Imported Disease Annotations - ClinVarObject Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Grk6 | Mouse | Ehlers-Danlos syndrome dermatosparaxis type | | ISO | GRK6 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Ehlers-Danlos syndrome and dermatosparaxis type | ClinVar | PMID:16770806 more ... | Grk6 | Mouse | Ehlers-Danlos syndrome spondylodysplastic type 2 | | ISO | GRK6 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Ehlers-Danlos syndrome progeroid type | ClinVar | PMID:28492532 | Grk6 | Mouse | Marfanoid Mental Retardation Syndrome, Autosomal | | ISO | GRK6 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Marfanoid habitus and intellectual disability | ClinVar | PMID:25741868 | Grk6 | Mouse | Sotos syndrome | | ISO | GRK6 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Sotos syndrome | ClinVar | PMID:12464997 more ... | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Imported Disease Annotations - CTD
Gene-Chemical Interaction Annotations Click to see Annotation Detail View
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Biological Process
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Imported Annotations - KEGG (archival)
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Altered expression and subcellular distribution of GRK subtypes in the dopamine-depleted rat basal ganglia is not normalized by l-DOPA treatment. | Ahmed MR, etal., J Neurochem. 2008 Mar;104(6):1622-36. Epub 2007 Nov 7. |
| 2. | Lentiviral overexpression of GRK6 alleviates L-dopa-induced dyskinesia in experimental Parkinson's disease. | Ahmed MR, etal., Sci Transl Med. 2010 Apr 21;2(28):28ra28. |
| 3. | The physiology, signaling, and pharmacology of dopamine receptors. | Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8. |
| 4. | Decreased immunodensities of micro-opioid receptors, receptor kinases GRK 2/6 and beta-arrestin-2 in postmortem brains of opiate addicts. | Ferrer-Alcón M, etal., Brain Res Mol Brain Res. 2004 Feb 5;121(1-2):114-22. doi: 10.1016/j.molbrainres.2003.11.009. |
| 5. | Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice. | Fong AM, etal., Proc Natl Acad Sci U S A 2002 May 28;99(11):7478-83. |
| 6. | Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice. | Gainetdinov RR, etal., Neuron. 2003 Apr 24;38(2):291-303. |
| 7. | The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology. | Hillhouse EW and Grammatopoulos DK, Endocr Rev. 2006 May;27(3):260-86. Epub 2006 Feb 16. |
| 8. | Decreased expression and activity of G-protein-coupled receptor kinases in peripheral blood mononuclear cells of patients with rheumatoid arthritis. | Lombardi MS, etal., FASEB J. 1999 Apr;13(6):715-25. |
| 9. | Electronic Transfer of Homolog Data | MGD and Homologene mouse data transfer |
| 10. | MGDs mouse GO annotations | MGD data from the GO Consortium |
| 11. | MGD IEA | MGD IEA |
| 12. | Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. | Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73. |
| 13. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
| 14. | The GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservation. | Premont RT, etal., J Biol Chem 1999 Oct 8;274(41):29381-9. |
| 15. | Mouse MP Annotation Import Pipeline | RGD automated import pipeline |
| 16. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 17. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 18. | Authentically phosphorylated alpha-synuclein at Ser129 accelerates neurodegeneration in a rat model of familial Parkinson's disease. | Sato H, etal., J Neurosci. 2011 Nov 16;31(46):16884-94. |
| 19. | Angiotensin II-stimulated signaling through G proteins and beta-arrestin. | Shenoy SK and Lefkowitz RJ, Sci STKE. 2005 Nov 22;2005(311):cm14. |
| 20. | Expression of G-protein-coupled receptor kinase 6 (GRK6) after acute spinal cord injury in adult rat. | Sun B, etal., J Mol Histol. 2013 Jun;44(3):259-70. doi: 10.1007/s10735-013-9486-7. Epub 2013 Jan 29. |
| 21. | Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN). | Tarrant TK, etal., Clin Immunol. 2008 Oct;129(1):115-22. Epub 2008 Jul 26. |
| 22. | Renoprotective effects of berberine and its possible molecular mechanisms in combination of high-fat diet and low-dose streptozotocin-induced diabetic rats. | Wang FL, etal., Mol Biol Rep. 2013 Mar;40(3):2405-18. doi: 10.1007/s11033-012-2321-5. Epub 2012 Nov 30. |
Additional References at PubMed
| PMID:8889548 | PMID:10349636 | PMID:10446210 | PMID:10486211 | PMID:11042159 | PMID:11076861 | PMID:11217851 | PMID:11812828 | PMID:12477932 | PMID:12520002 | PMID:14610273 | PMID:14634128 |
| PMID:14704365 | PMID:15716360 | PMID:15782199 | PMID:16141072 | PMID:16141073 | PMID:16302968 | PMID:16602821 | PMID:16980298 | PMID:17060617 | PMID:17538017 | PMID:17786238 | PMID:18180038 |
| PMID:18799693 | PMID:18977289 | PMID:19497686 | PMID:19801552 | PMID:20530803 | PMID:20861385 | PMID:21267068 | PMID:21873635 | PMID:22393477 | PMID:22869904 | PMID:23443560 | PMID:23589623 |
| PMID:24510965 | PMID:25881508 | PMID:26234352 | PMID:26886170 | PMID:27245949 | PMID:27882944 | PMID:28457871 | PMID:28939643 | PMID:29166587 | PMID:29627294 | PMID:29969579 | PMID:30576947 |
| PMID:32325033 | PMID:32343709 | PMID:32486261 | PMID:36030052 | PMID:36451830 |
Genomics
Comparative Map Data
| Grk6 (Mus musculus - house mouse) |
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| GRK6 (Homo sapiens - human) |
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| Grk6 (Rattus norvegicus - Norway rat) |
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| Grk6 (Chinchilla lanigera - long-tailed chinchilla) |
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| GRK6 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| GRK6 (Canis lupus familiaris - dog) |
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| Grk6 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| GRK6 (Sus scrofa - pig) |
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| GRK6 (Chlorocebus sabaeus - green monkey) |
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| Grk6 (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Grk6
471 total Variants 
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