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Gene: C4b (complement component 4B (Chido blood group)) Mus musculus
Symbol: C4b
Name: complement component 4B (Chido blood group)
Description: Predicted to have carbohydrate binding activity and complement component C1q complex binding activity. Involved in complement activation and immunoglobulin mediated immune response. Localizes to extracellular space. Is expressed in brain; liver; and reproductive system. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in autistic disorder; autoimmune hypersensitivity disease (multiple); complement deficiency (multiple); renal cell carcinoma; and rheumatoid arthritis. Orthologous to several human genes including C4B (complement C4B (Chido blood group)); PARTICIPATES IN classical complement pathway; coagulation cascade pathway; complement system pathway; INTERACTS WITH (R)-lipoic acid; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C4; complement C4-B; complement component 4 (within H-2S); complement component 4B (Childo blood group); Ss
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1734,728,380 - 34,743,882 (-)EnsemblGRCm38mm10GRCm38
GRCm381734,728,139 - 34,743,902 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371734,865,325 - 34,880,842 (-)NCBIGRCm37mm9NCBIm37
MGSCv361734,336,443 - 34,351,939 (-)NCBImm8
Celera1737,826,575 - 37,840,058 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.29NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on C4b
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10257
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.