Klhl41 (kelch-like 41) - Rat Genome Database

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Gene: Klhl41 (kelch-like 41) Mus musculus
Analyze
Symbol: Klhl41
Name: kelch-like 41
RGD ID: 1332188
MGI Page MGI
Description: Involved in several processes, including regulation of myoblast differentiation; regulation of myoblast proliferation; and skeletal muscle cell differentiation. Acts upstream of or within regulation of skeletal muscle cell differentiation. Located in M band; cytoskeleton; and sarcoplasmic reticulum membrane. Is expressed in heart; myotome; skeletal muscle; and somite. Used to study nemaline myopathy. Human ortholog(s) of this gene implicated in nemaline myopathy 9. Orthologous to human KLHL41 (kelch like family member 41); INTERACTS WITH 4,4'-sulfonyldiphenol; bisphenol F; dioxygen.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Gm112; Kbtbd10; kelch repeat and BTB (POZ) domain containing 10; kelch repeat and BTB domain-containing protein 10; kelch-like protein 41; SARCOSIN
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39269,500,464 - 69,514,583 (+)NCBIGRCm39mm39
GRCm39 Ensembl269,500,464 - 69,514,574 (+)Ensembl
GRCm38269,670,120 - 69,684,239 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl269,670,120 - 69,684,230 (+)EnsemblGRCm38mm10GRCm38
MGSCv37269,508,177 - 69,522,296 (+)NCBIGRCm37mm9NCBIm37
MGSCv36269,470,959 - 69,485,078 (+)NCBImm8
Celera271,339,447 - 71,353,726 (+)NCBICelera
Cytogenetic Map2C2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12692149   PMID:16141072   PMID:16141073   PMID:18178185   PMID:21267068   PMID:21368295  
PMID:21677750   PMID:21873635   PMID:22562206   PMID:24268659   PMID:24960163   PMID:28378742   PMID:28826497   PMID:32325033  


Genomics

Comparative Map Data
Klhl41
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39269,500,464 - 69,514,583 (+)NCBIGRCm39mm39
GRCm39 Ensembl269,500,464 - 69,514,574 (+)Ensembl
GRCm38269,670,120 - 69,684,239 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl269,670,120 - 69,684,230 (+)EnsemblGRCm38mm10GRCm38
MGSCv37269,508,177 - 69,522,296 (+)NCBIGRCm37mm9NCBIm37
MGSCv36269,470,959 - 69,485,078 (+)NCBImm8
Celera271,339,447 - 71,353,726 (+)NCBICelera
Cytogenetic Map2C2NCBI
KLHL41
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2169,509,702 - 169,526,258 (+)EnsemblGRCh38hg38GRCh38
GRCh382169,509,702 - 169,526,258 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372170,366,212 - 170,382,768 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362170,074,458 - 170,091,018 (+)NCBINCBI36hg18NCBI36
Build 342170,191,718 - 170,208,279NCBI
Celera2163,985,145 - 164,001,693 (+)NCBI
Cytogenetic Map2q31.1NCBI
HuRef2162,256,791 - 162,273,335 (+)NCBIHuRef
CHM1_12170,372,126 - 170,388,680 (+)NCBICHM1_1
Klhl41
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2354,434,291 - 54,447,415 (+)NCBI
Rnor_6.0 Ensembl355,910,177 - 55,923,303 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0355,910,177 - 55,923,303 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0362,521,998 - 62,535,124 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4351,816,016 - 51,829,140 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1351,712,387 - 51,725,512 (+)NCBI
Celera353,994,900 - 54,008,018 (+)NCBICelera
Cytogenetic Map3q21NCBI
Klhl41
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554495,023,362 - 5,061,705 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554495,023,362 - 5,041,006 (-)NCBIChiLan1.0ChiLan1.0
KLHL41
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B174,248,884 - 174,265,508 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B174,248,884 - 174,265,508 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B56,778,475 - 56,798,317 (+)NCBIMhudiblu_PPA_v0panPan3
KLHL41
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13614,235,845 - 14,251,621 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3614,235,941 - 14,251,083 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3614,246,436 - 14,262,204 (+)NCBI
ROS_Cfam_1.03614,352,500 - 14,368,230 (+)NCBI
UMICH_Zoey_3.13614,436,418 - 14,452,160 (+)NCBI
UNSW_CanFamBas_1.03614,426,418 - 14,442,160 (+)NCBI
UU_Cfam_GSD_1.03614,538,249 - 14,553,986 (+)NCBI
Klhl41
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303131,493,634 - 131,508,703 (+)NCBI
SpeTri2.0NW_00493650947,298 - 62,608 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLHL41
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1575,852,198 - 75,895,016 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11575,875,694 - 75,893,789 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21584,996,215 - 85,014,712 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KLHL41
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11055,023,978 - 55,044,196 (+)NCBI
Vero_WHO_p1.0NW_023666040144,487,050 - 144,505,140 (-)NCBI
Klhl41
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247877,065,121 - 7,077,857 (+)NCBI

Position Markers
Klhl41  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2C2UniSTS
cM Map240.92UniSTS
Klhl41  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2C2UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388608993591306Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220892967119064359Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220892967119064359Mouse
1357829Lvrq1_mliver weight QTL 1 (mouse)Not determined220892967119064359Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220892967119064359Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220892967119064359Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220892967119064359Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220892967119064359Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220892967119064359Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220892967119064359Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220892967119064359Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224334620148858457Mouse
1300577Capsq1_mcapsaicin sensitivity related QTL 1 (mouse)Not determined22771204884183040Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229417935148533014Mouse
4141236Hbnr5_mHeligmosomoides bakeri nematode resistance 5 (mouse)Not determined31324555105313225Mouse
4142447Pbwg1.7_mpostnatal body weight growth 1.7 (mouse)Not determined3590731269907394Mouse
4141186Pbwg1.8_mpostnatal body weight growth 1.8 (mouse)Not determined3590731269907394Mouse
4142133Pbwg1.6_mpostnatal body weight growth 1.6 (mouse)Not determined3590731269907394Mouse
1559001Eae33_mexperimental allergic encephalomyelitis susceptibility 33 (mouse)Not determined23610166771779068Mouse
11038703Ltpr1_mLeishmania tropica response 1 (mouse)24008165374081799Mouse
1301109Dntcs2_mdental caries susceptibility 2 (mouse)Not determined240995481115079684Mouse
1301480Pbwg1_mpostnatal body weight growth 1 (mouse)Not determined24193070775930831Mouse
1301411Pitm1_mprion incubation time 1 (mouse)Not determined24369026877690412Mouse
4141069Pbwg1.5_mpostnatal body weight growth 1.5 (mouse)Not determined4369026877690412Mouse
1301402Ap2q_malcohol preference 2 QTL (mouse)Not determined24369026877690412Mouse
1300788Cia2_mcollagen induced arthritis QTL 2 (mouse)Not determined24369026877690412Mouse
1300671Cia4_mcollagen induced arthritis QTL 4 (mouse)Not determined24369026877690412Mouse
10755532Lymph5_mlymphocyte differential 5 (mouse)24436867378368673Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245457623145470727Mouse
4141809Pbwg1.1_mpostnatal body weight growth 1.1 (mouse)Not determined4830206882302151Mouse
11532740Pbwg1.10_mpostnatal body weight growth 1.10 (mouse)24830206882302151Mouse
1301235Alcw4_malcohol withdrawal 4 (mouse)Not determined24843940282439590Mouse
1301747Eae21_mexperimental allergic encephalomyelitis 21 (mouse)Not determined24843940282439590Mouse
1302085Mobe1_mmodifier of obesity 1 (mouse)Not determined24843940282439590Mouse
1300568Hdl1_mhigh density lipoprotein (HDL) level 1 (mouse)Not determined24843940282439590Mouse
1558820Moo1_mmodifier of Odc1 (mouse)Not determined174843940282439590Mouse
10755526Lymph1_mlymphocyte differential 1 (mouse)25098897084988970Mouse
1300875Taste1_mtaste-saccharin preference 1 (mouse)Not determined25109283185092934Mouse
1300761Lgth1_mbody length 1 (mouse)Not determined25187293285873081Mouse
13464141Hbbcq3_mhemoglobin concentration QTL 3 (mouse)25261767586617792Mouse
13463471Hctq6_mhematocrit QTL 6 (mouse)25261767586617792Mouse
4142299Pbwg1.4_mpostnatal body weight growth 1.4 (mouse)Not determined5562407289624172Mouse
4141406Alpq2_malcohol preference QTL 2 (mouse)Not determined25769377391693944Mouse
12738429Lfibq18_mliver fibrosis QTL 18 (mouse)25808964792089647Mouse
1357577Trmq3_mT cell ratio modifier QTL 3 (mouse)Not determined260690268119525037Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)262000000137000000Mouse
1300662Etohila_methanol induced locomotor activity (mouse)Not determined26317561097175769Mouse
1301405Etohr_methanol response acute (mouse)Not determined26317561097175769Mouse
1301703Bomd3_mbone mineral density 3 (mouse)Not determined26317561097175769Mouse
10044002Hdl7_mHDL level 7 (mouse)Not determined26317561097175769Mouse
10053681Lith24_mlithogenic gene 24 (mouse)Not determined26317561097175769Mouse
1301048Actre2_mactivity response to ethanol 2 (mouse)Not determined26317561097175769Mouse
1301873Hsl1_mhyperoxia susceptibility locus 1 (mouse)Not determined26373981097739957Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265439402162677006Mouse
1301059Hrtfm1_mheart failure modifier 1 (mouse)Not determined26776159675134589Mouse
1301660Iba1_minduction of brown adipocytes 1 (mouse)Not determined267817543101817798Mouse
13463482Mchq17_mmean corpuscular hemoglobin QTL 17 (mouse)267817543101817798Mouse
1301948Elsgp3_melevated serum gp70 3 (mouse)Not determined268893925102894063Mouse
1301882Etohc2_methanol consumption 2 (mouse)Not determined268893925102894063Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:164
Count of miRNA genes:142
Interacting mature miRNAs:150
Transcripts:ENSMUST00000100050
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000100050   ⟹   ENSMUSP00000097627
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl269,670,120 - 69,684,230 (+)Ensembl
RefSeq Acc Id: NM_001081087   ⟹   NP_001074556
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39269,500,464 - 69,514,583 (+)NCBI
GRCm38269,670,120 - 69,684,239 (+)ENTREZGENE
MGSCv37269,508,177 - 69,522,296 (+)RGD
Celera271,339,447 - 71,353,726 (+)RGD
cM Map2 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001074556 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A2AUC9 (Get FASTA)   NCBI Sequence Viewer  
  AAI50699 (Get FASTA)   NCBI Sequence Viewer  
  BAE21267 (Get FASTA)   NCBI Sequence Viewer  
  EDL27039 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001074556   ⟸   NM_001081087
- UniProtKB: A2AUC9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000097627   ⟸   ENSMUST00000100050
Protein Domains
BACK   BTB

Promoters
RGD ID:6877502
Promoter ID:EPDNEW_M2201
Type:initiation region
Name:Klhl41_1
Description:Mus musculus kelch-like 41 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38269,670,120 - 69,670,180EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2683854 AgrOrtholog
Ensembl Genes ENSMUSG00000075307 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000097627 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000100050 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.120.10.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.710.10 UniProtKB/Swiss-Prot
InterPro BACK UniProtKB/Swiss-Prot
  BTB-kelch_protein UniProtKB/Swiss-Prot
  BTB/POZ_dom UniProtKB/Swiss-Prot
  Kelch-typ_b-propeller UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KLHL41 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot
KEGG Report mmu:228003 UniProtKB/Swiss-Prot
MGD MGI:2683854 ENTREZGENE
NCBI Gene 228003 ENTREZGENE
PANTHER PTHR24412:SF146 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BACK UniProtKB/Swiss-Prot
  BTB UniProtKB/Swiss-Prot
  Kelch_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Klhl41 PhenoGen
PIRSF Kelch-like_protein_gigaxonin UniProtKB/Swiss-Prot
PROSITE BTB UniProtKB/Swiss-Prot
SMART BACK UniProtKB/Swiss-Prot
  BTB UniProtKB/Swiss-Prot
  Kelch UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF117281 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54695 UniProtKB/Swiss-Prot
UniProt A2AUC9 ENTREZGENE, UniProtKB/Swiss-Prot
  Q3V184_MOUSE UniProtKB/TrEMBL
UniProt Secondary B2RWT7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-22 Klhl41  kelch-like 41  Kbtbd10  kelch repeat and BTB (POZ) domain containing 10  Symbol and/or name change 5135510 APPROVED