Srprb (signal recognition particle receptor, B subunit) - Rat Genome Database
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Gene: Srprb (signal recognition particle receptor, B subunit) Mus musculus
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Symbol: Srprb
Name: signal recognition particle receptor, B subunit
RGD ID: 1624076
MGI Page MGI
Description: Predicted to have ubiquitin protein ligase binding activity. Predicted to be involved in protein targeting to ER. Predicted to localize to cytoplasmic microtubule and signal recognition particle receptor complex. Is expressed in bone; naris; and rib. Orthologous to human SRPRB (SRP receptor subunit beta); INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: AA409543; signal recognition particle receptor subunit beta; SR-beta
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399103,065,232 - 103,079,264 (-)NCBIGRCm39mm39
GRCm389103,188,033 - 103,202,065 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9103,188,032 - 103,202,137 (-)EnsemblGRCm38mm10GRCm38
MGSCv379103,090,363 - 103,104,395 (-)NCBIGRCm37mm9NCBIm37
MGSCv369103,046,183 - 103,060,215 (-)NCBImm8
Celera9102,738,664 - 102,752,618 (-)NCBICelera
Cytogenetic Map9F1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7844142   PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11125038   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12904583   PMID:14610273  
PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21873635   PMID:22375059   PMID:27113764   PMID:28378742   PMID:30196744   PMID:30335684   PMID:30457570  


Genomics

Comparative Map Data
Srprb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399103,065,232 - 103,079,264 (-)NCBIGRCm39mm39
GRCm389103,188,033 - 103,202,065 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9103,188,032 - 103,202,137 (-)EnsemblGRCm38mm10GRCm38
MGSCv379103,090,363 - 103,104,395 (-)NCBIGRCm37mm9NCBIm37
MGSCv369103,046,183 - 103,060,215 (-)NCBImm8
Celera9102,738,664 - 102,752,618 (-)NCBICelera
Cytogenetic Map9F1NCBI
SRPRB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3133,784,023 - 133,825,772 (+)EnsemblGRCh38hg38GRCh38
GRCh383133,784,023 - 133,828,574 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373133,502,877 - 133,540,336 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363135,007,367 - 135,022,213 (+)NCBINCBI36hg18NCBI36
Build 343135,007,374 - 135,022,221NCBI
Celera3131,929,996 - 131,966,138 (+)NCBI
Cytogenetic Map3q22.1NCBI
HuRef3130,882,540 - 130,918,525 (+)NCBIHuRef
CHM1_13133,466,291 - 133,504,281 (+)NCBICHM1_1
Srprb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08111,673,479 - 111,687,426 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08111,064,462 - 111,078,409 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48108,196,684 - 108,210,631 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18108,216,139 - 108,230,086 (-)NCBI
Celera8103,146,886 - 103,160,831 (-)NCBICelera
Cytogenetic Map8q32NCBI
Srprb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555014,784,266 - 4,796,587 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555014,784,266 - 4,796,587 (-)NCBIChiLan1.0ChiLan1.0
SRPRB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13138,325,988 - 138,342,056 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3138,325,988 - 138,342,056 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03130,850,953 - 130,865,940 (+)NCBIMhudiblu_PPA_v0panPan3
SRPRB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2330,687,554 - 30,710,245 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12330,687,508 - 30,711,275 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Srprb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365296,952,472 - 6,967,542 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRPRB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1374,975,418 - 75,010,212 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11374,976,030 - 75,010,200 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21382,474,463 - 82,508,621 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SRPRB
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11556,545,201 - 56,580,591 (-)NCBI
ChlSab1.1 Ensembl1556,544,391 - 56,560,045 (-)Ensembl
Srprb
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473010,114,870 - 10,131,833 (+)NCBI

Position Markers
RH126543  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389103,189,126 - 103,189,375UniSTSGRCm38
MGSCv379103,091,456 - 103,091,705UniSTSGRCm37
Celera9102,739,757 - 102,740,006UniSTS
Cytogenetic Map9F1UniSTS
Whitehead/MRC_RH91053.84UniSTS
RH124868  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389103,189,280 - 103,189,368UniSTSGRCm38
MGSCv379103,091,610 - 103,091,698UniSTSGRCm37
Celera9102,739,911 - 102,739,999UniSTS
Cytogenetic Map9F1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959990000109260000Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1301302Pas4_mpulmonary adenoma susceptibility 4 (mouse)Not determined969239845103239920Mouse
1301621Hpic1_mhaloperidol-induced catalepsy 1 (mouse)Not determined969546513103546645Mouse
1301573Etohcta8_methanol conditioned taste aversion 8 (mouse)Not determined972977005106977152Mouse
10054068El8_mepilepsy 8 (mouse)Not determined972977005106977152Mouse
1301725Lifespan1_mlife span 1 (mouse)Not determined974368177108368325Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976535936110536130Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
10412180Msam3_mmuscle, skeletal, activity measure 3 (mouse)Not determined985897510108641186Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:988
Count of miRNA genes:514
Interacting mature miRNAs:632
Transcripts:ENSMUST00000035157, ENSMUST00000163567
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_009275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC156633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK007859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK008383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK015469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK030437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK075583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK167039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK182239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U17343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000035157   ⟹   ENSMUSP00000035157
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9103,188,032 - 103,202,137 (-)Ensembl
RefSeq Acc Id: ENSMUST00000163567
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9103,189,090 - 103,202,129 (-)Ensembl
RefSeq Acc Id: ENSMUST00000190760   ⟹   ENSMUSP00000151899
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9103,190,401 - 103,192,312 (-)Ensembl
RefSeq Acc Id: NM_009275   ⟹   NP_033301
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399103,065,232 - 103,079,264 (-)NCBI
GRCm389103,188,033 - 103,202,065 (-)ENTREZGENE
MGSCv379103,090,363 - 103,104,395 (-)RGD
Celera9102,738,664 - 102,752,618 (-)RGD
cM Map9 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_033301   ⟸   NM_009275
- UniProtKB: P47758 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000035157   ⟸   ENSMUST00000035157
RefSeq Acc Id: ENSMUSP00000151899   ⟸   ENSMUST00000190760

Promoters
RGD ID:6845212
Promoter ID:MM_KWN:58576
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:UC009RGH.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369103,094,776 - 103,095,276 (-)MPROMDB
RGD ID:6845213
Promoter ID:MM_KWN:58577
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000035157
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369103,104,101 - 103,104,601 (-)MPROMDB
RGD ID:8670628
Promoter ID:EPDNEW_M13345
Type:initiation region
Name:Srprb_1
Description:Mus musculus signal recognition particle receptor, B subunit, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389103,202,129 - 103,202,189EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:102964 AgrOrtholog
Ensembl Genes ENSMUSG00000032553 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000035157 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000151899 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000035157 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000190760 UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRP_receptor_beta_su UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20818 UniProtKB/Swiss-Prot
MGD MGI:102964 ENTREZGENE
NCBI Gene 20818 ENTREZGENE
PANTHER PTHR11485:SF34 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SRPRB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Srprb PhenoGen
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.273053 ENTREZGENE
UniProt A0A1W2P830_MOUSE UniProtKB/TrEMBL
  P47758 ENTREZGENE
  Q542X6_MOUSE UniProtKB/TrEMBL
  SRPRB_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q544X9 UniProtKB/Swiss-Prot
  Q9D872 UniProtKB/Swiss-Prot