID:31594836   PMID:31614978   PMID:31629659   PMID:31678594   PMID:31683747   PMID:31704454   PMID:31713888  
PMID:31782098   PMID:31869286   PMID:31929186   PMID:31982456   PMID:32014906   PMID:32120345   PMID:32142731   PMID:32258142   PMID:32269221   PMID:32296183   PMID:32298475   PMID:32325455  
PMID:32343674   PMID:32377739   PMID:32497722   PMID:32570218   PMID:32721231   PMID:32784428   PMID:32867330   PMID:32892155   PMID:32910289   PMID:32933059   PMID:32961822   PMID:32967762  
PMID:33220258   PMID:33231084   PMID:33368050   PMID:33450350   PMID:33802591   PMID:33804860   PMID:33814269   PMID:33957017   PMID:34038004   PMID:34071270   PMID:34135327   PMID:34158490  
PMID:34199596   PMID:34281248  


Genomics

Candidate Gene Status
PPARGC1A is a candidate Gene for QTL BW99_H
PPARGC1A is a candidate Gene for QTL INSUL23_H
Comparative Map Data
PPARGC1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl423,755,041 - 23,904,089 (-)EnsemblGRCh38hg38GRCh38
GRCh38423,792,021 - 24,472,905 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37423,793,644 - 24,474,528 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36423,402,742 - 23,500,798 (-)NCBINCBI36hg18NCBI36
Build 34423,469,913 - 23,567,969NCBI
Celera424,243,466 - 24,341,439 (-)NCBI
Cytogenetic Map4p15.2NCBI
HuRef423,138,364 - 23,236,560 (-)NCBIHuRef
CHM1_1423,791,582 - 23,889,913 (-)NCBICHM1_1
Ppargc1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39551,611,591 - 52,273,337 (-)NCBIGRCm39mm39
GRCm39 Ensembl551,611,592 - 51,725,068 (-)Ensembl
GRCm38551,454,249 - 52,115,853 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl551,454,250 - 51,567,726 (-)EnsemblGRCm38mm10GRCm38
MGSCv37551,845,488 - 51,945,160 (-)NCBIGRCm37mm9NCBIm37
MGSCv36551,745,901 - 51,842,109 (-)NCBImm8
Celera548,830,811 - 48,929,055 (-)NCBICelera
Cytogenetic Map5C1NCBI
Ppargc1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21458,860,752 - 59,516,525 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1458,861,144 - 59,512,656 (+)Ensembl
Rnor_6.01463,095,291 - 63,190,688 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1463,095,720 - 63,187,009 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01463,182,479 - 63,286,252 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41464,278,115 - 64,370,912 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11464,280,505 - 64,373,303 (+)NCBI
Celera1458,516,257 - 58,607,916 (+)NCBICelera
Cytogenetic Map14q11NCBI
Ppargc1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554801,078,322 - 1,188,435 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955480543,397 - 1,188,376 (+)NCBIChiLan1.0ChiLan1.0
PPARGC1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1423,483,377 - 24,160,574 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl423,483,377 - 23,581,212 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0418,196,431 - 18,876,889 (-)NCBIMhudiblu_PPA_v0panPan3
PPARGC1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1385,645,942 - 86,284,570 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl386,016,140 - 86,281,269 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha388,158,508 - 88,796,824 (+)NCBI
ROS_Cfam_1.0386,620,570 - 87,261,415 (+)NCBI
UMICH_Zoey_3.1385,752,591 - 86,391,823 (+)NCBI
UNSW_CanFamBas_1.0385,858,991 - 86,497,911 (+)NCBI
UU_Cfam_GSD_1.0386,243,892 - 86,883,362 (+)NCBI
Ppargc1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528551,179,331 - 51,786,516 (+)NCBI
SpeTri2.0NW_0049364774,881,230 - 5,488,208 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPARGC1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl817,841,844 - 17,961,909 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1817,841,844 - 18,527,953 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pig Cytomap8p2.1-p2.3NCBI
PPARGC1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12725,882,385 - 26,563,530 (+)NCBI
ChlSab1.1 Ensembl2726,465,499 - 26,564,582 (+)Ensembl
Vero_WHO_p1.0NW_02366604772,634,061 - 73,114,795 (+)NCBI
Ppargc1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247557,826,219 - 8,460,746 (+)NCBI

Position Markers
RH93032  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37423,793,759 - 23,793,894UniSTSGRCh37
Build 36423,402,857 - 23,402,992RGDNCBI36
Celera424,243,581 - 24,243,716RGD
Cytogenetic Map4p15.1UniSTS
HuRef423,138,479 - 23,138,614UniSTS
GeneMap99-GB4 RH Map488.34UniSTS
MARC_49176-49177:1118326844:1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37423,815,733 - 23,816,217UniSTSGRCh37
Build 36423,424,831 - 23,425,315RGDNCBI36
Celera424,265,520 - 24,266,004RGD
HuRef423,160,433 - 23,160,917UniSTS
MARC_11849-11850:1029349088:1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37423,814,687 - 23,815,527UniSTSGRCh37
Build 36423,423,785 - 23,424,625RGDNCBI36
Celera424,264,474 - 24,265,314RGD
PPARGC1A__5755  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37423,793,635 - 23,794,515UniSTSGRCh37
Build 36423,402,733 - 23,403,613RGDNCBI36
Celera424,243,457 - 24,244,337RGD
HuRef423,138,355 - 23,139,235UniSTS
PPARGC1A  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37423,815,439 - 23,815,667UniSTSGRCh37
Celera424,265,226 - 24,265,454UniSTS
HuRef423,160,139 - 23,160,367UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR378Ahsa-miR-378a-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
MIR23Ahsa-miR-23a-3pOncomiRDBexternal_infoNANA22318941

Predicted Target Of
Summary Value
Count of predictions:5629
Count of miRNA genes:1411
Interacting mature miRNAs:1900
Transcripts:ENST00000264867, ENST00000503714, ENST00000505469, ENST00000506055, ENST00000507342, ENST00000507380, ENST00000508380, ENST00000509642, ENST00000509702, ENST00000512169, ENST00000513205, ENST00000514479, ENST00000514494, ENST00000514517, ENST00000515534
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 159 493 828 290 12 209 756 708 74 212 24 638 81 7 604
Low 2195 1432 861 315 310 237 3522 1425 3560 168 1186 836 82 1188 2164
Below cutoff 47 981 26 14 1026 14 68 43 71 23 183 91 3 9 20 3 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_028250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001330751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001330752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001330753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001354825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001354826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001354827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001354828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_013261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_148981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_148982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_148983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_148984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_148985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_148986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_148987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005248131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005248132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005248134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011513766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011513768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011513769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011513771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024453878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB061325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC006229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC092834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC092846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC108028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC108071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC108076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC115110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF106698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF159714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF186379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH008808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK024990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK296591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK309261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY382576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC029800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM976883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX282397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU280319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ695733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ772116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ772117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ772118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ772119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ772120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ772121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF457749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF457751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000264867   ⟹   ENSP00000264867
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl423,792,021 - 23,890,047 (-)Ensembl
RefSeq Acc Id: ENST00000503714
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl423,875,782 - 23,884,931 (-)Ensembl
RefSeq Acc Id: ENST00000505469
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl423,877,696 - 23,882,113 (-)Ensembl
RefSeq Acc Id: ENST00000506055   ⟹   ENSP00000423075
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl423,795,698 - 23,890,032 (-)Ensembl
RefSeq Acc Id: ENST00000507342
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl423,831,707 - 23,899,318 (-)Ensembl
RefSeq Acc Id: ENST00000507380   ⟹   ENSP00000424181
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl423,882,679 - 23,890,035 (-)Ensembl
RefSeq Acc Id: ENST00000508380
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl423,828,562 - 23,882,111 (-)Ensembl