Cndp1 (carnosine dipeptidase 1) - Rat Genome Database

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Gene: Cndp1 (carnosine dipeptidase 1) Mus musculus
Analyze
Symbol: Cndp1
Name: carnosine dipeptidase 1
RGD ID: 1550277
MGI Page MGI
Description: Enables dipeptidase activity. Acts upstream of or within proteolysis and regulation of protein metabolic process. Located in cytosol. Is expressed in alimentary system; genitourinary system; integumental system; sensory organ; and tail. Human ortholog(s) of this gene implicated in glomerulonephritis. Orthologous to human CNDP1 (carnosine dipeptidase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI746433; beta-Ala-His dipeptidase; carnosinase 1; carnosine dipeptidase 1 (metallopeptidase M20 family); Cn; Cn1; CNDP dipeptidase 1
RGD Orthologs
Human
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391884,628,509 - 84,668,359 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1884,628,634 - 84,668,220 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381884,610,384 - 84,650,234 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1884,610,509 - 84,650,095 (-)Ensemblmm10GRCm38
MGSCv371884,779,901 - 84,819,487 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361884,744,708 - 84,784,277 (-)NCBIMGSCv36mm8
Celera1885,677,210 - 85,716,349 (-)NCBICelera
Cytogenetic Map18E4NCBI
cM Map1857.53NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA,IDA,ISO)
extracellular region  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Association of variants in the carnosine peptidase 1 gene (CNDP1) with diabetic nephropathy in American Indians. Chakkera HA, etal., Mol Genet Metab. 2011 Jun;103(2):185-90. doi: 10.1016/j.ymgme.2011.02.010. Epub 2011 Feb 19.
2. Is carnosinase 1 gene (CNDP1) polymorphism associated with chronic kidney disease progression in children and young adults? results of a family-based study. Kilis-Pstrusinska K, etal., Arch Med Res. 2010 Jul;41(5):356-62. doi: 10.1016/j.arcmed.2010.07.006.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Prenatal differentiation of mouse vomeronasal neurones. Tarozzo G, etal., Eur J Neurosci 1998 Jan;10(1):392-6.
9. Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase. Teufel M, etal., J Biol Chem 2003 Feb 21;278(8):6521-31. Epub 2002 Dec 6.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:14681479   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16603319   PMID:20562862   PMID:21267068  
PMID:21873635   PMID:24891507   PMID:32664451   PMID:36670928   PMID:37372000  


Genomics

Comparative Map Data
Cndp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391884,628,509 - 84,668,359 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1884,628,634 - 84,668,220 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381884,610,384 - 84,650,234 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1884,610,509 - 84,650,095 (-)Ensemblmm10GRCm38
MGSCv371884,779,901 - 84,819,487 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361884,744,708 - 84,784,277 (-)NCBIMGSCv36mm8
Celera1885,677,210 - 85,716,349 (-)NCBICelera
Cytogenetic Map18E4NCBI
cM Map1857.53NCBI
CNDP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381874,534,500 - 74,587,212 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1874,534,400 - 74,587,212 (+)Ensemblhg38GRCh38
GRCh371872,201,735 - 72,254,448 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361870,352,672 - 70,403,241 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341870,352,841 - 70,403,239NCBI
Celera1869,068,799 - 69,119,423 (+)NCBICelera
Cytogenetic Map18q22.3NCBI
HuRef1868,933,787 - 68,984,414 (+)NCBIHuRef
CHM1_11872,197,014 - 72,247,620 (+)NCBICHM1_1
T2T-CHM13v2.01874,761,868 - 74,814,586 (+)NCBIT2T-CHM13v2.0
Cndp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81880,254,499 - 80,305,845 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1880,255,784 - 80,282,643 (-)EnsemblGRCr8
mRatBN7.21877,984,886 - 78,030,837 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1877,984,907 - 78,007,765 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1880,086,454 - 80,110,173 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01880,758,521 - 80,782,238 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01878,594,182 - 78,617,904 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01881,466,717 - 81,512,841 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1881,466,716 - 81,499,051 (-)Ensemblrn6Rnor6.0
Rnor_5.01880,511,683 - 80,543,876 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41881,160,681 - 81,183,558 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1876,601,918 - 76,624,795 (-)NCBICelera
RGSC_v3.11881,234,131 - 81,257,008 (-)NCBI
Cytogenetic Map18q12.3NCBI
Cndp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540257,970,161 - 58,019,479 (+)Ensembl
ChiLan1.0NW_00495540257,970,205 - 58,019,980 (+)NCBIChiLan1.0ChiLan1.0
CNDP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.114,875,790 - 4,912,148 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl14,876,794 - 4,911,976 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha15,883,238 - 5,919,596 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.014,686,276 - 4,722,647 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl14,686,288 - 4,722,599 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.114,725,208 - 4,761,560 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.014,678,690 - 4,715,036 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.014,849,563 - 4,885,988 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cndp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494418,634,365 - 18,662,891 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366163,955,847 - 3,984,021 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CNDP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1149,521,510 - 149,562,623 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11149,523,983 - 149,564,728 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21165,549,109 - 165,588,550 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CNDP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1185,317,101 - 5,364,323 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl185,317,542 - 5,364,277 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606020,519,189 - 20,567,010 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cndp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248066,113,227 - 6,169,745 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248066,113,052 - 6,169,943 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Cndp1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11547,723,498 - 47,757,276 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cndp1
1599 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:502
Count of miRNA genes:387
Interacting mature miRNAs:427
Transcripts:ENSMUST00000070139, ENSMUST00000130579, ENSMUST00000145981
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302099Hdlq30_mHDL QTL 30 (mouse)Not determined185166830085668468Mouse
11252137Modvl5_mmodifier of vacuolated lens 5 (mouse)185105215685052311Mouse
4141757Sicd1_mseizure-induced cell death 1 (mouse)Not determined188017526489590914Mouse
15014786Mvlq2_mmacrovesicular liver lesion QTL 2 (mouse)187156938890720763Mouse
12880428V125Dq14_mvitamin D active form serum level QTL 14 (mouse)185743307190720763Mouse
1357630Tgq1_mtriglyceride QTL 1 (mouse)Not determined185105215685052311Mouse
10412244Par5_mpulmonary adenoma resistance 5 (mouse)Not determined185166830085668468Mouse
12880430Fgf23lq4_mFGF23 serum level QTL 4 (mouse)185643307190433071Mouse
11039492Ltpr8a_mLeishmania tropica response 8a (mouse)185918009290720763Mouse
1301853Heal9_mwound healing/regeneration 9 (mouse)Not determined185280527686805416Mouse
1302109Sluc28_msusceptibility to lung cancer 28 (mouse)Not determined185993532190720763Mouse
10401904Sicd4_mseizure-induced cell death 4 (mouse)Not determined186980527685514143Mouse
1301500Szs4_mseizure susceptibility 4 (mouse)Not determined185497587385514143Mouse
11039495Ltpr8c_mLeishmania tropica response 8c (mouse)185918009290720763Mouse
1357639Obsty4_mobesity 4 (mouse)Not determined183961991484638778Mouse
4140971Mbmq1_mmale body mass QTL 1 (mouse)Not determined5799028190720763Mouse
11049564Lmr29_mleishmaniasis resistance 29 (mouse)185918009290720763Mouse
1301798Hdlq31_mHDL QTL 31 (mouse)Not determined186714438990720763Mouse
1301353Lbw6_mlupus NZB x NZW 6 (mouse)Not determined185756233890720763Mouse
1301103Pgia11_mproteoglycan induced arthritis 11 (mouse)Not determined185991418490720763Mouse
12880410V125Dq13_mvitamin D active form serum level QTL 13 (mouse)185643307190433071Mouse

Markers in Region
D18Mit213  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381884,620,529 - 84,620,653UniSTSGRCm38
MGSCv371884,789,921 - 84,790,045UniSTSGRCm37
Celera1885,687,254 - 85,687,372UniSTS
Cytogenetic Map18E4UniSTS
cM Map1855.0UniSTS
Whitehead Genetic1837.2UniSTS
MTH1585  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381884,620,901 - 84,621,022UniSTSGRCm38
MGSCv371884,790,293 - 84,790,414UniSTSGRCm37
Celera1885,687,620 - 85,687,735UniSTS
Cytogenetic Map18E4UniSTS
cM Map1855.0UniSTS
Whitehead Genetic1837.2UniSTS
D18Mit214.2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381884,620,744 - 84,620,884UniSTSGRCm38
MGSCv371884,790,136 - 84,790,276UniSTSGRCm37
Celera1885,687,463 - 85,687,603UniSTS
Cytogenetic Map18E4UniSTS
cM Map1855.0UniSTS
cM Map18 UniSTS
Whitehead_YAC18 UniSTS
UniSTS:237859  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381884,610,671 - 84,610,871UniSTSGRCm38
MGSCv371884,780,063 - 84,780,263UniSTSGRCm37
Celera1885,677,372 - 85,677,572UniSTS
Cytogenetic Map18E4UniSTS
UniSTS:237861  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381884,611,416 - 84,611,755UniSTSGRCm38
MGSCv371884,780,808 - 84,781,147UniSTSGRCm37
Celera1885,678,118 - 85,678,457UniSTS
Cytogenetic Map18E4UniSTS
AI746433  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381884,610,662 - 84,610,778UniSTSGRCm38
MGSCv371884,780,054 - 84,780,170UniSTSGRCm37
Celera1885,677,363 - 85,677,479UniSTS
Cytogenetic Map18E4UniSTS
Whitehead/MRC_RH18981.22UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000070139   ⟹   ENSMUSP00000069699
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1884,628,634 - 84,668,220 (-)Ensembl
GRCm38.p6 Ensembl1884,610,509 - 84,650,095 (-)Ensembl
Ensembl Acc Id: ENSMUST00000130579
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1884,648,984 - 84,668,071 (-)Ensembl
GRCm38.p6 Ensembl1884,630,859 - 84,649,946 (-)Ensembl
Ensembl Acc Id: ENSMUST00000145981
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1884,646,816 - 84,668,171 (-)Ensembl
GRCm38.p6 Ensembl1884,628,691 - 84,650,046 (-)Ensembl
Ensembl Acc Id: ENSMUST00000235618
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1884,646,813 - 84,668,180 (-)Ensembl
GRCm38.p6 Ensembl1884,628,688 - 84,650,055 (-)Ensembl
Ensembl Acc Id: ENSMUST00000236714   ⟹   ENSMUSP00000157579
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1884,655,945 - 84,665,826 (-)Ensembl
GRCm38.p6 Ensembl1884,637,820 - 84,647,701 (-)Ensembl
Ensembl Acc Id: ENSMUST00000236723
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1884,646,813 - 84,668,206 (-)Ensembl
GRCm38.p6 Ensembl1884,628,688 - 84,650,081 (-)Ensembl
RefSeq Acc Id: NM_177450   ⟹   NP_803233
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391884,628,634 - 84,668,220 (-)NCBI
GRCm381884,610,509 - 84,650,095 (-)NCBI
MGSCv371884,779,901 - 84,819,487 (-)RGD
Celera1885,677,210 - 85,716,349 (-)RGD
cM Map18 ENTREZGENE
Sequence:
RefSeq Acc Id: XR_386374
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391884,628,509 - 84,668,359 (-)NCBI
GRCm381884,610,384 - 84,650,234 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_803233 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH43305 (Get FASTA)   NCBI Sequence Viewer  
  BAC39417 (Get FASTA)   NCBI Sequence Viewer  
  BAE36717 (Get FASTA)   NCBI Sequence Viewer  
  BAE38346 (Get FASTA)   NCBI Sequence Viewer  
  EDL09361 (Get FASTA)   NCBI Sequence Viewer  
  EDL09362 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000069699
GenBank Protein Q8BUG2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_803233   ⟸   NM_177450
- UniProtKB: Q80XP5 (UniProtKB/Swiss-Prot),   Q8BUG2 (UniProtKB/Swiss-Prot),   A0A0R4J0V0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000069699   ⟸   ENSMUST00000070139
Ensembl Acc Id: ENSMUSP00000157579   ⟸   ENSMUST00000236714
Protein Domains
Peptidase M20 dimerisation

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BUG2-F1-model_v2 AlphaFold Q8BUG2 1-492 view protein structure

Promoters
RGD ID:13678292
Promoter ID:EPDNEW_M23295
Type:initiation region
Name:Cndp1_1
Description:Mus musculus carnosine dipeptidase 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381884,650,084 - 84,650,144EPDNEW
RGD ID:6829150
Promoter ID:MM_KWN:25867
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:NM_177450,   OTTMUST00000069855,   UC008FUS.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361884,819,421 - 84,819,921 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2451097 AgrOrtholog
Ensembl Genes ENSMUSG00000056162 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000070139 ENTREZGENE
Gene3D-CATH 3.30.70.360 UniProtKB/Swiss-Prot
  Zn peptidases UniProtKB/Swiss-Prot
InterPro ArgE/DapE_CS UniProtKB/Swiss-Prot
  CNDP/DUG1 UniProtKB/Swiss-Prot
  Cyt/Met_Dipeptidase UniProtKB/Swiss-Prot
  Peptidase_M20 UniProtKB/Swiss-Prot
  Peptidase_M20_dimer UniProtKB/Swiss-Prot
KEGG Report mmu:338403 UniProtKB/Swiss-Prot
MGD MGI:2451097 ENTREZGENE
NCBI Gene 338403 ENTREZGENE
PANTHER BETA-ALA-HIS DIPEPTIDASE UniProtKB/Swiss-Prot
  BETA-ALA-HIS DIPEPTIDASE UniProtKB/Swiss-Prot
Pfam M20_dimer UniProtKB/Swiss-Prot
  Peptidase_M20 UniProtKB/Swiss-Prot
PhenoGen Cndp1 PhenoGen
PIRSF CNDP_dipeptidase UniProtKB/Swiss-Prot
PROSITE ARGE_DAPE_CPG2_2 UniProtKB/Swiss-Prot
Superfamily-SCOP Zn-dependent exopeptidases UniProtKB/Swiss-Prot
UniProt A0A0R4J0V0 ENTREZGENE, UniProtKB/TrEMBL
  A0A494B9E5_MOUSE UniProtKB/TrEMBL
  CNDP1_MOUSE UniProtKB/Swiss-Prot
  Q3TMU4_MOUSE UniProtKB/TrEMBL
  Q3TSF8_MOUSE UniProtKB/TrEMBL
  Q80XP5 ENTREZGENE
  Q8BUG2 ENTREZGENE
UniProt Secondary Q80XP5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-07-04 Cndp1  carnosine dipeptidase 1  Cndp1  carnosine dipeptidase 1 (metallopeptidase M20 family)  Symbol and/or name change 5135510 APPROVED