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Gene: A2m (alpha-2-macroglobulin) Mus musculus
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Symbol: A2m
Name: alpha-2-macroglobulin
Description: Predicted to have several functions, including cytokine binding activity; growth factor binding activity; and protein homodimerization activity. Involved in stem cell differentiation. Predicted to localize to the extracellular space. Human ortholog(s) of this gene implicated in background diabetic retinopathy; neurodegenerative disease (multiple); and obstructive lung disease. Is expressed in several structures, including brain; embryo mesenchyme; liver; meninges; and retina. Orthologous to human A2M (alpha-2-macroglobulin); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; Alzheimer's disease pathway; immune response pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A2mp; alpha-2-macroglobulin-P
Orthologs:
Homo sapiens (human) : A2M (alpha-2-macroglobulin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : A2m (alpha-2-macroglobulin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102021956 (alpha-2-macroglobulin)
Canis lupus familiaris (dog) : LOC477699 (alpha-2-macroglobulin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : A2m (alpha-2-macroglobulin)
Sus scrofa (pig) : A2M (alpha-2-macroglobulin)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl6121,635,376 - 121,679,227 (+)Ensembl
GRCm386121,636,165 - 121,679,238 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv376121,586,191 - 121,629,256 (+)NCBIGRCm37mm9NCBIm37
MGSCv366121,593,574 - 121,644,846 (+)NCBImm8
MGSCv366122,445,338 - 122,497,328 (+)NCBImm8
Celera6123,474,284 - 123,517,770 (+)NCBICelera
Cytogenetic Map6 F1NCBI
cM Map657.49NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on A2m
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10050
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-01-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.