Cyp8b1 (cytochrome P450, family 8, subfamily b, polypeptide 1) - Rat Genome Database

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Gene: Cyp8b1 (cytochrome P450, family 8, subfamily b, polypeptide 1) Mus musculus
Analyze
Symbol: Cyp8b1
Name: cytochrome P450, family 8, subfamily b, polypeptide 1
RGD ID: 732213
MGI Page MGI
Description: Predicted to have sterol 12-alpha-hydroxylase activity. Involved in bile acid biosynthetic process and positive regulation of intestinal cholesterol absorption. Predicted to localize to endoplasmic reticulum and integral component of membrane. Is expressed in several structures, including liver; lung; skeletal muscle; spleen; and testis. Orthologous to human CYP8B1 (cytochrome P450 family 8 subfamily B member 1); PARTICIPATES IN bile acid biosynthetic pathway; bile acid signaling pathway; cerebrotendinous xanthomatosis pathway; INTERACTS WITH (S)-amphetamine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase; 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase; CYPVIIIB1; cytochrome P450 8B1; cytochrome P450, 8b1, sterol 12 alpha-hydrolase; sterol 12-alpha-hydrolase; sterol 12-alpha-hydroxylase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399121,743,422 - 121,745,371 (-)NCBIGRCm39mm39
GRCm39 Ensembl9121,743,422 - 121,745,371 (-)Ensembl
GRCm389121,914,356 - 121,916,305 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9121,914,356 - 121,916,305 (-)EnsemblGRCm38mm10GRCm38
MGSCv379121,823,474 - 121,825,423 (-)NCBIGRCm37mm9NCBIm37
MGSCv369121,763,054 - 121,764,989 (-)NCBImm8
Celera9122,389,259 - 122,391,208 (-)NCBICelera
Cytogenetic Map9F4NCBI
cM Map972.73NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(S)-amphetamine  (EXP)
1-(3-(trifluoromethyl)phenyl)piperazine  (ISO)
1-benzylpiperazine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
1H-pyrazole  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-arachidonoylglycerol  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-amino-2,6-dinitrotoluene  (ISO)
4-hydroxyphenyl retinamide  (EXP)
8-Br-cAMP  (ISO)
acetamide  (ISO)
aflatoxin B1  (EXP,ISO)
AM-251  (EXP)
ammonium chloride  (ISO)
andrographolide  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP,ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[k]fluoranthene  (EXP)
beta-hexachlorocyclohexane  (EXP,ISO)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bromobenzene  (ISO)
buspirone  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (EXP)
cefalotin  (EXP)
cerium trichloride  (EXP)
chenodeoxycholic acid  (EXP,ISO)
chlorpromazine  (ISO)
cholesterol  (ISO)
cholic acid  (EXP,ISO)
choline  (EXP)
chrysophanol  (ISO)
ciguatoxin CTX1B  (EXP)
clofibrate  (EXP,ISO)
cyclosporin A  (EXP,ISO)
DDE  (EXP,ISO)
deoxycholic acid  (EXP,ISO)
dexamethasone  (ISO)
diclofenac  (EXP)
dieldrin  (ISO)
elemental selenium  (EXP)
emodin  (ISO)
endosulfan  (ISO)
erythromycin estolate  (ISO)
ethanol  (EXP)
fenofibrate  (ISO)
fipronil  (ISO)
fumonisin B1  (EXP)
ginsenoside Re  (ISO)
guggulsterone  (EXP)
GW 4064  (ISO)
Heliotrine  (ISO)
imipenem hydrate  (EXP)
kojic acid  (ISO)
L-methionine  (EXP)
lithocholic acid  (EXP)
melatonin  (EXP)
metacetamol  (EXP)
metformin  (ISO)
methapyrilene  (ISO)
methoxsalen  (ISO)
microcystin-LR  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nefazodone  (ISO)
neomycin  (EXP)
O-methyleugenol  (ISO)
obeticholic acid  (EXP,ISO)
oleanolic acid  (EXP)
orphenadrine  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
perfluorodecanoic acid  (EXP)
perfluorononanoic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (ISO)
phenobarbital  (EXP,ISO)
physcion  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
pyrazinecarboxamide  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
ritodrine  (EXP)
ritonavir  (ISO)
rotenone  (ISO)
selenium atom  (EXP)
senecionine  (ISO)
Senkirkine  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
streptozocin  (EXP,ISO)
sulindac  (ISO)
tamoxifen  (EXP,ISO)
Tesaglitazar  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thioacetamide  (ISO)
thyroxine  (ISO)
toluene  (ISO)
triadimefon  (EXP)
Triptolide  (EXP)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (EXP,ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
Yangonin  (EXP)

References

Additional References at PubMed
PMID:10051404   PMID:11682476   PMID:12393855   PMID:12477932   PMID:12745259   PMID:14681479   PMID:15489334   PMID:15994119   PMID:16264196   PMID:16516849   PMID:16763287   PMID:17237956  
PMID:17585019   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22111624   PMID:22737085   PMID:23262749   PMID:24226095   PMID:25338812   PMID:26824238   PMID:27146480   PMID:27197076  
PMID:28377401   PMID:29066462  


Genomics

Comparative Map Data
Cyp8b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399121,743,422 - 121,745,371 (-)NCBIGRCm39mm39
GRCm39 Ensembl9121,743,422 - 121,745,371 (-)Ensembl
GRCm389121,914,356 - 121,916,305 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9121,914,356 - 121,916,305 (-)EnsemblGRCm38mm10GRCm38
MGSCv379121,823,474 - 121,825,423 (-)NCBIGRCm37mm9NCBIm37
MGSCv369121,763,054 - 121,764,989 (-)NCBImm8
Celera9122,389,259 - 122,391,208 (-)NCBICelera
Cytogenetic Map9F4NCBI
cM Map972.73NCBI
CYP8B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl342,856,005 - 42,875,898 (-)EnsemblGRCh38hg38GRCh38
GRCh38342,872,192 - 42,875,879 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37342,913,684 - 42,917,371 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36342,888,688 - 42,892,637 (-)NCBINCBI36hg18NCBI36
Build 34342,888,687 - 42,892,637NCBI
Celera342,851,598 - 42,855,548 (-)NCBI
Cytogenetic Map3p22.1NCBI
HuRef342,956,837 - 42,960,786 (-)NCBIHuRef
CHM1_1342,863,684 - 42,867,633 (-)NCBICHM1_1
Cyp8b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28121,578,123 - 121,580,093 (-)NCBI
Rnor_6.0 Ensembl8130,548,418 - 130,550,388 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.08130,548,418 - 130,550,388 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08129,723,896 - 129,725,866 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48127,018,908 - 127,020,878 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18127,038,644 - 127,040,615 (+)NCBI
Celera8120,702,850 - 120,704,820 (-)NCBICelera
Cytogenetic Map8q32NCBI
LOC102019604
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542027,988,067 - 27,990,637 (+)NCBIChiLan1.0ChiLan1.0
CYP8B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1343,838,315 - 43,842,260 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl343,824,423 - 43,842,716 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0342,775,679 - 42,779,440 (-)NCBIMhudiblu_PPA_v0panPan3
CYP8B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12311,965,685 - 11,968,994 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2311,967,341 - 11,968,846 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2311,939,545 - 11,942,820 (-)NCBI
ROS_Cfam_1.02312,255,398 - 12,258,673 (-)NCBI
UMICH_Zoey_3.12312,057,378 - 12,060,653 (-)NCBI
UNSW_CanFamBas_1.02312,199,554 - 12,202,829 (-)NCBI
UU_Cfam_GSD_1.02312,202,997 - 12,206,280 (-)NCBI
LOC101977223
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118199,911,411 - 199,913,713 (+)NCBI
SpeTri2.0NW_0049366952,263,868 - 2,265,373 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP8B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1326,330,171 - 26,337,379 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11326,330,233 - 26,331,738 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CYP8B1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1224,323,840 - 4,326,459 (-)NCBI
ChlSab1.1 Ensembl224,324,396 - 4,325,901 (-)Ensembl

Position Markers
Cyp8b1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389121,915,600 - 121,915,990UniSTSGRCm38
MGSCv379121,824,718 - 121,825,108UniSTSGRCm37
Celera9122,390,503 - 122,390,893UniSTS
Cytogenetic Map9F4UniSTS
cM Map971.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:221
Count of miRNA genes:178
Interacting mature miRNAs:192
Transcripts:ENSMUST00000062474
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000062474   ⟹   ENSMUSP00000052989
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9121,914,356 - 121,916,305 (-)Ensembl
RefSeq Acc Id: NM_010012   ⟹   NP_034142
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399121,743,422 - 121,745,371 (-)NCBI
GRCm389121,914,356 - 121,916,305 (-)ENTREZGENE
MGSCv379121,823,474 - 121,825,423 (-)RGD
Celera9122,389,259 - 122,391,208 (-)RGD
cM Map9 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034142   ⟸   NM_010012
- UniProtKB: O88962 (UniProtKB/Swiss-Prot),   A0A0R4J0N7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000052989   ⟸   ENSMUST00000062474

Promoters
RGD ID:6844385
Promoter ID:MM_KWN:59220
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Liver,   Lung,   Spleen
Transcripts:NM_010012
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369121,823,916 - 121,825,567 (-)MPROMDB
RGD ID:8671284
Promoter ID:EPDNEW_M13672
Type:multiple initiation site
Name:Cyp8b1_1
Description:Mus musculus cytochrome P450, family 8, subfamily b, polypeptide1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389121,916,305 - 121,916,365EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1338044 AgrOrtholog
Ensembl Genes ENSMUSG00000050445 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000052989 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000062474 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CYP7A1-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-IV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cytochrome_CYP8B1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13124 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1338044 ENTREZGENE
NCBI Gene 13124 ENTREZGENE
PANTHER PTHR24306:SF0 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cyp8b1 PhenoGen
PIRSF Cytochrome_CYP8B1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cytochrome_CYPVIIA1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS EP450IV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0R4J0N7 ENTREZGENE, UniProtKB/TrEMBL
  CP8B1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q9R217 UniProtKB/Swiss-Prot