Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Srd5a1 (steroid 5 alpha-reductase 1) Mus musculus
Symbol: Srd5a1
Name: steroid 5 alpha-reductase 1
RGD ID: 11341
Description: Exhibits 3-oxo-5-alpha-steroid 4-dehydrogenase activity. Involved in androgen biosynthetic process. Predicted to localize to several cellular components, including cell body fiber; neuronal cell body; and perinuclear region of cytoplasm. Is expressed in alimentary system; genitourinary system; hypothalamus; and liver. Human ortholog(s) of this gene implicated in prostate cancer and prostatic hypertrophy. Orthologous to human SRD5A1 (steroid 5 alpha-reductase 1); PARTICIPATES IN testosterone biosynthetic pathway; steroid hormone biosynthetic pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 3',5'-cyclic AMP.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 0610031P22Rik; 3-oxo-5-alpha-steroid 4-dehydrogenase 1; 4930435F02Rik; S5AR 1; SR type 1; Srd5; Srd5a-1; steroid 5-alpha-reductase 1; type 1 5alpha-reductase
Homo sapiens (human) : SRD5A1 (steroid 5 alpha-reductase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Srd5a1 (steroid 5 alpha-reductase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Srd5a1 (steroid 5 alpha-reductase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SRD5A1 (steroid 5 alpha-reductase 1)
Canis lupus familiaris (dog) : SRD5A1 (steroid 5 alpha-reductase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Srd5a1 (steroid 5 alpha-reductase 1)
Sus scrofa (pig) : SRD5A1 (steroid 5 alpha-reductase 1)
Chlorocebus sabaeus (African green monkey) : SRD5A1 (steroid 5 alpha-reductase 1)
Heterocephalus glaber (naked mole-rat) : Srd5a1 (steroid 5 alpha-reductase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1369,573,449 - 69,611,442 (-)EnsemblGRCm38mm10GRCm38
GRCm381369,573,449 - 69,611,485 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371369,712,327 - 69,750,341 (-)NCBIGRCm37mm9NCBIm37
MGSCv361370,040,821 - 70,078,835 (-)NCBImm8
Celera1371,919,533 - 71,956,201 (-)NCBICelera
Cytogenetic Map13B3-C1NCBI
cM Map1335.55NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Srd5a1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11341
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.