RGD Reference Report - Impact of exercise on mitochondrial transcription factor expression and damage in the striatum of a chronic mouse model of Parkinson's disease. - Rat Genome Database

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Impact of exercise on mitochondrial transcription factor expression and damage in the striatum of a chronic mouse model of Parkinson's disease.

Authors: Patki, G  Lau, YS 
Citation: Patki G and Lau YS, Neurosci Lett. 2011 Nov 21;505(3):268-72. Epub 2011 Oct 21.
RGD ID: 6484267
Pubmed: PMID:22040668   (View Abstract at PubMed)
PMCID: PMC3227723   (View Article at PubMed Central)
DOI: DOI:10.1016/j.neulet.2011.10.036   (Journal Full-text)

The etiology of neurodegenerative disorders like Parkinson's disease remains unknown, although many genetic and environmental factors are suggested as likely causes. Neuronal oxidative stress and mitochondrial dysfunction have been implicated as possible triggers for the onset and progression of Parkinson's neurodegeneration. We have recently shown that long-term treadmill exercise prevented neurological, mitochondrial and locomotor deficits in a chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and probenecid-induced mouse model of Parkinson's disease that was originally established in our laboratory. In the present study, we further demonstrated that long-term exercise attenuated both cytochrome c release and elevated levels of p53, which are known to be associated with mitochondrial dysfunction in the striatum of this chronic model. On the other hand, the expressions of mitochondrial transcription factor A and peroxisome proliferator-activated receptor gamma coactivator 1alpha were unexpectedly upregulated in the striatum of this chronic model, but long-term exercise training brought their levels down closer to normal. Our findings suggest that maintaining normal mitochondrial function is essential for preventing the process of Parkinson's disease-like neurodegeneration, whereas stimulating the mitochondrial transcription factors for biogenesis is not obligatory.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Parkinsonism  ISOPpargc1a (Mus musculus)6484267; 6484267 RGD 
Parkinsonism  IDA 6484267 RGD 
Parkinsonism  ISOTfam (Mus musculus)6484267; 6484267mRNA:increased expression:striatumRGD 
Parkinsonism  IEP 6484267mRNA:increased expression:striatumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ppargc1a  (PPARG coactivator 1 alpha)
Tfam  (transcription factor A, mitochondrial)

Genes (Mus musculus)
Ppargc1a  (peroxisome proliferative activated receptor, gamma, coactivator 1 alpha)
Tfam  (transcription factor A, mitochondrial)

Genes (Homo sapiens)
PPARGC1A  (PPARG coactivator 1 alpha)
TFAM  (transcription factor A, mitochondrial)


Additional Information