Rgs2 (regulator of G-protein signaling 2) - Rat Genome Database

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Gene: Rgs2 (regulator of G-protein signaling 2) Mus musculus
Analyze
Symbol: Rgs2
Name: regulator of G-protein signaling 2
RGD ID: 732361
MGI Page MGI
Description: Enables adenylate cyclase inhibitor activity. Involved in several processes, including negative regulation of signal transduction; regulation of muscle system process; and relaxation of cardiac muscle. Acts upstream of or within brown fat cell differentiation. Located in cytoplasmic side of plasma membrane and cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and immune system. Orthologous to human RGS2 (regulator of G protein signaling 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GO; GOS8
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391143,875,076 - 143,879,887 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1143,875,076 - 143,879,899 (-)EnsemblGRCm39 Ensembl
GRCm381143,999,338 - 144,004,149 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1143,999,338 - 144,004,161 (-)EnsemblGRCm38mm10GRCm38
MGSCv371145,846,468 - 145,851,279 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361145,762,215 - 145,766,367 (-)NCBIMGSCv36mm8
Celera1146,559,706 - 146,564,519 (-)NCBICelera
Cytogenetic Map1FNCBI
cM Map162.56NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (EXP)
1,2,4-trimethylbenzene  (ISO)
1,2-dichloroethane  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (ISO)
2-butoxyethanol  (EXP)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (ISO)
3-iodobenzyl-5'-N-methylcarboxamidoadenosine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
Benzo[ghi]perylene  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
caffeine  (EXP)
captan  (EXP)
carbon nanotube  (EXP)
CGP 52608  (ISO)
CGS-21680  (ISO)
chlordecone  (EXP)
chloropicrin  (ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP)
cholesterol  (ISO)
choline  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP,ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (EXP)
dieldrin  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
enzalutamide  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
flavonoids  (ISO)
folic acid  (EXP)
folpet  (EXP)
formaldehyde  (ISO)
furan  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
glycine betaine  (ISO)
haloperidol  (ISO)
hydrogen peroxide  (ISO)
indole-3-methanol  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
ketamine  (ISO)
L-methionine  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melphalan  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
mitoxantrone  (ISO)
Muraglitazar  (ISO)
mycophenolic acid  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naphthalenes  (ISO)
nickel dichloride  (ISO)
nicotine  (EXP)
ochratoxin A  (ISO)
ouabain  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenformin  (ISO)
phenylephrine  (EXP,ISO)
potassium chromate  (ISO)
profenofos  (ISO)
progesterone  (EXP,ISO)
quercetin  (ISO)
quinolinic acid  (ISO)
ranitidine  (ISO)
reserpine  (ISO)
risperidone  (ISO)
rotenone  (ISO)
SCH 23390  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
sulforaphane  (ISO)
T-2 toxin  (ISO)
tamoxifen  (EXP)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
thapsigargin  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
torcetrapib  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
Triptolide  (ISO)
triptonide  (EXP)
troglitazone  (EXP,ISO)
trovafloxacin  (EXP)
undecane  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vanadyl sulfate  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The physiology, signaling, and pharmacology of dopamine receptors. Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8.
2. An abnormal gene expression of the beta-adrenergic system contributes to the pathogenesis of cardiomyopathy in cirrhotic rats. Ceolotto G, etal., Hepatology. 2008 Dec;48(6):1913-23. doi: 10.1002/hep.22533.
3. Vascular microarray profiling in two models of hypertension identifies Cav-1, Rgs2 and Rgs5 as antihypertensive targets. Grayson TH, etal., BMC Genomics. 2007 Nov 7;8(1):404.
4. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
5. Gene expression changes following extinction testing in a heroin behavioral incubation model. Kuntz-Melcavage KL, etal., BMC Neurosci. 2009 Aug 7;10:95. doi: 10.1186/1471-2202-10-95.
6. RGS2: a "turn-off" in hypertension. Le TH and Coffman TM, J Clin Invest. 2003 Feb;111(4):441-3.
7. Molecular mechanisms related to parturition-induced stress urinary incontinence. Lin G, etal., Eur Urol. 2009 May;55(5):1213-22. doi: 10.1016/j.eururo.2008.02.027. Epub 2008 Mar 18.
8. MGDs mouse GO annotations MGD data from the GO Consortium
9. MGD IEA MGD IEA
10. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
11. Calcium-sensing receptor activation of rho involves filamin and rho-guanine nucleotide exchange factor. Pi M, etal., Endocrinology. 2002 Oct;143(10):3830-8.
12. Mouse MP Annotation Import Pipeline RGD automated import pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. RGS Proteins in Heart: Brakes on the Vagus. Stewart A, etal., Front Physiol. 2012 Apr 13;3:95. doi: 10.3389/fphys.2012.00095. eCollection 2012.
15. Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure. Tang KM, etal., Nat Med. 2003 Dec;9(12):1506-12. doi: 10.1038/nm958. Epub 2003 Nov 9.
16. Impaired response of regulator of Gaq signaling-2 mRNA to angiotensin II and hypertensive renal injury in Dahl salt-sensitive rats. Wu Y, etal., Hypertens Res. 2016 Apr;39(4):210-6. doi: 10.1038/hr.2015.132. Epub 2015 Nov 26.
17. Identification of potential therapeutic targets in hypertension-associated bladder dysfunction. Yono M, etal., BJU Int. 2010 Mar;105(6):877-83. doi: 10.1111/j.1464-410X.2009.08809.x. Epub 2009 Aug 18.
Additional References at PubMed
PMID:9079700   PMID:10203790   PMID:10349636   PMID:10614620   PMID:10779778   PMID:10922068   PMID:11027316   PMID:11042159   PMID:11076861   PMID:11342430   PMID:11829488   PMID:11968023  
PMID:11996904   PMID:12477932   PMID:12588882   PMID:12968938   PMID:14581517   PMID:14681479   PMID:14976183   PMID:15292238   PMID:15457338   PMID:15489334   PMID:15489855   PMID:15563583  
PMID:15609325   PMID:15661635   PMID:15661972   PMID:16085706   PMID:16135533   PMID:16141072   PMID:16141073   PMID:16269576   PMID:16380388   PMID:16602821   PMID:16895908   PMID:16950156  
PMID:16950788   PMID:17464283   PMID:17475820   PMID:17507294   PMID:17613534   PMID:17644703   PMID:17681944   PMID:17965710   PMID:18067675   PMID:18287559   PMID:18492766   PMID:18625716  
PMID:18726905   PMID:18987636   PMID:19127022   PMID:19175184   PMID:19262744   PMID:19294649   PMID:19736320   PMID:19966055   PMID:20032508   PMID:20352235   PMID:20847141   PMID:21048919  
PMID:21164481   PMID:21179467   PMID:21267068   PMID:21291891   PMID:21308776   PMID:21447383   PMID:21494556   PMID:21500190   PMID:21510939   PMID:21677750   PMID:22040681   PMID:22057271  
PMID:22080612   PMID:22120521   PMID:22158566   PMID:22354966   PMID:22704538   PMID:22802950   PMID:22922103   PMID:24105430   PMID:24524188   PMID:24846582   PMID:24973550   PMID:25289860  
PMID:25368964   PMID:25909889   PMID:25970626   PMID:26160904   PMID:26193676   PMID:26811058   PMID:27303056   PMID:27463806   PMID:27528587   PMID:27549302   PMID:28107494   PMID:28542139  
PMID:28641980   PMID:28974581   PMID:29212953   PMID:29649180   PMID:29932914   PMID:30412338   PMID:30826455   PMID:31030617   PMID:31633064   PMID:31865781   PMID:32325033   PMID:32679115  
PMID:34873237   PMID:35661621   PMID:36259376   PMID:36307046  


Genomics

Comparative Map Data
Rgs2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391143,875,076 - 143,879,887 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1143,875,076 - 143,879,899 (-)EnsemblGRCm39 Ensembl
GRCm381143,999,338 - 144,004,149 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1143,999,338 - 144,004,161 (-)EnsemblGRCm38mm10GRCm38
MGSCv371145,846,468 - 145,851,279 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361145,762,215 - 145,766,367 (-)NCBIMGSCv36mm8
Celera1146,559,706 - 146,564,519 (-)NCBICelera
Cytogenetic Map1FNCBI
cM Map162.56NCBI
RGS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381192,809,039 - 192,812,275 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1192,809,039 - 192,812,275 (+)EnsemblGRCh38hg38GRCh38
GRCh371192,778,169 - 192,781,405 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361191,044,794 - 191,048,026 (+)NCBINCBI36Build 36hg18NCBI36
Build 341189,509,827 - 189,513,060NCBI
Celera1165,887,766 - 165,891,002 (+)NCBICelera
Cytogenetic Map1q31.2NCBI
HuRef1164,013,977 - 164,017,213 (+)NCBIHuRef
CHM1_11194,199,847 - 194,203,081 (+)NCBICHM1_1
T2T-CHM13v2.01192,156,109 - 192,159,345 (+)NCBIT2T-CHM13v2.0
Rgs2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21355,799,749 - 55,802,354 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1355,798,829 - 55,802,385 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1358,360,545 - 58,363,155 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01359,628,437 - 59,631,073 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01356,918,817 - 56,921,454 (-)NCBIRnor_WKY
Rnor_6.01360,846,458 - 60,849,061 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1360,846,308 - 60,849,094 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01365,831,386 - 65,833,989 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41357,891,849 - 57,894,452 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11357,905,025 - 57,908,545 (-)NCBI
Celera1355,875,644 - 55,878,228 (-)NCBICelera
Cytogenetic Map13q21NCBI
Rgs2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540630,261,757 - 30,266,005 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540630,261,757 - 30,265,389 (+)NCBIChiLan1.0ChiLan1.0
RGS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11172,566,701 - 172,569,955 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1172,566,701 - 172,569,955 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01168,273,112 - 168,276,348 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
RGS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1386,200,237 - 6,203,491 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl386,200,657 - 6,203,494 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha386,297,498 - 6,300,827 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0386,217,614 - 6,220,944 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl386,217,616 - 6,220,924 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1386,216,415 - 6,219,748 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0386,582,061 - 6,585,388 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0386,817,823 - 6,821,151 (-)NCBIUU_Cfam_GSD_1.0
Rgs2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934481,075,734 - 81,079,076 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366381,065,832 - 1,069,247 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366381,065,866 - 1,068,649 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RGS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl10936,789 - 940,098 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.110936,836 - 940,083 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2102,543,481 - 2,546,729 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap10pNCBI
RGS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12536,620,047 - 36,623,367 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2536,619,140 - 36,623,308 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605537,569,789 - 37,573,061 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rgs2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624814753,164 - 758,192 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624814754,743 - 758,148 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1174
Count of miRNA genes:584
Interacting mature miRNAs:739
Transcripts:ENSMUST00000027606, ENSMUST00000127206, ENSMUST00000134817, ENSMUST00000153527
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163920002153557562Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173755175147125370Mouse
4141914Gcsfis_mG-CSF induced splenomegaly (mouse)Not determined74516235148715579Mouse
27095928Pglq6_mpelvic girdle length QTL 6, 10 week (mouse)175976637148775742Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)175976637181327565Mouse
1301350Nidd4k_mNidd4 on KK-A (mouse)Not determined782291982147125370Mouse
27095913Scvln2_msacral vertebrae length 2, 5 week (mouse)194127725148775742Mouse
27095901Scvln8_msacral vertebrae length 2, 10 week (mouse)194127725172027567Mouse
27226779Tibl1_mtibia length 1, 5 week (mouse)195527725162027569Mouse
10412162Nobq3_mNew Zealand obese QTL 3 (mouse)Not determined1103933405191225397Mouse
1357600Obq17_mobesity QTL 17 (mouse)Not determined1110553179144553298Mouse
10401248Bglu12_mblood glucose level 12 (mouse)Not determined1110553179144553298Mouse
1301149Lrnx12_mlearning-contextual 12 (mouse)Not determined1112008822168186402Mouse
1302098Eila1_methanol induced locomotor activity 1 (mouse)Not determined1112008822175468938Mouse
1301249Sbw1_msplenomegaly-NZB x NZW 1 (mouse)Not determined1112131005146131085Mouse
10045640Jckm4_mjuvenile cystic kidney modifier 4 (mouse)Not determined1116290836150290937Mouse
27095915Scvln13_msacral vertebrae length 2, 16 week (mouse)1117527730179827565Mouse
1302161Exq2_mexploratory and excitability QTL 2 (mouse)Not determined1118099720152099816Mouse
27226740Metcl13_mmetatarsal-calcaneal length 13, 16 week (mouse)1121727729153775746Mouse
27226743Metcl7_mmetatarsal-calcaneal length 7, 10 week (mouse)1121727729153875746Mouse
27226767Tibl10_mtibia length 10, 10 week (mouse)1121727729164827569Mouse
27226799Feml5_mfemur length 5, 5 week (mouse)1122027729164827569Mouse
12880408V125Dq3_mvitamin D active form serum level QTL 3 (mouse)1122927738156927738Mouse
27095935Ulnl5_mulna length 5, 10 week (mouse)1128727737181327565Mouse
1301608Emo3_memotionality 3 (mouse)Not determined1129130858163130993Mouse
1302128Ity3_mimmunity to S. typhimurium 3 (mouse)Not determined11131156308165139464Mouse
14746980Manh50_mmandible shape 50 (mouse)1134131564168131564Mouse
13504831Bacszq1_mbaculum size QTL 1 (mouse)1134331161148128608Mouse
1301458Skts8_mskin tumor susceptibility 8 (mouse)Not determined1135794822169795012Mouse
1301408Lore8_mloss of righting induced by ethanol 8 (mouse)Not determined1135877901169878015Mouse
1357434Obsty1_mobesity 1 (mouse)Not determined1136209950170210094Mouse
4141160Cq1_mcholesterol QTL 1 (mouse)Not determined1139452188173452308Mouse
1301523Ccrs1_mcorpus callosum hemisphere surface size 1 (mouse)Not determined1139602037173602216Mouse
1300696Bpq2_mblood pressure QTL 2 (mouse)Not determined1139602037173602216Mouse
1357602Vtbt2_mvertebral trabecular bone trait 2 (mouse)Not determined1139602037173602216Mouse
1301710Bmd5_mbone mineral density 5 (mouse)Not determined1139602037173602216Mouse
11049576Lmr8a_mleishmaniasis resistance 8a (mouse)1139602037173602216Mouse
1301894Skull2_mskull morphology 2 (mouse)Not determined1139602037173602216Mouse
1302193Cpfd1_mcerebellum pattern fissures (mouse)Not determined1139602037173602216Mouse
1300740Tne1_mtotal number errors (mouse)Not determined1139602037173602216Mouse
4142014Wbcq5_mwhite blood cell quantitative locus 5 (mouse)Not determined1141095010175095156Mouse
1301467Pcir1_mperiosteal circumference 1 (mouse)Not determined1141233173175233272Mouse
1301191Stia1_mserum transfer induced arthritis 1 (mouse)Not determined1141233173175233272Mouse
11533913Rd6m1_mretinal degeneration 6 modifier 1 (mouse)1141233173175233272Mouse
4141233Femwf12_mfemur work to failure 12 (mouse)Not determined141233173175233272Mouse
1301151Hdlq14_mHDL QTL 14 (mouse)Not determined1142489543176489734Mouse
1558720Bpq8_mblood pressure QTL 8 (mouse)Not determined1143284665177284803Mouse
10766465Emo5_memotionality 5 (mouse)1143875076146778212Mouse

Markers in Region
RH131031  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381144,001,038 - 144,001,232UniSTSGRCm38
MGSCv371145,848,168 - 145,848,362UniSTSGRCm37
Celera1146,561,406 - 146,561,600UniSTS
Cytogenetic Map1FUniSTS
cM Map178.0UniSTS
Rgs2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1FUniSTS
cM Map178.0UniSTS
U67187  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381144,001,367 - 144,001,516UniSTSGRCm38
MGSCv371145,848,497 - 145,848,646UniSTSGRCm37
Celera1146,561,735 - 146,561,884UniSTS
Cytogenetic Map1FUniSTS
cM Map178.0UniSTS
Whitehead/MRC_RH11823.2UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000027606   ⟹   ENSMUSP00000139964
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1143,877,418 - 143,879,873 (-)Ensembl
GRCm38.p6 Ensembl1144,001,680 - 144,004,135 (-)Ensembl
RefSeq Acc Id: ENSMUST00000127206   ⟹   ENSMUSP00000115558
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1143,875,076 - 143,879,899 (-)Ensembl
GRCm38.p6 Ensembl1143,999,338 - 144,004,161 (-)Ensembl
RefSeq Acc Id: ENSMUST00000134817
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1143,878,255 - 143,879,859 (-)Ensembl
GRCm38.p6 Ensembl1144,002,517 - 144,004,121 (-)Ensembl
RefSeq Acc Id: ENSMUST00000153527   ⟹   ENSMUSP00000140548
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1143,877,621 - 143,879,770 (-)Ensembl
GRCm38.p6 Ensembl1144,001,883 - 144,004,032 (-)Ensembl
RefSeq Acc Id: NM_009061   ⟹   NP_033087
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391143,875,076 - 143,879,887 (-)NCBI
GRCm381143,999,338 - 144,004,149 (-)ENTREZGENE
MGSCv371145,846,468 - 145,851,279 (-)RGD
Celera1146,559,706 - 146,564,519 (-)RGD
cM Map1 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_033087   ⟸   NM_009061
- UniProtKB: Q9JL24 (UniProtKB/Swiss-Prot),   O08849 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000139964   ⟸   ENSMUST00000027606
RefSeq Acc Id: ENSMUSP00000115558   ⟸   ENSMUST00000127206
RefSeq Acc Id: ENSMUSP00000140548   ⟸   ENSMUST00000153527
Protein Domains
RGS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08849-F1-model_v2 AlphaFold O08849 1-211 view protein structure

Promoters
RGD ID:6875174
Promoter ID:EPDNEW_M1037
Type:multiple initiation site
Name:Rgs2_1
Description:Mus musculus regulator of G-protein signaling 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381144,004,149 - 144,004,209EPDNEW
RGD ID:6848946
Promoter ID:MM_XEF:383
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_4Hour,   Brain,   Lung
Transcripts:NM_204395
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361145,849,761 - 145,850,757 (-)MPROMDB
RGD ID:6818390
Promoter ID:MM_KWN:2339
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000049364,   OTTMUST00000049365,   OTTMUST00000049366,   OTTMUST00000049367
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361145,850,881 - 145,852,182 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1098271 AgrOrtholog
Ensembl Genes ENSMUSG00000026360 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000115558 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000139964.2 UniProtKB/TrEMBL
  ENSMUSP00000140548.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000027606.4 UniProtKB/TrEMBL
  ENSMUST00000127206 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000153527.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.167.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.196.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_subdom1/3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_subdomain_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:19735 UniProtKB/Swiss-Prot
MGD MGI:1098271 ENTREZGENE
NCBI Gene 19735 ENTREZGENE
PANTHER PTHR10845:SF43 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rgs2 PhenoGen
PRINTS RGSPROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48097 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087WPY2_MOUSE UniProtKB/TrEMBL
  A0A087WRB0_MOUSE UniProtKB/TrEMBL
  O08849 ENTREZGENE
  Q9JL24 ENTREZGENE
  RGS2_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q544S7 UniProtKB/Swiss-Prot
  Q91WX1 UniProtKB/Swiss-Prot
  Q9JL24 UniProtKB/Swiss-Prot