Rab8a (RAB8A, member RAS oncogene family)

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Gene: Rab8a (RAB8A, member RAS oncogene family) Mus musculus

Analyze

Symbol:

Rab8a

Name:

RAB8A, member RAS oncogene family

RGD ID:

1621605

MGI Page

MGI

Description:

Predicted to have several functions, including GTPase activity; myosin V binding activity; and purine ribonucleoside binding activity. Predicted to be involved in several processes, including plasma membrane bounded cell projection organization; protein transport; and regulation of long-term neuronal synaptic plasticity. Localizes to several cellular components, including ciliary basal body; ciliary base; and cytoplasmic vesicle. Predicted to colocalize with Golgi apparatus. Is expressed in neural retina and photoreceptor layer. Orthologous to human RAB8A (RAB8A, member RAS oncogene family); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rab family mediated signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 17alpha-ethynylestradiol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

AA409338; cell line NK14 derived transforming oncogene; Me; Mel; oncogene c-mel; ras-related protein Rab-8A

RGD Orthologs

Human

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RAB8A (RAB8A, member RAS oncogene family)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, Panther, Treefam
Rattus norvegicus (Norway rat):	Rab8a (RAB8A, member RAS oncogene family)	HGNC	EggNOG, NCBI, OMA, HomoloGene, Inparanoid, Panther, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Rab8a (RAB8A, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RAB8A (RAB8A, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RAB8A (RAB8A, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rab8a (RAB8A, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RAB8A (RAB8A, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	RAB8A (RAB8A, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rab8a (RAB8A, member RAS oncogene family)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	RAB8B (RAB8B, member RAS oncogene family)	HGNC	OrthoDB
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Rab8a (RAB8A, member RAS oncogene family)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Homo sapiens (human):	RAB8A (RAB8A, member RAS oncogene family)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam)
Danio rerio (zebrafish):	rab8a (RAB8A, member RAS oncogene family)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam\|ZFIN)
Saccharomyces cerevisiae (baker's yeast):	SEC4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup)
Caenorhabditis elegans (roundworm):	rab-8	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|Roundup\|TreeFam)
Drosophila melanogaster (fruit fly):	Rab8	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam)

Latest Assembly:

GRCm38 - Mouse Genome Assembly GRCm38

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	72,915,044 - 72,935,210 (+)	NCBI	GRCm39		mm39
GRCm38	8	72,161,200 - 72,181,366 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	72,161,200 - 72,183,904 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	74,685,099 - 74,705,265 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	8	75,090,189 - 75,110,355 (+)	NCBI			mm8
Celera	8	76,516,674 - 76,537,034 (+)	NCBI		Celera
Cytogenetic Map	8	B3.3	NCBI
cM Map	8	34.84	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

rheumatoid arthritis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (EXP)

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (EXP)

17alpha-ethynylestradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,6-dinitrotoluene (ISO)

3,4-methylenedioxymethamphetamine (EXP)

5-fluorouracil (ISO)

aflatoxin B1 (ISO)

aflatoxin B2 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (ISO)

antirheumatic drug (ISO)

benzo[a]pyrene (EXP,ISO)

benzo[e]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (ISO)

carbon nanotube (EXP)

cefixime (EXP)

cisplatin (ISO)

coumestrol (ISO)

curcumin (ISO)

cyclosporin A (ISO)

dicrotophos (ISO)

doxorubicin (ISO)

Enterolactone (ISO)

folic acid (EXP)

fonofos (ISO)

gemcitabine (ISO)

gentamycin (ISO)

haloperidol (ISO)

isobutanol (ISO)

lead(0) (ISO)

lead(2+) (ISO)

methapyrilene (ISO)

mono(2-ethylhexyl) phthalate (ISO)

paracetamol (ISO)

parathion (ISO)

piroxicam (ISO)

resveratrol (EXP)

rotenone (EXP)

sodium arsenate (EXP)

sodium fluoride (EXP)

sunitinib (ISO)

terbufos (ISO)

tert-butyl hydroperoxide (ISO)

thalidomide (EXP)

trichloroethene (ISO)

valproic acid (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

autophagy (IEA)

axonogenesis (ISO)

cell projection organization (IEA)

cellular response to insulin stimulus (IBA,ISO)

cilium assembly (ISO)

endocytic recycling (ISO)

Golgi vesicle fusion to target membrane (IBA,ISO)

neurotransmitter receptor transport to postsynaptic membrane (IBA,ISO)

neurotransmitter receptor transport, endosome to postsynaptic membrane (ISO)

protein localization to plasma membrane (IBA,ISO)

protein secretion (IBA)

protein transport (IEA)

regulation of autophagy (ISO)

regulation of exocytosis (IBA)

regulation of long-term neuronal synaptic plasticity (ISO)

regulation of protein localization (ISO)

regulation of protein transport (ISO)

vesicle docking involved in exocytosis (IBA,ISO)

vesicle-mediated transport in synapse (ISO)

Cellular Component

cell projection (IEA)

centrosome (ISO)

ciliary basal body (IDA)

ciliary base (IDA)

cilium (IDA,IMP,ISO)

cytoplasm (IEA)

cytoplasmic vesicle (ISO)

cytoplasmic vesicle membrane (TAS)

cytoskeleton (IEA)

dendrite (ISO)

dendritic spine (IBA,ISO)

endosome (IBA)

exocytic vesicle (ISO)

glutamatergic synapse (ISO)

Golgi apparatus (ISO)

membrane (IEA)

midbody (ISO)

neuronal cell body (ISO)

non-motile cilium (IDA,ISO)

phagocytic vesicle (ISO)

plasma membrane (IBA,IDA,ISO)

postsynaptic density (ISO)

recycling endosome (IDA)

recycling endosome membrane (ISO)

synapse (ISO)

synaptic vesicle (IBA)

trans-Golgi network transport vesicle (IBA,IDA)

Molecular Function

GDP binding (ISO)

GTP binding (ISO)

GTPase activity (ISO,TAS)

myosin V binding (ISO)

nucleotide binding (IEA)

protein binding (IPI)

protein kinase binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

insulin responsive facilitative sugar transporter mediated glucose transport pathway (ISO)

Rab family mediated signaling pathway (ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal cellular glucose uptake (IAGP)

abnormal crypts of Lieberkuhn morphology (IAGP)

abnormal grip strength (IEA)

abnormal intestinal absorption (IAGP)

abnormal intestine physiology (IAGP)

abnormal lean body mass (IEA)

abnormal Paneth cell morphology (IAGP)

abnormal small intestinal microvillus morphology (IAGP)

abnormal small intestine morphology (IAGP)

accumulation of giant lysosomes in kidney/renal tubule cells (IAGP)

cachexia (IAGP)

decreased lean body mass (IEA)

decreased small intestinal microvillus size (IAGP)

diarrhea (IAGP)

intestinal edema (IAGP)

postnatal lethality, complete penetrance (IAGP)

premature death (IAGP)

References

References - curated


1.	Ishikura S and Klip A, Am J Physiol Cell Physiol. 2008 Oct;295(4):C1016-25. Epub 2008 Aug 13.
2.	Kaddai V, etal., Acta Physiol (Oxf). 2008 Jan;192(1):75-88.
3.	Larance M, etal., Mol Endocrinol. 2008 Feb;22(2):226-33. Epub 2007 Aug 23.
4.	RGD automated import pipeline
5.	RGD automated import pipeline for gene-chemical interactions
6.	Watson RT and Pessin JE, Cell Signal. 2007 Nov;19(11):2209-17. Epub 2007 Jun 21.
7.	Zaid H, etal., Biochem J. 2008 Jul 15;413(2):201-15.

Additional References at PubMed

PMID:1675193	PMID:1886711	PMID:1981054	PMID:8643544	PMID:8649810	PMID:8833158	PMID:8833245	PMID:8889548	PMID:10349636	PMID:10501980	PMID:10922068	PMID:11042159
PMID:11076861	PMID:11217851	PMID:11266470	PMID:11773082	PMID:11856727	PMID:12466851	PMID:12477932	PMID:12520002	PMID:12578829	PMID:12590134	PMID:14722103	PMID:15099020
PMID:15489334	PMID:15782199	PMID:16093251	PMID:16141072	PMID:16141073	PMID:16923123	PMID:17597763	PMID:17765678	PMID:18094055	PMID:18381201	PMID:18650435	PMID:18799693
PMID:19061864	PMID:19625297	PMID:20048263	PMID:20059953	PMID:20360068	PMID:20551175	PMID:20592197	PMID:21041651	PMID:21267068	PMID:21677750	PMID:21873635	PMID:22068051
PMID:22315395	PMID:22354172	PMID:23175844	PMID:23583738	PMID:24213529	PMID:24399445	PMID:24421332	PMID:24469809	PMID:24947469	PMID:24983211	PMID:25063677	PMID:25158853
PMID:25860027	PMID:26015543	PMID:26034069	PMID:26410627	PMID:26587735	PMID:26833786	PMID:27019864	PMID:27103069	PMID:27529348	PMID:28076793	PMID:28079283	PMID:28130450
PMID:28378742	PMID:28596241	PMID:28696211	PMID:29330353	PMID:30209134	PMID:30285101	PMID:30626697	PMID:30631919	PMID:30966999

Genomics

Comparative Map Data

Rab8a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	72,915,044 - 72,935,210 (+)	NCBI	GRCm39		mm39
GRCm38	8	72,161,200 - 72,181,366 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	72,161,200 - 72,183,904 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	74,685,099 - 74,705,265 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	8	75,090,189 - 75,110,355 (+)	NCBI			mm8
Celera	8	76,516,674 - 76,537,034 (+)	NCBI		Celera
Cytogenetic Map	8	B3.3	NCBI
cM Map	8	34.84	NCBI

RAB8A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	19	16,111,889 - 16,134,234 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	19	16,111,889 - 16,134,234 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	19	16,222,490 - 16,244,445 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	16,083,490 - 16,105,445 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	19	16,083,489 - 16,105,443	NCBI
Celera	19	16,124,417 - 16,146,398 (+)	NCBI
Cytogenetic Map	19	p13.11	NCBI
HuRef	19	15,793,443 - 15,815,391 (+)	NCBI		HuRef
CHM1_1	19	16,221,978 - 16,243,940 (+)	NCBI		CHM1_1

Rab8a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	16	19,355,047 - 19,376,776 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	19,355,048 - 19,376,776 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	19,213,378 - 19,235,107 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	18,078,519 - 18,099,882 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	16	18,079,199 - 18,089,589 (-)	NCBI
Celera	16	17,868,660 - 17,890,021 (-)	NCBI		Celera
Cytogenetic Map	16	p14	NCBI

Rab8a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955524	1,403,811 - 1,416,005 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955524	1,403,811 - 1,416,005 (-)	NCBI	ChiLan1.0	ChiLan1.0

RAB8A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	19	16,580,720 - 16,602,189 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	16,580,720 - 16,602,189 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	19	15,598,029 - 15,619,988 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

RAB8A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	20	46,334,601 - 46,351,907 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	20	46,334,601 - 46,351,907 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Rab8a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936596	4,385,788 - 4,403,393 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RAB8A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	61,418,055 - 61,450,413 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	61,430,680 - 61,450,351 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	61,176,944 - 61,196,619 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RAB8A
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	14,611,938 - 14,634,086 (+)	NCBI
ChlSab1.1 Ensembl	6	14,611,868 - 14,634,487 (+)	Ensembl

Rab8a
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624908	1,119,356 - 1,132,029 (-)	NCBI

Position Markers

RH124845

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	8	72,180,779 - 72,181,029	UniSTS	GRCm38
MGSCv37	8	74,704,678 - 74,704,928	UniSTS	GRCm37
Celera	8	76,536,447 - 76,536,697	UniSTS
Cytogenetic Map	8	B3.3	UniSTS

QTLs in Region (GRCm38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4140967	Bmd39_m	bone mineral density 39 (mouse)			Not determined		8	32016544	117238700	Mouse
1558875	Eae31_m	experimental allergic encephalomyelitis susceptibility 31 (mouse)			Not determined		8	34642776	114837007	Mouse
1301013	Capsq4_m	capsaicin sensitivity related QTL 4 (mouse)			Not determined		8	36163000	92728652	Mouse
27226754	Femd6_m	femur midshaft diameter 6, 10 week (mouse)					8	37400000	109600000	Mouse
12904744	Carcdq1_m	cardiac collagen deposition QTL 1 (mouse)					8	39709256	94689598	Mouse
1301544	Iba3_m	induction of brown adipocytes 3 (mouse)			Not determined		8	44294880	78295025	Mouse
1301717	Adip4_m	adiposity 4 (mouse)			Not determined		8	47637030	81637146	Mouse
10766453	Char11_m	P. chabaudi malaria resistance QTL 11 (mouse)					8	47637030	81637146	Mouse
1301441	Skull11_m	skull morphology 11 (mouse)			Not determined		8	47737134	81737254	Mouse
1357715	Alaa3_m	alopecia areata 3 (mouse)			Not determined		8	48792939	82793021	Mouse
14746987	Manh64_m	mandible shape 64 (mouse)					8	50053306	84053306	Mouse
14747005	Mancz7_m	mandible centroid size 7 (mouse)					8	50053306	84053306	Mouse
14700686	Civq3_m	cerebral infarct volume QTL 3 (mouse)					8	51882191	85882191	Mouse
1301506	Aevm1_m	autoimmune extremity vasculitis in MRL mice 1 (mouse)			Not determined		8	54287817	88287993	Mouse
1301952	Im3_m	immunoregulatory 3 (mouse)			Not determined		8	54706614	88706763	Mouse
10412287	Carg3_m	Candida albicans resistance gene 3 (mouse)			Not determined		8	55545028	89545028	Mouse
11353828	Gf7_m	gonadal fat pad weight 7 (mouse)					8	58201479	92201479	Mouse
10043975	Obq31_m	obesity QTL 31 (mouse)			Not determined		8	58409776	92409776	Mouse
1301688	Orch6_m	autoimmune orchitis resistance 6 (mouse)			Not determined		8	60786850	94786976	Mouse
4141285	Tgq18_m	triglyceride QTL 18 (mouse)			Not determined			63460107	97460107	Mouse
4141797	Skmw16_m	skeletal muscle weight 16 (mouse)			Not determined		8	63939547	97939696	Mouse
1357787	Vtbt5_m	vertebral trabecular bone trait 5 (mouse)			Not determined		8	65357768	99357920	Mouse
10043992	Hbnr11_m	Heligmosomoides bakeri nematode resistance 11 (mouse)			Not determined		8	65600207	99600347	Mouse
10766466	Char12_m	P. chabaudi malaria resistance QTL 12 (mouse)					8	68269827	82600347	Mouse
1301767	Fcsa2_m	femoral cross-sectional area 2 (mouse)			Not determined		8	70305375	104305495	Mouse
4142283	Imraq2_m	immune response to AAV2 QTL 2 (mouse)			Not determined		8	70305375	104305495	Mouse
1558780	Idd22_m	insulin dependent diabetes susceptibility 22 (mouse)			Not determined		8	71102903	105103009	Mouse
4141395	Char2a_m	P. chabaudi malaria resistance QTL 2a (mouse)			Not determined			71136783	90202598	Mouse
4142023	W3q5_m	weight 3 weeks QTL 5 (mouse)			Not determined			71287817	123895615	Mouse
1357708	Orq1_m	ovulation rate QTL 1 (mouse)			Not determined		8	71287817	123895615	Mouse
1301872	Cd4ts3_m	CD4 T cell subset 3 (mouse)			Not determined		8	71396181	105396393	Mouse

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	1739
Count of miRNA genes:	739
Interacting mature miRNAs:	949
Transcripts:	ENSMUST00000003121, ENSMUST00000128203, ENSMUST00000135613
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_023126	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB232600	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC158898	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK003319	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK009259	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK010862	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK011128	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK076048	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK079306	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK080740	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK147178	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK165690	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK212780	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY974570	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC019990	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BY279480	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BY700504	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466525	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	S53270	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSMUST00000003121 ⟹ ENSMUSP00000003121

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	8	72,161,200 - 72,183,904 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000128203

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	8	72,161,359 - 72,176,057 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000135613

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	8	72,161,313 - 72,175,863 (+)	Ensembl

RefSeq Acc Id:

NM_023126 ⟹ NP_075615

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	8	72,915,044 - 72,935,210 (+)	NCBI
GRCm38	8	72,161,200 - 72,181,366 (+)	ENTREZGENE
MGSCv37	8	74,685,099 - 74,705,265 (+)	RGD
Celera	8	76,516,674 - 76,537,034 (+)	RGD
cM Map	8		ENTREZGENE

Sequence:

show sequence

GGGCTCTCTGCGACAGGCGGGGCTCCGGGTGGCGGGCGTAGGCCTGGATGATGCGCGGCGGGCA
GGGGGCCAATAGGGGGCGGGATCTGAGATGATAGACGGGTCCAGCGACCAGTGGCGAGGCGCCG
GCCGTACTTCCCGTCGGGGAGAGAGTGTAATATGGCGAAGACCTACGATTACCTGTTCAAGCTG
CTGCTGATCGGGGACTCGGGGGTAGGGAAGACCTGTGTCCTGTTCCGCTTCTCCGAGGACGCCT
TCAACTCCACATTCATCTCTACCATAGGAATTGACTTTAAAATTAGGACCATAGAGCTCGATGG
CAAGAGGATTAAACTGCAGATATGGGACACGGCCGGCCAGGAGCGGTTTCGAACAATCACGACA
GCCTACTACAGGGGTGCCATGGGTATCATGCTGGTCTACGACATTACCAATGAGAAGTCCTTTG
ACAACATCCGGAATTGGATTCGGAACATTGAAGAGCATGCCTCTGCAGACGTGGAGAAGATGAT
ACTGGGGAATAAGTGTGATGTGAATGACAAGAGACAGGTGTCCAAGGAACGGGGAGAAAAGCTG
GCACTCGACTATGGGATCAAGTTCATGGAGACCAGTGCAAAGGCCAACATCAATGTGGAGAATG
CATTTTTCACTCTTGCCAGGGATATCAAAGCAAAAATGGACAAAAAATTGGAAGGGAACAGCCC
GCAGGGGAGCAGCCATGGAGTCAAGATCACAGTGGAGCAGCAGAAGAGGACCAGCTTCTTCCGG
TGCAGTCTCCTGTGAGGACAAGGTCTCTGCCCATTCTGAGCCTGTGCTCAGCCCAGCTGACTGT
GCCTGCCCCGGGCCAGCCTCCACCTCTGATGTTTGGACACGGCTGCCCGGACTCGATTGAGAAA
TTGATTATTTTTTAGTAACCGTCTGATCTTTTCCACCTTCAGAGATGGAGAGAGTTAGAATTTT
GCTGTTTTTCCTATGTCATCTGCCAGTCAGGCCTATCCGTCCCCTGCCTCATAGGCACAGATGG
AGAGAGGTTGGGTGGGGGCCCGGCAGCCTCCATTTCCAGCCTTCTGTCCTTCCAGCACAGAAGG
TAGCCAGCGGTAGTGCCCAGCCTGCCTGGCCCCCATACTCCAAGCACCACCACCGGGGCCACTG
AGGGACAAGCCTGCACCTGCCTTCAGCTGTTCTCAGTTGTGGACAAGTGACAGCCATGTCCACT
GTCTCCTTACGTGTCAAACCAAAGGGAAGCACAAACTAAGGAAAGCTCACTTAGAGGATTTTGG
AAGAAGTGGACCGCTTCCATGGCCAGAGCAGGATGGGAGTCTGCGATTCAGACTGAGGTGACGT
CACCACCATTCTCCCATGACCCACTGTCATTGGGCCACCTGCCTCAGTGGCACCAAAACCGCCT
CCCCAATCTTCTCTGGCTGGCTCTAATCGGATGTTCATTTTCTATCTAAGATGATTTTTTTATT
TTTCCAGATTCCTAACACCATGAAATGAATCTGTCTTTGATTTTCTAGCAGCATACCTGGGAAA
TTGGGAACCAGAATGACTGCCCTGTGCCCACAGGGCACCTGGTCCCTGAGTCCCAGACAAGCAT
TCCATGGCACAGCGCTCCCCTGCTGTCTTTACCCAGTTGTGATGTGACAGCTCTGTCCTCCTGG
GGAGACTGATTGGGACTGATGTCCTGGTGGGAGGGTGTCCTGGTGGGACTGATGTCCTGGTGGG
ACTGATGTCCTGGTGGGAGGGTGTCCTGGTGGGACTGATGTCCTGGTGGGACTGATGTCCTGGT
GGGAGGGTGTCCTTTGGGAGCACCTTTCTTTTTACTCTAACTCTTCCCCCAAGCTCCAAGCTGC
TGTCAGTCCAAGCTGTCAGTATCAAAATCTCTCCCTTTTTTGAAATTAAAACCAACGTACCAGC
AATAGTCACCTGCCCTCCCCTGGAGTCTCTGATGTACCATGTTTACACTGACTAGTGCACTCAG
AAAATTAGATTAAAGTGCATTTAAAAAG

hide sequence

Protein Sequences


Protein RefSeqs	NP_075615	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB19682	(Get FASTA)	NCBI Sequence Viewer
	AAH19990	(Get FASTA)	NCBI Sequence Viewer
	BAC36146	(Get FASTA)	NCBI Sequence Viewer
	BAC37603	(Get FASTA)	NCBI Sequence Viewer
	BAC38003	(Get FASTA)	NCBI Sequence Viewer
	BAE27741	(Get FASTA)	NCBI Sequence Viewer
	BAF02862	(Get FASTA)	NCBI Sequence Viewer
	EDL10784	(Get FASTA)	NCBI Sequence Viewer
	EDL10785	(Get FASTA)	NCBI Sequence Viewer
	EDL10786	(Get FASTA)	NCBI Sequence Viewer
	EDL10787	(Get FASTA)	NCBI Sequence Viewer
	P55258	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_075615 ⟸ NM_023126

- UniProtKB:

P55258 (UniProtKB/Swiss-Prot), Q0PD50 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAKTYDYLFKLLLIGDSGVGKTCVLFRFSEDAFNSTFISTIGIDFKIRTIELDGKRIKLQIWDT
AGQERFRTITTAYYRGAMGIMLVYDITNEKSFDNIRNWIRNIEEHASADVEKMILGNKCDVNDK
RQVSKERGEKLALDYGIKFMETSAKANINVENAFFTLARDIKAKMDKKLEGNSPQGSSHGVKIT
VEQQKRTSFFRCSLL

hide sequence

RefSeq Acc Id:

ENSMUSP00000003121 ⟸ ENSMUST00000003121

Promoters

RGD ID:

8667453

Promoter ID:

EPDNEW_M11758

Type:

multiple initiation site

Name:

Rab8a_2

Description:

Mus musculus RAB8A, member RAS oncogene family , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_M11759

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	8	72,161,128 - 72,161,188	EPDNEW

RGD ID:

8667455

Promoter ID:

EPDNEW_M11759

Type:

multiple initiation site

Name:

Rab8a_1

Description:

Mus musculus RAB8A, member RAS oncogene family , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_M11758

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	8	72,161,346 - 72,161,406	EPDNEW

RGD ID:

6843683

Promoter ID:

MM_KWN:54855

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day0, 3T3L1_Day1, 3T3L1_Day2, 3T3L1_Day3, 3T3L1_Day4, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, Kidney, Liver, Lung, MEF_B4, MEF_B6, Spleen

Transcripts:

ENSMUST00000098631, OTTMUST00000052947, OTTMUST00000052948, OTTMUST00000052949, OTTMUST00000074566, UC009MFJ.1

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	8	74,683,631 - 74,685,422 (+)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:96960	AgrOrtholog
Ensembl Genes	ENSMUSG00000003037	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSMUSP00000003121	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSMUST00000003121	ENTREZGENE, UniProtKB/Swiss-Prot
InterPro	P-loop_NTPase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Small_GTP-bd_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Small_GTPase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:17274	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD	MGI:96960	ENTREZGENE
NCBI Gene	17274	ENTREZGENE
Pfam	Ras	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Rab8a	PhenoGen
PROSITE	RAB	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF52540	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs	small_GTP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene	Mm.162811	ENTREZGENE
UniProt	P55258	ENTREZGENE
	Q0PD50	ENTREZGENE, UniProtKB/TrEMBL
	Q3UHW5_MOUSE	UniProtKB/TrEMBL
	RAB8A_MOUSE	UniProtKB/Swiss-Prot
UniProt Secondary	Q8VCF6	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

RGD Manual Annotations