Penk (preproenkephalin) - Rat Genome Database

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Gene: Penk (preproenkephalin) Mus musculus
Analyze
Symbol: Penk
Name: preproenkephalin
RGD ID: 68999
MGI Page MGI
Description: Enables opioid peptide activity and opioid receptor binding activity. Involved in G protein-coupled opioid receptor signaling pathway; regulation of long-term synaptic depression; and transmission of nerve impulse. Acts upstream of or within several processes, including behavioral fear response; sensory perception of pain; and startle response. Predicted to be located in several cellular components, including cell body fiber; perikaryon; and symmetric synapse. Predicted to be active in several cellular components, including axon terminus; cytoplasmic vesicle lumen; and neuronal cell body. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in overactive bladder syndrome. Orthologous to human PENK (proenkephalin).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI326464; EN; ENK; Pe; Pen; Penk1; PPA; preproenkephalin 1; proenkephalin-A; spermatogenic-specific proenkephalin
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3944,133,536 - 4,138,815 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl44,133,531 - 4,138,819 (-)EnsemblGRCm39 Ensembl
GRCm3844,133,536 - 4,138,815 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl44,133,531 - 4,138,819 (-)EnsemblGRCm38mm10GRCm38
MGSCv3744,060,683 - 4,065,592 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3644,060,683 - 4,065,592 (-)NCBIMGSCv36mm8
Celera44,092,742 - 4,097,651 (-)NCBICelera
Cytogenetic Map4A1NCBI
cM Map42.31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (ISO)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,7-dihydropurine-6-thione  (ISO)
3-nitropropanoic acid  (ISO)
3alpha-hydroxy-5beta-pregnan-20-one  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxynon-2-enal  (EXP)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
aconitine  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
apomorphine  (ISO)
arsenite(3-)  (EXP,ISO)
atrazine  (ISO)
baclofen  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
chlorpyrifos  (ISO)
clozapine  (ISO)
cocaine  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (ISO)
Cuprizon  (ISO)
D-glucose  (EXP)
DDT  (ISO)
diazepam  (ISO)
dibutyl phthalate  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
dizocilpine maleate  (ISO)
dorsomorphin  (ISO)
ethanol  (EXP,ISO)
finasteride  (ISO)
fluoxetine  (ISO)
flurbiprofen  (EXP)
folic acid  (EXP)
fomepizole  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
fructose  (EXP)
furan  (ISO)
glucose  (EXP)
haloperidol  (EXP,ISO)
Indeno[1,2,3-cd]pyrene  (EXP)
isoprenaline  (ISO)
Isradipine  (ISO)
istradefylline  (ISO)
kainic acid  (ISO)
medroxyprogesterone acetate  (ISO)
memantine  (ISO)
mercaptopurine  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
Methanandamide  (ISO)
methylmercury chloride  (ISO)
metoprolol  (ISO)
morphine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
nicotine  (EXP)
oxaliplatin  (ISO)
oxidopamine  (EXP,ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
PCB138  (EXP)
pentobarbital  (ISO)
phenformin  (ISO)
phosphatidic acid  (ISO)
progesterone  (EXP)
propranolol  (ISO)
purine-6-thiol  (ISO)
reserpine  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
scopolamine  (ISO)
serotonin  (ISO)
SL-327  (ISO)
Soman  (ISO)
sulforaphane  (EXP)
tamoxifen  (EXP)
terbufos  (ISO)
testosterone  (EXP)
thioacetamide  (ISO)
thiopental  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP,ISO)
triclosan  (ISO)
U69593  (ISO)
undecane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Prolonged generalized dystonia after chronic cerebellar application of kainic acid. Alvarez-Fischer D, etal., Brain Res. 2012 Jun 29;1464:82-8. doi: 10.1016/j.brainres.2012.05.007. Epub 2012 May 15.
2. Increased enkephalin in brain of rats prone to overconsuming a fat-rich diet. Chang GQ, etal., Physiol Behav. 2010 Oct 5;101(3):360-9. doi: 10.1016/j.physbeh.2010.06.005. Epub 2010 Jul 21.
3. Relevance between striatal expression of Fos, proenkephalin mRNA, prodynorphin mRNA and rotation induced by l-stepholidine in 6-hydroxydopamine-lesioned rats. Ding YM, etal., Acta Pharmacol Sin. 2000 Oct;21(10):885-92.
4. [Affection of acupotomy lysis on leu-enkephalin (L-ENK) content in different parts of centrum of rats with knee osteoarthritis]. Guo CQ, etal., Zhongguo Gu Shang. 2011 Aug;24(8):656-8.
5. Transcription of the rat and mouse proenkephalin genes is initiated at distinct sites in spermatogenic and somatic cells. Kilpatrick DL, etal., Mol Cell Biol 1990 Jul;10(7):3717-26.
6. Calcium-permeable AMPA receptors are involved in the induction and expression of l-DOPA-induced dyskinesia in Parkinson's disease. Kobylecki C, etal., J Neurochem. 2010 Jul;114(2):499-511. doi: 10.1111/j.1471-4159.2010.06776.x. Epub 2010 Apr 28.
7. The influence of group III metabotropic glutamate receptor stimulation by (1S,3R,4S)-1-aminocyclo-pentane-1,3,4-tricarboxylic acid on the parkinsonian-like akinesia and striatal proenkephalin and prodynorphin mRNA expression in rats. Konieczny J, etal., Neuroscience. 2007 Mar 16;145(2):611-20. doi: 10.1016/j.neuroscience.2006.12.006. Epub 2007 Jan 16.
8. Proenkephalin and prodynorphin mRNA level in brain of rats with absence epilepsy. Lasoń W, etal., Neuropeptides. 1994 Dec;27(6):343-7. doi: 10.1016/0143-4179(94)90060-4.
9. Embryonic ventral mesencephalic grafts improve levodopa-induced dyskinesia in a rat model of Parkinson's disease. Lee CS, etal., Brain. 2000 Jul;123 ( Pt 7):1365-79. doi: 10.1093/brain/123.7.1365.
10. From unilateral to bilateral parkinsonism: Effects of lateralization on dyskinesias and associated molecular mechanisms. Marin C, etal., Neuropharmacology. 2015 Oct;97:365-75. doi: 10.1016/j.neuropharm.2015.06.004. Epub 2015 Jun 22.
11. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
12. MGDs mouse GO annotations MGD data from the GO Consortium
13. Disturbances in behavior and cortical enkephalin gene expression during the anticipation of ethanol in rats characterized as high drinkers. Morganstern I, etal., Alcohol. 2012 Sep;46(6):559-68. doi: 10.1016/j.alcohol.2012.05.003. Epub 2012 Jun 14.
14. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
15. Enkephalin downregulation in the nucleus accumbens underlies chronic stress-induced anhedonia. Poulin JF, etal., Stress. 2014 Jan;17(1):88-96. doi: 10.3109/10253890.2013.850669. Epub 2013 Oct 31.
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Proenkephalin mediates the enduring effects of adolescent cannabis exposure associated with adult opiate vulnerability. Tomasiewicz HC, etal., Biol Psychiatry. 2012 Nov 15;72(10):803-10. doi: 10.1016/j.biopsych.2012.04.026. Epub 2012 Jun 8.
19. Comparative effectiveness of antinociceptive gene therapies in animal models of diabetic neuropathic pain. Wang Y, etal., Gene Ther. 2013 Jul;20(7):742-50. doi: 10.1038/gt.2012.90. Epub 2012 Dec 13.
20. HPLC/MS/MS for quantification of two types of neurotransmitters in rat brain and application: myocardial ischemia and protection of Sheng-Mai-San. Xu N, etal., J Pharm Biomed Anal. 2011 Apr 28;55(1):101-8. doi: 10.1016/j.jpba.2010.12.015. Epub 2010 Dec 21.
21. Effects of herpes simplex virus vector-mediated enkephalin gene therapy on bladder overactivity and nociception. Yokoyama H, etal., Hum Gene Ther. 2013 Feb;24(2):170-80. doi: 10.1089/hum.2011.180. Epub 2013 Feb 14.
Additional References at PubMed
PMID:1537850   PMID:2011497   PMID:2784565   PMID:2938259   PMID:6933569   PMID:7631421   PMID:7752808   PMID:8603595   PMID:8750842   PMID:8849726   PMID:8861630   PMID:9191109  
PMID:9502813   PMID:9653660   PMID:9746745   PMID:9876181   PMID:10349636   PMID:10357937   PMID:10520752   PMID:10540203   PMID:10808051   PMID:10934256   PMID:10998124   PMID:11042159  
PMID:11060228   PMID:11076861   PMID:11125007   PMID:11172058   PMID:11180952   PMID:11217851   PMID:11356033   PMID:12223579   PMID:12477932   PMID:12486185   PMID:12724834   PMID:12864972  
PMID:12869695   PMID:14681479   PMID:14975719   PMID:15142957   PMID:15197532   PMID:15217369   PMID:15388297   PMID:15689546   PMID:15813947   PMID:16095981   PMID:16125819   PMID:16141072  
PMID:16141073   PMID:16602821   PMID:16865686   PMID:16987237   PMID:17049174   PMID:17375141   PMID:17460091   PMID:17467916   PMID:17904656   PMID:18280051   PMID:18313668   PMID:18400903  
PMID:18430798   PMID:18443282   PMID:18463254   PMID:18603407   PMID:18634777   PMID:18721803   PMID:18780300   PMID:19030180   PMID:19046386   PMID:19386638   PMID:19523041   PMID:19554387  
PMID:19997907   PMID:20080794   PMID:20204609   PMID:20406487   PMID:20589901   PMID:20921407   PMID:21124002   PMID:21205893   PMID:21267068   PMID:21779533   PMID:21800302   PMID:21873635  
PMID:22067363   PMID:22991444   PMID:23012479   PMID:23364326   PMID:23532063   PMID:24040390   PMID:24082127   PMID:24194600   PMID:24351932   PMID:24804898   PMID:24855103   PMID:24952961  
PMID:25071457   PMID:25754760   PMID:25810521   PMID:26389685   PMID:26511239   PMID:26634308   PMID:26743624   PMID:27452460   PMID:27626380   PMID:28162807   PMID:28289129   PMID:28433741  
PMID:28535371   PMID:28685891   PMID:29043563   PMID:29122676   PMID:29183737   PMID:29576387   PMID:29967281   PMID:30007418   PMID:30040980   PMID:30186122   PMID:30382198   PMID:30635555  
PMID:31365875   PMID:31491374   PMID:31543264   PMID:31638440   PMID:31666704   PMID:31784286   PMID:32049028   PMID:32170006   PMID:32187545   PMID:32241803   PMID:32322067   PMID:32541007  
PMID:32561725   PMID:32586976   PMID:33288908   PMID:33654118   PMID:33667158   PMID:33712552   PMID:33789083   PMID:33798452   PMID:33846639   PMID:33932339   PMID:34004146   PMID:34013328  
PMID:34569705   PMID:34851821   PMID:35045339   PMID:35060903   PMID:35156680   PMID:35201898   PMID:35342336   PMID:35615067   PMID:35937204   PMID:36070775   PMID:36081908   PMID:36292593  
PMID:36317965   PMID:36596814   PMID:36774552   PMID:37298722   PMID:37968381   PMID:38424161  


Genomics

Comparative Map Data
Penk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3944,133,536 - 4,138,815 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl44,133,531 - 4,138,819 (-)EnsemblGRCm39 Ensembl
GRCm3844,133,536 - 4,138,815 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl44,133,531 - 4,138,819 (-)EnsemblGRCm38mm10GRCm38
MGSCv3744,060,683 - 4,065,592 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3644,060,683 - 4,065,592 (-)NCBIMGSCv36mm8
Celera44,092,742 - 4,097,651 (-)NCBICelera
Cytogenetic Map4A1NCBI
cM Map42.31NCBI
PENK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38856,440,957 - 56,446,641 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl856,436,674 - 56,446,671 (-)EnsemblGRCh38hg38GRCh38
GRCh37857,353,516 - 57,359,200 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36857,516,070 - 57,521,143 (-)NCBINCBI36Build 36hg18NCBI36
Build 34857,516,069 - 57,521,143NCBI
Celera853,344,310 - 53,350,077 (-)NCBICelera
Cytogenetic Map8q12.1NCBI
HuRef852,820,608 - 52,826,373 (-)NCBIHuRef
CHM1_1857,405,395 - 57,411,158 (-)NCBICHM1_1
T2T-CHM13v2.0856,818,203 - 56,823,883 (-)NCBIT2T-CHM13v2.0
Penk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8521,981,381 - 21,987,074 (-)NCBIGRCr8
mRatBN7.2517,183,799 - 17,189,160 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl517,183,806 - 17,189,129 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx519,402,516 - 19,407,452 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0521,001,023 - 21,005,959 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0520,754,402 - 20,759,344 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0517,056,412 - 17,061,762 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl517,056,419 - 17,061,837 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0521,834,409 - 21,839,759 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4517,509,323 - 17,514,265 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1517,516,079 - 17,517,452 (-)NCBI
Celera516,529,164 - 16,534,106 (-)NCBICelera
Cytogenetic Map5q12NCBI
Penk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545415,426,017 - 15,426,685 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545415,425,712 - 15,426,685 (-)NCBIChiLan1.0ChiLan1.0
PENK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2772,075,726 - 72,081,540 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1847,800,250 - 47,806,064 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0852,864,388 - 52,870,144 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1850,234,170 - 50,239,949 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl850,234,170 - 50,239,949 (-)Ensemblpanpan1.1panPan2
PENK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1297,757,543 - 7,763,137 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl297,757,857 - 7,762,398 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha298,069,914 - 8,075,462 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0297,832,106 - 7,837,657 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1297,844,842 - 7,850,120 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0297,975,639 - 7,980,923 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0298,254,882 - 8,260,429 (-)NCBIUU_Cfam_GSD_1.0
Penk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530371,763,745 - 71,769,230 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364963,016,218 - 3,021,738 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364963,016,247 - 3,021,726 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PENK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl475,525,555 - 75,530,876 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1475,525,497 - 75,530,403 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2482,444,889 - 82,449,745 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PENK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1852,458,113 - 52,463,933 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl852,457,904 - 52,463,859 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603989,329,730 - 89,335,563 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Penk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248863,595,450 - 3,613,593 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248863,595,485 - 3,613,117 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Penk
113 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:321
Count of miRNA genes:258
Interacting mature miRNAs:283
Transcripts:ENSMUST00000070375, ENSMUST00000133567
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11049579Lmr9b_mleishmaniasis resistance 9b (mouse)4120657234Mouse
11049580Lmr9a_mleishmaniasis resistance 9 (mouse)4120657234Mouse
1301274Lmr9_mleishmaniasis resistance 9 (mouse)Not determined4120657234Mouse
10412079Sm1_msusceptibility to Schistosoma mansoni infection 1 (mouse)Not determined4122955614Mouse
1301510Bbaa13_mB.burgdorferi-associated arthritis 13 (mouse)Not determined4126395649Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse

Markers in Region
AI326464  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3844,133,826 - 4,133,967UniSTSGRCm38
MGSCv3744,060,973 - 4,061,114UniSTSGRCm37
Celera44,093,032 - 4,093,173UniSTS
Cytogenetic Map4A1UniSTS
cM Map40.8UniSTS
Whitehead/MRC_RH411.47UniSTS
M13227  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3844,133,732 - 4,133,845UniSTSGRCm38
MGSCv3744,060,879 - 4,060,992UniSTSGRCm37
Celera44,092,938 - 4,093,051UniSTS
Cytogenetic Map4A1UniSTS
cM Map40.8UniSTS
Whitehead/MRC_RH417.76UniSTS
Penk1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3844,133,589 - 4,133,702UniSTSGRCm38
MGSCv3744,060,736 - 4,060,849UniSTSGRCm37
Celera44,092,795 - 4,092,908UniSTS
Cytogenetic Map4A1UniSTS
cM Map97.0UniSTS
cM Map40.8UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000070375   ⟹   ENSMUSP00000066822
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl44,133,531 - 4,138,477 (-)Ensembl
GRCm38.p6 Ensembl44,133,531 - 4,138,477 (-)Ensembl
RefSeq Acc Id: ENSMUST00000133567   ⟹   ENSMUSP00000122389
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl44,134,112 - 4,138,819 (-)Ensembl
GRCm38.p6 Ensembl44,134,112 - 4,138,819 (-)Ensembl
RefSeq Acc Id: NM_001002927   ⟹   NP_001002927
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3944,133,536 - 4,138,445 (-)NCBI
GRCm3844,133,536 - 4,138,445 (-)NCBI
MGSCv3744,060,683 - 4,065,592 (-)RGD
Celera44,092,742 - 4,097,651 (-)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001348209   ⟹   NP_001335138
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3944,133,536 - 4,138,815 (-)NCBI
GRCm3844,133,536 - 4,138,815 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001002927   ⟸   NM_001002927
- Peptide Label: precursor
- UniProtKB: Q68G73 (UniProtKB/Swiss-Prot),   P22005 (UniProtKB/Swiss-Prot),   Q3UXY8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001335138   ⟸   NM_001348209
- Peptide Label: precursor
- UniProtKB: Q68G73 (UniProtKB/Swiss-Prot),   P22005 (UniProtKB/Swiss-Prot),   Q3UXY8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000066822   ⟸   ENSMUST00000070375
RefSeq Acc Id: ENSMUSP00000122389   ⟸   ENSMUST00000133567

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P22005-F1-model_v2 AlphaFold P22005 1-268 view protein structure

Promoters
RGD ID:6835860
Promoter ID:MM_KWN:36563
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:MEF_B4
Transcripts:OTTMUST00000009988,   OTTMUST00000009989,   UC008RXA.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3644,065,066 - 4,065,566 (-)MPROMDB
RGD ID:6882744
Promoter ID:EPDNEW_M4822
Type:initiation region
Name:Penk_1
Description:Mus musculus preproenkephalin , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3844,138,788 - 4,138,848EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104629 AgrOrtholog
Ensembl Genes ENSMUSG00000045573 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000070375 ENTREZGENE
  ENSMUST00000070375.8 UniProtKB/Swiss-Prot
  ENSMUST00000133567.2 UniProtKB/TrEMBL
InterPro Opioid_neupept UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Proenkphlin_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18619 UniProtKB/Swiss-Prot
MGD MGI:104629 ENTREZGENE
NCBI Gene 18619 ENTREZGENE
PANTHER PTHR11438 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11438:SF3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Opiods_neuropep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Penk PhenoGen
PRINTS OPIOIDPRCRSR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PENKAPRCRSR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE OPIOIDS_PRECURSOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
UniProt B1AZQ0_MOUSE UniProtKB/TrEMBL
  P22005 ENTREZGENE, UniProtKB/Swiss-Prot
  Q3UXY8 ENTREZGENE, UniProtKB/TrEMBL
  Q62256_MOUSE UniProtKB/TrEMBL
  Q68G73 ENTREZGENE
UniProt Secondary Q68G73 UniProtKB/Swiss-Prot