A2m (alpha-2-macroglobulin) - Rat Genome Database

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Gene: A2m (alpha-2-macroglobulin) Mus musculus
Analyze
Symbol: A2m
Name: alpha-2-macroglobulin
RGD ID: 10050
MGI Page MGI
Description: Predicted to enable several functions, including cytokine binding activity; growth factor binding activity; and serine-type endopeptidase inhibitor activity. Acts upstream of or within stem cell differentiation. Predicted to be active in extracellular space. Is expressed in several structures, including brain; embryo mesenchyme; liver; meninges; and retina. Human ortholog(s) of this gene implicated in COVID-19; background diabetic retinopathy; multiple sclerosis; neurodegenerative disease (multiple); and obstructive lung disease. Orthologous to human A2M (alpha-2-macroglobulin).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A2; A2mp; alpha-2-macroglobulin-P
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396121,612,920 - 121,656,197 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6121,612,335 - 121,656,186 (+)EnsemblGRCm39 Ensembl
GRCm386121,636,165 - 121,679,238 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6121,635,376 - 121,679,227 (+)EnsemblGRCm38mm10GRCm38
MGSCv376121,586,191 - 121,629,256 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366121,593,574 - 121,644,846 (+)NCBIMGSCv36mm8
MGSCv366122,445,338 - 122,497,328 (+)NCBIMGSCv36mm8
Celera6123,474,284 - 123,517,770 (+)NCBICelera
Cytogenetic Map6F1NCBI
cM Map657.49NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(+)-schisandrin B  (ISO)
(S)-amphetamine  (ISO)
1-methylphenanthrene  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-deoxy-D-glucose  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-aminohexanoate  (ISO)
6-aminohexanoic acid  (ISO)
6-propyl-2-thiouracil  (ISO)
7-nitroindazole  (ISO)
acrylamide  (EXP)
Actein  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP,ISO)
allethrin  (ISO)
allopurinol  (ISO)
ammonium chloride  (ISO)
antimony(0)  (ISO)
apigenin  (ISO)
arotinoid acid  (ISO)
arsenous acid  (ISO)
bacitracin  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (EXP)
carbonyl sulfide  (ISO)
carnosic acid  (EXP)
CHIR 99021  (ISO)
chlorohydrocarbon  (ISO)
chlorpyrifos  (EXP)
cholate  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
corticosterone  (ISO)
cortisol  (ISO)
Cuprizon  (ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
D-glucose  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dichloroacetic acid  (EXP)
diclofenac  (EXP)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
fenvalerate  (ISO)
fluoranthene  (ISO)
flutamide  (ISO)
fructose  (EXP)
furan  (ISO)
gemcitabine  (ISO)
genistein  (EXP)
gentamycin  (ISO)
glafenine  (ISO)
glucose  (EXP)
glycidyl methacrylate  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
isoniazide  (ISO)
isoprenaline  (EXP)
isotretinoin  (ISO)
ketoconazole  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (EXP,ISO)
melamine  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
N(6),N(6)-dimethyladenine  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
naphthalene  (EXP,ISO)
nickel atom  (ISO)
nitrofen  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
olanzapine  (ISO)
orphenadrine  (ISO)
ouabain  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (EXP)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (EXP)
phenethyl caffeate  (ISO)
phenformin  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
potassium bromate  (ISO)
prednisone  (ISO)
progesterone  (EXP)
propanal  (ISO)
pyrethrins  (ISO)
pyrogallol  (EXP)
rac-lactic acid  (ISO)
S-nitrosoglutathione  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
Soman  (ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (ISO)
tauroursodeoxycholic acid  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (ISO)
XAV939  (ISO)
XL147  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular space  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Role of prostaglandins in acute phase proteins in inflammation. Anbalagan K and Sadique J, Biochem Med. 1984 Apr;31(2):236-45.
2. Intrahepatic STAT-3 activation and acute phase gene expression predict outcome after CLP sepsis in the rat. Andrejko KM, etal., Am J Physiol. 1998 Dec;275(6 Pt 1):G1423-9.
3. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
4. Alpha-2 macroglobulin is genetically associated with Alzheimer disease. Blacker D, etal., Nat Genet 1998 Aug;19(4):357-60.
5. Alpha 2 macroglobulin activity in rats infected with Typanosoma lewisi and treated with cyclophosphamide and its effect on the malignancy of the disease. Budovsky A, etal., J Vector Borne Dis. 2007 Jun;44(2):128-36.
6. Association of alpha 2-macroglobulin polymorphisms and Alzheimer disease in Mainland Han Chinese. Chen D, etal., J Neurol Sci. 2004 Jan 15;217(1):13-5.
7. Gene expression profiles of livers from thermally injured rats. Dasu MR, etal., Gene. 2004 Feb 18;327(1):51-60.
8. Alpha-2 macroglobulin polymorphism and Alzheimer disease risk in the UK. Dow DJ, etal., Nat Genet 1999 May;22(1):16-7; author reply 21-2.
9. Inflammatory and metalloproteinases profiles predict three-month poor outcomes in ischemic stroke treated with thrombolysis. Gori AM, etal., J Cereb Blood Flow Metab. 2017 Sep;37(9):3253-3261. doi: 10.1177/0271678X17695572. Epub 2017 Mar 7.
10. 6-sulphanilamidoindazole arthritis of rats: relation between acute-phase proteins, degree of arthritis and treatment with soybean trypsin inhibitor. Hirschelmann R, etal., Agents Actions. 1980 Nov;10(5):431-4.
11. Isolation of bona fide differentially expressed genes in the 18-hour sepsis liver by suppression subtractive hybridization. Hsieh YC, etal., Shock. 2004 Jun;21(6):549-55.
12. Suppression of experimental allergic encephalomyelitis by alpha 2-macroglobulin. Hunter N, etal., Immunology. 1991 May;73(1):58-63.
13. New insights into the pathogenesis of glucocorticoid-induced avascular necrosis: microarray analysis of gene expression in a rat model. Kerachian MA, etal., Arthritis Res Ther. 2010;12(3):R124. doi: 10.1186/ar3062. Epub 2010 Jun 25.
14. Ontology searching and browsing at the Rat Genome Database. Laulederkind SJ, etal., Database (Oxford). 2012 Mar 20;2012:bas016. Print 2012.
15. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
16. MGDs mouse GO annotations MGD data from the GO Consortium
17. MGD IEA MGD IEA
18. The kallikrein-kinin system: current and future pharmacological targets. Moreau ME, etal., J Pharmacol Sci. 2005 Sep;99(1):6-38.
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. The Rat Genome Database pathway portal. Petri V, etal., Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011.
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
23. Detection of an alteration of the alpha 2-macroglobulin gene in a patient with chronic lung disease and serum alpha 2-macroglobulin deficiency. Poller W, etal., Hum Genet 1989 Aug;83(1):93-6.
24. Direct injection and expression in vivo of full-length cDNA of the cardiac isoform of alpha-2 macroglobulin induces cardiac hypertrophy in the rat heart. Rajan S, etal., Basic Res Cardiol 2003 Feb;98(1):39-49.
25. Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection. Ramlall V, etal., Nat Med. 2020 Aug 3. pii: 10.1038/s41591-020-1021-2. doi: 10.1038/s41591-020-1021-2.
26. Mouse MP Annotation Import Pipeline RGD automated import pipeline
27. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. Comprehensive gene review and curation RGD comprehensive gene curation
30. Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin. Saunders AJ, etal., Hum Mol Genet. 2003 Nov 1;12(21):2765-76. Epub 2003 Sep 9.
31. No association of three polymorphisms in the alpha-2-macroglobulin and lipoprotein related receptor genes with multiple sclerosis. Schweer D, etal., J Neuroimmunol 2001 Aug 30;118(2):300-3.
32. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Shi Y and Massague J, Cell. 2003 Jun 13;113(6):685-700.
33. No genetic association between alpha-2 macroglobulin I1000V polymorphism and Japanese sporadic Alzheimer's disease. Shibata N, etal., Neurosci Lett. 2000 Aug 25;290(2):154-6.
34. Beneficial effects of Psidium guajava leaf extract on diabetic myocardium. Soman S, etal., Exp Toxicol Pathol. 2013 Jan;65(1-2):91-5. doi: 10.1016/j.etp.2011.06.005. Epub 2011 Jul 13.
35. Serum alpha 2-macroglobulin and alpha 1-inhibitor 3 concentrations are increased in hypoalbuminemia by post-transcriptional mechanisms. Stevenson FT, etal., Kidney Int. 1998 Jan;53(1):67-75.
36. Cardiac isoform of alpha 2 macroglobulin and its reliability as a cardiac marker in HIV patients. Subbiah R, etal., Heart Lung Circ. 2010 Feb;19(2):93-5. doi: 10.1016/j.hlc.2009.10.005. Epub 2009 Dec 11.
37. alpha(2)-Macroglobulin: a novel cytochemical marker characterizing preneoplastic and neoplastic rat liver lesions negative for hitherto established cytochemical markers. Sukata T, etal., Am J Pathol 2004 Nov;165(5):1479-88.
38. Alpha-2 macroglobulin I1000 V polymorphism in Chinese sporadic Alzheimer's disease and Parkinson's disease. Tang G, etal., Neurosci Lett. 2002 Aug 9;328(2):195-7.
39. Alpha 2 macroglobulin of the rat, an acute phase protein, mitigates the early course of endotoxin shock. van Vugt H, etal., Br J Exp Pathol. 1986 Jun;67(3):313-9.
40. Fever and acute phase reactants in the rat. van Vugt H, etal., Br J Exp Pathol. 1988 Aug;69(4):577-88.
41. Alpha-2-macroglobulin and albumin are useful serum proteins to detect subclinical peritonitis in the rat. van Westrhenen R, etal., Perit Dial Int. 2006 Jan-Feb;26(1):101-7.
42. Improvement of visual acuity in patients suffering from diabetic retinopathy after membrane differential filtration: a pilot study. Widder RA, etal., Transfus Sci. 1999 Dec;21(3):201-6.
Additional References at PubMed
PMID:1280217   PMID:1379499   PMID:6179545   PMID:7514554   PMID:7528166   PMID:7544347   PMID:8485155   PMID:8662686   PMID:8798779   PMID:8889548   PMID:9022715   PMID:9027502  
PMID:9169139   PMID:9177771   PMID:10438936   PMID:10487856   PMID:10860661   PMID:10922068   PMID:12069948   PMID:12114513   PMID:12183561   PMID:12477932   PMID:12631277   PMID:12819125  
PMID:14580373   PMID:14691545   PMID:15355875   PMID:15389876   PMID:15489334   PMID:16081825   PMID:16103213   PMID:16141072   PMID:16297527   PMID:16407218   PMID:16602821   PMID:16624897  
PMID:16641085   PMID:16959875   PMID:17404289   PMID:17920016   PMID:19536284   PMID:19796622   PMID:20568116   PMID:21267068   PMID:21320498   PMID:21858045   PMID:21873635   PMID:22260730  
PMID:22496890   PMID:22808246   PMID:23846698   PMID:24952961   PMID:25775517   PMID:27031383   PMID:27626380   PMID:28378742   PMID:31040226   PMID:31351040   PMID:32325033   PMID:33382037  
PMID:34050187   PMID:36577057   PMID:38355793   PMID:39351969  


Genomics

Comparative Map Data
A2m
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396121,612,920 - 121,656,197 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6121,612,335 - 121,656,186 (+)EnsemblGRCm39 Ensembl
GRCm386121,636,165 - 121,679,238 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6121,635,376 - 121,679,227 (+)EnsemblGRCm38mm10GRCm38
MGSCv376121,586,191 - 121,629,256 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366121,593,574 - 121,644,846 (+)NCBIMGSCv36mm8
MGSCv366122,445,338 - 122,497,328 (+)NCBIMGSCv36mm8
Celera6123,474,284 - 123,517,770 (+)NCBICelera
Cytogenetic Map6F1NCBI
cM Map657.49NCBI
A2M
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38129,067,708 - 9,116,229 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl129,067,664 - 9,116,229 (-)EnsemblGRCh38hg38GRCh38
GRCh37129,220,304 - 9,268,825 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36129,111,571 - 9,159,825 (-)NCBINCBI36Build 36hg18NCBI36
Build 34129,111,576 - 9,159,754NCBI
Celera1210,757,430 - 10,805,676 (-)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef129,000,837 - 9,049,088 (-)NCBIHuRef
CHM1_1129,189,284 - 9,237,532 (-)NCBICHM1_1
T2T-CHM13v2.0129,049,893 - 9,098,416 (-)NCBIT2T-CHM13v2.0
A2m
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84156,570,163 - 156,619,870 (+)NCBIGRCr8
mRatBN7.24154,897,770 - 154,947,787 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4154,897,877 - 154,947,786 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4161,158,697 - 161,208,341 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04156,942,158 - 156,991,802 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04155,571,666 - 155,634,340 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04154,309,426 - 154,359,138 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4154,309,426 - 154,359,137 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl4154,423,209 - 154,472,924 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04221,393,233 - 221,442,945 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44158,103,711 - 158,153,423 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14158,348,624 - 158,398,358 (+)NCBI
Celera4143,730,195 - 143,781,190 (+)NCBICelera
Cytogenetic Map4q42NCBI
LOC102021956
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554136,019,082 - 6,062,529 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554136,019,457 - 6,062,366 (+)NCBIChiLan1.0ChiLan1.0
LOC100979269
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21014,596,200 - 14,644,826 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11214,592,959 - 14,641,585 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0129,154,457 - 9,202,833 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1129,385,359 - 9,434,011 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl129,385,359 - 9,433,979 (-)Ensemblpanpan1.1panPan2
A2M
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12736,654,328 - 36,695,775 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha279,920,641 - 9,962,291 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02737,002,478 - 37,044,674 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2737,002,374 - 37,044,672 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12736,883,699 - 36,925,608 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02736,918,717 - 36,960,000 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0279,452,043 - 9,493,920 (-)NCBIUU_Cfam_GSD_1.0
LOC101959212
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494598,303,198 - 98,346,620 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936870424,951 - 468,167 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936870424,832 - 468,303 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
A2M
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl562,440,810 - 62,483,678 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1562,406,928 - 62,483,690 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2565,274,903 - 65,320,342 (+)NCBISscrofa10.2Sscrofa10.2susScr3
A2M
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1118,885,903 - 8,934,503 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl118,883,181 - 8,934,638 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666089986,142 - 1,034,949 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in A2m
2492 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:53
Interacting mature miRNAs:54
Transcripts:ENSMUST00000032203
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142079Skmw15_mskeletal muscle weight 15 (mouse)Not determined6116829851149588044Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683690851146954059Mouse
11252138Clas1_mcarcinogen-induced lung adenoma susceptibility 1 (mouse)6112246918146954059Mouse
1300887Pabr1_mplasma apolipoprotein B (human) regulator 1 (mouse)Not determined6103754405136400690Mouse
1301915Chab3_mcholesterol absorption 3 (mouse)Not determined698908709132916997Mouse
1301083Bhr5_mbronchial hyperresponsiveness 5 (mouse)Not determined6115694477132578150Mouse
1301658Radpf3_mradiation pulmonary fibrosis 3 (mouse)Not determined6115219814146330736Mouse
10043923Bhr7_mbronchial hyperresponsiveness 7 (mouse)Not determined698219814132219938Mouse
4141940W6q5_mweight 6 weeks QTL 5 (mouse)Not determined96632912146535124Mouse
4140980Mvwf2_mmodifier of von Willebrand factor 2 (mouse)Not determined114345693145601739Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46912919136400690Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648696934125336963Mouse
4141295Rua_mraffinose acetate tasting (mouse)Not determined115546805149549364Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648696934148351498Mouse
1301509Sluc3_msusceptibility to lung cancer 3 (mouse)Not determined6104480321127019938Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648703490125333748Mouse
1301262Gasa3_mgastritis type A susceptibility locus 3 (mouse)Not determined688982366122982564Mouse
1301518Bbaa5_mB.burgdorferi-associated arthritis 5 (mouse)Not determined698483798145881170Mouse
11353842Bmiq4_mbody mass index QTL 4 (mouse)692584287146330736Mouse
1302131Bmd8_mbone mineral density 8 (mouse)Not determined699132089133132228Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645290993128811995Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
1357555Tesq2_mtestis weight QTL 2 (mouse)Not determined696632912146535124Mouse
10043891Tilss4_mTNF-induced lethal shock susceptibility 3 (mouse)Not determined6112246918125333748Mouse
1301244Ichs_mimmediate cutaneous hypersensitivity QTL (mouse)Not determined690772571124772807Mouse
4142416Egq11_mearly growth QTL 11 (mouse)Not determined96632912146535124Mouse
1301923Lith6_mlithogenic gene 6 (mouse)Not determined698694477132694676Mouse
10412207Cypr5_mcytokine production 5 (mouse)Not determined6110815180144815323Mouse
1300704Cia3_mcollagen induced arthritis QTL 3 (mouse)Not determined696324286130324483Mouse
1301152Athsq2_matherosclerosis susceptibility QTL 2 (mouse)Not determined6117059949149588044Mouse
13463481Mcvq14_mmean corpuscular volume QTL 14 (mouse)6111142448145142541Mouse
1301927Etohcta6_methanol conditioned taste aversion 6 (mouse)Not determined6115578005149578150Mouse
4141194Cyx_mcycloheximide tasting (mouse)Not determined115546805149549364Mouse
4141064Ath37_matherosclerosis 37 (mouse)Not determined6116641858128495988Mouse
1357806Aaj3_manxiety in A/J 3 (mouse)Not determined6104480321136400690Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673476983134676963Mouse
4141889Qui_mquinine sensitivity, taste (mouse)Not determined115546805149549364Mouse
1301292Cfbw2_mcystic fibrosis body weight 2 (mouse)Not determined694981612128981699Mouse
11040599Lmr4b_mleishmaniasis resistance 4b (mouse)696324286130324483Mouse
1301804Bulb2_mbulb size 2 (mouse)Not determined6120416806149588044Mouse

Markers in Region
D4Arb40  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386121,632,619 - 121,632,871UniSTSGRCm38
MGSCv376121,582,637 - 121,582,889UniSTSGRCm37
Cytogenetic Map6F1UniSTS
cM Map661.7UniSTS
A2m  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6F1UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000032203   ⟹   ENSMUSP00000032203
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6121,613,187 - 121,656,186 (+)Ensembl
GRCm38.p6 Ensembl6121,636,228 - 121,679,227 (+)Ensembl
Ensembl Acc Id: ENSMUST00000203413
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6121,635,572 - 121,638,150 (+)Ensembl
GRCm38.p6 Ensembl6121,658,613 - 121,661,191 (+)Ensembl
Ensembl Acc Id: ENSMUST00000204850   ⟹   ENSMUSP00000144862
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6121,612,335 - 121,615,347 (+)Ensembl
GRCm38.p6 Ensembl6121,635,376 - 121,638,388 (+)Ensembl
RefSeq Acc Id: NM_175628   ⟹   NP_783327
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396121,613,132 - 121,656,197 (+)NCBI
GRCm386121,636,173 - 121,679,238 (+)NCBI
MGSCv376121,586,191 - 121,629,256 (+)RGD
Celera6123,474,284 - 123,517,770 (+)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011241322   ⟹   XP_011239624
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396121,612,920 - 121,641,657 (+)NCBI
GRCm386121,636,165 - 121,664,698 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_783327 (Get FASTA)   NCBI Sequence Viewer  
  XP_011239624 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH72642 (Get FASTA)   NCBI Sequence Viewer  
  AAO25741 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000032203
  ENSMUSP00000032203.8
GenBank Protein Q6GQT1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_783327   ⟸   NM_175628
- Peptide Label: precursor
- UniProtKB: E9QMQ7 (UniProtKB/Swiss-Prot),   Q811S0 (UniProtKB/Swiss-Prot),   Q6GQT1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011239624   ⟸   XM_011241322
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSMUSP00000032203   ⟸   ENSMUST00000032203
Ensembl Acc Id: ENSMUSP00000144862   ⟸   ENSMUST00000204850

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6GQT1-F1-model_v2 AlphaFold Q6GQT1 1-1474 view protein structure

Promoters
RGD ID:6838786
Promoter ID:MM_KWN:47454
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:NM_175628
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366121,586,101 - 121,586,601 (+)MPROMDB
RGD ID:6890884
Promoter ID:EPDNEW_M8893
Type:initiation region
Name:A2m_1
Description:Mus musculus alpha-2-macroglobulin , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm386121,636,226 - 121,636,286EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2449119 AgrOrtholog
Ensembl Genes ENSMUSG00000030111 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000032203 ENTREZGENE
  ENSMUST00000032203.9 UniProtKB/Swiss-Prot
Gene3D-CATH 1.50.10.20 UniProtKB/Swiss-Prot
  2.20.130.20 UniProtKB/Swiss-Prot
  2.60.120.1540 UniProtKB/Swiss-Prot
  2.60.40.10 UniProtKB/Swiss-Prot
  2.60.40.1930 UniProtKB/Swiss-Prot
  2.60.40.1940 UniProtKB/Swiss-Prot
  2.60.40.690 UniProtKB/Swiss-Prot
InterPro A-macroglobulin_rcpt-bd UniProtKB/Swiss-Prot
  A-macroglobulin_rcpt-bd_sf UniProtKB/Swiss-Prot
  A2M/Complement_sys UniProtKB/Swiss-Prot
  A2M_N_BRD UniProtKB/Swiss-Prot
  A2M_TED UniProtKB/Swiss-Prot
  Alpha-macroglob_thiol-ester_cl UniProtKB/Swiss-Prot
  Alpha-macroglobulin_TED UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_E-set UniProtKB/Swiss-Prot
  Macroglobln_a2 UniProtKB/Swiss-Prot
  MacrogloblnA2_CS UniProtKB/Swiss-Prot
  MG2 UniProtKB/Swiss-Prot
  MG3 UniProtKB/Swiss-Prot
  MG4 UniProtKB/Swiss-Prot
  Terpenoid_cyclase/PrenylTrfase UniProtKB/Swiss-Prot
KEGG Report mmu:232345 UniProtKB/Swiss-Prot
MGD MGI:2449119 ENTREZGENE
NCBI Gene 232345 ENTREZGENE
PANTHER ALPHA-2-MACROGLOBULIN UniProtKB/Swiss-Prot
  MACROGLOBULIN / COMPLEMENT UniProtKB/Swiss-Prot
Pfam A2M UniProtKB/Swiss-Prot
  A2M_BRD UniProtKB/Swiss-Prot
  A2M_recep UniProtKB/Swiss-Prot
  MG2 UniProtKB/Swiss-Prot
  MG3 UniProtKB/Swiss-Prot
  MG4 UniProtKB/Swiss-Prot
  TED_complement UniProtKB/Swiss-Prot
PhenoGen A2m PhenoGen
PROSITE ALPHA_2_MACROGLOBULIN UniProtKB/Swiss-Prot
SMART A2M UniProtKB/Swiss-Prot
  A2M_N_2 UniProtKB/Swiss-Prot
  A2M_recep UniProtKB/Swiss-Prot
  Thiol-ester_cl UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48239 UniProtKB/Swiss-Prot
  SSF49410 UniProtKB/Swiss-Prot
  SSF81296 UniProtKB/Swiss-Prot
UniProt A0A0N4SUX6_MOUSE UniProtKB/TrEMBL
  A2MG_MOUSE UniProtKB/Swiss-Prot
  E9QMQ7 ENTREZGENE
  Q6GQT1 ENTREZGENE
  Q811S0 ENTREZGENE
UniProt Secondary E9QMQ7 UniProtKB/Swiss-Prot
  Q811S0 UniProtKB/Swiss-Prot