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Gene: A2m (alpha-2-macroglobulin) Mus musculus
Symbol: A2m
Name: alpha-2-macroglobulin
Description: Predicted to have several functions, including cytokine binding activity; growth factor binding activity; and protein homodimerization activity. Involved in stem cell differentiation. Predicted to localize to the extracellular space. Human ortholog(s) of this gene implicated in background diabetic retinopathy; neurodegenerative disease (multiple); and obstructive lung disease. Is expressed in several structures, including brain; embryo mesenchyme; liver; meninges; and retina. Orthologous to human A2M (alpha-2-macroglobulin); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; Alzheimer's disease pathway; immune response pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A2mp; alpha-2-macroglobulin-P
Homo sapiens (human) : A2M (alpha-2-macroglobulin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : A2m (alpha-2-macroglobulin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102021956 (alpha-2-macroglobulin)
Canis lupus familiaris (dog) : LOC477699 (alpha-2-macroglobulin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : A2m (alpha-2-macroglobulin)
Sus scrofa (pig) : A2M (alpha-2-macroglobulin)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl6121,635,376 - 121,679,227 (+)Ensembl
GRCm386121,636,165 - 121,679,238 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv376121,586,191 - 121,629,256 (+)NCBIGRCm37mm9NCBIm37
MGSCv366121,593,574 - 121,644,846 (+)NCBImm8
MGSCv366122,445,338 - 122,497,328 (+)NCBImm8
Celera6123,474,284 - 123,517,770 (+)NCBICelera
Cytogenetic Map6 F1NCBI
cM Map657.49NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on A2m
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10050
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-01-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.