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Gene: Prlr (prolactin receptor) Mus musculus
Symbol: Prlr
Name: prolactin receptor
Description: Exhibits prolactin receptor activity. Involved in several processes, including gland development; positive regulation of cold-induced thermogenesis; and receptor signaling pathway via JAK-STAT. Predicted to localize to external side of plasma membrane and receptor complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and limb segment. Used to study familial medullary thyroid carcinoma. Human ortholog(s) of this gene implicated in hyperprolactinemia. Orthologous to human PRLR (prolactin receptor); PARTICIPATES IN Jak-Stat signaling pathway; INTERACTS WITH 1,1-dichloroethene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI987712; Pr-1; Pr-3; PRL-R; Prlr-rs1; prolactin receptor related sequence 1
Homo sapiens (human) : PRLR (prolactin receptor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Prlr (prolactin receptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prlr (prolactin receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : PRLR (prolactin receptor)
Canis lupus familiaris (dog) : PRLR (prolactin receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prlr (prolactin receptor)
Sus scrofa (pig) : PRLR (prolactin receptor)
Chlorocebus sabaeus (African green monkey) : PRLR (prolactin receptor)
Heterocephalus glaber (naked mole-rat) : Prlr (prolactin receptor)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1510,177,238 - 10,349,180 (+)EnsemblGRCm38mm10GRCm38
GRCm381510,177,238 - 10,349,190 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371510,106,993 - 10,266,775 (+)NCBIGRCm37mm9NCBIm37
MGSCv361510,122,380 - 10,274,111 (+)NCBImm8
Celera159,973,912 - 10,134,326 (+)NCBICelera
Cytogenetic Map15A1NCBI
cM Map155.23NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Prlr
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11157
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.