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Gene: Casp2 (caspase 2) Mus musculus
Symbol: Casp2
Name: caspase 2
Description: Exhibits cysteine-type endopeptidase activity involved in apoptotic process. Involved in ectopic germ cell programmed cell death; extrinsic apoptotic signaling pathway in absence of ligand; and positive regulation of apoptotic signaling pathway. Localizes to cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human CASP2 (caspase 2).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CASP-2; Caspase-2; ICH-1; NEDD-2; Nedd2; neural precursor cell expressed developmentally down-regulated protein 2; protease ICH-1
Homo sapiens (human) : CASP2 (caspase 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Casp2 (caspase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Casp2 (caspase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : CASP2 (caspase 2)
Canis lupus familiaris (dog) : CASP2 (caspase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Casp2 (caspase 2)
Sus scrofa (pig) : CASP2 (caspase 2)
Chlorocebus sabaeus (African green monkey) : CASP2 (caspase 2)
Heterocephalus glaber (naked mole-rat) : Casp2 (caspase 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl642,264,985 - 42,282,508 (+)EnsemblGRCm38mm10GRCm38
GRCm38642,264,902 - 42,282,508 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37642,215,038 - 42,232,495 (+)NCBIGRCm37mm9NCBIm37
MGSCv36642,194,646 - 42,212,103 (+)NCBImm8
Celera642,209,337 - 42,226,794 (+)NCBICelera
Cytogenetic Map6B2.1NCBI
cM Map620.54NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Casp2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731460
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.