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Gene: Cyp8b1 (cytochrome P450, family 8, subfamily b, polypeptide 1) Mus musculus
Symbol: Cyp8b1
Name: cytochrome P450, family 8, subfamily b, polypeptide 1
Description: ENCODES a protein that exhibits sterol 12-alpha-hydroxylase activity (ortholog); INVOLVED IN oxidation-reduction process (inferred); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; congenital bile acid synthesis defect pathway; ASSOCIATED WITH abnormal bile salt homeostasis; abnormal bile salt level; abnormal bile secretion; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); cholestasis (ortholog); FOUND IN integral component of membrane (inferred); intracellular membrane-bounded organelle (inferred); membrane (inferred); INTERACTS WITH (S)-amphetamine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase; 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase; CYPVIIIB1; cytochrome P450 8B1; cytochrome P450, 8b1, sterol 12 alpha-hydrolase; sterol 12-alpha-hydrolase; sterol 12-alpha-hydroxylase
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm389121,914,356 - 121,916,305 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv379121,823,474 - 121,825,423 (-)NCBIGRCm37mm9NCBIm37
MGSCv369121,763,054 - 121,764,989 (-)NCBImm8
Celera9122,389,259 - 122,391,208 (-)NCBICelera
Cytogenetic Map9 F4NCBI
cM Map972.73NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Cyp8b1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732213
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.