Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Grk6 (G protein-coupled receptor kinase 6) Mus musculus
Symbol: Grk6
Name: G protein-coupled receptor kinase 6
Description: Exhibits protein kinase activity. Involved in protein phosphorylation. Predicted to localize to cytosol and plasma membrane. Is expressed in several structures, including genitourinary system; liver; lung; spleen; and submandibular gland primordium. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human GRK6 (G protein-coupled receptor kinase 6); PARTICIPATES IN angiotensin II signaling pathway via AT1 receptor; corticotropin-releasing hormone signaling pathway; dopamine signaling pathway via D1 family of receptors; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: g protein-coupled receptor kinase GRK6; Gpr; Gprk6
Homo sapiens (human) : GRK6 (G protein-coupled receptor kinase 6)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Grk6 (G protein-coupled receptor kinase 6)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grk6 (G protein-coupled receptor kinase 6)
Pan paniscus (bonobo/pygmy chimpanzee) : GRK6 (G protein-coupled receptor kinase 6)
Canis lupus familiaris (dog) : GRK6 (G protein-coupled receptor kinase 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grk6 (G protein-coupled receptor kinase 6)
Sus scrofa (pig) : GRK6 (G protein-coupled receptor kinase 6)
Chlorocebus sabaeus (African green monkey) : GRK6 (G protein-coupled receptor kinase 6)
Heterocephalus glaber (naked mole-rat) : Grk6 (G protein-coupled receptor kinase 6)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1355,445,072 - 55,460,927 (+)EnsemblGRCm38mm10GRCm38
GRCm381355,445,072 - 55,460,927 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371355,546,695 - 55,562,288 (+)NCBIGRCm37mm9NCBIm37
MGSCv361355,455,083 - 55,470,548 (+)NCBImm8
Celera1356,499,490 - 56,514,953 (+)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1330.06NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Grk6
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 62278
Created: 2001-04-11
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.