Gja1 (gap junction protein, alpha 1) - Rat Genome Database

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Gene: Gja1 (gap junction protein, alpha 1) Mus musculus
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Symbol: Gja1
Name: gap junction protein, alpha 1
RGD ID: 10649
MGI Page MGI
Description: Enables several functions, including beta-tubulin binding activity; glutathione transmembrane transporter activity; and scaffold protein binding activity. Involved in several processes, including cellular response to amyloid-beta; glutamate secretion; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including cell communication by chemical coupling; circulatory system development; and regulation of gene expression. Located in several cellular components, including fascia adherens; gap junction; and lateral plasma membrane. Is expressed in several structures, including alimentary system; embryo ectoderm; genitourinary system; sensory organ; and skin. Used to study oculodentodigital dysplasia. Human ortholog(s) of this gene implicated in several diseases, including bone disease (multiple); congenital heart disease (multiple); erythrokeratodermia variabilis (multiple); oculodentodigital dysplasia; and palmoplantar keratoderma and congenital alopecia 1. Orthologous to human GJA1 (gap junction protein alpha 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha 1 connexin; AU042049; AW546267; Cnx4; Cnx43; conne; connexin 43; connexin k1; connexin-43; connexin43; Cx43; Cx43al; Cx43alpha1; Cxnk1; gap junction 43 kDa heart protein; gap junction alpha-1 protein; gap junction membrane channel protein alpha 1; Gja-; Gja-1; Npm1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391056,253,297 - 56,266,519 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1056,253,426 - 56,278,609 (+)EnsemblGRCm39 Ensembl
GRCm381056,377,300 - 56,390,419 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1056,377,330 - 56,402,513 (+)EnsemblGRCm38mm10GRCm38
MGSCv371056,097,106 - 56,110,225 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361056,065,762 - 56,078,833 (+)NCBIMGSCv36mm8
Celera1057,194,935 - 57,208,041 (+)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1028.64NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
adenoma  (ISO)
amnestic disorder  (ISO)
arrhythmogenic right ventricular cardiomyopathy  (ISO)
atrial fibrillation  (IMP,ISO)
atrioventricular septal defect  (ISO)
Atrioventricular Septal Defect 3  (ISO)
autistic disorder  (ISO)
autoimmune thyroiditis  (ISO)
autosomal recessive craniometaphyseal dysplasia  (ISO)
Basaran Yilmaz Syndrome  (ISO)
borna disease  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiac Fibrosis  (ISO)
chronic kidney disease  (ISO)
Chylothorax  (IMP)
coronary aneurysm  (ISO)
Diabetic Foot  (ISO)
Diaphragmatic Hernia  (ISO)
dilated cardiomyopathy  (ISO)
Disease Progression  (ISO)
epilepsy  (ISO)
erythrokeratodermia variabilis  (ISO)
erythrokeratodermia variabilis et progressiva 3  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (ISO)
genetic disease  (ISO)
Hearing Loss  (ISO)
Hemorrhagic Shock  (ISO)
hereditary lymphedema IA  (ISO)
high grade glioma  (ISO)
Huntington's disease  (ISO)
Hyperalgesia  (ISO)
hypertension  (ISO)
hypoplastic left heart syndrome  (ISO)
Hypoplastic Left Heart Syndrome 1  (ISO)
impotence  (ISO)
intellectual disability  (ISO)
ischemia  (ISO)
Lung Neoplasms  (ISO)
Lymphatic Abnormalities  (IMP)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
myocarditis  (ISO)
Neuralgia  (IMP)
Nonsyndromic Sensorineural Hearing Loss  (ISO)
oculodentodigital dysplasia  (IAGP,IMP,ISO)
Oculodentodigital Dysplasia, Autosomal Recessive  (ISO)
overactive bladder syndrome  (ISO)
palmoplantar keratoderma and congenital alopecia 1  (ISO)
palmoplantar keratosis  (ISO)
Parkinsonism  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary hypertension  (ISO)
renovascular hypertension  (ISO)
Schwartz-Lelek Syndrome  (ISO)
Skin Neoplasms  (ISO)
Spinal Cord Injuries  (ISO)
Sudden Cardiac Death  (IEP)
syndactyly  (ISO)
syndactyly type 3  (ISO)
syndactyly type 5  (ISO)
tetralogy of Fallot  (ISO)
tongue squamous cell carcinoma  (ISO)
transient cerebral ischemia  (IDA,ISO)
type 2 diabetes mellitus  (ISO)
urethral obstruction  (ISO)
visual epilepsy  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-antofine  (ISO)
(R)-lipoic acid  (EXP,ISO)
(R,R)-tramadol  (ISO)
(S)-colchicine  (ISO)
1,3-dinitrobenzene  (ISO)
1-heptanol  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexabromobiphenyl  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (EXP)
2,6-di-tert-butyl-4-methylphenol  (EXP,ISO)
2-acetamidofluorene  (ISO)
2-butoxyethanol  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3,5-dibromo-4-hydroxybenzonitrile  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxyphenyl retinamide  (EXP)
4-phenylbutyric acid  (EXP)
4-tert-Octylphenol  (ISO)
4-vinylcyclohexene dioxide  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (ISO)
5-fluorouracil  (EXP,ISO)
7,12-dimethyltetraphene  (EXP,ISO)
8-Br-cAMP  (ISO)
acadesine  (ISO)
acetamide  (ISO)
acetylleucyl-leucyl-norleucinal  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
ametryn  (ISO)
amiodarone  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
anastrozole  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimycin A  (ISO)
apocynin  (ISO)
Aroclor 1254  (EXP)
arotinoid acid  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
astaxanthin  (EXP)
atenolol  (ISO)
atorvastatin calcium  (ISO)
ATP  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
bafilomycin A1  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
Benzoyl peroxide  (EXP)
beta-carotene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
BQ 123  (ISO)
bucladesine  (ISO)
busulfan  (EXP)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcidiol  (ISO)
calciol  (ISO)
capsanthin  (ISO)
carbendazim  (ISO)
CARBENOXOLONE  (ISO)
carbon nanotube  (EXP)
carvedilol  (ISO)
chaetoglobosin A  (ISO)
CHIR 99021  (ISO)
chloral hydrate  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP)
chloroquine  (EXP,ISO)
chlorothalonil  (EXP)
choline  (EXP)
chromium atom  (ISO)
cisplatin  (EXP,ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cylindrospermopsin  (ISO)
D-glucose  (EXP,ISO)
dapagliflozin  (ISO)
DDT  (EXP,ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (EXP)
Didecyldimethylammonium  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (EXP)
dimethyl sulfoxide  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
doxycycline  (EXP)
ebselen  (ISO)
endosulfan  (ISO)
erastin  (ISO)
ethanol  (EXP,ISO)
ethidium  (ISO)
etoposide  (EXP)
ferric oxide  (EXP)
fluoranthene  (EXP)
fluorene  (EXP)
fluoxetine  (ISO)
flutamide  (ISO)
folic acid  (EXP,ISO)
fructose  (ISO)
fucoxanthin  (ISO)
fulvestrant  (ISO)
furan  (ISO)
gamma-hexachlorocyclohexane  (EXP,ISO)
Gastrodin  (ISO)
genistein  (ISO)
ginsenoside Rg1  (EXP)
glafenine  (ISO)
glucose  (EXP,ISO)
glutaraldehyde  (ISO)
gossypol  (ISO)
griseofulvin  (ISO)
haloperidol  (ISO)
heptachlor  (ISO)
Heptachlor epoxide  (EXP,ISO)
hydrogen peroxide  (ISO)
hydrogen sulfide  (EXP)
hydroxyflutamide  (ISO)
imidacloprid  (ISO)
indoxyl sulfate  (ISO)
ioxynil  (ISO)
iprodione  (ISO)
irinotecan  (ISO)
isocarbophos  (ISO)
isoprenaline  (EXP,ISO)
KN-93  (EXP)
L-ascorbic acid  (EXP,ISO)
L-methionine  (EXP)
lactacystin  (EXP)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
leflunomide  (EXP,ISO)
letrozole  (ISO)
leupeptin  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (ISO)
lithium chloride  (ISO)
lithium hydride  (ISO)
losartan  (ISO)
LY294002  (ISO)
lycopene  (EXP,ISO)
lysophosphatidylcholine  (ISO)
manganese(II) chloride  (ISO)
medroxyprogesterone acetate  (ISO)
menadione  (EXP)
mercury dichloride  (ISO)
methoxychlor  (EXP)
methylseleninic acid  (ISO)
metoprolol  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Muconic dialdehyde  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
nickel sulfate  (ISO)
nitric oxide  (ISO)
nitrofen  (EXP,ISO)
Norfluoxetine  (ISO)
ochratoxin A  (ISO)
okadaic acid  (EXP)
oxaliplatin  (ISO)
ozone  (EXP)
p-cresol  (ISO)
p-tert-Amylphenol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenethyl isothiocyanate  (EXP,ISO)
phenobarbital  (EXP)
phenol  (ISO)
phenol red  (ISO)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
picoxystrobin  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propranolol  (ISO)
quercetin  (EXP,ISO)
radicicol  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
Ro 41-5253  (EXP)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (EXP,ISO)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sirolimus  (ISO)
sodium arsenate  (EXP,ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP)
sodium sulfide (anhydrous)  (EXP)
Soman  (ISO)
succimer  (EXP)
sulfur dioxide  (EXP)
tamoxifen  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
tolbutamide  (ISO)
toluene  (ISO)
topotecan  (ISO)
toxaphene  (ISO)
tramadol  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
triclocarban  (EXP)
triclosan  (EXP,ISO)
Triptolide  (EXP)
triptonide  (EXP)
trovafloxacin  (EXP)
urethane  (EXP)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vinclozolin  (ISO)
vincristine  (EXP)
vitamin E  (ISO)
WIN 55212-2  (EXP)
wortmannin  (ISO)
zardaverine  (ISO)
zinc atom  (ISO)
zinc dichloride  (EXP)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult heart development  (IMP)
apoptotic process  (ISO)
ATP transport  (ISO)
atrial ventricular junction remodeling  (IGI)
blood vessel morphogenesis  (IMP)
bone development  (IMP)
bone remodeling  (IMP)
cardiac conduction  (IMP)
cell communication  (ISO)
cell communication by chemical coupling  (IDA)
cell communication by electrical coupling  (IDA,ISO)
cell-cell junction organization  (IMP)
cell-cell signaling  (IDA,ISO)
cellular response to amyloid-beta  (IMP)
cellular response to mechanical stimulus  (ISO)
cellular response to parathyroid hormone stimulus  (ISO)
cellular response to pH  (IDA)
cellular response to platelet-derived growth factor stimulus  (ISO)
chronic inflammatory response  (ISO)
columnar/cuboidal epithelial cell maturation  (IMP)
decidualization  (ISO)
embryonic digit morphogenesis  (IMP)
embryonic heart tube development  (IMP)
endothelium development  (ISO)
epicardial cell to mesenchymal cell transition  (TAS)
epididymis development  (ISO)
establishment of epithelial cell polarity  (TAS)
establishment of mitotic spindle orientation  (ISO)
export across plasma membrane  (IMP)
glutamate secretion  (IMP)
heart development  (IMP,ISO)
heart looping  (IMP)
in utero embryonic development  (IMP)
lens development in camera-type eye  (IMP)
maintenance of protein localization in endoplasmic reticulum  (ISO)
male gonad development  (IMP)
microtubule-based transport  (ISO)
milk ejection reflex  (IMP)
monoatomic ion transmembrane transport  (ISO)
negative regulation of cardiac muscle cell proliferation  (ISO)
negative regulation of cell growth  (IMP,ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of DNA biosynthetic process  (ISO)
negative regulation of endothelial cell proliferation  (ISO)
negative regulation of gene expression  (IMP)
negative regulation of gonadotropin secretion  (ISO)
negative regulation of trophoblast cell migration  (ISO)
negative regulation of wound healing  (ISO)
neuroblast migration  (IMP)
neuron migration  (IMP)
neuron projection morphogenesis  (ISO)
osteoblast differentiation  (IMP)
positive regulation of behavioral fear response  (ISO)
positive regulation of cell communication by chemical coupling  (ISO)
positive regulation of cold-induced thermogenesis  (IMP)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of establishment of Sertoli cell barrier  (ISO)
positive regulation of gene expression  (IMP,ISO)
positive regulation of glomerular filtration  (ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
positive regulation of insulin secretion  (ISO)
positive regulation of meiotic nuclear division  (ISO)
positive regulation of mesodermal cell differentiation  (ISO)
positive regulation of morphogenesis of an epithelium  (ISO)
positive regulation of protein catabolic process  (ISO)
positive regulation of smooth muscle cell chemotaxis  (ISO)
positive regulation of stem cell proliferation  (ISO)
positive regulation of striated muscle tissue development  (IMP)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
positive regulation of vasoconstriction  (ISO)
protein localization  (ISO)
regulation of actin filament organization  (ISO)
regulation of apoptotic process  (ISO)
regulation of atrial cardiac muscle cell membrane depolarization  (IMP)
regulation of bicellular tight junction assembly  (ISO)
regulation of blood vessel remodeling  (TAS)
regulation of bone mineralization  (IMP)
regulation of bone remodeling  (IMP)
regulation of calcium ion transport  (ISO)
regulation of cell communication by electrical coupling  (ISO)
regulation of heart contraction  (IMP)
regulation of transmembrane transporter activity  (ISO)
regulation of ventricular cardiac muscle cell membrane depolarization  (IGI,IMP)
regulation of ventricular cardiac muscle cell membrane repolarization  (IGI,IMP)
response to estradiol  (ISO)
response to fluid shear stress  (ISO)
response to glucose  (ISO)
response to ischemia  (ISO)
response to lipopolysaccharide  (ISO)
response to peptide hormone  (ISO)
response to pH  (ISO)
response to retinoic acid  (ISO)
response to wounding  (ISO)
signal transduction  (ISO)
skeletal muscle tissue regeneration  (IDA)
spermatogenesis  (IMP,ISO)
T cell activation  (IDA)
T cell proliferation  (IMP)
transmembrane transport  (ISO)
vascular transport  (ISO)
vasodilation  (ISO)
xenobiotic transport  (IMP)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal alisphenoid bone morphology  (IAGP)
abnormal ascending aorta and coronary artery attachment  (IAGP)
abnormal atrioventricular bundle conduction  (IAGP)
abnormal behavior  (IAGP)
abnormal blood circulation  (IAGP)
abnormal blood homeostasis  (IAGP)
abnormal bone marrow cell morphology/development  (IAGP)
abnormal brain morphology  (IAGP)
abnormal breathing pattern  (IAGP)
abnormal cardiac muscle contractility  (IAGP)
abnormal cardiac outflow tract development  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal cell physiology  (IAGP)
abnormal cerebellar cortex morphology  (IAGP)
abnormal cerebellar granule layer morphology  (IAGP)
abnormal cerebellar lobule formation  (IAGP)
abnormal cerebellar Purkinje cell layer  (IAGP)
abnormal cerebellum external granule cell layer morphology  (IAGP)
abnormal cerebellum morphology  (IAGP)
abnormal circulating hormone level  (IAGP)
abnormal coronary artery morphology  (IAGP)
abnormal coronary vein morphology  (IAGP)
abnormal coronary vessel morphology  (IAGP)
abnormal cortical ventricular zone morphology  (IAGP)
abnormal craniofacial bone morphology  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal cranium morphology  (IAGP)
abnormal dentate gyrus morphology  (IAGP)
abnormal digit morphology  (IAGP)
abnormal epidermis stratum corneum morphology  (IAGP)
abnormal epidermis stratum granulosum morphology  (IAGP)
abnormal gait  (IAGP)
abnormal glial cell physiology  (IAGP)
abnormal granulosa cell morphology  (IAGP)
abnormal heart development  (IAGP)
abnormal heart electrocardiography waveform feature  (IAGP)
abnormal heart morphology  (IAGP)
abnormal heart rate  (IAGP)
abnormal heart right ventricle morphology  (IAGP)
abnormal heart right ventricle outflow tract morphology  (IAGP)
abnormal heart shape  (IAGP)
abnormal heart ventricle morphology  (IAGP)
abnormal hippocampus morphology  (IAGP)
abnormal impulse conducting system conduction  (IAGP)
abnormal incisor morphology  (IAGP)
abnormal interventricular septum morphology  (IAGP)
abnormal iris morphology  (IAGP)
abnormal lactation  (IAGP)
abnormal lymphatic vessel morphology  (IAGP)
abnormal mammary gland alveolus morphology  (IAGP)
abnormal mammary gland growth during pregnancy  (IAGP)
abnormal mammary gland luminal epithelium morphology  (IAGP)
abnormal milk ejection  (IAGP)
abnormal motor capabilities/coordination/movement  (IAGP)
abnormal muscle regeneration  (IAGP)
abnormal myocardial fiber physiology  (IAGP)
abnormal myocardial trabeculae morphology  (IAGP)
abnormal myocardium layer morphology  (IAGP)
abnormal nasal bone morphology  (IAGP)
abnormal nervous system development  (IAGP)
abnormal neurocranium morphology  (IAGP)
abnormal neutrophil physiology  (IAGP)
abnormal occipital bone morphology  (IAGP)
abnormal osteoblast differentiation  (IAGP)
abnormal osteoblast physiology  (IAGP)
abnormal ovarian follicle morphology  (IAGP)
abnormal ovarian follicle number  (IAGP)
abnormal ovary morphology  (IAGP)
abnormal parietal bone morphology  (IAGP)
abnormal phalanx morphology  (IAGP)
abnormal postnatal subventricular zone morphology  (IAGP)
abnormal proerythroblast morphology  (IAGP)
abnormal pulmonary gas exchange  (IAGP)
abnormal pulmonary valve morphology  (IAGP)
abnormal R wave  (IAGP)
abnormal radial glial cell morphology  (IAGP)
abnormal rib morphology  (IAGP)
abnormal semilunar valve morphology  (IAGP)
abnormal seminiferous tubule morphology  (IAGP)
abnormal Sertoli cell morphology  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal skin condition  (IAGP)
abnormal spermatid morphology  (IAGP)
abnormal spermatocyte morphology  (IAGP)
abnormal spermatogenesis  (IAGP)
abnormal spermatogonia morphology  (IAGP)
abnormal suckling behavior  (IAGP)
abnormal thoracic cage morphology  (IAGP)
abnormal tooth development  (IAGP)
abnormal tooth hard tissue morphology  (IAGP)
abnormal tooth morphology  (IAGP)
abnormal trabecula carnea morphology  (IAGP)
abnormal trabecular bone morphology  (IAGP)
abnormal vascular smooth muscle physiology  (IAGP)
abnormal vascular wound healing  (IAGP)
abnormal zygomatic arch morphology  (IAGP)
absent corpus luteum  (IAGP)
absent lymphatic vessels  (IAGP)
absent mature ovarian follicles  (IAGP)
arrest of spermatogenesis  (IAGP)
ataxia  (IAGP)
atrioventricular block  (IAGP)
azoospermia  (IAGP)
brittle teeth  (IAGP)
cardiac fibrosis  (IAGP)
cardiac hypertrophy  (IAGP)
cataract  (IAGP)
corneal opacity  (IAGP)
coronary artery aneurysm  (IAGP)
coronary fistula  (IAGP)
cyanosis  (IAGP)
decreased birth body size  (IAGP)
decreased birth weight  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone marrow cell number  (IAGP)
decreased bone mineral content  (IAGP)
decreased bone mineral density  (IAGP)
decreased bone strength  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased germ cell number  (IAGP)
decreased granulosa cell proliferation  (IAGP)
decreased heart rate  (IAGP)
decreased litter size  (IAGP)
decreased male germ cell number  (IAGP)
decreased mature ovarian follicle number  (IAGP)
decreased ovulation rate  (IAGP)
decreased QRS amplitude  (IAGP)
decreased superovulation rate  (IAGP)
decreased systemic arterial systolic blood pressure  (IAGP)
decreased testis weight  (IAGP)
decreased trabecular bone mass  (IAGP)
decreased tympanic ring size  (IAGP)
decreased ventricle muscle contractility  (IAGP)
delaminated cerebellar granule layer  (IAGP)
delaminated Purkinje cell layer  (IAGP)
delayed bone ossification  (IAGP)
delayed endochondral bone ossification  (IAGP)
delayed intramembranous bone ossification  (IAGP)
depressed nasal bridge  (IAGP)
dilated heart left ventricle  (IAGP)
ectopic cerebellar granule cells  (IAGP)
edema  (IAGP)
enlarged brain ventricles  (IAGP)
enlarged lateral ventricles  (IAGP)
female infertility  (IAGP)
heart inflammation  (IAGP)
heart right ventricle hypertrophy  (IAGP)
heart right ventricle outflow tract stenosis  (IAGP)
hypotension  (IAGP)
impaired luteinization  (IAGP)
impaired ovarian folliculogenesis  (IAGP)
impaired skin barrier function  (IAGP)
increased granulosa cell apoptosis  (IAGP)
increased heart rate  (IAGP)
increased Leydig cell number  (IAGP)
increased Sertoli cell number  (IAGP)
interparietal bone hypoplasia  (IAGP)
irregular heartbeat  (IAGP)
irregularly shaped pupil  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
lymphedema  (IAGP)
male infertility  (IAGP)
maternal effect  (IAGP)
microcephaly  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
oligozoospermia  (IAGP)
ovary cyst  (IAGP)
patent cardiac foramen ovale  (IAGP)
perinatal lethality  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
pointed snout  (IAGP)
poor grooming  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
prolonged P wave  (IAGP)
prolonged PR interval  (IAGP)
prolonged QRS complex duration  (IAGP)
prolonged QT interval  (IAGP)
reduced enamel thickness  (IAGP)
reduced female fertility  (IAGP)
semilunar valve regurgitation  (IAGP)
short zygomatic bone  (IAGP)
shortened QT interval  (IAGP)
small cerebellum  (IAGP)
small cranium  (IAGP)
small face  (IAGP)
small frontal bone  (IAGP)
small heart  (IAGP)
small hippocampus  (IAGP)
small lower incisors  (IAGP)
small mandible  (IAGP)
small maxilla  (IAGP)
small nasal bone  (IAGP)
small neurocranium  (IAGP)
small ovary  (IAGP)
small seminiferous tubules  (IAGP)
small snout  (IAGP)
small testis  (IAGP)
sparse hair  (IAGP)
syndactyly  (IAGP)
thick aortic valve  (IAGP)
thick pulmonary valve  (IAGP)
thin external granule cell layer  (IAGP)
thin myocardium compact layer  (IAGP)
thin parietal bone  (IAGP)
thin ventricular wall  (IAGP)
ventricular fibrillation  (IAGP)
ventricular premature beat  (IAGP)
ventricular tachycardia  (IAGP)
References

References - curated
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Additional References at PubMed
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