Grk6 (G protein-coupled receptor kinase 6) - Rat Genome Database

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Gene: Grk6 (G protein-coupled receptor kinase 6) Mus musculus
Analyze
Symbol: Grk6
Name: G protein-coupled receptor kinase 6
RGD ID: 62278
MGI Page MGI
Description: Predicted to enable G protein-coupled receptor kinase activity and beta-adrenergic receptor kinase activity. Predicted to be involved in desensitization of G protein-coupled receptor signaling pathway; negative regulation of anion channel activity; and protein phosphorylation. Predicted to act upstream of or within Wnt signaling pathway and phosphorylation. Predicted to be located in cytosol. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including genitourinary system; liver; lung; spleen; and submandibular gland primordium. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human GRK6 (G protein-coupled receptor kinase 6).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: g protein-coupled receptor kinase GRK6; Gpr; Gprk6
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391355,592,865 - 55,608,740 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1355,592,885 - 55,608,740 (+)EnsemblGRCm39 Ensembl
GRCm381355,445,072 - 55,460,927 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1355,445,072 - 55,460,927 (+)EnsemblGRCm38mm10GRCm38
MGSCv371355,546,695 - 55,562,288 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361355,455,083 - 55,470,548 (+)NCBIMGSCv36mm8
Celera1356,499,490 - 56,514,953 (+)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1330.06NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Altered expression and subcellular distribution of GRK subtypes in the dopamine-depleted rat basal ganglia is not normalized by l-DOPA treatment. Ahmed MR, etal., J Neurochem. 2008 Mar;104(6):1622-36. Epub 2007 Nov 7.
2. Lentiviral overexpression of GRK6 alleviates L-dopa-induced dyskinesia in experimental Parkinson's disease. Ahmed MR, etal., Sci Transl Med. 2010 Apr 21;2(28):28ra28.
3. The physiology, signaling, and pharmacology of dopamine receptors. Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8.
4. Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice. Fong AM, etal., Proc Natl Acad Sci U S A 2002 May 28;99(11):7478-83.
5. Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice. Gainetdinov RR, etal., Neuron. 2003 Apr 24;38(2):291-303.
6. The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology. Hillhouse EW and Grammatopoulos DK, Endocr Rev. 2006 May;27(3):260-86. Epub 2006 Feb 16.
7. Decreased expression and activity of G-protein-coupled receptor kinases in peripheral blood mononuclear cells of patients with rheumatoid arthritis. Lombardi MS, etal., FASEB J. 1999 Apr;13(6):715-25.
8. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
9. MGDs mouse GO annotations MGD data from the GO Consortium
10. MGD IEA MGD IEA
11. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. The GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservation. Premont RT, etal., J Biol Chem 1999 Oct 8;274(41):29381-9.
14. Mouse MP Annotation Import Pipeline RGD automated import pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Authentically phosphorylated alpha-synuclein at Ser129 accelerates neurodegeneration in a rat model of familial Parkinson's disease. Sato H, etal., J Neurosci. 2011 Nov 16;31(46):16884-94.
18. Angiotensin II-stimulated signaling through G proteins and beta-arrestin. Shenoy SK and Lefkowitz RJ, Sci STKE. 2005 Nov 22;2005(311):cm14.
19. Expression of G-protein-coupled receptor kinase 6 (GRK6) after acute spinal cord injury in adult rat. Sun B, etal., J Mol Histol. 2013 Jun;44(3):259-70. doi: 10.1007/s10735-013-9486-7. Epub 2013 Jan 29.
20. Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN). Tarrant TK, etal., Clin Immunol. 2008 Oct;129(1):115-22. Epub 2008 Jul 26.
21. Renoprotective effects of berberine and its possible molecular mechanisms in combination of high-fat diet and low-dose streptozotocin-induced diabetic rats. Wang FL, etal., Mol Biol Rep. 2013 Mar;40(3):2405-18. doi: 10.1007/s11033-012-2321-5. Epub 2012 Nov 30.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10446210   PMID:10486211   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11812828   PMID:12477932   PMID:12520002   PMID:14610273   PMID:14634128  
PMID:14704365   PMID:15716360   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16302968   PMID:16602821   PMID:16980298   PMID:17060617   PMID:17538017   PMID:17786238   PMID:18180038  
PMID:18799693   PMID:18977289   PMID:19497686   PMID:19801552   PMID:20530803   PMID:20861385   PMID:21267068   PMID:21873635   PMID:22393477   PMID:22869904   PMID:23443560   PMID:23589623  
PMID:24510965   PMID:25881508   PMID:26234352   PMID:26886170   PMID:27245949   PMID:27882944   PMID:28457871   PMID:28939643   PMID:29166587   PMID:29627294   PMID:29969579   PMID:30576947  
PMID:32325033   PMID:32343709   PMID:32486261   PMID:36030052  


Genomics

Comparative Map Data
Grk6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391355,592,865 - 55,608,740 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1355,592,885 - 55,608,740 (+)EnsemblGRCm39 Ensembl
GRCm381355,445,072 - 55,460,927 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1355,445,072 - 55,460,927 (+)EnsemblGRCm38mm10GRCm38
MGSCv371355,546,695 - 55,562,288 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361355,455,083 - 55,470,548 (+)NCBIMGSCv36mm8
Celera1356,499,490 - 56,514,953 (+)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1330.06NCBI
GRK6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385177,425,523 - 177,442,891 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5177,403,204 - 177,442,901 (+)EnsemblGRCh38hg38GRCh38
GRCh375176,853,677 - 176,869,892 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365176,786,293 - 176,802,456 (+)NCBINCBI36Build 36hg18NCBI36
Build 345176,786,293 - 176,802,437NCBI
Celera5171,631,577 - 171,647,739 (-)NCBICelera
Cytogenetic Map5q35.3NCBI
HuRef5171,774,137 - 171,790,304 (+)NCBIHuRef
CHM1_15176,287,084 - 176,303,247 (+)NCBICHM1_1
T2T-CHM13v2.05177,969,927 - 177,986,142 (+)NCBIT2T-CHM13v2.0
Grk6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2179,177,018 - 9,192,644 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,177,019 - 9,192,644 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx179,193,134 - 9,208,842 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01710,723,188 - 10,738,879 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0179,189,522 - 9,205,228 (-)NCBIRnor_WKY
Rnor_6.0179,705,917 - 9,721,921 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,703,453 - 9,721,574 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01711,814,901 - 11,830,762 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41715,220,992 - 15,236,617 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11715,221,263 - 15,236,617 (-)NCBI
Celera179,255,527 - 9,271,204 (-)NCBICelera
Cytogenetic Map17p14NCBI
Grk6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540829,665,260 - 29,684,207 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540829,665,534 - 29,684,225 (+)NCBIChiLan1.0ChiLan1.0
GRK6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15179,790,665 - 179,807,473 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5179,790,662 - 179,807,410 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05172,704,978 - 172,744,907 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
GRK6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1435,927,470 - 35,943,218 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl435,913,472 - 35,943,221 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha435,894,854 - 35,910,623 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0436,293,886 - 36,309,656 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl436,293,889 - 36,309,637 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1436,119,132 - 36,134,901 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0436,305,102 - 36,320,864 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0436,814,574 - 36,830,339 (-)NCBIUU_Cfam_GSD_1.0
Grk6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213122,681,758 - 122,697,463 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365971,706,665 - 1,722,370 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365971,706,671 - 1,722,370 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRK6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl280,508,979 - 80,527,210 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1280,496,105 - 80,527,208 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GRK6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12379,437,056 - 79,454,213 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2379,437,078 - 79,453,113 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607510,628,695 - 10,645,867 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grk6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473312,633,565 - 12,661,284 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:584
Count of miRNA genes:408
Interacting mature miRNAs:456
Transcripts:ENSMUST00000001115, ENSMUST00000099482
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13395000076048119Mouse
1301015Sysbp2_msystolic blood pressure 2 (mouse)Not determined132047761259821605Mouse
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse
1357591Tesq1_mtestis weight QTL 1 (mouse)Not determined132061551255720517Mouse
4142009Pregq3_mpregnancy QTL 3 (mouse)Not determined132061551272385189Mouse
4142489Ath25_matherosclerosis 25 (mouse)Not determined2583652959836529Mouse
10401111Pgia40_mproteoglycan induced arthritis 40 (mouse)Not determined132791846961918560Mouse
1300710Pcd4ts2_mp-glycoprotein positive CD4 T cell subset 2 (mouse)Not determined132821044262210544Mouse
1357802Vtbt15_mvertebral trabecular bone trait 15 (mouse)Not determined132821737962217515Mouse
10045621Heal21_mwound healing/regeneration 21 (mouse)Not determined132821737962217515Mouse
10755533Chol18_mcholesterol 18 (mouse)133096946764969467Mouse
10755517Chol15_mcholesterol 15 (mouse)133096946764969467Mouse
12738439Twq4_mtestis weight QTL 4 (mouse)133112911065129110Mouse
14696729Kidlq2_mkidney weight, left QTL 2 (mouse)133134473665344736Mouse
1301299Sluc23_msusceptibility to lung cancer 23 (mouse)Not determined133492194368922081Mouse
10412235Scgq5_mspontaneous crescentic glomerulonephritis QTL 5 (mouse)Not determined133606090896239162Mouse
1357587Pfat3_mpredicted fat percentage 3 (mouse)Not determined133610153070101640Mouse
1301734Acsns2_mAngiostrongylus costaricensis nematode susceptibility 2 (mouse)Not determined133610153070101640Mouse
1300561Heal7_mwound healing/regeneration 7 (mouse)Not determined133614482070144904Mouse
1300862Cfbw5_mcystic fibrosis body weight 5 (mouse)Not determined133872035872720517Mouse
1300985Bmd13_mbone mineral density 13 (mouse)Not determined133962924973629397Mouse
1302157Bwem2_mbody weight day 30 males 2 (mouse)Not determined133962924973629397Mouse
1301801Cpfd5_mcerebellum pattern fissures (mouse)Not determined133962924973629397Mouse
15039353Nmrs35_mNAFLD-associated magnetic resonance shift 35 (mouse)134058825374588253Mouse
1300668Pas10_mpulmonary adenoma susceptibility 10 (mouse)Not determined134148904275489158Mouse
4142331Bxs6_mBXSB/MpJ autoimmune nephritis 6 (mouse)Not determined4521044283744746Mouse
10412109Bxs7_mBXSB/MpJ autoimmune nephritis 7 (mouse)Not determined134521044283744746Mouse
26884396Humsd4_mhumerus midshaft diameter 4, 10 week (mouse)134785347673148119Mouse
4142372Moo2_mmodifier of Odc2 (mouse)Not determinedX5031841184318559Mouse
1301666Eae13_msusceptibility to experimental allergic encephalomyelitis 13 (mouse)Not determined135031841184318559Mouse
1300573Elsgp2_melevated serum gp70 2 (mouse)Not determined135061682884617027Mouse
14746975Manh74_mmandible shape 74 (mouse)135247726986477269Mouse
1302073Pgct1_mprimordial germ cell tumor locus 1 (mouse)Not determined135382078387820897Mouse
1357563Bmch6_mbone mechanical trait 6 (mouse)Not determined135538498089385140Mouse

Markers in Region
Gprk6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381355,453,174 - 55,453,523UniSTSGRCm38
MGSCv371355,554,535 - 55,554,884UniSTSGRCm37
Celera1356,507,202 - 56,507,551UniSTS
Cytogenetic Map13B1-3UniSTS
cM Map1335.0UniSTS
Y15798  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381355,460,230 - 55,460,357UniSTSGRCm38
GRCm384100,850,842 - 100,850,969UniSTSGRCm38
MGSCv371355,561,591 - 55,561,718UniSTSGRCm37
MGSCv374100,523,447 - 100,523,574UniSTSGRCm37
Celera1356,514,256 - 56,514,383UniSTS
Celera499,206,830 - 99,206,957UniSTS
Cytogenetic Map4C6UniSTS
Cytogenetic Map13B1-3UniSTS
Whitehead/MRC_RH13568.97UniSTS
RH141163  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381355,460,590 - 55,460,786UniSTSGRCm38
GRCm384100,850,404 - 100,850,600UniSTSGRCm38
MGSCv371355,561,951 - 55,562,147UniSTSGRCm37
MGSCv374100,523,009 - 100,523,205UniSTSGRCm37
Celera1356,514,616 - 56,514,812UniSTS
Celera499,206,392 - 99,206,588UniSTS
Cytogenetic Map4C6UniSTS
Cytogenetic Map13B1-3UniSTS
Grk6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13B1-3UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001038018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001112711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001286063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001286064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001286065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001286066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001377076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001377077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF040747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF040748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF040749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF040754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK051405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK180303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK187852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW048460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC057206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC075719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA528447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD354984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ179645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT009762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y15797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y15798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y15799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y15800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y17967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000001115   ⟹   ENSMUSP00000001115
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1355,593,151 - 55,608,740 (+)Ensembl
GRCm38.p6 Ensembl1355,445,338 - 55,460,927 (+)Ensembl
RefSeq Acc Id: ENSMUST00000099482   ⟹   ENSMUSP00000097081
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1355,593,274 - 55,607,589 (+)Ensembl
GRCm38.p6 Ensembl1355,445,461 - 55,459,776 (+)Ensembl
RefSeq Acc Id: ENSMUST00000224118   ⟹   ENSMUSP00000152968
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1355,593,274 - 55,607,868 (+)Ensembl
GRCm38.p6 Ensembl1355,445,461 - 55,460,055 (+)Ensembl
RefSeq Acc Id: ENSMUST00000224532
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1355,606,052 - 55,606,886 (+)Ensembl
GRCm38.p6 Ensembl1355,458,239 - 55,459,073 (+)Ensembl
RefSeq Acc Id: ENSMUST00000224653   ⟹   ENSMUSP00000153623
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1355,592,885 - 55,608,735 (+)Ensembl
GRCm38.p6 Ensembl1355,445,072 - 55,460,922 (+)Ensembl
RefSeq Acc Id: ENSMUST00000224995   ⟹   ENSMUSP00000153344
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1355,593,159 - 55,608,740 (+)Ensembl
GRCm38.p6 Ensembl1355,445,346 - 55,460,927 (+)Ensembl
RefSeq Acc Id: ENSMUST00000225925   ⟹   ENSMUSP00000153668
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1355,593,270 - 55,608,738 (+)Ensembl
GRCm38.p6 Ensembl1355,445,457 - 55,460,925 (+)Ensembl
RefSeq Acc Id: NM_001038018   ⟹   NP_001033107
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391355,593,142 - 55,608,740 (+)NCBI
GRCm381355,445,331 - 55,460,927 (+)NCBI
MGSCv371355,546,695 - 55,562,288 (+)RGD
Celera1356,499,193 - 56,514,953 (+)NCBI
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001112711   ⟹   NP_001106182
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391355,593,144 - 55,608,740 (+)NCBI
GRCm381355,445,331 - 55,460,927 (+)NCBI
MGSCv371355,546,695 - 55,562,288 (+)RGD
Celera1356,499,193 - 56,514,953 (+)NCBI
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001286063   ⟹   NP_001272992
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391355,592,865 - 55,608,740 (+)NCBI
GRCm381355,445,072 - 55,460,927 (+)NCBI
Celera1356,499,193 - 56,514,953 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001286064   ⟹   NP_001272993
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391355,593,142 - 55,608,740 (+)NCBI
GRCm381355,445,331 - 55,460,927 (+)NCBI
Celera1356,499,193 - 56,514,953 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001286065   ⟹   NP_001272994
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391355,593,144 - 55,608,740 (+)NCBI
GRCm381355,445,331 - 55,460,927 (+)NCBI
Celera1356,499,193 - 56,514,953 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001286066   ⟹   NP_001272995
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391355,593,142 - 55,608,740 (+)NCBI
GRCm381355,445,329 - 55,460,927 (+)NCBI
Celera1356,499,193 - 56,514,953 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001377076   ⟹   NP_001364005
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391355,593,142 - 55,608,740 (+)NCBI
GRCm381355,445,329 - 55,460,927 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001377077   ⟹   NP_001364006
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391355,593,142 - 55,608,740 (+)NCBI
GRCm381355,445,329 - 55,460,927 (+)NCBI
Sequence:
RefSeq Acc Id: NM_011938   ⟹   NP_036068
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391355,593,142 - 55,608,740 (+)NCBI
GRCm381355,445,329 - 55,460,927 (+)NCBI
MGSCv371355,546,695 - 55,562,288 (+)RGD
Celera1356,499,193 - 56,514,953 (+)NCBI
cM Map13 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001033107 (Get FASTA)   NCBI Sequence Viewer  
  NP_001106182 (Get FASTA)   NCBI Sequence Viewer  
  NP_001272992 (Get FASTA)   NCBI Sequence Viewer  
  NP_001272993 (Get FASTA)   NCBI Sequence Viewer  
  NP_001272994 (Get FASTA)   NCBI Sequence Viewer  
  NP_001272995 (Get FASTA)   NCBI Sequence Viewer  
  NP_001364005 (Get FASTA)   NCBI Sequence Viewer  
  NP_001364006 (Get FASTA)   NCBI Sequence Viewer  
  NP_036068 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC09263 (Get FASTA)   NCBI Sequence Viewer  
  AAC09264 (Get FASTA)   NCBI Sequence Viewer  
  AAC09265 (Get FASTA)   NCBI Sequence Viewer  
  AAC09268 (Get FASTA)   NCBI Sequence Viewer  
  AAC09269 (Get FASTA)   NCBI Sequence Viewer  
  AAC09270 (Get FASTA)   NCBI Sequence Viewer  
  AAH75719 (Get FASTA)   NCBI Sequence Viewer  
  BAE26914 (Get FASTA)   NCBI Sequence Viewer  
  BAE36212 (Get FASTA)   NCBI Sequence Viewer  
  CAA75788 (Get FASTA)   NCBI Sequence Viewer  
  CAA75789 (Get FASTA)   NCBI Sequence Viewer  
  CAA75790 (Get FASTA)   NCBI Sequence Viewer  
  CAA75791 (Get FASTA)   NCBI Sequence Viewer  
  CAA76974 (Get FASTA)   NCBI Sequence Viewer  
  CAA76975 (Get FASTA)   NCBI Sequence Viewer  
  CAA76976 (Get FASTA)   NCBI Sequence Viewer  
  CAA76977 (Get FASTA)   NCBI Sequence Viewer  
  EDL41192 (Get FASTA)   NCBI Sequence Viewer  
  EDL41193 (Get FASTA)   NCBI Sequence Viewer  
  EDL41194 (Get FASTA)   NCBI Sequence Viewer  
  EDL41195 (Get FASTA)   NCBI Sequence Viewer  
  EDL41196 (Get FASTA)   NCBI Sequence Viewer  
  O70293 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_036068   ⟸   NM_011938
- Peptide Label: isoform b
- UniProtKB: O70293 (UniProtKB/Swiss-Prot),   Q9EP84 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001033107   ⟸   NM_001038018
- Peptide Label: isoform a
- UniProtKB: O70293 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001106182   ⟸   NM_001112711
- Peptide Label: isoform c
- UniProtKB: Q6DI67 (UniProtKB/Swiss-Prot),   O70293 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001272992   ⟸   NM_001286063
- Peptide Label: isoform d
- UniProtKB: O70293 (UniProtKB/Swiss-Prot),   A0A286YDZ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001272994   ⟸   NM_001286065
- Peptide Label: isoform f
- UniProtKB: O70293 (UniProtKB/Swiss-Prot),   A0A286YE10 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001272993   ⟸   NM_001286064
- Peptide Label: isoform e
- UniProtKB: O70293 (UniProtKB/Swiss-Prot),   A0A286YDA5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001272995   ⟸   NM_001286066
- Peptide Label: isoform g
- UniProtKB: Q9EP84 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001364005   ⟸   NM_001377076
- Peptide Label: isoform h
RefSeq Acc Id: NP_001364006   ⟸   NM_001377077
- Peptide Label: isoform i
RefSeq Acc Id: ENSMUSP00000097081   ⟸   ENSMUST00000099482
RefSeq Acc Id: ENSMUSP00000001115   ⟸   ENSMUST00000001115
RefSeq Acc Id: ENSMUSP00000153668   ⟸   ENSMUST00000225925
RefSeq Acc Id: ENSMUSP00000153344   ⟸   ENSMUST00000224995
RefSeq Acc Id: ENSMUSP00000153623   ⟸   ENSMUST00000224653
RefSeq Acc Id: ENSMUSP00000152968   ⟸   ENSMUST00000224118
Protein Domains
AGC-kinase C-terminal   Protein kinase   RGS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O70293-F1-model_v2 AlphaFold O70293 1-576 view protein structure

Promoters
RGD ID:8680448
Promoter ID:EPDNEW_M18254
Type:initiation region
Name:Grk6_1
Description:Mus musculus G protein-coupled receptor kinase 6 , transcriptvariant 6, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381355,445,336 - 55,445,396EPDNEW
RGD ID:6824001
Promoter ID:MM_KWN:14241
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_001038018,   NM_001112711,   NM_011938,   UC007QQW.1,   UC007QQY.1,   UC007QQZ.1,   UC007QRA.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361355,545,891 - 55,546,857 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1347078 AgrOrtholog
Ensembl Genes ENSMUSG00000074886 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000001115.9 UniProtKB/Swiss-Prot
  ENSMUSP00000097081 ENTREZGENE
  ENSMUSP00000097081.4 UniProtKB/TrEMBL
  ENSMUSP00000152968 ENTREZGENE
  ENSMUSP00000152968.2 UniProtKB/Swiss-Prot
  ENSMUSP00000153344.2 UniProtKB/TrEMBL
  ENSMUSP00000153623 ENTREZGENE
  ENSMUSP00000153623.2 UniProtKB/TrEMBL
  ENSMUSP00000153668 ENTREZGENE
  ENSMUSP00000153668.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000001115.16 UniProtKB/Swiss-Prot
  ENSMUST00000099482 ENTREZGENE
  ENSMUST00000099482.5 UniProtKB/TrEMBL
  ENSMUST00000224118 ENTREZGENE
  ENSMUST00000224118.2 UniProtKB/Swiss-Prot
  ENSMUST00000224653 ENTREZGENE
  ENSMUST00000224653.2 UniProtKB/TrEMBL
  ENSMUST00000224995.2 UniProtKB/TrEMBL
  ENSMUST00000225925 ENTREZGENE
  ENSMUST00000225925.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.167.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.287.1270 UniProtKB/TrEMBL
  6.10.250.2260 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_subdomain_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:26385 UniProtKB/Swiss-Prot
MGD MGI:1347078 ENTREZGENE
NCBI Gene 26385 ENTREZGENE
PANTHER G PROTEIN-COUPLED RECEPTOR KINASE 6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Grk6 PhenoGen
PRINTS GPCRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TK_X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48097 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A286YDA5 ENTREZGENE, UniProtKB/TrEMBL
  A0A286YDZ5 ENTREZGENE, UniProtKB/TrEMBL
  A0A286YE10 ENTREZGENE, UniProtKB/TrEMBL
  GRK6_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  O70296_MOUSE UniProtKB/TrEMBL
  Q3TTW2_MOUSE UniProtKB/TrEMBL
  Q3UK88_MOUSE UniProtKB/TrEMBL
  Q6DI67 ENTREZGENE
  Q792R0_MOUSE UniProtKB/TrEMBL
  Q9EP84 ENTREZGENE, UniProtKB/TrEMBL
  Q9EPB9_MOUSE UniProtKB/TrEMBL
UniProt Secondary O70294 UniProtKB/Swiss-Prot
  O70295 UniProtKB/Swiss-Prot
  Q6DI67 UniProtKB/Swiss-Prot