Casp2 (caspase 2) - Rat Genome Database

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Gene: Casp2 (caspase 2) Mus musculus
Analyze
Symbol: Casp2
Name: caspase 2
RGD ID: 731460
MGI Page MGI
Description: Enables cysteine-type endopeptidase activity involved in apoptotic process. Acts upstream of or within ectopic germ cell programmed cell death; extrinsic apoptotic signaling pathway in absence of ligand; and positive regulation of apoptotic signaling pathway. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human CASP2 (caspase 2).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Casp; CASP-2; Caspase-2; Ich-; ICH-1; Nedd; NEDD-2; Nedd2; neural precursor cell expressed developmentally down-regulated protein 2; protease ICH-1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39642,241,841 - 42,259,442 (+)NCBIGRCm39mm39
GRCm39 Ensembl642,241,919 - 42,259,442 (+)Ensembl
GRCm38642,264,902 - 42,282,508 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl642,264,985 - 42,282,508 (+)EnsemblGRCm38mm10GRCm38
MGSCv37642,215,038 - 42,232,495 (+)NCBIGRCm37mm9NCBIm37
MGSCv36642,194,646 - 42,212,103 (+)NCBImm8
Celera642,209,337 - 42,226,794 (+)NCBICelera
Cytogenetic Map6B2.1NCBI
cM Map620.54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-dexrazoxane  (EXP)
(-)-citrinin  (ISO)
(-)-demecolcine  (ISO)
(R)-noradrenaline  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1-nitropyrene  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-methoxyethanol  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-nitropropanoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (ISO)
4-vinylcyclohexene dioxide  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
acrolein  (EXP)
actinomycin D  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
amsacrine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP,ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (ISO)
bortezomib  (ISO)
brefeldin A  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
camptothecin  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carboplatin  (ISO)
casticin  (ISO)
chelerythrine  (ISO)
chromium(6+)  (ISO)
Cinobufotalin  (ISO)
cisplatin  (EXP,ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
cocaine  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diepoxybutane  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
epichlorohydrin  (ISO)
ethanol  (ISO)
etoposide  (ISO)
flavanones  (ISO)
folic acid  (EXP)
furan  (ISO)
furosemide  (ISO)
gardenin B  (ISO)
gentamycin  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
isobutanol  (ISO)
isoflurane  (ISO)
isoprenaline  (ISO)
L-ascorbic acid  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP)
lithocholic acid  (ISO)
lovastatin  (EXP,ISO)
LY294002  (ISO)
manganese(II) chloride  (ISO)
mechlorethamine  (ISO)
menadione  (EXP)
methamphetamine  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
Mitotane  (ISO)
mitoxantrone  (ISO)
N-[2-amino-6-[(4-fluorophenyl)methylamino]-3-pyridinyl]carbamic acid ethyl ester  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
nickel dichloride  (ISO)
nicotine  (ISO)
norfloxacin  (ISO)
NS-398  (ISO)
ochratoxin A  (ISO)
orphenadrine  (ISO)
oxaliplatin  (ISO)
oxybenzone  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctanoic acid  (ISO)
phenylephrine  (ISO)
picoxystrobin  (ISO)
picrotoxin  (ISO)
podophyllotoxin  (ISO)
Pranoprofen  (ISO)
propylparaben  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
silibinin  (ISO)
silicon dioxide  (EXP)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium cyanate  (ISO)
sodium dichromate  (EXP)
staurosporine  (ISO)
tamoxifen  (EXP)
tauroursodeoxycholic acid  (ISO)
Terfenadine  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
theophylline  (ISO)
thioacetamide  (ISO)
topotecan  (EXP,ISO)
Tributyltin oxide  (ISO)
tunicamycin  (ISO)
undecane  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
violacein  (EXP)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

Additional References at PubMed
PMID:1378265   PMID:1449490   PMID:7654317   PMID:7958843   PMID:8087842   PMID:8889548   PMID:8896603   PMID:9038361   PMID:9209399   PMID:9573047   PMID:9723184   PMID:10087912  
PMID:10101687   PMID:10222134   PMID:10349636   PMID:10377054   PMID:10403638   PMID:10452843   PMID:10578172   PMID:10618441   PMID:10655542   PMID:10671365   PMID:10739653   PMID:10931486  
PMID:11042159   PMID:11076861   PMID:11217851   PMID:11438576   PMID:11536012   PMID:11978827   PMID:12107826   PMID:12477715   PMID:12477932   PMID:12480175   PMID:12488331   PMID:12520002  
PMID:14610273   PMID:15210727   PMID:15262979   PMID:15326356   PMID:15489334   PMID:15590671   PMID:15640352   PMID:15782199   PMID:15983031   PMID:16012953   PMID:16141072   PMID:16141073  
PMID:16172118   PMID:16183742   PMID:16215683   PMID:16362053   PMID:16481596   PMID:16495337   PMID:17082817   PMID:17188333   PMID:17245644   PMID:17265069   PMID:17666435   PMID:18311719  
PMID:18426910   PMID:18461459   PMID:19035350   PMID:19279217   PMID:19332555   PMID:19364921   PMID:19531356   PMID:19801895   PMID:20022306   PMID:20057499   PMID:21216964   PMID:21419766  
PMID:21464087   PMID:21538476   PMID:21674587   PMID:21873635   PMID:21903589   PMID:22322383   PMID:22343713   PMID:22365665   PMID:22498700   PMID:22515271   PMID:22595758   PMID:22927979  
PMID:23042294   PMID:23504374   PMID:23645208   PMID:23645210   PMID:23748737   PMID:23811850   PMID:23815625   PMID:24248351   PMID:24287941   PMID:24292555   PMID:24691516   PMID:24741061  
PMID:24830635   PMID:24879153   PMID:25144718   PMID:25301067   PMID:25531319   PMID:25611376   PMID:25645943   PMID:25706292   PMID:25796569   PMID:25798619   PMID:25857265   PMID:26341399  
PMID:26890135   PMID:27518436   PMID:27723722   PMID:27906175   PMID:27991927   PMID:28087670   PMID:28129024   PMID:28765049   PMID:30220454   PMID:30670683   PMID:30779911   PMID:30878284  
PMID:31399584   PMID:32402333  


Genomics

Comparative Map Data
Casp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39642,241,841 - 42,259,442 (+)NCBIGRCm39mm39
GRCm39 Ensembl642,241,919 - 42,259,442 (+)Ensembl
GRCm38642,264,902 - 42,282,508 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl642,264,985 - 42,282,508 (+)EnsemblGRCm38mm10GRCm38
MGSCv37642,215,038 - 42,232,495 (+)NCBIGRCm37mm9NCBIm37
MGSCv36642,194,646 - 42,212,103 (+)NCBImm8
Celera642,209,337 - 42,226,794 (+)NCBICelera
Cytogenetic Map6B2.1NCBI
cM Map620.54NCBI
CASP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7143,288,215 - 143,307,696 (+)EnsemblGRCh38hg38GRCh38
GRCh387143,288,351 - 143,307,696 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377142,985,444 - 143,004,789 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367142,695,524 - 142,714,907 (+)NCBINCBI36hg18NCBI36
Celera7137,822,267 - 137,841,650 (+)NCBI
Cytogenetic Map7q34NCBI
HuRef7137,322,670 - 137,342,153 (+)NCBIHuRef
CHM1_17142,922,195 - 142,941,676 (+)NCBICHM1_1
CRA_TCAGchr7v27142,387,424 - 142,406,906 (+)NCBI
Casp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2471,149,632 - 71,167,388 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl471,149,669 - 71,167,379 (+)Ensembl
Rnor_6.0471,652,358 - 71,670,228 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl471,652,354 - 71,670,239 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04136,454,723 - 136,474,625 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4470,029,728 - 70,047,164 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1470,305,857 - 70,323,294 (+)NCBI
Celera466,080,364 - 66,098,003 (+)NCBICelera
Cytogenetic Map4q24NCBI
Casp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955494353,310 - 368,873 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955494353,572 - 369,207 (-)NCBIChiLan1.0ChiLan1.0
CASP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17147,773,749 - 147,792,958 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7147,773,749 - 147,792,958 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v07135,283,072 - 135,307,855 (+)NCBIMhudiblu_PPA_v0panPan3
CASP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1166,378,447 - 6,396,251 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl166,379,913 - 6,396,646 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha167,368,808 - 7,385,123 (-)NCBI
ROS_Cfam_1.0166,232,171 - 6,251,272 (-)NCBI
UMICH_Zoey_3.1166,181,045 - 6,197,357 (-)NCBI
UNSW_CanFamBas_1.0166,032,942 - 6,049,262 (-)NCBI
UU_Cfam_GSD_1.0166,108,280 - 6,124,667 (-)NCBI
Casp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511812,149,166 - 12,164,126 (-)NCBI
SpeTri2.0NW_004936527739,325 - 754,259 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CASP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl186,902,542 - 6,966,092 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1186,946,432 - 6,966,088 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2187,183,208 - 7,206,964 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CASP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121112,172,614 - 112,189,574 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl21112,172,733 - 112,188,744 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660728,895,441 - 8,914,545 (+)NCBIVero_WHO_p1.0
Casp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462480011,451,784 - 11,468,791 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH127476  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38642,282,313 - 42,282,495UniSTSGRCm38
MGSCv37642,232,312 - 42,232,494UniSTSGRCm37
Celera642,226,611 - 42,226,793UniSTS
Cytogenetic Map6B2.1UniSTS
Y13085  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38642,281,136 - 42,281,255UniSTSGRCm38
MGSCv37642,231,135 - 42,231,254UniSTSGRCm37
Celera642,225,434 - 42,225,553UniSTS
Cytogenetic Map6B2.1UniSTS
Whitehead/MRC_RH6333.4UniSTS
Casp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37642,232,301 - 42,232,461UniSTSGRCm37
Celera642,226,600 - 42,226,760UniSTS
Cytogenetic Map6B2.1UniSTS
cM Map620.5UniSTS
cM Map620.5UniSTS
UniSTS:493102  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38642,263,514 - 42,264,262UniSTSGRCm38
MGSCv37642,213,513 - 42,214,261UniSTSGRCm37
Celera642,207,812 - 42,208,560UniSTS
Cytogenetic Map6B2.1UniSTS
Casp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6B2.1UniSTS
Casp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6B2.1UniSTS
cM Map620.5UniSTS
Casp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38642,282,302 - 42,282,462UniSTSGRCm38
MGSCv37642,232,301 - 42,232,461UniSTSGRCm37
Celera642,226,600 - 42,226,760UniSTS
Cytogenetic Map6B2.1UniSTS
cM Map620.5UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487426034Mouse
11353840Bmiq2_mbody mass index QTL 2 (mouse)6450382345314181Mouse
1357481Aaj2_manxiety in A/J 2 (mouse)Not determined6450382348726677Mouse
1357520Axtq2_manxiety QTL 2 (mouse)Not determined6450382348726677Mouse
11353841Bmiq3_mbody mass index QTL 3 (mouse)6450382348726677Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080600000Mouse
1302051Sluc7_msusceptibility to lung cancer 7 (mouse)Not determined6929707543297169Mouse
10043869Cia6a_mcollagen induced arthritis QTL 6a (mouse)Not determined61211797246118070Mouse
1301998Bts2_mbladder tumor susceptibility 2 (mouse)Not determined61275122246751334Mouse
4141749Obrq2_mobesity resistance QTL 2 (mouse)Not determined1275122246751334Mouse
27226726Tibmd7_mtibia midshaft diameter 7, 16 week (mouse)61770000053500000Mouse
1301724Pcd4ts1_mp-glycoprotein positive CD4 T cell subset 1 (mouse)Not determined61773466351734784Mouse
4140989Spqq2_msperm quality QTL 2 (mouse)Not determined1773466351734784Mouse
1301850Fglu_mfasting glucose (mouse)Not determined61773466351734784Mouse
1357442Dbts1_mdiabetes 1 (mouse)Not determined61823414873387692Mouse
12904940Edlmmq5_mextensor digitorum longus muscle mass QTL 5 (mouse)61963941153639411Mouse
12904943Tammq4_mtibialis anterior muscle mass QTL 4 (mouse)61963941153639411Mouse
12904952Gmmq4_mgastrocnemius muscle mass QTL 4 (mouse)61963941153639411Mouse
10412213Sxbq2_mSGC/Knj cross B6 QTL 2 (mouse)Not determined61991268671322775Mouse
10412107Desp4_mdespair 4 (mouse)Not determined62007289554072895Mouse
14700690Ccs6_mcolon cancer susceptibility 6 (mouse)62380000057800000Mouse
13208564Bmiq7_mbody mass index QTL 7 (mouse)62500000080000000Mouse
4141988Obrq3_mobesity resistance QTL 3 (mouse)Not determined2831405962314181Mouse
4141454Obrq4_mobesity resistance QTL 4 (mouse)Not determined3172656565726677Mouse
12880425V25Dq5_mvitamin D inactive form serum level QTL 5 (mouse)63270000066700000Mouse
4141782Mrdq5_mmodifier of retinal degeneration QTL 5 (mouse)Not determined3285065078238974Mouse
1300959Lxw2_mlupus BXSB x NZW 2 (mouse)Not determined63389528167895420Mouse
11252142Mom12_mModifier of Min 12 (mouse)63389528167895420Mouse
1300767Aliq4_macute lung injury QTL 4 (mouse)Not determined63629634770296450Mouse
1357539Bsbob3_mBSB obesity 3 (mouse)Not determined63647147170471591Mouse
4141094Hrtr1_mheart rate 1 (mouse)Not determined3676447870764478Mouse
14746995Manh60_mmandible shape 60 (mouse)63722567771225677Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
1301326Trbv4c2_mT cell receptor beta variable 4 (mouse)Not determined64089129671379171Mouse
12880424V25Dq4_mvitamin D inactive form serum level QTL 4 (mouse)64160000075600000Mouse
1301266Lmr4_mleishmaniasis resistance 4 (mouse)Not determined64211637376116515Mouse
11040600Lmr4c_mleishmaniasis resistance 4c (mouse)64211637376116515Mouse
11040601Lmr4a_mleishmaniasis resistance 4a (mouse)64211637376116515Mouse
11533915Mts4_mmammary tumor susceptibility 4 (mouse)64211637376116515Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2839
Count of miRNA genes:852
Interacting mature miRNAs:1133
Transcripts:ENSMUST00000031895, ENSMUST00000132246, ENSMUST00000132398, ENSMUST00000139930, ENSMUST00000141669, ENSMUST00000141727, ENSMUST00000144821, ENSMUST00000152893, ENSMUST00000156829
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_007610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003956158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_377417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_377418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC153915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK042072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK133829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK142569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK183288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK183931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK184247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK214788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW046437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC034262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY074786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D28492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y13085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000031895   ⟹   ENSMUSP00000031895
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl642,241,919 - 42,259,442 (+)Ensembl
GRCm38.p6 Ensembl642,264,985 - 42,282,508 (+)Ensembl
RefSeq Acc Id: ENSMUST00000132246
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl642,244,325 - 42,244,964 (+)Ensembl
GRCm38.p6 Ensembl642,267,391 - 42,268,030 (+)Ensembl
RefSeq Acc Id: ENSMUST00000132398
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl642,253,421 - 42,257,467 (+)Ensembl
GRCm38.p6 Ensembl642,276,487 - 42,280,533 (+)Ensembl
RefSeq Acc Id: ENSMUST00000139930
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl642,241,990 - 42,246,056 (+)Ensembl
GRCm38.p6 Ensembl642,265,056 - 42,269,122 (+)Ensembl
RefSeq Acc Id: ENSMUST00000141669
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl642,244,944 - 42,246,541 (+)Ensembl
GRCm38.p6 Ensembl642,268,010 - 42,269,607 (+)Ensembl
RefSeq Acc Id: ENSMUST00000141727
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl642,256,715 - 42,257,575 (+)Ensembl
GRCm38.p6 Ensembl642,279,781 - 42,280,641 (+)Ensembl
RefSeq Acc Id: ENSMUST00000144821
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl642,246,219 - 42,256,831 (+)Ensembl
GRCm38.p6 Ensembl642,269,285 - 42,279,897 (+)Ensembl
RefSeq Acc Id: ENSMUST00000152893
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl642,256,571 - 42,257,424 (+)Ensembl
GRCm38.p6 Ensembl642,279,637 - 42,280,490 (+)Ensembl
RefSeq Acc Id: ENSMUST00000156829   ⟹   ENSMUSP00000121184
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl642,242,054 - 42,257,426 (+)Ensembl
GRCm38.p6 Ensembl642,265,120 - 42,280,492 (+)Ensembl
RefSeq Acc Id: ENSMUST00000203089
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl642,256,741 - 42,257,701 (+)Ensembl
GRCm38.p6 Ensembl642,279,807 - 42,280,767 (+)Ensembl
RefSeq Acc Id: NM_007610   ⟹   NP_031636
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39642,241,919 - 42,259,442 (+)NCBI
GRCm38642,264,985 - 42,282,508 (+)NCBI
MGSCv37642,215,038 - 42,232,495 (+)RGD
Celera642,209,337 - 42,226,794 (+)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XR_003956158
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39642,241,841 - 42,259,442 (+)NCBI
GRCm38642,264,902 - 42,276,785 (+)NCBI
Sequence:
RefSeq Acc Id: XR_377417
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39642,241,847 - 42,259,442 (+)NCBI
GRCm38642,264,908 - 42,282,508 (+)NCBI
Sequence:
RefSeq Acc Id: XR_377418
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39642,241,851 - 42,259,442 (+)NCBI
GRCm38642,264,912 - 42,282,508 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_031636   ⟸   NM_007610
- Peptide Label: precursor
- UniProtKB: P29594 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000031895   ⟸   ENSMUST00000031895
RefSeq Acc Id: ENSMUSP00000121184   ⟸   ENSMUST00000156829
Protein Domains
CARD   CASPASE_P20

Promoters
RGD ID:6839050
Promoter ID:MM_KWN:45774
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   Spleen
Transcripts:ENSMUST00000095987,   NM_175408,   OTTMUST00000057721,   OTTMUST00000057722,   OTTMUST00000057723,   OTTMUST00000057724,   OTTMUST00000057725,   OTTMUST00000057726
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36642,211,736 - 42,215,192 (+)MPROMDB
RGD ID:6889532
Promoter ID:EPDNEW_M8217
Type:initiation region
Name:Casp2_1
Description:Mus musculus caspase 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38642,265,008 - 42,265,068EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97295 AgrOrtholog
Ensembl Genes ENSMUSG00000029863 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000031895 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000121184 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000031895 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000156829 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Caspase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Caspase_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Caspase_cys_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Caspase_his_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_C14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_C14_p10 UniProtKB/Swiss-Prot
  Pept_C14_p20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_C14A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12366 UniProtKB/Swiss-Prot
MGD MGI:97295 ENTREZGENE
NCBI Gene 12366 ENTREZGENE
PANTHER PTHR10454 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10454:SF151 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Casp2 PhenoGen
PRINTS IL1BCENZYME UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CASPASE_CYS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CASPASE_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CASPASE_P10 UniProtKB/Swiss-Prot
  CASPASE_P20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CASc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52129 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CASP2_MOUSE UniProtKB/Swiss-Prot
  D6RFN6_MOUSE UniProtKB/TrEMBL
  P29594 ENTREZGENE
UniProt Secondary O08737 UniProtKB/Swiss-Prot
  Q3TCM0 UniProtKB/Swiss-Prot
  Q8C9H7 UniProtKB/Swiss-Prot
  Q8K241 UniProtKB/Swiss-Prot