Lhb (luteinizing hormone beta) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Lhb (luteinizing hormone beta) Mus musculus
Analyze
Symbol: Lhb
Name: luteinizing hormone beta
RGD ID: 10869
MGI Page MGI
Description: Predicted to enable hormone activity. Acts upstream of or within luteinizing hormone signaling pathway involved in ovarian follicle development. Located in cytoplasm. Is expressed in alimentary system; brain; genitourinary system; and heart. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 23 with or without anosmia. Orthologous to several human genes including LHB (luteinizing hormone subunit beta).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Gm29035; hypothetical LOC100040019; L; leu; leutropin; LH; LH-B; LOC100040019; LSH-B; LSH-beta; luteinizing hormone subunit beta; lutropin beta chain; lutropin subunit beta
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,070,370 - 45,071,278 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,070,244 - 45,071,321 (+)EnsemblGRCm39 Ensembl
GRCm38745,417,608 - 45,421,855 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,418,353 - 45,421,854 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl745,420,820 - 45,421,897 (+)EnsemblGRCm38mm10GRCm38
MGSCv37752,676,316 - 52,677,224 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36745,288,988 - 45,289,896 (+)NCBIMGSCv36mm8
Celera740,876,980 - 40,877,888 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
LhbMousesevere acute respiratory syndrome  ISOLHB (Homo sapiens)28711759protein:increased expression:adenohypophysis (human)RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
LhbMousedevelopmental and epileptic encephalopathy 12  ISOLHB (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental and epileptic encephalopathy and 12ClinVarPMID:28492532
LhbMousehypogonadotropic hypogonadism 23 with or without anosmia  ISOLHB (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11384661 more ...
LhbMouseprogressive familial heart block type IB  ISOLHB (Homo sapiens)8554872ClinVar Annotator: match by term: Progressive familial heart block type IBClinVarPMID:28492532
1 to 16 of 16 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
LhbMousealcohol use disorder  ISOLHB (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:8590623
LhbMouseBradycardia  ISOLHB (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:6350720
LhbMouseCocaine-Related Disorders  ISOLHB (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12893845
LhbMouseDelayed Puberty  ISOLHB (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15602022
LhbMouseFemale Infertility  ISOLHB (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9457942
LhbMousehyperprolactinemia  ISOLHB (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:6770916
LhbMousehypertension  ISOLHB (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:6350720
LhbMousehypogonadism  ISOLHB (Homo sapiens)11554173CTD more ...CTDPMID:1727547 more ...
LhbMousehypogonadotropic hypogonadism 23 with or without anosmia  ISOLHB (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
LhbMouseHypothermia  ISOLHB (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:6350720
LhbMouseLeydig cell tumor  ISOLHB (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25289773
LhbMousemale infertility  ISOLHB (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:387166 more ...
LhbMousenicotine dependence  ISOLHB (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12893845
LhbMousepolycystic ovary syndrome  ISOLHB (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11889176 and PMID:20378617
LhbMousePrecocious Puberty  ISOLHB (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18345393
LhbMouseTachycardia  ISOLHB (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:6350720
1 to 16 of 16 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
LhbMousehypogonadotropic hypogonadism 23 with or without anosmia  ISOLHB (Homo sapiens)7240710 OMIM 

1 to 20 of 570 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
LhbMouse(+)-pilocarpine decreases expressionISOLhb (Rattus norvegicus)6480464Pilocarpine results in decreased expression of LHB proteinCTDPMID:9761326
LhbMouse(+)-taxifolin multiple interactionsISOLhb (Rattus norvegicus)6480464Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of LHB protein]] more ...CTDPMID:35465754
LhbMouse(R)-carnitine multiple interactionsISOLhb (Rattus norvegicus)6480464Carnitine inhibits the reaction [carbendazim results in decreased expression of LHB protein]CTDPMID:33965443
LhbMouse(R)-lipoic acid multiple interactionsISOLhb (Rattus norvegicus)6480464Thioctic Acid inhibits the reaction [Cadmium Chloride results in decreased expression of LHB protein] and Thioctic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of LHB mRNA]CTDPMID:20957662 and PMID:28070105
LhbMouse(R)-noradrenaline multiple interactionsISOLhb (Rattus norvegicus)6480464Norepinephrine results in decreased secretion of and results in decreased expression of LHB protein more ...CTDPMID:3953791
LhbMouse(S)-naringenin multiple interactionsISOLhb (Rattus norvegicus)6480464naringenin inhibits the reaction [lead acetate results in decreased expression of LHB protein]CTDPMID:36807407
LhbMouse(S)-nicotine decreases expressionISOLhb (Rattus norvegicus)6480464Nicotine results in decreased expression of LHB mRNA and Nicotine results in decreased expression of LHB proteinCTDPMID:20498001 and PMID:28986172
LhbMouse(S)-nicotine increases secretionISOLHB (Homo sapiens)6480464Nicotine results in increased secretion of LHB proteinCTDPMID:12893845
LhbMouse1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane multiple interactionsISOLhb (Rattus norvegicus)64804642 more ...CTDPMID:21664964 and PMID:24451217
LhbMouse1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane multiple interactionsISOLhb (Rattus norvegicus)6480464o and p'-DDT affects the reaction [LHB protein results in increased susceptibility to GNRH1 protein]CTDPMID:17596564
LhbMouse1,2-Dibromo-3-chloropropane increases expressionISOLhb (Rattus norvegicus)64804641 and 2-dibromo-3-chloropropane results in increased expression of LHB proteinCTDPMID:3228205 and PMID:6487690
LhbMouse1,2-Dibromo-3-chloropropane decreases expressionISOLhb (Rattus norvegicus)64804641 and 2-dibromo-3-chloropropane results in decreased expression of LHB mRNACTDPMID:9571776
LhbMouse1,3-dinitrobenzene decreases expressionISOLhb (Rattus norvegicus)64804643-dinitrobenzene results in decreased expression of LHB mRNACTDPMID:22841810
LhbMouse1-methylnicotinamide multiple interactionsISOLhb (Rattus norvegicus)6480464N(1)-methylnicotinamide inhibits the reaction [Letrozole results in increased secretion of LHB protein]CTDPMID:32298659
LhbMouse17alpha-ethynylestradiol multiple interactionsISOLHB (Homo sapiens)6480464[Ethinyl Estradiol co-treated with Cyproterone Acetate] results in decreased expression of LHB protein more ...CTDPMID:16002536 more ...
LhbMouse17alpha-ethynylestradiol decreases activityISOLHB (Homo sapiens)6480464Ethinyl Estradiol results in decreased activity of LHB proteinCTDPMID:31212720
LhbMouse17alpha-ethynylestradiol increases secretionISOLhb (Rattus norvegicus)6480464Ethinyl Estradiol results in increased secretion of LHB proteinCTDPMID:28522409
LhbMouse17alpha-ethynylestradiol decreases expressionISOLhb (Rattus norvegicus)6480464Ethinyl Estradiol results in decreased expression of LHBCTDPMID:25615539
LhbMouse17alpha-ethynylestradiol decreases expressionISOLHB (Homo sapiens)6480464Ethinyl Estradiol results in decreased expression of LHB proteinCTDPMID:10843175 and PMID:11907703
LhbMouse17beta-estradiol multiple interactionsISOLhb (Rattus norvegicus)6480464[[Estradiol co-treated with Testosterone] results in decreased secretion of LHB protein] which results in decreased abundance of Testosterone more ...CTDPMID:16574160 more ...

1 to 20 of 570 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
LhbMouseG protein-coupled receptor signaling pathway involved_inIBAPANTHER:PTN000162063 more ...2290270 GO_CentralGO_REF:0000033
LhbMouseluteinizing hormone signaling pathway involved in ovarian follicle development acts_upstream_of_or_withinIDA 2290270 PMID:19474061MGIPMID:19474061
LhbMouseovarian follicle development acts_upstream_of_or_withinIDA 2290270 PMID:19474061MGIPMID:19474061

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
LhbMousecytoplasm is_active_inIBAPANTHER:PTN000162063 more ...2290270 GO_CentralGO_REF:0000033
LhbMousecytoplasm located_inIDA 2290270 PMID:24739304MGIPMID:24739304
LhbMouseextracellular region located_inIEAUniProtKB-SubCell:SL-02432290270 UniProtGO_REF:0000044
LhbMouseextracellular space is_active_inIBAPANTHER:PTN000162063 more ...2290270 GO_CentralGO_REF:0000033
LhbMousepituitary gonadotropin complex part_ofISOUniProtKB:P0DN862290270 GO_CentralGO_REF:0000119

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
LhbMousehormone activity enablesISOUniProtKB:A6NKQ9 and UniProtKB:Q6NT522290270 GO_CentralGO_REF:0000119
LhbMousehormone activity enablesIEAUniProtKB-KW:KW-03722290270 UniProtGO_REF:0000043
LhbMouseprotein binding enablesISOUniProtKB:Q13643 more ...9068941 PMID:32296183IntActPMID:32296183

Imported Annotations - SMPDB

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
LhbMouseluteinizing hormone signaling pathway  ISOLHB (Homo sapiens)10402751 SMPDBSMP:00338

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
LhbMousegonadotropin-releasing hormone signaling pathway  IEA 6907045 KEGGmmu:04912
1 to 20 of 38 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
LhbMouseabnormal female reproductive system morphology  IAGP 5509061 MGIPMID:15569941
LhbMouseabnormal gametogenesis  IAGP 5509061 MGIPMID:15569941
LhbMouseabnormal Leydig cell differentiation  IAGP 5509061 MGIPMID:17350160
LhbMouseabnormal male germ cell apoptosis  IAGP 5509061 MGIPMID:17350160
LhbMouseabnormal male reproductive system morphology  IAGP 5509061 MGIPMID:15569941
LhbMouseabnormal sex gland secretion  IAGP 5509061 MGIPMID:15569941
LhbMouseabnormal tertiary ovarian follicle morphology  IAGP 5509061 MGIPMID:17350160
LhbMouseabsent corpus luteum  IAGP 5509061 MGIPMID:15569941
LhbMouseabsent estrous cycle  IAGP 5509061 MGIPMID:17350160
LhbMouseabsent mature ovarian follicles  IAGP 5509061 MGIPMID:15569941
LhbMousearrest of spermatogenesis  IAGP 5509061 MGIPMID:17350160
LhbMousearrest of spermatogenesis  IAGP 5509061 MGIPMID:15569941
LhbMouseazoospermia  IAGP 5509061 MGIPMID:15569941
LhbMouseazoospermia  IAGP 5509061 MGIPMID:17350160
LhbMousedecreased circulating estradiol level  IAGP 5509061 MGIPMID:15569941
LhbMousedecreased circulating progesterone level  IAGP 5509061 MGIPMID:15569941
LhbMousedecreased circulating testosterone level  IAGP 5509061 MGIPMID:15569941
LhbMousedecreased elongated spermatid number  IAGP 5509061 MGIPMID:17350160
LhbMousedecreased Leydig cell number  IAGP 5509061 MGIPMID:17350160
LhbMousedecreased Leydig cell number  IAGP 5509061 MGIPMID:15569941
1 to 20 of 38 rows

1 to 12 of 12 rows
#
Reference Title
Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Hypogonadism in a patient with a mutation in the luteinizing hormone beta-subunit gene. Valdes-Socin H, etal., N Engl J Med. 2004 Dec 16;351(25):2619-25.
12. Endocrine cells of the adenohypophysis in severe acute respiratory syndrome (SARS). Wei L, etal., Biochem Cell Biol. 2010 Aug;88(4):723-30. doi: 10.1139/O10-022.
1 to 12 of 12 rows
1 to 10 of 18 rows
PMID:1505020   PMID:1727547   PMID:1981054   PMID:2307474   PMID:2842249   PMID:6581542   PMID:6582507   PMID:6690234   PMID:7508931   PMID:7659091   PMID:7877975   PMID:8027530  
PMID:8389457   PMID:8397485   PMID:8452817   PMID:8543188   PMID:8601493   PMID:8784083   PMID:8812484   PMID:8833259   PMID:8903733   PMID:8923471   PMID:9231809   PMID:9388186  
PMID:9501026   PMID:9620855   PMID:10049363   PMID:10067870   PMID:10319325   PMID:10342846   PMID:10349636   PMID:10367888   PMID:10451227   PMID:10465256   PMID:10588713   PMID:10618427  
PMID:10628753   PMID:10949077   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11544199   PMID:11807026   PMID:12040011   PMID:12040015   PMID:12183375   PMID:12193554   PMID:12429736  
PMID:12520002   PMID:12651892   PMID:12746302   PMID:12748296   PMID:12801993   PMID:12907761   PMID:12960102   PMID:13679314   PMID:14585811   PMID:14610273   PMID:14871891   PMID:15037319  
PMID:15459176   PMID:15569941   PMID:15606491   PMID:15761027   PMID:15814897   PMID:16141072   PMID:16141073   PMID:16141355   PMID:16384867   PMID:16537498   PMID:16602821   PMID:16678101  
PMID:16806148   PMID:16840533   PMID:16840539   PMID:16932809   PMID:17015435   PMID:17244763   PMID:17299135   PMID:17350160   PMID:17359964   PMID:17367776   PMID:17371839   PMID:17376589  
PMID:17392792   PMID:17426285   PMID:17478551   PMID:17569755   PMID:17699734   PMID:17710732   PMID:17717072   PMID:17959774   PMID:18037398   PMID:18308464   PMID:18351662   PMID:18431515  
PMID:18462884   PMID:18480465   PMID:18495683   PMID:18657590   PMID:18775421   PMID:19093031   PMID:19139274   PMID:19474061   PMID:19647136   PMID:19929279   PMID:20068010   PMID:20431921  
PMID:20546829   PMID:20593419   PMID:20702576   PMID:20797425   PMID:20805495   PMID:20807761   PMID:20934421   PMID:21084383   PMID:21108604   PMID:21228153   PMID:21247964   PMID:21262217  
1 to 10 of 18 rows



Lhb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,070,370 - 45,071,278 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,070,244 - 45,071,321 (+)EnsemblGRCm39 Ensembl
GRCm38745,417,608 - 45,421,855 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,418,353 - 45,421,854 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl745,420,820 - 45,421,897 (+)EnsemblGRCm38mm10GRCm38
MGSCv37752,676,316 - 52,677,224 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36745,288,988 - 45,289,896 (+)NCBIMGSCv36mm8
Celera740,876,980 - 40,877,888 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.3NCBI
LHB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381949,015,980 - 49,019,498 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1949,015,980 - 49,017,091 (-)EnsemblGRCh38hg38GRCh38
GRCh371949,519,237 - 49,520,348 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,211,049 - 54,212,159 (-)NCBINCBI36Build 36hg18NCBI36
Build 341954,211,048 - 54,212,159NCBI
Celera1946,386,444 - 46,387,554 (-)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1945,895,957 - 45,897,067 (-)NCBIHuRef
CHM1_11949,521,461 - 49,522,571 (-)NCBICHM1_1
T2T-CHM13v2.01952,010,754 - 52,014,273 (-)NCBIT2T-CHM13v2.0
Lhb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,037,457 - 105,038,446 (+)NCBIGRCr8
mRatBN7.2195,898,269 - 95,901,973 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,900,984 - 95,901,972 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl195,898,267 - 95,901,963 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,286,408 - 101,287,397 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,759,086 - 109,760,075 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,049,485 - 103,050,474 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,409,992 - 101,413,725 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,410,019 - 101,413,724 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,489,421 - 102,493,135 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,892,999 - 95,893,988 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1195,971,118 - 95,972,098 (+)NCBI
Celera190,156,575 - 90,157,564 (+)NCBICelera
Cytogenetic Map1q22NCBI
Lhb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555591,656,106 - 1,657,192 (+)NCBIChiLan1.0ChiLan1.0
LOC100992969
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22055,150,366 - 55,159,280 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11957,069,851 - 57,078,655 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01946,053,779 - 46,055,250 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11954,738,139 - 54,739,424 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1954,738,139 - 54,739,424 (+)Ensemblpanpan1.1panPan2
LHB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,382,855 - 107,384,029 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
ROS_Cfam_1.01107,907,413 - 107,908,590 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11107,575,256 - 107,576,428 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01107,221,425 - 107,222,599 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01108,057,035 - 108,058,209 (+)NCBIUU_Cfam_GSD_1.0
LHB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,263,576 - 54,271,086 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1654,263,574 - 54,269,286 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2650,063,469 - 50,065,072 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap6q21NCBI
LHB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1642,247,254 - 42,248,822 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607322,134,416 - 22,135,718 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

.

.
Variants in Lhb
43 total Variants

Predicted Target Of
Summary Value
Count of predictions:800
Count of miRNA genes:413
Interacting mature miRNAs:469
Transcripts:ENSMUST00000072453, ENSMUST00000127256, ENSMUST00000137350, ENSMUST00000155591
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 44 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1303248547032621Mouse
1301969Lbw5_mlupus NZB x NZW 5 (mouse)Not determined72684761560851775Mouse
38501071Stsl6_mSalmonella typhimurium susceptibility locus 6 (mouse)73419942551149748Mouse
1357586Mdmsc3_mmodifier of muscularity 3 (mouse)Not determined73444786968448018Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
39128210Lwq19_mliver weight QTL 19 (mouse)73349772758148965Mouse
11252140Fdr1_mfat response to dietary restriction 1 (mouse)74114882075148965Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71333392547349748Mouse
1357469Kidq5_mkidney weight QTL 5 (mouse)Not determined73349772758148965Mouse

1 to 10 of 44 rows
Lhb  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38745,421,471 - 45,421,594UniSTSGRCm38
MGSCv37752,676,841 - 52,676,964UniSTSGRCm37
Celera740,877,505 - 40,877,628UniSTS
Cytogenetic Map7B4UniSTS
Cytogenetic Map7B2UniSTS
cM Map723.0UniSTS







Ensembl Acc Id: ENSMUST00000072453   ⟹   ENSMUSP00000072276
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl745,070,244 - 45,071,321 (+)Ensembl
GRCm38.p6 Ensembl745,420,820 - 45,421,897 (+)Ensembl
Ensembl Acc Id: ENSMUST00000238437   ⟹   ENSMUSP00000158793
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl745,067,796 - 45,071,060 (+)Ensembl
GRCm38.p6 Ensembl745,418,372 - 45,421,636 (+)Ensembl
Ensembl Acc Id: ENSMUST00000238581
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl745,067,777 - 45,071,278 (+)Ensembl
GRCm38.p6 Ensembl745,418,353 - 45,421,854 (+)Ensembl
Ensembl Acc Id: ENSMUST00000238591   ⟹   ENSMUSP00000158785
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl745,067,777 - 45,071,269 (+)Ensembl
GRCm38.p6 Ensembl745,418,353 - 45,421,845 (+)Ensembl
Ensembl Acc Id: ENSMUST00000238638   ⟹   ENSMUSP00000158821
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl745,067,794 - 45,069,788 (+)Ensembl
GRCm38.p6 Ensembl745,418,370 - 45,420,364 (+)Ensembl
RefSeq Acc Id: NM_008497   ⟹   NP_032523
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39745,070,370 - 45,071,278 (+)NCBI
GRCm38745,420,946 - 45,421,854 (+)NCBI
MGSCv37752,676,316 - 52,677,224 (+)RGD
Celera740,876,980 - 40,877,888 (+)RGD
cM Map7 ENTREZGENE
Sequence:
Protein RefSeqs NP_032523 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA92841 (Get FASTA)   NCBI Sequence Viewer  
  CAA71445 (Get FASTA)   NCBI Sequence Viewer  
  EDL22853 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000072276
GenBank Protein O09108 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_032523   ⟸   NM_008497
- Peptide Label: precursor
- UniProtKB: Q60844 (UniProtKB/Swiss-Prot),   O09108 (UniProtKB/Swiss-Prot),   G3X9G6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000158785   ⟸   ENSMUST00000238591
Ensembl Acc Id: ENSMUSP00000158793   ⟸   ENSMUST00000238437
Ensembl Acc Id: ENSMUSP00000072276   ⟸   ENSMUST00000072453
Ensembl Acc Id: ENSMUSP00000158821   ⟸   ENSMUST00000238638
Glycoprotein hormone subunit beta

Name Modeler Protein Id AA Range Protein Structure
AF-O09108-F1-model_v2 AlphaFold O09108 1-141 view protein structure

RGD ID:8664021
Promoter ID:EPDNEW_M10040
Type:multiple initiation site
Name:Lhb_1
Description:Mus musculus luteinizing hormone beta , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38745,420,946 - 45,421,006EPDNEW
RGD ID:6841418
Promoter ID:MM_KWN:50397
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:OTTMUST00000058303,   OTTMUST00000058304,   OTTMUST00000078980
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36752,673,631 - 52,674,131 (+)MPROMDB
RGD ID:6841417
Promoter ID:MM_KWN:50398
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Brain,   Lung,   Spleen
Transcripts:OTTMUST00000058302
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36752,675,306 - 52,676,282 (+)MPROMDB


1 to 26 of 26 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000038194
  ENSMUSG00000100916 Ensembl, ENTREZGENE
  ENSMUSG00000118462 Ensembl
Ensembl Transcript ENSMUST00000072453 ENTREZGENE
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot
  Glyco_hormone_CN UniProtKB/Swiss-Prot
  Gonadotropin_bsu UniProtKB/Swiss-Prot
  Gonadotropin_bsu_CS UniProtKB/Swiss-Prot
MGD MGI:96782 ENTREZGENE
NCBI Gene 16866 ENTREZGENE
PANTHER LUTROPIN SUBUNIT BETA UniProtKB/Swiss-Prot
  PTHR11515 UniProtKB/Swiss-Prot
Pfam Cys_knot UniProtKB/Swiss-Prot
PhenoGen Lhb PhenoGen
PROSITE GLYCO_HORMONE_BETA_1 UniProtKB/Swiss-Prot
  GLYCO_HORMONE_BETA_2 UniProtKB/Swiss-Prot
SMART GHB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot
UniProt A0A571BEK4_MOUSE UniProtKB/TrEMBL
  A0A571BEL8_MOUSE UniProtKB/TrEMBL
  G3X9G6 ENTREZGENE, UniProtKB/TrEMBL
  LSHB_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UUG9_MOUSE UniProtKB/TrEMBL
  Q60844 ENTREZGENE
UniProt Secondary Q60844 UniProtKB/Swiss-Prot
1 to 26 of 26 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-16 Lhb  luteinizing hormone beta  LOC100040019  hypothetical LOC100040019  Data merged from RGD:2299670 737654 PROVISIONAL
2016-04-12 LOC100040019  hypothetical LOC100040019  Gm683  gene model 683, (NCBI)  Symbol and/or name change 5135510 APPROVED