Rab8a (RAB8A, member RAS oncogene family) - Rat Genome Database
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Gene: Rab8a (RAB8A, member RAS oncogene family) Mus musculus
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Symbol: Rab8a
Name: RAB8A, member RAS oncogene family
RGD ID: 1621605
MGI Page MGI
Description: Predicted to have several functions, including GTPase activity; myosin V binding activity; and purine ribonucleoside binding activity. Predicted to be involved in several processes, including plasma membrane bounded cell projection organization; protein transport; and regulation of long-term neuronal synaptic plasticity. Localizes to several cellular components, including ciliary basal body; ciliary base; and cytoplasmic vesicle. Predicted to colocalize with Golgi apparatus. Is expressed in neural retina and photoreceptor layer. Orthologous to human RAB8A (RAB8A, member RAS oncogene family); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rab family mediated signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AA409338; cell line NK14 derived transforming oncogene; Me; Mel; oncogene c-mel; ras-related protein Rab-8A
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39872,915,044 - 72,935,210 (+)NCBIGRCm39mm39
GRCm38872,161,200 - 72,181,366 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl872,161,200 - 72,183,904 (+)EnsemblGRCm38mm10GRCm38
MGSCv37874,685,099 - 74,705,265 (+)NCBIGRCm37mm9NCBIm37
MGSCv36875,090,189 - 75,110,355 (+)NCBImm8
Celera876,516,674 - 76,537,034 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.84NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

Additional References at PubMed
PMID:1675193   PMID:1886711   PMID:1981054   PMID:8643544   PMID:8649810   PMID:8833158   PMID:8833245   PMID:8889548   PMID:10349636   PMID:10501980   PMID:10922068   PMID:11042159  
PMID:11076861   PMID:11217851   PMID:11266470   PMID:11773082   PMID:11856727   PMID:12466851   PMID:12477932   PMID:12520002   PMID:12578829   PMID:12590134   PMID:14722103   PMID:15099020  
PMID:15489334   PMID:15782199   PMID:16093251   PMID:16141072   PMID:16141073   PMID:16923123   PMID:17597763   PMID:17765678   PMID:18094055   PMID:18381201   PMID:18650435   PMID:18799693  
PMID:19061864   PMID:19625297   PMID:20048263   PMID:20059953   PMID:20360068   PMID:20551175   PMID:20592197   PMID:21041651   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22068051  
PMID:22315395   PMID:22354172   PMID:23175844   PMID:23583738   PMID:24213529   PMID:24399445   PMID:24421332   PMID:24469809   PMID:24947469   PMID:24983211   PMID:25063677   PMID:25158853  
PMID:25860027   PMID:26015543   PMID:26034069   PMID:26410627   PMID:26587735   PMID:26833786   PMID:27019864   PMID:27103069   PMID:27529348   PMID:28076793   PMID:28079283   PMID:28130450  
PMID:28378742   PMID:28596241   PMID:28696211   PMID:29330353   PMID:30209134   PMID:30285101   PMID:30626697   PMID:30631919   PMID:30966999  


Genomics

Comparative Map Data
Rab8a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39872,915,044 - 72,935,210 (+)NCBIGRCm39mm39
GRCm38872,161,200 - 72,181,366 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl872,161,200 - 72,183,904 (+)EnsemblGRCm38mm10GRCm38
MGSCv37874,685,099 - 74,705,265 (+)NCBIGRCm37mm9NCBIm37
MGSCv36875,090,189 - 75,110,355 (+)NCBImm8
Celera876,516,674 - 76,537,034 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.84NCBI
RAB8A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1916,111,889 - 16,134,234 (+)EnsemblGRCh38hg38GRCh38
GRCh381916,111,889 - 16,134,234 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371916,222,490 - 16,244,445 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361916,083,490 - 16,105,445 (+)NCBINCBI36hg18NCBI36
Build 341916,083,489 - 16,105,443NCBI
Celera1916,124,417 - 16,146,398 (+)NCBI
Cytogenetic Map19p13.11NCBI
HuRef1915,793,443 - 15,815,391 (+)NCBIHuRef
CHM1_11916,221,978 - 16,243,940 (+)NCBICHM1_1
Rab8a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01619,355,047 - 19,376,776 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1619,355,048 - 19,376,776 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01619,213,378 - 19,235,107 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41618,078,519 - 18,099,882 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11618,079,199 - 18,089,589 (-)NCBI
Celera1617,868,660 - 17,890,021 (-)NCBICelera
Cytogenetic Map16p14NCBI
Rab8a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555241,403,811 - 1,416,005 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555241,403,811 - 1,416,005 (-)NCBIChiLan1.0ChiLan1.0
RAB8A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11916,580,720 - 16,602,189 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1916,580,720 - 16,602,189 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01915,598,029 - 15,619,988 (+)NCBIMhudiblu_PPA_v0panPan3
RAB8A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2046,334,601 - 46,351,907 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12046,334,601 - 46,351,907 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Rab8a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365964,385,788 - 4,403,393 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAB8A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl261,418,055 - 61,450,413 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1261,430,680 - 61,450,351 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2261,176,944 - 61,196,619 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RAB8A
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1614,611,938 - 14,634,086 (+)NCBI
ChlSab1.1 Ensembl614,611,868 - 14,634,487 (+)Ensembl
Rab8a
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249081,119,356 - 1,132,029 (-)NCBI

Position Markers
RH124845  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38872,180,779 - 72,181,029UniSTSGRCm38
MGSCv37874,704,678 - 74,704,928UniSTSGRCm37
Celera876,536,447 - 76,536,697UniSTS
Cytogenetic Map8B3.3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86826982782600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1739
Count of miRNA genes:739
Interacting mature miRNAs:949
Transcripts:ENSMUST00000003121, ENSMUST00000128203, ENSMUST00000135613
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_023126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB232600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC158898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK003319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK009259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK010862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK076048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK079306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK080740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY974570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC019990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY279480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY700504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S53270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000003121   ⟹   ENSMUSP00000003121
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl872,161,200 - 72,183,904 (+)Ensembl
RefSeq Acc Id: ENSMUST00000128203
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl872,161,359 - 72,176,057 (+)Ensembl
RefSeq Acc Id: ENSMUST00000135613
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl872,161,313 - 72,175,863 (+)Ensembl
RefSeq Acc Id: NM_023126   ⟹   NP_075615
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39872,915,044 - 72,935,210 (+)NCBI
GRCm38872,161,200 - 72,181,366 (+)ENTREZGENE
MGSCv37874,685,099 - 74,705,265 (+)RGD
Celera876,516,674 - 76,537,034 (+)RGD
cM Map8 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_075615   ⟸   NM_023126
- UniProtKB: P55258 (UniProtKB/Swiss-Prot),   Q0PD50 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000003121   ⟸   ENSMUST00000003121

Promoters
RGD ID:8667453
Promoter ID:EPDNEW_M11758
Type:multiple initiation site
Name:Rab8a_2
Description:Mus musculus RAB8A, member RAS oncogene family , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M11759  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38872,161,128 - 72,161,188EPDNEW
RGD ID:8667455
Promoter ID:EPDNEW_M11759
Type:multiple initiation site
Name:Rab8a_1
Description:Mus musculus RAB8A, member RAS oncogene family , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M11758  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38872,161,346 - 72,161,406EPDNEW
RGD ID:6843683
Promoter ID:MM_KWN:54855
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000098631,   OTTMUST00000052947,   OTTMUST00000052948,   OTTMUST00000052949,   OTTMUST00000074566,   UC009MFJ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36874,683,631 - 74,685,422 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96960 AgrOrtholog
Ensembl Genes ENSMUSG00000003037 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000003121 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000003121 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17274 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:96960 ENTREZGENE
NCBI Gene 17274 ENTREZGENE
Pfam Ras UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rab8a PhenoGen
PROSITE RAB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs small_GTP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.162811 ENTREZGENE
UniProt P55258 ENTREZGENE
  Q0PD50 ENTREZGENE, UniProtKB/TrEMBL
  Q3UHW5_MOUSE UniProtKB/TrEMBL
  RAB8A_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q8VCF6 UniProtKB/Swiss-Prot