Mif (macrophage migration inhibitory factor (glycosylation-inhibiting factor)) - Rat Genome Database

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Gene: Mif (macrophage migration inhibitory factor (glycosylation-inhibiting factor)) Mus musculus
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Symbol: Mif
Name: macrophage migration inhibitory factor (glycosylation-inhibiting factor)
RGD ID: 734204
MGI Page MGI
Description: Enables cytokine activity; phenylpyruvate tautomerase activity; and protease binding activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of icosanoid secretion; and regulation of signal transduction. Acts upstream of or within DNA damage response, signal transduction by p53 class mediator; cellular senescence; and regulation of cell population proliferation. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in allergic disease; asthma; cystic fibrosis; lung disease (multiple); and obesity. Orthologous to human MIF (macrophage migration inhibitory factor).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: delayed early response protein 6; DER6; GIF; Gl; Glif; glycosylation-inhibiting factor; L-dopachrome isomerase; L-dopachrome tautomerase; macrophage migration inhibitory factor; MGC107654; phenylpyruvate tautomerase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm16379   Gm5228   Gm6990   Mif-ps   Mif-ps10   Mif-ps11   Mif-ps13   Mif-ps2   Mif-ps5  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391075,695,187 - 75,696,111 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1075,695,187 - 75,696,074 (-)EnsemblGRCm39 Ensembl
GRCm381075,859,353 - 75,860,277 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1075,859,353 - 75,860,240 (-)EnsemblGRCm38mm10GRCm38
MGSCv371075,322,098 - 75,322,995 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361075,303,069 - 75,303,966 (-)NCBIMGSCv36mm8
Celera1076,904,043 - 76,904,940 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1038.59NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute necrotizing pancreatitis  (ISO)
agammaglobulinemia 2  (ISO)
Alcoholic Liver Diseases  (ISO)
allergic disease  (ISO)
Animal Mammary Neoplasms  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
anxiety disorder  (ISO)
arteriosclerosis  (IDA)
asthma  (IMP,ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
borna disease  (ISO)
Brain Injuries  (ISO)
Breast Neoplasms  (ISO)
Bronchial Hyperreactivity  (IMP)
bronchopulmonary dysplasia  (ISO)
Burns  (ISO)
carcinoma  (ISO)
cardiomyopathy  (ISO)
chronic obstructive pulmonary disease  (ISO)
Chylothorax  (ISO)
colitis  (ISO)
Coronary Disease  (ISO)
cystic fibrosis  (ISO)
cystitis  (ISO)
depressive disorder  (ISO)
Disease Progression  (ISO)
Endotoxemia  (ISO)
epilepsy  (ISO)
Experimental Arthritis  (ISO)
Experimental Colitis  (IDA)
Experimental Diabetes Mellitus  (IDA)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
Granuloma  (ISO)
Hamartoma  (ISO)
Hypercholesterolemia  (ISO)
hypertension  (ISO)
Inflammation  (IDA,ISO)
Insulin Resistance  (ISO)
Keloid  (ISO)
kidney disease  (ISO)
lung disease  (IEP,IMP,ISO)
lung non-small cell carcinoma  (ISO)
malignant mesothelioma  (ISO)
Memory Disorders  (ISO)
myocardial infarction  (ISO)
myocarditis  (ISO)
newborn respiratory distress syndrome  (IMP)
obesity  (ISO)
pneumonia  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary edema  (IDA)
pulmonary hypertension  (ISO)
pulmonary tuberculosis  (ISO)
Radiation Pneumonitis  (ISO)
Reperfusion Injury  (IMP)
retinitis  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (IMP,ISO)
schizophrenia  (ISO)
Sepsis  (ISO)
Spinal Cord Injuries  (ISO)
Stevens-Johnson syndrome  (ISO)
Stroke  (ISO)
Systemic Juvenile Rheumatoid Arthritis  (ISO)
toxic shock syndrome  (ISO)
type 2 diabetes mellitus  (ISO)
viral pneumonia  (IMP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinic acid  (ISO)
(+)-catechin  (ISO)
(1->4)-beta-D-glucan  (EXP)
(Z)-3-butylidenephthalide  (ISO)
1,10-phenanthroline  (ISO)
1,2,4-trimethylbenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
2-bromohexadecanoic acid  (ISO)
3-phenylprop-2-enal  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-Isoxazoleacetic acid, 4,5-dihydro-3-(4-hydroxyphenyl)-, methyl ester  (EXP)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (ISO)
amphibole asbestos  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
apocynin  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
asperentin  (EXP)
atrazine  (ISO)
azoxystrobin  (ISO)
benzalkonium chloride  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (ISO)
Brevianamide A  (EXP)
bromobenzene  (ISO)
buspirone  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP,ISO)
cerium trichloride  (EXP)
CGP 52608  (ISO)
chlorohydrocarbon  (ISO)
chloropicrin  (ISO)
chlorothalonil  (ISO)
chlorpyrifos  (EXP,ISO)
chromium(6+)  (EXP)
clofibric acid  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cobalt(2+) sulfate  (ISO)
copper(II) sulfate  (ISO)
cumene  (EXP)
cyclophosphamide  (ISO)
dexamethasone  (EXP)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
diazinon  (EXP,ISO)
dibutyl phthalate  (ISO)
dinitrogen  (ISO)
dioxygen  (EXP,ISO)
diquat  (EXP)
disulfiram  (ISO)
doxorubicin  (ISO)
emamectin benzoate  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP)
ethanol  (ISO)
finasteride  (ISO)
flavonoids  (ISO)
fluoxetine  (ISO)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (ISO)
glyphosate  (ISO)
heparin  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (ISO)
hydrogen sulfide  (EXP)
imidacloprid  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
ivermectin  (ISO)
kojic acid  (ISO)
L-methionine  (EXP)
lipopolysaccharide  (EXP,ISO)
Mesaconitine  (ISO)
metam  (EXP)
methamphetamine  (ISO)
methidathion  (EXP)
methimazole  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
mycophenolic acid  (EXP)
mycotoxin  (EXP)
N-nitrosodiethylamine  (ISO)
naphthalenes  (ISO)
naproxen  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nickel sulfate  (EXP)
nitrofen  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
oleanolic acid  (EXP)
ozone  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
pyrogallol  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
rottlerin  (ISO)
sarin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sterigmatocystin  (EXP)
sumatriptan  (ISO)
tanespimycin  (ISO)
temozolomide  (ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (ISO)
thiabendazole  (ISO)
thyroxine  (ISO)
titanium dioxide  (EXP,ISO)
TMC-120A  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
tungsten  (EXP,ISO)
Tungsten carbide  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vorinostat  (EXP)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
brain renin-angiotensin system  (ISO)
carboxylic acid metabolic process  (ISO)
cell surface receptor signaling pathway  (IEA,ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to hypoxia  (ISO)
cellular senescence  (IMP)
DNA damage response, signal transduction by p53 class mediator  (IMP)
drinking behavior  (ISO)
hair follicle development  (ISO)
inflammatory response  (IEA)
innate immune response  (IEA)
negative regulation of apoptotic process  (IDA,ISO)
negative regulation of cell migration  (ISO)
negative regulation of cellular senescence  (IEA,ISO)
negative regulation of DNA damage response, signal transduction by p53 class mediator  (IDA,ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (IEA,ISO)
negative regulation of macrophage chemotaxis  (IEA,ISO)
negative regulation of mature B cell apoptotic process  (IDA)
negative regulation of myeloid cell apoptotic process  (IMP)
negative regulation of protein metabolic process  (IDA)
positive chemotaxis  (IEA)
positive regulation of acute inflammatory response  (ISO)
positive regulation of adaptive immune response  (NAS)
positive regulation of arachidonate secretion  (IDA)
positive regulation of axon regeneration  (ISO)
positive regulation of B cell proliferation  (IEA,ISO)
positive regulation of cAMP/PKA signal transduction  (IEA)
positive regulation of cell population proliferation  (ISO)
positive regulation of chemokine (C-X-C motif) ligand 2 production  (IDA)
positive regulation of cytokine production  (ISO)
positive regulation of D-glucose import  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IDA,ISO)
positive regulation of fibroblast proliferation  (IDA,ISO)
positive regulation of glycolytic process  (ISO)
positive regulation of immune response  (ISO)
positive regulation of lipopolysaccharide-mediated signaling pathway  (IMP)
positive regulation of MAP kinase activity  (IDA)
positive regulation of myeloid leukocyte cytokine production involved in immune response  (IMP)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphorylation  (ISO)
positive regulation of potassium ion transport  (ISO)
positive regulation of prostaglandin secretion involved in immune response  (IMP)
positive regulation of protein kinase A signaling  (ISO)
positive regulation of protein phosphorylation  (IDA)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of tumor necrosis factor production  (IEA,ISO)
prostaglandin biosynthetic process  (IEA,ISO)
protein homotrimerization  (IEA,ISO)
regulation of cell population proliferation  (IMP)
response to estradiol  (ISO)
response to glucocorticoid  (ISO)
response to hormone  (ISO)
response to insulin  (ISO)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
response to menaquinone  (ISO)
response to progesterone  (ISO)
response to vitamin E  (ISO)
response to xenobiotic stimulus  (ISO)
skin development  (ISO)
spermatogenesis  (ISO)

Cellular Component
cell surface  (IEA,ISO)
cytoplasm  (ISO)
cytosol  (IEA,ISO)
extracellular region  (ISO)
extracellular space  (HDA,IBA,IDA,ISO)
myelin sheath  (HDA)
nucleoplasm  (IEA,ISO)
plasma membrane  (IEA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The role of macrophage migration inhibitory factor in the cascade of events leading to reperfusion-induced inflammatory injury and lethality. Amaral FA, etal., Am J Pathol. 2007 Dec;171(6):1887-93. Epub 2007 Nov 30.
2. Borna disease virus-induced accumulation of macrophage migration inhibitory factor in rat brain astrocytes is associated with inhibition of macrophage infiltration. Bacher M, etal., Glia. 2002 Mar 15;37(4):291-306.
3. Macrophage migration inhibitory factor may contribute to vasculopathy in systemic sclerosis. Becker H, etal., Clin Rheumatol. 2008 Oct;27(10):1307-11. Epub 2008 Jul 11.
4. MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment. Bernhagen J, etal., Nat Med. 2007 May;13(5):587-96. Epub 2007 Apr 15.
5. Endotoxin-induced myocardial dysfunction: effects of macrophage migration inhibitory factor neutralization. Chagnon F, etal., Circ Res. 2005 May 27;96(10):1095-102. Epub 2005 May 5.
6. Proinflammatory macrophage migratory inhibition factor and interleukin-6 are concentrated in pleural effusion of human fetuses with prenatal chylothorax. Chen M, etal., Prenat Diagn. 2007 May;27(5):435-41.
7. Critical role of macrophage migration inhibitory factor activity in experimental autoimmune diabetes. Cvetkovic I, etal., Endocrinology. 2005 Jul;146(7):2942-51. Epub 2005 Mar 24.
8. Increased plasma concentration of macrophage migration inhibitory factor (MIF) and MIF mRNA in mononuclear cells in the obese and the suppressive action of metformin. Dandona P, etal., J Clin Endocrinol Metab. 2004 Oct;89(10):5043-7.
9. Cardiovascular protective role for activated protein C during endotoxemia in rats. Favory R, etal., Intensive Care Med. 2006 Jun;32(6):899-905. Epub 2006 Apr 7.
10. Polymorphisms of the macrophage inhibitory factor and C-reactive protein genes in subjects with Alzheimer's dementia. Flex A, etal., Dement Geriatr Cogn Disord. 2004;18(3-4):261-4. Epub 2004 Jul 29.
11. Macrophage migration inhibitory factor in acute lung injury: expression, biomarker, and associations. Gao L, etal., Transl Res. 2007 Jul;150(1):18-29. Epub 2007 May 25.
12. Spironolactone prevents diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats. Han SY, etal., J Am Soc Nephrol. 2006 May;17(5):1362-72. Epub 2006 Mar 29.
13. Redox regulation of macrophage migration inhibitory factor expression in rat neurons. Harrison RA and Sumners C, Biochem Biophys Res Commun. 2009 Dec 4;390(1):171-5. Epub 2009 Sep 30.
14. Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer. Hildebrandt MA, etal., PLoS One. 2010 Aug 25;5(8):e12402.
15. Functional polymorphisms in the promoter region of macrophage migration inhibitory factor and atopy. Hizawa N, etal., Am J Respir Crit Care Med. 2004 May 1;169(9):1014-8. Epub 2004 Feb 12.
16. Immunohistochemical study of macrophage migration inhibitory factor in rat liver fibrosis induced by thioacetamide. Hori Y, etal., Eur J Histochem. 2003;47(4):317-24.
17. Role of macrophage migration inhibitory factor in influenza H5N1 virus pneumonia. Hou XQ, etal., Acta Virol. 2009;53(4):225-31.
18. Sex steroid regulation of macrophage migration inhibitory factor in normal and inflamed colon in the female rat. Houdeau E, etal., Gastroenterology. 2007 Mar;132(3):982-93. Epub 2006 Dec 17.
19. Downregulation of migration inhibitory factor is critical for estrogen-mediated attenuation of lung tissue damage following trauma-hemorrhage. Hsieh YC, etal., Am J Physiol Lung Cell Mol Physiol. 2007 May;292(5):L1227-32. Epub 2007 Feb 2.
20. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
21. The -173 G/C polymorphism of the promoter region macrophage migration inhibitory factor gene is not associated with incidence of pulmonary hamartoma. Kaznowska E, etal., Pol J Pathol. 2007;58(3):189-92.
22. A role for macrophage migration inhibitory factor in the neonatal respiratory distress syndrome. Kevill KA, etal., J Immunol. 2008 Jan 1;180(1):601-8.
23. Involvement of macrophage migration inhibitory factor (MIF) in experimental uric acid nephropathy. Kim YG, etal., Mol Med. 2000 Oct;6(10):837-48.
24. Inhibition of experimental autoimmune uveoretinitis with anti-macrophage migration inhibitory factor antibodies. Kitaichi N, etal., Curr Eye Res. 2000 Feb;20(2):109-14.
25. Differences in the hepatic signal transcription pathway and cytokine expression between thermal injury and sepsis. Klein D, etal., Shock. 2003 Dec;20(6):536-43.
26. Role of macrophage migration inhibitory factor in ovalbumin-induced airway inflammation in rats. Kobayashi M, etal., Eur Respir J. 2006 Apr;27(4):726-34. Epub 2006 Feb 2.
27. Up-regulation of macrophage migration-inhibitory factor expression after compression-induced spinal cord injury in rats. Koda M, etal., Acta Neuropathol (Berl). 2004 Jul;108(1):31-6. Epub 2004 Apr 6.
28. Regulation of macrophage migration inhibitory factor by endogenous glucocorticoids in rat adjuvant-induced arthritis. Leech M, etal., Arthritis Rheum. 2000 Apr;43(4):827-33.
29. [Myocardial inflammation and injury induced by coronary microembolization in rats: role of ERK1/2 signaling pathway]. Li L, etal., Zhonghua Yi Xue Za Zhi. 2010 Mar 2;90(8):558-63.
30. Uncaria rhynchophylla upregulates the expression of MIF and cyclophilin A in kainic acid-induced epilepsy rats: A proteomic analysis. Lo WY, etal., Am J Chin Med. 2010;38(4):745-59.
31. Macrophage migration inhibitory factor is essential for allergic asthma but not for Th2 differentiation. Magalhaes ES, etal., Eur J Immunol. 2007 Apr;37(4):1097-106.
32. Effect of anti-macrophage migration inhibitory factor antibody on lipopolysaccharide-induced pulmonary neutrophil accumulation. Makita H, etal., Am J Respir Crit Care Med. 1998 Aug;158(2):573-9.
33. Role of macrophage migration inhibitory factor in acute lung injury in mice with acute pancreatitis complicated by endotoxemia. Matsuda N, etal., Am J Respir Cell Mol Biol. 2006 Aug;35(2):198-205. Epub 2006 Mar 30.
34. Blockade of macrophage migration inhibitory factor ameliorates experimental autoimmune myocarditis. Matsui Y, etal., J Mol Cell Cardiol. 2004 Aug;37(2):557-66.
35. MGDs mouse GO annotations MGD data from the GO Consortium
36. MGD IEA MGD IEA
37. Up-regulation of macrophage colony-stimulating factor (M-CSF) and migration inhibitory factor (MIF) expression and monocyte recruitment during lipid-induced glomerular injury in the exogenous hypercholesterolaemic (ExHC) rat. Miyazaki K, etal., Clin Exp Immunol. 1997 May;108(2):318-23.
38. Role for macrophage migration inhibitory factor in asthma. Mizue Y, etal., Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14410-5. Epub 2005 Sep 26.
39. Macrophage migration inhibitory factor in allergic rhinitis: its identification in eosinophils at the site of inflammation. Nakamaru Y, etal., Ann Otol Rhinol Laryngol. 2004 Mar;113(3 Pt 1):205-9.
40. Macrophage migration inhibitory factor (MIF) contributes to the development of allergic rhinitis. Nakamaru Y, etal., Cytokine. 2005 Jul 21;31(2):103-8.
41. Macrophage migration inhibitory factor expression in male and female ethanol-fed rats. Nanji AA, etal., J Interferon Cytokine Res. 2001 Dec;21(12):1055-62.
42. Transgenic over-expression of macrophage migration inhibitory factor renders mice markedly more susceptible to experimental colitis. Ohkawara T, etal., Clin Exp Immunol. 2005 May;140(2):241-8. doi: 10.1111/j.1365-2249.2005.02771.x.
43. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
44. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
45. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
46. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
47. Cystic fibrosis, disease severity, and a macrophage migration inhibitory factor polymorphism. Plant BJ, etal., Am J Respir Crit Care Med. 2005 Dec 1;172(11):1412-5. Epub 2005 Sep 22.
48. Mouse MP Annotation Import Pipeline RGD automated import pipeline
49. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
50. Human circulating eosinophils secrete macrophage migration inhibitory factor (MIF). Potential role in asthma. Rossi AG, etal., J Clin Invest. 1998 Jun 15;101(12):2869-74.
51. Analysis of MIF, FCGR2A and FCGR3A gene polymorphisms with susceptibility to pulmonary tuberculosis in Moroccan population. Sadki K, etal., J Genet Genomics. 2010 Apr;37(4):257-64.
52. Macrophage migration inhibitory factor is a critical mediator of severe acute pancreatitis. Sakai Y, etal., Gastroenterology 2003 Mar;124(3):725-36.
53. Promoter polymorphism in the macrophage migration inhibitory factor gene is associated with obesity. Sakaue S, etal., Int J Obes (Lond). 2006 Feb;30(2):238-42.
54. Lung-derived macrophage migration inhibitory factor in sepsis induces cardio-circulatory depression. Sakuragi T, etal., Surg Infect (Larchmt). 2007 Feb;8(1):29-40.
55. The effect of therapeutic hypothermia on the expression of inflammatory response genes following moderate traumatic brain injury in the rat. Truettner JS, etal., Brain Res Mol Brain Res. 2005 Aug 18;138(2):124-34.
56. Hydrochloric acid induced changes in macrophage migration inhibitory factor in the bladder, peripheral and central nervous system of the rat. Vera PL, etal., J Urol. 2003 Aug;170(2 Pt 1):623-7.
57. Cyclophosphamide-induced cystitis increases bladder CXCR4 expression and CXCR4-macrophage migration inhibitory factor association. Vera PL, etal., PLoS One. 2008;3(12):e3898. Epub 2008 Dec 10.
58. Plasma concentrations of macrophage migration inhibitory factor are elevated in Pima Indians compared to Caucasians and are associated with insulin resistance. Vozarova B, etal., Diabetologia. 2002 Dec;45(12):1739-41. Epub 2002 Nov 16.
59. [Role of macrophage migration inhibitory factor in septic shock-induced cardiovascular dysfunction: experiment with rats] Wang FZ, etal., Zhonghua Yi Xue Za Zhi. 2007 Mar 20;87(11):768-73.
60. Upregulation of macrophage migration inhibitory factor gene expression in stroke. Wang L, etal., Stroke. 2009 Mar;40(3):973-6. Epub 2009 Jan 8.
61. Macrophage migration inhibitory factor and CXC chemokine expression in non-small cell lung cancer: role in angiogenesis and prognosis. White ES, etal., Clin Cancer Res. 2003 Feb;9(2):853-60.
62. Association of MIF promoter polymorphisms with childhood asthma in a northeastern Chinese population. Wu J, etal., Tissue Antigens. 2009 Apr;73(4):302-6.
63. Reversal of established rat crescentic glomerulonephritis by blockade of macrophage migration inhibitory factor (MIF): potential role of MIF in regulating glucocorticoid production. Yang N, etal., Mol Med. 1998 Jun;4(6):413-24.
64. The influence of macrophage migration inhibitory factor gene polymorphisms on outcome from community-acquired pneumonia. Yende S, etal., FASEB J. 2009 Aug;23(8):2403-11. Epub 2009 Apr 3.
65. Elevation of plasma level of macrophage migration inhibitory factor in patients with acute myocardial infarction. Yu CM, etal., Am J Cardiol. 2001 Oct 1;88(7):774-7.
66. Expression of macrophage migration inhibitory factor in acute ischemic myocardial injury. Yu CM, etal., J Histochem Cytochem. 2003 May;51(5):625-31.
Additional References at PubMed
PMID:791062   PMID:1508193   PMID:7558020   PMID:7558021   PMID:7679497   PMID:7706726   PMID:7947826   PMID:8234256   PMID:8413654   PMID:8832282   PMID:8835541   PMID:8889548  
PMID:8903731   PMID:8958058   PMID:9002552   PMID:9027512   PMID:9164975   PMID:9395080   PMID:9628829   PMID:9653653   PMID:9716662   PMID:9892616   PMID:10051316   PMID:10349636  
PMID:10360941   PMID:10364264   PMID:10473131   PMID:10613844   PMID:10706738   PMID:10809963   PMID:10922068   PMID:10933783   PMID:11042159   PMID:11076861   PMID:11488984   PMID:11668338  
PMID:11756671   PMID:11773615   PMID:11780066   PMID:12209330   PMID:12218292   PMID:12271144   PMID:12297513   PMID:12477932   PMID:12538581   PMID:12538686   PMID:12727922   PMID:12778465  
PMID:12788306   PMID:12796500   PMID:12814949   PMID:12865817   PMID:12878730   PMID:12919089   PMID:12946935   PMID:12958152   PMID:12964047   PMID:14502271   PMID:14610273   PMID:14681479  
PMID:14717917   PMID:14736878   PMID:14751814   PMID:15197138   PMID:15388499   PMID:15489334   PMID:15645444   PMID:15664192   PMID:15709171   PMID:15751084   PMID:15761851   PMID:15782199  
PMID:15840582   PMID:15942688   PMID:15947793   PMID:16141072   PMID:16141073   PMID:16162108   PMID:16237048   PMID:16283355   PMID:16285950   PMID:16293799   PMID:16314467   PMID:16314470  
PMID:16442103   PMID:16442105   PMID:16522371   PMID:16602821   PMID:16636133   PMID:16714544   PMID:16751997   PMID:16753018   PMID:16835407   PMID:16860715   PMID:16872482   PMID:16982923  
PMID:17015758   PMID:17045821   PMID:17049622   PMID:17056501   PMID:17142669   PMID:17210698   PMID:17290223   PMID:17316137   PMID:17390393   PMID:17620429   PMID:17634366   PMID:17640378  
PMID:17650334   PMID:17652722   PMID:17786542   PMID:17854804   PMID:17909632   PMID:17911626   PMID:18022162   PMID:18056708   PMID:18064633   PMID:18171979   PMID:18235500   PMID:18287559  
PMID:18311142   PMID:18436209   PMID:18439915   PMID:18606868   PMID:18624729   PMID:18641325   PMID:18653719   PMID:18684922   PMID:18703634   PMID:18815136   PMID:18821693   PMID:18832726  
PMID:18852457   PMID:18952710   PMID:19009023   PMID:19034004   PMID:19036925   PMID:19088181   PMID:19125256   PMID:19155217   PMID:19179453   PMID:19188446   PMID:19188484   PMID:19196797  
PMID:19286569   PMID:19413900   PMID:19478200   PMID:19584138   PMID:19591967   PMID:19695172   PMID:19744492   PMID:19747950   PMID:19776337   PMID:19905972   PMID:19920350   PMID:19966563  
PMID:20004020   PMID:20096683   PMID:20127836   PMID:20169062   PMID:20177408   PMID:20203087   PMID:20219983   PMID:20331989   PMID:20361053   PMID:20539011   PMID:20566490   PMID:20581170  
PMID:20606117   PMID:20638132   PMID:20684790   PMID:20829434   PMID:20831446   PMID:20923497   PMID:20939898   PMID:20950810   PMID:21106847   PMID:21116636   PMID:21152395   PMID:21191413  
PMID:21215754   PMID:21239607   PMID:21267068   PMID:21281800   PMID:21293254   PMID:21325249   PMID:21411731   PMID:21452319   PMID:21518974   PMID:21536912   PMID:21559932   PMID:21571101  
PMID:21677750   PMID:21714902   PMID:21730129   PMID:21817065   PMID:21873635   PMID:21905163   PMID:21969590   PMID:21977228   PMID:22016007   PMID:22064706   PMID:22110382   PMID:22217210  
PMID:22253816   PMID:22271573   PMID:22340465   PMID:22454509   PMID:22461508   PMID:22575600   PMID:22592805   PMID:22774990   PMID:22778413   PMID:22826223   PMID:22848081   PMID:22972922  
PMID:23085580   PMID:23118218   PMID:23125418   PMID:23137174   PMID:23144312   PMID:23172918   PMID:23174952   PMID:23372160   PMID:23376686   PMID:23390297   PMID:23410506   PMID:23503937  
PMID:23526214   PMID:23637753   PMID:23649333   PMID:23674514   PMID:23753877   PMID:23776208   PMID:23777345   PMID:23797673   PMID:23804488   PMID:23823021   PMID:23834778   PMID:23868943  
PMID:23882081   PMID:24003215   PMID:24006456   PMID:24098445   PMID:24154525   PMID:24334905   PMID:24441872   PMID:24472542   PMID:24490973   PMID:24504014   PMID:24586879   PMID:24683185  
PMID:24760155   PMID:24862346   PMID:24928996   PMID:24970391   PMID:24983315   PMID:25016026   PMID:25022960   PMID:25118614   PMID:25122558   PMID:25172501   PMID:25194790   PMID:25255103  
PMID:25266363   PMID:25329068   PMID:25398607   PMID:25412423   PMID:25425146   PMID:25561410   PMID:25609432   PMID:25647268   PMID:25647395   PMID:25661015   PMID:25706271   PMID:25712805  
PMID:25826675   PMID:25853607   PMID:25943202   PMID:25961459   PMID:25985394   PMID:26020638   PMID:26028220   PMID:26091949   PMID:26139098   PMID:26310191   PMID:26338025   PMID:26348853  
PMID:26400205   PMID:26403072   PMID:26455966   PMID:26858459   PMID:26868525   PMID:26927414   PMID:26940544   PMID:27035848   PMID:27049059   PMID:27082509   PMID:27129368   PMID:27157615  
PMID:27163877   PMID:27164411   PMID:27181906   PMID:27197190   PMID:27273604   PMID:27364992   PMID:27528627   PMID:27551074   PMID:27564840   PMID:27632207   PMID:27699180   PMID:27825106  
PMID:27846469   PMID:27925200   PMID:27955690   PMID:28070752   PMID:28429502   PMID:28539339   PMID:28574571   PMID:28743960   PMID:28768722   PMID:28780379   PMID:28801314   PMID:28904129  
PMID:28919555   PMID:28923927   PMID:28990052   PMID:29084983   PMID:29247872   PMID:29263120   PMID:29350381   PMID:29401625   PMID:29440696   PMID:29504609   PMID:29543531   PMID:29679061  
PMID:29702687   PMID:29769287   PMID:29864117   PMID:29884801   PMID:29908183   PMID:30077612   PMID:30252532   PMID:30295645   PMID:30333830   PMID:30400058   PMID:30471926   PMID:30550785  
PMID:30567353   PMID:30569239   PMID:30708129   PMID:30713523   PMID:30737274   PMID:30804219   PMID:30817226   PMID:30893559   PMID:30944975   PMID:31221018   PMID:31292300   PMID:31381889  
PMID:31484822   PMID:31669150   PMID:31708110   PMID:31708913   PMID:31794879   PMID:31821259   PMID:31906137   PMID:31948762   PMID:32062385   PMID:32265835   PMID:32303185   PMID:32325033  
PMID:32339783   PMID:32885302   PMID:32947151   PMID:33246771   PMID:33525493   PMID:33542244   PMID:33661886   PMID:33945507   PMID:34273844   PMID:34669443   PMID:34743042   PMID:34850744  
PMID:34864396   PMID:34921640   PMID:35100435   PMID:35288645   PMID:35545089   PMID:35567291   PMID:35585040   PMID:35738135   PMID:36093199   PMID:36114006   PMID:36293380   PMID:36344253  
PMID:36417873   PMID:36632449   PMID:36693098   PMID:36794636   PMID:36852981   PMID:36857907   PMID:37019383   PMID:37061852   PMID:37464010   PMID:37567977   PMID:37652021   PMID:37732633  
PMID:37839992   PMID:37935315   PMID:37956411   PMID:37983963   PMID:37990413   PMID:38052787   PMID:38117649   PMID:38218386   PMID:38367848   PMID:38565329   PMID:38685050   PMID:38846956  
PMID:38924383   PMID:39153310   PMID:39416784  


Genomics

Comparative Map Data
Mif
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391075,695,187 - 75,696,111 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1075,695,187 - 75,696,074 (-)EnsemblGRCm39 Ensembl
GRCm381075,859,353 - 75,860,277 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1075,859,353 - 75,860,240 (-)EnsemblGRCm38mm10GRCm38
MGSCv371075,322,098 - 75,322,995 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361075,303,069 - 75,303,966 (-)NCBIMGSCv36mm8
Celera1076,904,043 - 76,904,940 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1038.59NCBI
MIF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382223,894,383 - 23,895,223 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2223,894,383 - 23,895,227 (+)EnsemblGRCh38hg38GRCh38
GRCh372224,236,570 - 24,237,410 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362222,566,565 - 22,567,409 (+)NCBINCBI36Build 36hg18NCBI36
Build 342222,561,118 - 22,561,963NCBI
Celera228,074,325 - 8,075,169 (+)NCBICelera
Cytogenetic Map22q11.23NCBI
HuRef227,221,904 - 7,222,748 (+)NCBIHuRef
CHM1_12224,248,957 - 24,249,801 (+)NCBICHM1_1
T2T-CHM13v2.02224,338,982 - 24,339,822 (+)NCBIT2T-CHM13v2.0
Mif
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82012,767,138 - 12,791,222 (+)NCBIGRCr8
mRatBN7.22012,790,919 - 12,791,784 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2012,790,902 - 12,799,504 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl4132,485,337 - 132,485,684 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2013,497,160 - 13,498,025 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02012,858,083 - 12,858,948 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02013,330,028 - 13,330,893 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02013,715,219 - 13,732,980 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2013,732,198 - 13,732,859 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02015,885,248 - 15,886,113 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42013,191,986 - 13,192,851 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12013,192,212 - 13,193,078 (+)NCBI
Celera2014,283,080 - 14,283,945 (+)NCBICelera
Cytogenetic Map20p12NCBI
Mif
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554558,367,566 - 8,368,460 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554558,367,566 - 8,368,460 (-)NCBIChiLan1.0ChiLan1.0
MIF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22333,619,974 - 33,623,761 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12236,356,394 - 36,360,177 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0224,646,986 - 4,647,831 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12222,729,245 - 22,732,009 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2222,730,807 - 22,732,009 (+)Ensemblpanpan1.1panPan2
MIF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha2627,715,404 - 27,716,260 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02630,047,047 - 30,047,902 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2630,047,057 - 30,047,856 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12628,128,386 - 28,129,245 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02627,746,427 - 27,747,273 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02628,734,407 - 28,735,264 (-)NCBIUU_Cfam_GSD_1.0
Mif
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118141,546,059 - 141,547,004 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366191,203,746 - 1,208,442 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366191,207,058 - 1,208,010 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MIF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1449,840,305 - 49,841,068 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11449,840,303 - 49,841,063 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21453,282,553 - 53,283,313 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MIF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1197,000,837 - 7,001,700 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl197,000,793 - 7,001,757 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666100368,099 - 370,934 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mif
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474710,303,919 - 10,308,821 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474710,307,826 - 10,308,649 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mif
18 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:188
Count of miRNA genes:178
Interacting mature miRNAs:185
Transcripts:ENSMUST00000038169
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302035Lmb4_mlupus in MRL and B6 F2 cross (mouse)Not determined106684818792258673Mouse
1300882Ath17_matherosclerosis 17 (mouse)Not determined105109149085091639Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101270405184079784Mouse
26884447Sklq9_mskull length QTL 9, 10 week (mouse)1067335830111735905Mouse
11353832Pcholq4_mplasma cholesterol QTL 4 (mouse)1073987216125515907Mouse
4142137Femwf3_mfemur work to failure 3 (mouse)Not determined75338568109338767Mouse
1301787Bsc1_mbrain size control 1 (mouse)Not determined105851696992517096Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1270405184079784Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101270405184079784Mouse
14746991Manh68_mmandible shape 68 (mouse)105228049786280497Mouse
10045641Jckm3_mjuvenile cystic kidney modifier 3 (mouse)Not determined104984818783848412Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
26884424Zlq9_mzygomatic length QTL 9, 16 week (mouse)1063935779115935905Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1270405184079784Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
1357632Vtbt9_mvertebral trabecular bone trait 9 (mouse)Not determined1075338568109338767Mouse
26884430Zlq5_mzygomatic length QTL 5, 10 week (mouse)1067835830124835905Mouse
1302150Bbaa18_mB.burgdorferi-associated arthritis 18 (mouse)Not determined104933801283338157Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101270405184079784Mouse
4142313Angvq1_mangiogenesis by VEGF QTL 1 (mouse)Not determined4672040382491121Mouse
1301380Cia8_mcollagen induced arthritis QTL 8 (mouse)Not determined105149340082491121Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101010826587401095Mouse
1301966Lifespan2_mlife span 2 (mouse)Not determined104984822283848397Mouse
11353843Gluq1_mblood glucose QTL 1 (mouse)1073987216125515907Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
11039497Ltpr5a_mLeishmania tropica response 5a (mouse)1073506901107507047Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1044876096115935905Mouse
4142107Obrq12_mobesity resistance QTL 12 (mouse)Not determined7398721682491121Mouse
1300597Skull14_mskull morphology 14 (mouse)Not determined104984818783848412Mouse
1300533Aem3_manti-erythrocyte autoantibody modifier 3 (mouse)Not determined106549093899491121Mouse
4142169Pbwg16_mpostnatal body weight growth 16 (mouse)Not determined104984818783848412Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102287589991035862Mouse
1301502Eae17_msusceptibility to experimental allergic encephalomyelitis 17 (mouse)Not determined105109149085091639Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045476096120635905Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069735830130430862Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021408154114217230Mouse
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059335822122335905Mouse
13208560Wght9_mweight 9 (mouse)1059835822120835905Mouse
1301737Insq9_minsulin QTL 9 (mouse)Not determined106549093899491121Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1270405184079784Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101270405184079784Mouse
1300975Fembrs3_mfemur breaking strength 3 (mouse)Not determined1075338568109338767Mouse
1357737Hpcr2_mhepatocarcinogen resistance 2 (mouse)Not determined104984822283848397Mouse
1302060El3_mepilepsy 3 (mouse)Not determined106549093899491121Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1270405184079784Mouse

Markers in Region
Mif  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7B1UniSTS
Cytogenetic Map10C1UniSTS
cM Map1040.9UniSTS
cM Map1040.9UniSTS
Mif  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10C1UniSTS
cM Map1040.9UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_010798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC007961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC142499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF033192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF204395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK008939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK010691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK013328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK015344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC024895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC086928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC100605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L02913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L07607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L10613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L39357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U19825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U20156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z23048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000038169   ⟹   ENSMUSP00000041149
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1075,695,187 - 75,696,074 (-)Ensembl
GRCm38.p6 Ensembl1075,859,353 - 75,860,240 (-)Ensembl
Ensembl Acc Id: ENSMUST00000218267
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1075,695,284 - 75,696,026 (-)Ensembl
GRCm38.p6 Ensembl1075,859,450 - 75,860,192 (-)Ensembl
RefSeq Acc Id: NM_010798   ⟹   NP_034928
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391075,695,187 - 75,696,111 (-)NCBI
GRCm381075,859,353 - 75,860,277 (-)NCBI
MGSCv371075,322,098 - 75,322,995 (-)RGD
Celera1076,904,043 - 76,904,940 (-)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_034928   ⟸   NM_010798
- UniProtKB: P34884 (UniProtKB/Swiss-Prot),   Q545F0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000041149   ⟸   ENSMUST00000038169

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P34884-F1-model_v2 AlphaFold P34884 1-115 view protein structure

Promoters
RGD ID:6819595
Promoter ID:MM_KWN:4594
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day4,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_010798
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361075,322,819 - 75,323,319 (-)MPROMDB
RGD ID:8672342
Promoter ID:EPDNEW_M14201
Type:initiation region
Name:Mif_1
Description:Mus musculus macrophage migration inhibitory factor (glycosylation-inhibitingfactor) , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381075,860,243 - 75,860,303EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96982 AgrOrtholog
Ensembl Genes ENSMUSG00000033307 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000038169 ENTREZGENE
  ENSMUST00000038169.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.429.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Macrophage_inhib_fac UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Macrophage_inhib_fac_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tautomerase/MIF_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17319 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:96982 ENTREZGENE
NCBI Gene 17319 ENTREZGENE
PANTHER MACROPHAGE MIGRATION INHIBITORY FACTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11954 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MIF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mif PhenoGen
PROSITE MIF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55331 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt MIF_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q545F0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-01-17 Mif  macrophage migration inhibitory factor (glycosylation-inhibiting factor)    macrophage migration inhibitory factor  Symbol and/or name change 5135510 APPROVED