Gpc3 (glypican 3) - Rat Genome Database

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Gene: Gpc3 (glypican 3) Mus musculus
Analyze
Symbol: Gpc3
Name: glypican 3
RGD ID: 10677
MGI Page MGI
Description: Predicted to enable peptidyl-dipeptidase inhibitor activity. Involved in mesenchymal cell proliferation involved in ureteric bud development. Acts upstream of or within several processes, including kidney development; positive regulation of transport; and regulation of signal transduction. Located in lysosome and plasma membrane. Is expressed in several structures, including branchial arch; embryo mesenchyme; future brain; lower jaw; and urinary system. Used to study Simpson-Golabi-Behmel syndrome type 1. Human ortholog(s) of this gene implicated in Simpson-Golabi-Behmel syndrome type 1; hepatocellular carcinoma; and nephroblastoma. Orthologous to human GPC3 (glypican 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glypican-3; OCI; OCI-5
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X51,361,303 - 51,702,851 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX51,361,303 - 51,702,827 (-)EnsemblGRCm39 Ensembl
GRCm38X52,272,426 - 52,613,974 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX52,272,426 - 52,613,950 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X49,625,603 - 49,967,151 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X48,517,053 - 48,858,548 (-)NCBIMGSCv36mm8
CeleraX39,684,455 - 40,028,880 (-)NCBICelera
Cytogenetic MapXA5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,2-dichloroethane  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-acetamidofluorene  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (ISO)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium sulfate  (EXP)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
chlorpyrifos  (ISO)
cisplatin  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
fenvalerate  (ISO)
fulvestrant  (ISO)
furan  (ISO)
gemcitabine  (ISO)
glycerol 2-phosphate  (EXP)
glycidol  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
indole-3-methanol  (ISO)
L-ascorbic acid  (EXP)
methapyrilene  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
Muraglitazar  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nickel atom  (ISO)
ozone  (EXP)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
PhIP  (ISO)
pirinixic acid  (EXP,ISO)
raloxifene  (ISO)
SB 431542  (ISO)
scopolamine  (ISO)
Tesaglitazar  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (EXP)
tolcapone  (ISO)
topotecan  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (IMP)
anterior/posterior axis specification  (IGI)
body morphogenesis  (IMP)
bone mineralization  (IMP)
branching involved in ureteric bud morphogenesis  (IGI)
canonical Wnt signaling pathway  (IMP)
cell migration  (IBA)
cell proliferation involved in kidney development  (IMP)
cell proliferation involved in metanephros development  (IMP)
coronary vasculature development  (IMP)
embryonic hindlimb morphogenesis  (IGI)
epithelial cell proliferation  (IMP)
kidney development  (IMP)
lung development  (IMP)
mesenchymal cell proliferation involved in ureteric bud development  (IMP)
mesonephric duct morphogenesis  (IMP)
negative regulation of canonical Wnt signaling pathway  (IMP,ISO)
negative regulation of cell population proliferation  (IGI)
negative regulation of epithelial cell proliferation  (IMP)
negative regulation of growth  (IMP)
negative regulation of peptidase activity  (IEA)
negative regulation of smoothened signaling pathway  (IGI,IMP)
osteoclast differentiation  (IMP)
positive regulation of BMP signaling pathway  (IMP)
positive regulation of canonical Wnt signaling pathway  (IBA,ISO)
positive regulation of endocytosis  (IDA)
positive regulation of glucose import  (IDA)
positive regulation of protein catabolic process  (IDA)
positive regulation of smoothened signaling pathway  (IMP)
positive regulation of Wnt signaling pathway, planar cell polarity pathway  (IMP,ISO)
regulation of canonical Wnt signaling pathway  (ISO)
regulation of growth  (IGI,IMP)
regulation of non-canonical Wnt signaling pathway  (ISO)
regulation of protein localization to membrane  (IBA)
regulation of signal transduction  (IEA)
response to bacterium  (IEP)
smoothened signaling pathway  (IMP)
Wnt signaling pathway, planar cell polarity pathway  (IMP)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal body size  (IAGP)
abnormal bone marrow cell morphology/development  (IAGP)
abnormal branching involved in ureteric bud morphogenesis  (IAGP)
abnormal calcaneum morphology  (IAGP)
abnormal coronary vessel morphology  (IAGP)
abnormal endochondral bone ossification  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal hematopoietic stem cell physiology  (IAGP)
abnormal hindlimb morphology  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal kidney collecting duct morphology  (IAGP)
abnormal kidney cortex morphology  (IAGP)
abnormal kidney development  (IAGP)
abnormal kidney medulla morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal kidney weight  (IAGP)
abnormal osteoclast differentiation  (IAGP)
abnormal perineum morphology  (IAGP)
abnormal rib morphology  (IAGP)
abnormal spleen B cell follicle morphology  (IAGP)
abnormal sternum ossification  (IAGP)
abnormal ureteric bud morphology  (IAGP)
abnormal ventral body wall morphology  (IAGP)
absent mandible  (IAGP)
asymmetric sternocostal joints  (IAGP)
belly spot  (IAGP)
common atrioventricular valve  (IAGP)
complete atrioventricular septal defect  (IAGP)
coronary fistula  (IAGP)
decreased hematopoietic stem cell number  (IAGP)
decreased spleen weight  (IAGP)
dilated renal tubule  (IAGP)
dilated uterus  (IAGP)
distended abdomen  (IAGP)
double outlet right ventricle  (IAGP)
enlarged kidney  (IAGP)
hydronephrosis  (IAGP)
hypoglycemia  (IAGP)
impaired branching involved in ureteric bud morphogenesis  (IAGP)
increased body size  (IAGP)
increased body weight  (IAGP)
increased embryo size  (IAGP)
increased lung weight  (IAGP)
increased placenta weight  (IAGP)
increased placental labyrinth size  (IAGP)
increased rib number  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
inlet ventricular septal defect  (IAGP)
kidney cortex atrophy  (IAGP)
kidney cortex cyst  (IAGP)
kidney corticomedullary cyst  (IAGP)
kidney cyst  (IAGP)
kidney medulla cyst  (IAGP)
lung inflammation  (IAGP)
mandible hypoplasia  (IAGP)
maternal imprinting  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
omphalocele  (IAGP)
patent ductus arteriosus  (IAGP)
paternal imprinting  (IAGP)
perimembraneous ventricular septal defect  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
polydactyly  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
rhinitis  (IAGP)
rib fusion  (IAGP)
small spleen  (IAGP)
split xiphoid process  (IAGP)
umbilical hernia  (IAGP)
vagina atresia  (IAGP)
ventricular septal defect  (IAGP)
white spotting  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Localisation of specific heparan sulfate proteoglycans during the proliferative phase of brain development. Ford-Perriss M, etal., Dev Dyn 2003 Jun;227(2):170-84.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. Regulatory variation at glypican-3 underlies a major growth QTL in mice. Oliver F, etal., PLoS Biol 2005 May;3(5):e135. Epub 2005 Apr 5.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. Mouse MP Annotation Import Pipeline RGD automated import pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Glypican-3 expression is correlated with poor prognosis in hepatocellular carcinoma. Shirakawa H, etal., Cancer Sci. 2009 Aug;100(8):1403-7. doi: 10.1111/j.1349-7006.2009.01206.x. Epub 2009 May 4.
14. K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney. Watanabe K, etal., J Cell Biol 1995 Sep;130(5):1207-18.
15. Large-scale screen for genes involved in gonad development. Wertz K and Herrmann BG, Mech Dev 2000 Nov;98(1-2):51-70.
16. Dally-like core protein and its mammalian homologues mediate stimulatory and inhibitory effects on Hedgehog signal response. Williams EH, etal., Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5869-74. Epub 2010 Mar 15.
17. Evaluation of antiglypican-3 therapy as a promising target for amelioration of hepatic tissue damage in hepatocellular carcinoma. Zaghloul RA, etal., Eur J Pharmacol. 2015 Jan 5;746:353-62. doi: 10.1016/j.ejphar.2014.11.008. Epub 2014 Nov 18.
Additional References at PubMed
PMID:7671812   PMID:9133586   PMID:9853964   PMID:10349636   PMID:10402475   PMID:10668924   PMID:10922068   PMID:10964473   PMID:11042159   PMID:11076861   PMID:11180950   PMID:11217851  
PMID:11431694   PMID:11846487   PMID:12477932   PMID:12520002   PMID:12904583   PMID:14610273   PMID:15489334   PMID:15537637   PMID:15665292   PMID:15925496   PMID:15936336   PMID:16141072  
PMID:16141073   PMID:16844427   PMID:17107664   PMID:17339267   PMID:17668883   PMID:17873295   PMID:18287559   PMID:18343214   PMID:18404367   PMID:18477453   PMID:18799693   PMID:18973680  
PMID:19288189   PMID:19479939   PMID:19501082   PMID:19590577   PMID:19733558   PMID:19762422   PMID:19838081   PMID:20812357   PMID:21152117   PMID:21267068   PMID:21491433   PMID:21677750  
PMID:21873635   PMID:22467855   PMID:22497843   PMID:23012479   PMID:23327927   PMID:23665349   PMID:23754746   PMID:23911103   PMID:24377529   PMID:24952961   PMID:25127920   PMID:25515659  
PMID:25542894   PMID:25624497   PMID:25789613   PMID:26116392   PMID:26393505   PMID:26517809   PMID:26616051   PMID:28178526   PMID:28426184   PMID:28558017   PMID:28705898   PMID:29183737  
PMID:30001951   PMID:30228991   PMID:30573358   PMID:32201259   PMID:32201365   PMID:32220631   PMID:32325033   PMID:33932339   PMID:34003106   PMID:35084365   PMID:35831318  


Genomics

Comparative Map Data
Gpc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X51,361,303 - 51,702,851 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX51,361,303 - 51,702,827 (-)EnsemblGRCm39 Ensembl
GRCm38X52,272,426 - 52,613,974 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX52,272,426 - 52,613,950 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X49,625,603 - 49,967,151 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X48,517,053 - 48,858,548 (-)NCBIMGSCv36mm8
CeleraX39,684,455 - 40,028,880 (-)NCBICelera
Cytogenetic MapXA5NCBI
GPC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X133,535,745 - 133,985,594 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX133,535,745 - 133,987,100 (-)EnsemblGRCh38hg38GRCh38
GRCh37X132,669,773 - 133,119,621 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X132,497,439 - 132,947,332 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X132,395,297 - 132,845,186NCBI
CeleraX133,056,670 - 133,506,461 (-)NCBICelera
Cytogenetic MapXq26.2NCBI
HuRefX122,070,349 - 122,518,471 (-)NCBIHuRef
CHM1_1X132,581,479 - 133,031,377 (-)NCBICHM1_1
T2T-CHM13v2.0X131,860,879 - 132,310,724 (-)NCBIT2T-CHM13v2.0
Gpc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X131,868,983 - 132,236,837 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX131,868,990 - 132,236,798 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX134,029,733 - 134,399,032 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X137,611,682 - 137,980,983 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X135,180,258 - 135,549,530 (-)NCBIRnor_WKY
Rnor_6.0X139,579,268 - 139,947,093 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX139,579,268 - 139,916,883 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X139,625,383 - 139,993,328 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X139,192,115 - 139,560,649 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X139,264,617 - 139,634,082 (-)NCBI
CeleraX130,783,069 - 131,149,772 (-)NCBICelera
Cytogenetic MapXq36NCBI
Gpc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955473969,800 - 1,431,483 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955473969,627 - 1,431,706 (+)NCBIChiLan1.0ChiLan1.0
GPC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X132,979,890 - 133,432,266 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX132,979,612 - 133,432,441 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X122,677,072 - 123,131,511 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
GPC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X104,313,426 - 104,751,215 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX104,313,591 - 104,751,756 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX90,423,525 - 90,861,387 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X106,172,656 - 106,610,807 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX106,172,666 - 106,610,973 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X103,586,071 - 104,023,982 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X105,451,609 - 105,889,924 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X105,234,374 - 105,675,118 (-)NCBIUU_Cfam_GSD_1.0
Gpc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X102,497,623 - 102,897,321 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366911,060,013 - 1,459,736 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX109,536,504 - 109,973,607 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X109,536,495 - 109,973,605 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X125,676,131 - 126,059,402 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GPC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X108,688,706 - 109,143,653 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606546,279,325 - 46,740,727 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479713,230,932 - 13,678,742 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479713,234,741 - 13,678,542 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:310
Count of miRNA genes:263
Interacting mature miRNAs:286
Transcripts:ENSMUST00000069360, ENSMUST00000114857
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse
13208553Wght11_mweight 11 (mouse)X1186623959045360Mouse
13208557Lgth13_mbody length 13 (mouse)X1186623959045360Mouse
27226750Femd9_mfemur midshaft diameter 9, 10 week (mouse)X3333746355845360Mouse
27226780Femd12_mfemur midshaft diameter 12, 16 week (mouse)X3466365356845360Mouse
13208567Bmiq12_mbody mass index QTL 12 (mouse)X3526365377043606Mouse
1301009Pbwg7_mpostnatal body weight growth 7 (mouse)Not determinedX3911371473113814Mouse
4141565Pbwg21_mpostnatal body weight growth 21 (mouse)Not determinedX3911371473113814Mouse
1300794Spha2_msperm head anomaly 2 (mouse)Not determinedX3992149886260137Mouse
4142200Rtwq1_mreduced testis weight QTL 1 (mouse)Not determined4147706075477203Mouse
1301278Bdln1_mbody length 1 (mouse)Not determinedX4170210675702218Mouse
1300702Fcsa4_mfemoral cross-sectional area 4 (mouse)Not determinedX4602744480027567Mouse
1301212Bw19_mbody weight QTL 19 (mouse)Not determinedX4637692052412327Mouse
4141630Gct6_mgranulosa cell tumorigenesis 6 (mouse)Not determined47179121129764756Mouse
1300853Aggr2_maggression 2 (mouse)Not determinedX4907116752259196Mouse
1301351Obq6_mobesity QTL 6 (mouse)Not determinedX5077237570434751Mouse

Markers in Region
Gpc3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXA3.3UniSTS
cM MapX UniSTS
MARC_48906-48908:1125346497:1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X52,428,647 - 52,429,132UniSTSGRCm38
MGSCv37X49,781,824 - 49,782,309UniSTSGRCm37
CeleraX39,843,785 - 39,844,270UniSTS
Cytogenetic MapXA3.3UniSTS
UniSTS:235510  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X52,314,859 - 52,314,979UniSTSGRCm38
MGSCv37X49,668,036 - 49,668,156UniSTSGRCm37
CeleraX39,727,214 - 39,727,334UniSTS
Cytogenetic MapXA3.3UniSTS
UniSTS:238023  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X52,589,314 - 52,589,623UniSTSGRCm38
MGSCv37X49,942,491 - 49,942,800UniSTSGRCm37
CeleraX40,004,026 - 40,004,335UniSTS
Cytogenetic MapXA5UniSTS
Cytogenetic MapXA3.3UniSTS
px-60f2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X52,312,104 - 52,312,455UniSTSGRCm38
MGSCv37X49,665,281 - 49,665,632UniSTSGRCm37
CeleraX39,724,535 - 39,724,886UniSTS
Cytogenetic MapXA3.3UniSTS
px-7f11  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X52,512,942 - 52,513,071UniSTSGRCm38
MGSCv37X49,866,119 - 49,866,248UniSTSGRCm37
CeleraX39,928,116 - 39,928,245UniSTS
Cytogenetic MapXA3.3UniSTS
px-12f2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X52,417,378 - 52,417,520UniSTSGRCm38
MGSCv37X49,770,555 - 49,770,697UniSTSGRCm37
CeleraX39,832,565 - 39,832,707UniSTS
Cytogenetic MapXA3.3UniSTS
RH79181  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X52,272,451 - 52,272,558UniSTSGRCm38
MGSCv37X49,625,628 - 49,625,735UniSTSGRCm37
CeleraX39,684,480 - 39,684,587UniSTS
Cytogenetic MapXA3.3UniSTS
L77880  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X52,429,031 - 52,429,105UniSTSGRCm38
MGSCv37X49,782,208 - 49,782,282UniSTSGRCm37
CeleraX39,844,169 - 39,844,243UniSTS
Cytogenetic MapXA3.3UniSTS
AL032586  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X52,610,515 - 52,610,687UniSTSGRCm38
MGSCv37X49,963,692 - 49,963,864UniSTSGRCm37
CeleraX40,025,425 - 40,025,597UniSTS
Cytogenetic MapXA5UniSTS
Cytogenetic MapXA3.3UniSTS
DXJti1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X52,424,230 - 52,424,330UniSTSGRCm38
MGSCv37X49,777,407 - 49,777,507UniSTSGRCm37
CeleraX39,839,368 - 39,839,468UniSTS
Cytogenetic MapXA3.3UniSTS
cM MapX17.0UniSTS
Gpc3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXA3.3UniSTS
Gpc3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXA3.3UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_016697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF185614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK077942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL663064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL671426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL672019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC036126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ166243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ321827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS208009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB867194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000069360   ⟹   ENSMUSP00000064131
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX51,361,303 - 51,702,798 (-)Ensembl
GRCm38.p6 EnsemblX52,272,426 - 52,613,921 (-)Ensembl
RefSeq Acc Id: ENSMUST00000114857   ⟹   ENSMUSP00000110507
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX51,476,541 - 51,702,827 (-)Ensembl
GRCm38.p6 EnsemblX52,387,664 - 52,613,950 (-)Ensembl
RefSeq Acc Id: NM_016697   ⟹   NP_057906
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X51,361,303 - 51,702,851 (-)NCBI
GRCm38X52,272,426 - 52,613,974 (-)NCBI
MGSCv37X49,625,603 - 49,967,151 (-)RGD
CeleraX39,684,455 - 40,028,880 (-)RGD
cM MapX ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_057906   ⟸   NM_016697
- Peptide Label: precursor
- UniProtKB: Q8CFZ4 (UniProtKB/Swiss-Prot),   Q3TWB2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000110507   ⟸   ENSMUST00000114857
RefSeq Acc Id: ENSMUSP00000064131   ⟸   ENSMUST00000069360

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CFZ4-F1-model_v2 AlphaFold Q8CFZ4 1-579 view protein structure

Promoters
RGD ID:6845791
Promoter ID:MM_KWN:60292
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell,   Kidney,   Lung
Transcripts:ENSMUST00000114857,   OTTMUST00000042115
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X49,967,039 - 49,967,539 (-)MPROMDB
RGD ID:13680458
Promoter ID:EPDNEW_M24378
Type:initiation region
Name:Gpc3_1
Description:Mus musculus glypican 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X52,613,950 - 52,614,010EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104903 AgrOrtholog
Ensembl Genes ENSMUSG00000055653 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000064131 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000110507.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000069360 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000114857.2 UniProtKB/TrEMBL
InterPro Glypican UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glypican-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glypican_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14734 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:104903 ENTREZGENE
NCBI Gene 14734 ENTREZGENE
PANTHER PTHR10822 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10822:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Glypican UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gpc3 PhenoGen
PROSITE GLYPICAN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B1ATR5_MOUSE UniProtKB/TrEMBL
  GPC3_MOUSE UniProtKB/Swiss-Prot
  Q3TWB2 ENTREZGENE, UniProtKB/TrEMBL
  Q3TX35_MOUSE UniProtKB/TrEMBL
  Q8CFZ4 ENTREZGENE
  Q9QZF1_MOUSE UniProtKB/TrEMBL