LHB (luteinizing hormone subunit beta) - Rat Genome Database

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Gene: LHB (luteinizing hormone subunit beta) Sus scrofa
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Symbol: LHB
Name: luteinizing hormone subunit beta
RGD ID: 13874726
Description: ENCODES a protein that exhibits hormone activity (inferred); INVOLVED IN luteinizing hormone signaling pathway involved in ovarian follicle development (ortholog); PARTICIPATES IN luteinizing hormone signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Bradycardia (ortholog); Delayed Puberty (ortholog); FOUND IN cytoplasm (ortholog); INTERACTS WITH 17beta-estradiol; androst-4-ene-3,17-dione; cobalt atom
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LH-B; LH-beta subunit; LSH-B; LSH-beta; luteinizing hormone beta polypeptide; luteinizing hormone beta subunit; lutropin beta chain; lutropin subunit beta
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1654,263,574 - 54,269,286 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2650,063,469 - 50,065,072 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap6q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:1701088   PMID:2744222   PMID:4770795   PMID:7789177   PMID:19212008   PMID:31905166  


Genomics

Comparative Map Data
LHB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1654,263,574 - 54,269,286 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2650,063,469 - 50,065,072 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap6q21NCBI
LHB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381949,015,980 - 49,019,498 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1949,015,980 - 49,017,091 (-)EnsemblGRCh38hg38GRCh38
GRCh371949,519,237 - 49,520,348 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,211,049 - 54,212,159 (-)NCBINCBI36hg18NCBI36
Build 341954,211,048 - 54,212,159NCBI
Celera1946,386,444 - 46,387,554 (-)NCBI
Cytogenetic Map19q13.33NCBI
HuRef1945,895,957 - 45,897,067 (-)NCBIHuRef
CHM1_11949,521,461 - 49,522,571 (-)NCBICHM1_1
T2T-CHM13v2.01952,010,754 - 52,011,864 (-)NCBI
Lhb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,066,912 - 45,071,279 (+)NCBIGRCm39mm39
GRCm39 Ensembl745,070,244 - 45,071,321 (+)Ensembl
GRCm39 Ensembl745,067,777 - 45,071,278 (+)Ensembl
GRCm38745,417,608 - 45,421,855 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,420,820 - 45,421,897 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl745,418,353 - 45,421,854 (+)EnsemblGRCm38mm10GRCm38
MGSCv37752,676,316 - 52,677,224 (+)NCBIGRCm37mm9NCBIm37
MGSCv36745,288,988 - 45,289,896 (+)NCBImm8
Celera740,876,980 - 40,877,888 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.3NCBI
Lhb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2195,898,269 - 95,901,973 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl195,900,984 - 95,901,972 (+)Ensembl
mRatBN7.2 Ensembl195,898,267 - 95,901,963 (+)Ensembl
Rnor_6.01101,409,992 - 101,413,725 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,410,019 - 101,413,724 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,489,421 - 102,493,135 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,892,999 - 95,893,988 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1195,971,118 - 95,972,098 (+)NCBI
Celera190,156,575 - 90,157,564 (+)NCBICelera
Cytogenetic Map1q22NCBI
Lhb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555591,656,106 - 1,657,192 (+)NCBIChiLan1.0ChiLan1.0
LOC100992969
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11954,738,139 - 54,739,424 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1954,738,139 - 54,739,424 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01946,053,779 - 46,055,250 (+)NCBIMhudiblu_PPA_v0panPan3
LHB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,382,855 - 107,384,029 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
ROS_Cfam_1.01107,907,413 - 107,908,590 (+)NCBI
UMICH_Zoey_3.11107,575,256 - 107,576,428 (+)NCBI
UNSW_CanFamBas_1.01107,221,425 - 107,222,599 (+)NCBI
UU_Cfam_GSD_1.01108,057,035 - 108,058,209 (+)NCBI
LHB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1642,247,254 - 42,248,822 (-)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607322,134,416 - 22,135,718 (-)NCBIVero_WHO_p1.0


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system reproductive system respiratory system
High
Medium
Low 3 7 1
Below cutoff 6 2 4 2 14 1 1

Sequence


Reference Sequences
RefSeq Acc Id: NM_214080   ⟹   NP_999245
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1654,263,643 - 54,264,684 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021093514   ⟹   XP_020949173
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1654,263,574 - 54,269,285 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021093516   ⟹   XP_020949175
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1654,264,950 - 54,269,286 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021093517   ⟹   XP_020949176
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1654,263,574 - 54,268,687 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021093518   ⟹   XP_020949177
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1654,263,574 - 54,268,248 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021093519   ⟹   XP_020949178
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1654,263,574 - 54,267,104 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021093520   ⟹   XP_020949179
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1654,264,950 - 54,267,329 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020949173   ⟸   XM_021093514
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020949176   ⟸   XM_021093517
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020949177   ⟸   XM_021093518
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020949178   ⟸   XM_021093519
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: NP_999245   ⟸   NM_214080
- Peptide Label: precursor
- UniProtKB: P01232 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_020949175   ⟸   XM_021093516
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020949179   ⟸   XM_021093520
- Peptide Label: isoform X4
- Sequence:
Protein Domains
Cys_knot


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000031086 UniProtKB/TrEMBL
  ENSSSCG00000044760 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015016010 UniProtKB/TrEMBL
  ENSSSCG00015016126 UniProtKB/Swiss-Prot
  ENSSSCG00025020194 UniProtKB/TrEMBL
  ENSSSCG00030065076 UniProtKB/TrEMBL
  ENSSSCG00035039384 UniProtKB/TrEMBL
  ENSSSCG00040014499 UniProtKB/TrEMBL
  ENSSSCG00040014539 UniProtKB/Swiss-Prot
  ENSSSCG00045012733 UniProtKB/TrEMBL
  ENSSSCG00045012778 UniProtKB/Swiss-Prot
  ENSSSCG00055006858 UniProtKB/TrEMBL
  ENSSSCG00055006892 UniProtKB/Swiss-Prot
  ENSSSCG00060078070 UniProtKB/TrEMBL
  ENSSSCG00060078080 UniProtKB/Swiss-Prot
  ENSSSCG00065054153 UniProtKB/TrEMBL
  ENSSSCG00065054246 UniProtKB/Swiss-Prot
  ENSSSCG00070027711 UniProtKB/TrEMBL
  ENSSSCG00070027728 UniProtKB/Swiss-Prot
Ensembl Protein ENSSSCP00000035033 ENTREZGENE
  ENSSSCP00000035033.2 UniProtKB/TrEMBL
  ENSSSCP00000039170.1 UniProtKB/TrEMBL
  ENSSSCP00015008339.1 UniProtKB/TrEMBL
  ENSSSCP00015008364.1 UniProtKB/TrEMBL
  ENSSSCP00015008399 UniProtKB/Swiss-Prot
  ENSSSCP00025011594.1 UniProtKB/TrEMBL
  ENSSSCP00030041856.1 UniProtKB/TrEMBL
  ENSSSCP00035021039.1 UniProtKB/TrEMBL
  ENSSSCP00040008048.1 UniProtKB/TrEMBL
  ENSSSCP00040008063 UniProtKB/Swiss-Prot
  ENSSSCP00045014938.1 UniProtKB/TrEMBL
  ENSSSCP00045014966 UniProtKB/Swiss-Prot
  ENSSSCP00055010450.1 UniProtKB/TrEMBL
  ENSSSCP00055010483 UniProtKB/Swiss-Prot
  ENSSSCP00060047762.1 UniProtKB/TrEMBL
  ENSSSCP00060047770 UniProtKB/Swiss-Prot
  ENSSSCP00065032319.1 UniProtKB/TrEMBL
  ENSSSCP00065032373 UniProtKB/Swiss-Prot
  ENSSSCP00070047202.1 UniProtKB/TrEMBL
  ENSSSCP00070047204.1 UniProtKB/TrEMBL
  ENSSSCP00070047244 UniProtKB/Swiss-Prot
Ensembl Transcript ENSSSCT00000053394.2 UniProtKB/TrEMBL
  ENSSSCT00000061205 ENTREZGENE
  ENSSSCT00000061205.2 UniProtKB/TrEMBL
  ENSSSCT00015021216.1 UniProtKB/TrEMBL
  ENSSSCT00015021278.1 UniProtKB/TrEMBL
  ENSSSCT00015021366 UniProtKB/Swiss-Prot
  ENSSSCT00025027412.1 UniProtKB/TrEMBL
  ENSSSCT00030090937.1 UniProtKB/TrEMBL
  ENSSSCT00035052318.1 UniProtKB/TrEMBL
  ENSSSCT00040019439.1 UniProtKB/TrEMBL
  ENSSSCT00040019465 UniProtKB/Swiss-Prot
  ENSSSCT00045021710.1 UniProtKB/TrEMBL
  ENSSSCT00045021755 UniProtKB/Swiss-Prot
  ENSSSCT00055013292.1 UniProtKB/TrEMBL
  ENSSSCT00055013332 UniProtKB/Swiss-Prot
  ENSSSCT00060107662.1 UniProtKB/TrEMBL
  ENSSSCT00060107671 UniProtKB/Swiss-Prot
  ENSSSCT00065074197.1 UniProtKB/TrEMBL
  ENSSSCT00065074311 UniProtKB/Swiss-Prot
  ENSSSCT00070055580.1 UniProtKB/TrEMBL
  ENSSSCT00070055582.1 UniProtKB/TrEMBL
  ENSSSCT00070055627 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hormone_CN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gonadotropin_bsu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gonadotropin_bsu_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397153 UniProtKB/Swiss-Prot
NCBI Gene LHB ENTREZGENE
PANTHER PTHR11515 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cys_knot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GLYCO_HORMONE_BETA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLYCO_HORMONE_BETA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART GHB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A287A5C6_PIG UniProtKB/TrEMBL
  A0A4X1VU24_PIG UniProtKB/TrEMBL
  A0A4X1VZ56_PIG UniProtKB/TrEMBL
  A0A5S6H6L9_PIG UniProtKB/TrEMBL
  LSHB_PIG UniProtKB/Swiss-Prot, ENTREZGENE
  Q6LC93_PIG UniProtKB/TrEMBL
UniProt Secondary Q7YRL0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-07-30 LHB  luteinizing hormone subunit beta  LHB  luteinizing hormone beta polypeptide  Symbol and/or name change 5135510 APPROVED