Dll1 (delta like canonical Notch ligand 1) - Rat Genome Database

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Gene: Dll1 (delta like canonical Notch ligand 1) Mus musculus
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Symbol: Dll1
Name: delta like canonical Notch ligand 1
RGD ID: 733843
MGI Page MGI
Description: Enables Notch binding activity and scaffold protein binding activity. Involved in several processes, including negative regulation of cell differentiation; nervous system development; and regionalization. Acts upstream of or within several processes, including inner ear development; negative regulation of cell differentiation; and regionalization. Located in several cellular components, including adherens junction; apical plasma membrane; and membrane raft. Is expressed in several structures, including alimentary system; brain; limb; metanephros; and sensory organ. Orthologous to human DLL1 (delta like canonical Notch ligand 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Delt; delta like-1; delta-like 1; delta-like 1 (Drosophila); delta-like protein 1; Delta1; drosophila Delta homolog 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391715,587,616 - 15,597,275 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1715,587,616 - 15,597,134 (-)EnsemblGRCm39 Ensembl
GRCm381715,367,354 - 15,376,932 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1715,367,354 - 15,376,872 (-)EnsemblGRCm38mm10GRCm38
MGSCv371715,504,318 - 15,512,787 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361715,072,317 - 15,080,550 (-)NCBIMGSCv36mm8
Celera1716,154,981 - 16,163,462 (-)NCBICelera
Cytogenetic Map17A2NCBI
cM Map178.95NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
acetohydrazide  (EXP)
acrylamide  (ISO)
all-trans-retinoic acid  (ISO)
alpha-naphthoflavone  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
antimycin A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butan-1-ol  (ISO)
butanal  (ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
calciol  (ISO)
cannabidiol  (EXP)
carbon nanotube  (EXP)
chlorpyrifos  (EXP,ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Dibutyl phosphate  (ISO)
dioxygen  (EXP,ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP)
ethanol  (ISO)
flavonoids  (ISO)
folic acid  (EXP)
furan  (EXP,ISO)
genistein  (EXP)
glycidol  (ISO)
glyphosate  (ISO)
hydrazine  (EXP)
imidacloprid  (ISO)
linuron  (ISO)
lipopolysaccharide  (ISO)
maneb  (EXP)
mercury dibromide  (ISO)
methimazole  (ISO)
methotrexate  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (ISO)
naphthalene  (EXP)
nitrofen  (ISO)
orphenadrine  (ISO)
p-chloromercuribenzoic acid  (ISO)
paraquat  (EXP)
pentachlorophenol  (EXP)
pentanal  (ISO)
permethrin  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
propanal  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
thiabendazole  (ISO)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
triadimefon  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triptonide  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (NAS)
astrocyte development  (IMP)
auditory receptor cell fate commitment  (NAS)
cell communication  (IEA)
cell differentiation  (IEA)
cell-cell signaling  (IDA)
cerebellar molecular layer formation  (IMP)
cerebellar Purkinje cell layer structural organization  (IMP)
clathrin-dependent endocytosis  (ISO)
compartment pattern specification  (IMP)
determination of left/right symmetry  (IMP)
endothelial tip cell fate specification  (IMP)
energy homeostasis  (IMP)
heart looping  (IMP)
in utero embryonic development  (NAS)
inhibition of neuroepithelial cell differentiation  (IMP)
inner ear auditory receptor cell differentiation  (IMP,NAS)
inner ear development  (IMP)
inner ear morphogenesis  (NAS)
lateral inhibition  (IDA,IMP)
left/right axis specification  (IMP)
loop of Henle development  (IEP)
marginal zone B cell differentiation  (IMP)
myeloid cell differentiation  (IDA)
negative regulation of cardiac muscle cell differentiation  (IMP)
negative regulation of cell differentiation  (IMP)
negative regulation of cell population proliferation  (IMP)
negative regulation of epidermal cell differentiation  (IMP)
negative regulation of epithelial cell differentiation  (IMP)
negative regulation of glial cell apoptotic process  (IMP)
negative regulation of inner ear auditory receptor cell differentiation  (IMP)
negative regulation of interleukin-10 production  (ISO)
negative regulation of myeloid cell differentiation  (IDA)
negative regulation of myoblast differentiation  (IMP)
negative regulation of neuron differentiation  (IMP)
negative regulation of Notch signaling pathway  (IBA)
nephron development  (IMP)
nervous system development  (NAS)
neuroepithelial cell differentiation  (IMP)
neuron differentiation  (IMP)
neuron fate specification  (IDA)
neuronal stem cell population maintenance  (IMP)
Notch signaling pathway  (IBA,IEP,IMP,ISO,TAS)
Notch signaling pathway involved in arterial endothelial cell fate commitment  (IMP)
odontogenesis of dentin-containing tooth  (NAS)
organ growth  (IMP)
positive regulation of cell population proliferation  (IMP)
positive regulation of endocytosis  (IDA)
positive regulation of gene expression  (IMP,ISO)
positive regulation of Notch signaling pathway  (IDA,IMP,ISO)
positive regulation of skeletal muscle tissue growth  (IMP)
positive regulation of sprouting angiogenesis  (IMP)
positive regulation of transcription by RNA polymerase II  (IMP)
proximal tubule development  (IEP)
proximal/distal pattern formation  (IMP)
regulation of blood pressure  (IMP)
regulation of cell adhesion  (IMP)
regulation of cell division  (IMP)
regulation of growth  (IMP)
regulation of neurogenesis  (IMP)
regulation of skeletal muscle tissue growth  (IMP)
regulation of somitogenesis  (IMP)
regulation of vascular endothelial growth factor receptor signaling pathway  (IMP)
regulation of vascular endothelial growth factor signaling pathway  (IMP)
retina development in camera-type eye  (IMP)
retina morphogenesis in camera-type eye  (IMP)
skeletal muscle tissue growth  (IMP)
skin epidermis development  (IMP)
somite specification  (IMP)
somitogenesis  (IGI,IMP)
spinal cord development  (IMP)
type B pancreatic cell development  (IMP)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal axial skeleton morphology  (IAGP)
abnormal bone mineral density  (IAGP)
abnormal brain development  (IAGP)
abnormal capillary branching pattern  (IAGP)
abnormal cochlear hair cell morphology  (IAGP)
abnormal defecation  (IAGP)
abnormal direction of embryo turning  (IAGP)
abnormal direction of heart looping  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal heart morphology  (IAGP)
abnormal muscle morphology  (IAGP)
abnormal myoblast differentiation  (IAGP)
abnormal myogenesis  (IAGP)
abnormal myotube differentiation  (IAGP)
abnormal nephron morphogenesis  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal notochord morphology  (IAGP)
abnormal organ of Corti morphology  (IAGP)
abnormal orientation of cochlear hair cell stereociliary bundles  (IAGP)
abnormal pancreas development  (IAGP)
abnormal paraxial mesoderm morphology  (IAGP)
abnormal primitive node morphology  (IAGP)
abnormal Q wave  (IAGP)
abnormal skin vasculature morphology  (IAGP)
abnormal somatic nervous system morphology  (IAGP)
abnormal somite border morphology  (IAGP)
abnormal somite development  (IAGP)
abnormal somite shape  (IAGP)
abnormal spinal nerve morphology  (IAGP)
abnormal utricular macula morphology  (IAGP)
abnormal vertebrae morphology  (IAGP)
abnormal vestibular saccular macula morphology  (IAGP)
absent embryonic cilia  (IAGP)
absent marginal zone B cells  (IAGP)
absent podocytes  (IAGP)
aorta stenosis  (IAGP)
artery stenosis  (IAGP)
caudal body truncation  (IAGP)
decreased B-1 B cell number  (IAGP)
decreased basal metabolism  (IAGP)
decreased blood uric acid level  (IAGP)
decreased body height  (IAGP)
decreased body length  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral content  (IAGP)
decreased bone mineral density  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased circulating cholesterol level  (IAGP)
decreased circulating total protein level  (IAGP)
decreased circulating triglyceride level  (IAGP)
decreased cochlea coiling  (IAGP)
decreased food intake  (IAGP)
decreased heart rate  (IAGP)
decreased IgA level  (IAGP)
decreased IgG1 level  (IAGP)
decreased IgG2b level  (IAGP)
decreased IgG3 level  (IAGP)
decreased lean body mass  (IAGP)
decreased locomotor activity  (IAGP)
decreased lumbar vertebrae number  (IAGP)
decreased nephron number  (IAGP)
decreased neuronal precursor cell number  (IAGP)
decreased organ of Corti supporting cell number  (IAGP)
decreased skeletal muscle mass  (IAGP)
decreased total body fat amount  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
enlarged floor plate  (IAGP)
fused dorsal root ganglion  (IAGP)
hemorrhage  (IAGP)
hyperactivity  (IAGP)
incomplete somite formation  (IAGP)
increased B cell number  (IAGP)
increased basal metabolism  (IAGP)
increased blood uric acid level  (IAGP)
increased bone mineral density  (IAGP)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased cochlear inner hair cell number  (IAGP)
increased cochlear outer hair cell number  (IAGP)
increased lean body mass  (IAGP)
increased mean systemic arterial blood pressure  (IAGP)
increased motor neuron number  (IAGP)
increased neuron number  (IAGP)
increased susceptibility to weight loss  (IAGP)
increased systemic arterial diastolic blood pressure  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP)
no abnormal phenotype detected  (IAGP)
no spontaneous movement  (IAGP)
perinatal lethality  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
short tail  (IAGP)
situs inversus  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. JAGGED1 and delta1 differentially regulate the outcome of experimental autoimmune encephalomyelitis. Elyaman W, etal., J Immunol. 2007 Nov 1;179(9):5990-8.
2. Cell and molecular biology of Notch. Fiuza UM and Arias AM, J Endocrinol. 2007 Sep;194(3):459-74.
3. A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway. Johnston SH, etal., Development 1997 Jun;124(11):2245-54.
4. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. HNF3beta and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior-posterior polarity in the mouse embryo. Perea-Gomez A, etal., Development 1999 Oct;126(20):4499-511.
8. Blocking the NOTCH pathway inhibits vascular inflammation in large-vessel vasculitis. Piggott K, etal., Circulation. 2011 Jan 25;123(3):309-18. Epub 2011 Jan 10.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11. Mouse MP Annotation Import Pipeline RGD automated import pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Pancreatic regeneration in chronic pancreatitis requires activation of the notch signaling pathway. Su Y, etal., J Gastrointest Surg. 2006 Nov;10(9):1230-41; discussion 1242.
Additional References at PubMed
PMID:3581995   PMID:7490078   PMID:7671806   PMID:8923452   PMID:9102301   PMID:9109488   PMID:9153393   PMID:9207795   PMID:9242490   PMID:9272948   PMID:9291577   PMID:9315665  
PMID:9315901   PMID:9490412   PMID:9539122   PMID:9539123   PMID:9662403   PMID:9690472   PMID:9690473   PMID:9716576   PMID:9739106   PMID:9858718   PMID:9858728   PMID:9876181  
PMID:9882480   PMID:10021340   PMID:10079256   PMID:10080181   PMID:10196361   PMID:10330372   PMID:10393122   PMID:10473134   PMID:10473135   PMID:10476967   PMID:10557208   PMID:10615124  
PMID:10631167   PMID:10675782   PMID:10704388   PMID:10804169   PMID:10821758   PMID:10837027   PMID:10842072   PMID:10878608   PMID:10879540   PMID:10906448   PMID:10932180   PMID:10952889  
PMID:10958687   PMID:11002339   PMID:11017084   PMID:11035934   PMID:11044610   PMID:11044625   PMID:11060244   PMID:11076679   PMID:11118901   PMID:11124811   PMID:11133162   PMID:11171333  
PMID:11262239   PMID:11562355   PMID:11567612   PMID:11578869   PMID:11581320   PMID:11713346   PMID:11731257   PMID:11739954   PMID:11747084   PMID:11807030   PMID:11823422   PMID:11900971  
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PMID:12730123   PMID:12730124   PMID:12794186   PMID:12839624   PMID:12846471   PMID:12866128   PMID:12900443   PMID:12925591   PMID:12971992   PMID:14517990   PMID:14529612   PMID:14651921  
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PMID:15198674   PMID:15242798   PMID:15257302   PMID:15314075   PMID:15459106   PMID:15465493   PMID:15465494   PMID:15469977   PMID:15485825   PMID:15486060   PMID:15494433   PMID:15496443  
PMID:15499562   PMID:15509766   PMID:15537664   PMID:15545628   PMID:15545629   PMID:15574878   PMID:15634781   PMID:15649475   PMID:15689374   PMID:15728481   PMID:15788413   PMID:15800025  
PMID:15821257   PMID:15845899   PMID:15857914   PMID:15866159   PMID:15902259   PMID:15908431   PMID:15927725   PMID:15930111   PMID:15937931   PMID:15976074   PMID:15979417   PMID:15986483  
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PMID:16368932   PMID:16393955   PMID:16410412   PMID:16412699   PMID:16452096   PMID:16467359   PMID:16469766   PMID:16495313   PMID:16508312   PMID:16518823   PMID:16602821   PMID:16621992  
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PMID:17150988   PMID:17179084   PMID:17194759   PMID:17196193   PMID:17210915   PMID:17229764   PMID:17234965   PMID:17251195   PMID:17257418   PMID:17273555   PMID:17306789   PMID:17319963  
PMID:17325035   PMID:17336907   PMID:17360776   PMID:17476283   PMID:17477400   PMID:17537796   PMID:17572911   PMID:17582329   PMID:17584735   PMID:17605079   PMID:17625108   PMID:17664336  
PMID:17666427   PMID:17670789   PMID:17681139   PMID:17685488   PMID:17823936   PMID:17878313   PMID:17880938   PMID:17898542   PMID:17928865   PMID:17937396   PMID:17960184   PMID:17986227  
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PMID:18287559   PMID:18299190   PMID:18346943   PMID:18371447   PMID:18381350   PMID:18400163   PMID:18495817   PMID:18505817   PMID:18547789   PMID:18590718   PMID:18591437   PMID:18676613  
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PMID:19562077   PMID:19686682   PMID:19701191   PMID:19723503   PMID:19723505   PMID:19853565   PMID:19897741   PMID:19906845   PMID:19914171   PMID:20017954   PMID:20081190   PMID:20231851  
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PMID:21791528   PMID:21829655   PMID:21873635   PMID:21880902   PMID:21915337   PMID:21931765   PMID:21949024   PMID:21963425   PMID:21985982   PMID:22015720   PMID:22031906   PMID:22069191  
PMID:22072963   PMID:22081605   PMID:22096075   PMID:22249198   PMID:22258620   PMID:22282195   PMID:22323600   PMID:22390640   PMID:22430492   PMID:22432025   PMID:22445366   PMID:22464328  
PMID:22484060   PMID:22529374   PMID:22554696   PMID:22624713   PMID:22675208   PMID:22675211   PMID:22771497   PMID:22819676   PMID:22940113   PMID:22944320   PMID:23000963   PMID:23072809  
PMID:23083737   PMID:23111325   PMID:23132245   PMID:23160044   PMID:23162128   PMID:23223237   PMID:23284862   PMID:23362346   PMID:23362348   PMID:23362349   PMID:23369715   PMID:23437001  
PMID:23499991   PMID:23665443   PMID:23671110   PMID:23688253   PMID:23695674   PMID:23699523   PMID:23806616   PMID:23988615   PMID:23988616   PMID:23988635   PMID:24015274   PMID:24025447  
PMID:24073291   PMID:24148613   PMID:24167636   PMID:24227653   PMID:24337118   PMID:24391519   PMID:24443808   PMID:24449764   PMID:24453338   PMID:24533113   PMID:24552588   PMID:24647000  
PMID:24673559   PMID:24711412   PMID:24715457   PMID:24801048   PMID:24859004   PMID:24909139   PMID:24929016   PMID:24943093   PMID:24952961   PMID:24971735   PMID:24982181   PMID:25015359  
PMID:25100656   PMID:25220152   PMID:25378482   PMID:25468943   PMID:25501905   PMID:25535917   PMID:25641698   PMID:25691540   PMID:25703143   PMID:25715394   PMID:25715395   PMID:25725069  
PMID:25813538   PMID:25919081   PMID:26114479   PMID:26387541   PMID:26450967   PMID:26453796   PMID:26514267   PMID:26522918   PMID:26651607   PMID:26728556   PMID:26801181   PMID:26811377  
PMID:26911688   PMID:26912775   PMID:26947267   PMID:26988119   PMID:27005988   PMID:27188577   PMID:27510977   PMID:27576369   PMID:27578777   PMID:27631609   PMID:27659682   PMID:27707753  
PMID:27719760   PMID:27894818   PMID:28089369   PMID:28319044   PMID:28334989   PMID:28402857   PMID:28537242   PMID:28656980   PMID:28699891   PMID:28714968   PMID:28718206   PMID:28863329  
PMID:29031500   PMID:29038036   PMID:29038527   PMID:29140246   PMID:29352015   PMID:29445148   PMID:29449451   PMID:29712641   PMID:29773667   PMID:29853617   PMID:29961574   PMID:30093553  
PMID:30168730   PMID:30181175   PMID:30189017   PMID:30201687   PMID:30289388   PMID:30292786   PMID:30538222   PMID:30590051   PMID:30692224   PMID:30699346   PMID:30796970   PMID:30872278  
PMID:30894800   PMID:30940183   PMID:31071093   PMID:31112136   PMID:31171666   PMID:31202705   PMID:31278348   PMID:31504280   PMID:31590629   PMID:31631837   PMID:31676552   PMID:31789450  
PMID:31843916   PMID:31899345   PMID:31934853   PMID:31988190   PMID:32023464   PMID:32029480   PMID:32059775   PMID:32060138   PMID:32094111   PMID:32161758   PMID:32499648   PMID:32719388  
PMID:32747435   PMID:32800756   PMID:32820046   PMID:32855167   PMID:33053343   PMID:33637744   PMID:33795231   PMID:33798452   PMID:33892704   PMID:34035167   PMID:34321999   PMID:34370738  
PMID:34407390   PMID:34438113   PMID:34519339   PMID:34519870   PMID:34583743   PMID:34698766   PMID:35091558   PMID:35103284   PMID:35247391   PMID:35320729   PMID:35371023   PMID:35429490  
PMID:35577801   PMID:35815610   PMID:36064547   PMID:36218069   PMID:36239412   PMID:36590296   PMID:36681690   PMID:37260223   PMID:37369584   PMID:37532879   PMID:37691936   PMID:37727504  
PMID:38072061   PMID:38345319   PMID:38355793  


Genomics

Comparative Map Data
Dll1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391715,587,616 - 15,597,275 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1715,587,616 - 15,597,134 (-)EnsemblGRCm39 Ensembl
GRCm381715,367,354 - 15,376,932 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1715,367,354 - 15,376,872 (-)EnsemblGRCm38mm10GRCm38
MGSCv371715,504,318 - 15,512,787 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361715,072,317 - 15,080,550 (-)NCBIMGSCv36mm8
Celera1716,154,981 - 16,163,462 (-)NCBICelera
Cytogenetic Map17A2NCBI
cM Map178.95NCBI
DLL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386170,282,206 - 170,291,078 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6170,282,206 - 170,306,565 (-)EnsemblGRCh38hg38GRCh38
GRCh376170,591,294 - 170,600,166 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366170,433,219 - 170,441,622 (-)NCBINCBI36Build 36hg18NCBI36
Build 346170,508,932 - 170,517,112NCBI
Celera6171,388,861 - 171,397,261 (-)NCBICelera
Cytogenetic Map6q27NCBI
HuRef6168,098,039 - 168,106,439 (-)NCBIHuRef
CHM1_16170,851,870 - 170,860,273 (-)NCBICHM1_1
T2T-CHM13v2.06171,640,900 - 171,649,769 (-)NCBIT2T-CHM13v2.0
Dll1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8164,985,161 - 64,993,274 (-)NCBIGRCr8
mRatBN7.2156,312,062 - 56,320,177 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl156,312,066 - 56,320,179 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx161,164,063 - 61,172,170 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0169,827,568 - 69,835,693 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0163,074,034 - 63,082,141 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0157,318,621 - 57,326,732 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl157,318,708 - 57,327,379 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01242,107,684 - 242,115,795 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4154,240,395 - 54,248,183 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1154,243,339 - 54,251,125 (-)NCBI
Celera152,521,212 - 52,529,325 (-)NCBICelera
Cytogenetic Map1q12NCBI
Dll1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554113,478,033 - 3,486,604 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554113,478,943 - 3,486,541 (+)NCBIChiLan1.0ChiLan1.0
DLL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25190,554,039 - 190,562,923 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16188,458,574 - 188,466,578 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06168,440,192 - 168,449,071 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16173,535,941 - 173,545,362 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6173,534,292 - 173,544,759 (-)Ensemblpanpan1.1panPan2
DLL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11272,265,078 - 72,272,347 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1272,265,682 - 72,272,348 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1272,029,118 - 72,036,680 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01273,251,013 - 73,258,571 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11272,524,902 - 72,532,408 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01272,346,638 - 72,354,211 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01272,737,393 - 72,744,967 (-)NCBIUU_Cfam_GSD_1.0
Dll1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946151,369,680 - 151,377,618 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004937098213,227 - 220,427 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004937098212,704 - 220,589 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DLL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1199,358 - 211,346 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11198,815 - 211,346 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21280,640 - 291,729 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DLL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11397,928,480 - 97,936,594 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1397,928,634 - 97,936,589 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604069,934,302 - 69,943,226 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dll1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248506,134,908 - 6,143,404 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248506,135,214 - 6,142,975 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dll1
328 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:795
Count of miRNA genes:506
Interacting mature miRNAs:587
Transcripts:ENSMUST00000014917, ENSMUST00000124196, ENSMUST00000129395, ENSMUST00000140784, ENSMUST00000143460, ENSMUST00000152416
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558807Ceat1_mchronic experimental autoimmune thyroiditis 1 (mouse)Not determined171263668226401133Mouse
12910982Pifs2_mpeptide-induced fatal syndrome 2 (mouse)17126189355Mouse
12910528Nrq1_mnoise-induced hearing loss resistant QTL 1 (mouse)17129198453Mouse
1302100Circp2_mcircadian photosensitivity 2 (mouse)Not determined17129198453Mouse
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17397489048866091Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined171008134086996400Mouse
1357789Kdnw3_mkidney weight 3 (mouse)Not determined17485475247885665Mouse
1300995Fembrs4_mfemur breaking strength 4 (mouse)Not determined171506165249061760Mouse
4142507Obrq13_mobesity resistance QTL 13 (mouse)Not determined1219832925076769Mouse
1300613Pcyts4_mplasmacytoma susceptibility 4 (mouse)Not determined17127081639Mouse
4141608Phl1_mprogressive hearing loss 1 (mouse)Not determined17787584329487423Mouse
1357452Vtbt18_mvertebral trabecular bone trait 18 (mouse)Not determined17120975022Mouse
1357902Obq19_mobesity QTL 19 (mouse)Not determined17125662076Mouse
1301327Lmr7_mleishmaniasis resistance 7 (mouse)Not determined17485475227715939Mouse
1302028Asbb3_mautoimmune susceptibility in C57BL/6J and BALB/c 3 (mouse)Not determined171087811944878219Mouse
1300787Cd8mts5_mCD8 memory T cell subset 5 (mouse)Not determined17858491442585149Mouse
4141215Mnic1_mmacronutrient intake, carbohydrate 1 (mouse)Not determined485475245670266Mouse
1300914Pcir4_mperiosteal circumference 4 (mouse)Not determined171506165249061760Mouse
13524847Asrq8a_macoustic startle response 8a (mouse)171264696146646961Mouse
14747010Mancz14_mmandible centroid size 14 (mouse)171199818445998184Mouse
1357680Idd23_minsulin dependent diabetes susceptibility 23 (mouse)Not determined17397489026401133Mouse
1302070Tbbmd7_mtotal body bone mineral density 7 (mouse)Not determined171506165249061760Mouse
1302196Myaa1_mmodifier of Yaa 1 (mouse)Not determined17120975022Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined485475265637357Mouse
10412276Leci2_mleukocyte endothelial cell interactions 2 (mouse)Not determined17334817537348299Mouse
1300706Alan1_malloantigen response 1 (mouse)Not determined17485475246469702Mouse
1558886Lgth9_mbody length 9 (mouse)Not determined171506165249061760Mouse
4141067Hbnr2_mHeligmosomoides bakeri nematode resistance 2 (mouse)Not determined1188597145886119Mouse
10043949Pbft7_mpercent body fat 7 (mouse)Not determined17689393640893936Mouse
12904946Tammq8_mtibialis anterior muscle mass QTL 8 (mouse)171245178746451787Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171228621183361768Mouse
4142342Lfnq4_mlung function QTL 4 (mouse)Not determined1120648439364059Mouse
11081168Tir7_mtrypanosome infection response 7 (mouse)171412337248123496Mouse
1357743Lith3_mlithogenic gene 3 (mouse)Not determined17126194456Mouse
12910527Nrq1a_mnoise-induced hearing loss resistant QTL 1a (mouse)17129198453Mouse
1301615Cfld3_mcystic fibrosis lung disease 3 (mouse)Not determined17127081639Mouse
1301935Skull24_mskull morphology 24 (mouse)Not determined17858491442585149Mouse
13524851Asrq8_macoustic startle response 8 (mouse)17131030170Mouse

Markers in Region
Dll1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17A2UniSTS
cM Map178.2UniSTS
UniSTS:237573  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381715,375,459 - 15,375,659UniSTSGRCm38
MGSCv371715,512,423 - 15,512,623UniSTSGRCm37
Celera1716,163,098 - 16,163,298UniSTS
Cytogenetic Map17A2UniSTS
cM Map178.2UniSTS
UniSTS:225019  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381715,367,806 - 15,367,966UniSTSGRCm38
MGSCv371715,504,770 - 15,504,930UniSTSGRCm37
Celera1716,155,433 - 16,155,593UniSTS
Cytogenetic Map17A2UniSTS
cM Map178.2UniSTS
PMC281641P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381715,374,728 - 15,374,820UniSTSGRCm38
MGSCv371715,511,692 - 15,511,784UniSTSGRCm37
Celera1716,162,367 - 16,162,459UniSTS
Cytogenetic Map17A2UniSTS
cM Map178.2UniSTS
Dll1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381715,367,871 - 15,368,602UniSTSGRCm38
MGSCv371715,504,835 - 15,505,566UniSTSGRCm37
Celera1716,155,498 - 16,156,229UniSTS
Cytogenetic Map17A2UniSTS
Dll1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17A2UniSTS
Dll1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17A2UniSTS
Dll1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17A2UniSTS
Dll1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381715,368,586 - 15,368,693UniSTSGRCm38
MGSCv371715,505,550 - 15,505,657UniSTSGRCm37
Celera1716,156,213 - 16,156,320UniSTS
Cytogenetic Map17A2UniSTS
Dll1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381715,367,796 - 15,368,040UniSTSGRCm38
MGSCv371715,504,760 - 15,505,004UniSTSGRCm37
Celera1716,155,423 - 16,155,667UniSTS
Cytogenetic Map17A2UniSTS
cM Map178.2UniSTS
Dll1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381715,367,697 - 15,368,495UniSTSGRCm38
MGSCv371715,504,661 - 15,505,459UniSTSGRCm37
Celera1716,155,324 - 16,156,122UniSTS
Cytogenetic Map17A2UniSTS
cM Map178.2UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000014917   ⟹   ENSMUSP00000014917
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1715,587,616 - 15,596,238 (-)Ensembl
GRCm38.p6 Ensembl1715,367,354 - 15,375,976 (-)Ensembl
Ensembl Acc Id: ENSMUST00000124196
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1715,591,886 - 15,595,362 (-)Ensembl
GRCm38.p6 Ensembl1715,371,624 - 15,375,100 (-)Ensembl
Ensembl Acc Id: ENSMUST00000129395
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1715,590,871 - 15,594,334 (-)Ensembl
GRCm38.p6 Ensembl1715,370,609 - 15,374,072 (-)Ensembl
Ensembl Acc Id: ENSMUST00000140784
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1715,587,787 - 15,588,652 (-)Ensembl
GRCm38.p6 Ensembl1715,367,525 - 15,368,390 (-)Ensembl
Ensembl Acc Id: ENSMUST00000143460   ⟹   ENSMUSP00000156341
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1715,595,056 - 15,597,134 (-)Ensembl
GRCm38.p6 Ensembl1715,374,794 - 15,376,872 (-)Ensembl
Ensembl Acc Id: ENSMUST00000152416
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1715,590,518 - 15,592,093 (-)Ensembl
GRCm38.p6 Ensembl1715,370,256 - 15,371,831 (-)Ensembl
RefSeq Acc Id: NM_001379042   ⟹   NP_001365971
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391715,587,618 - 15,597,194 (-)NCBI
GRCm381715,367,356 - 15,376,932 (-)NCBI
Sequence:
RefSeq Acc Id: NM_007865   ⟹   NP_031891
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391715,587,616 - 15,596,085 (-)NCBI
GRCm381715,367,354 - 15,375,823 (-)NCBI
MGSCv371715,504,318 - 15,512,787 (-)RGD
Celera1716,154,981 - 16,163,462 (-)RGD
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011246267   ⟹   XP_011244569
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391715,587,616 - 15,596,411 (-)NCBI
GRCm381715,367,354 - 15,376,048 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036160292   ⟹   XP_036016185
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391715,587,616 - 15,597,275 (-)NCBI
Sequence:
RefSeq Acc Id: NP_031891   ⟸   NM_007865
- Peptide Label: precursor
- UniProtKB: Q6PFV7 (UniProtKB/Swiss-Prot),   Q61483 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011244569   ⟸   XM_011246267
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001365971   ⟸   NM_001379042
- Peptide Label: precursor
- UniProtKB: Q61483 (UniProtKB/Swiss-Prot),   Q6PFV7 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSMUSP00000156341   ⟸   ENSMUST00000143460
Ensembl Acc Id: ENSMUSP00000014917   ⟸   ENSMUST00000014917
RefSeq Acc Id: XP_036016185   ⟸   XM_036160292
- Peptide Label: isoform X1
Protein Domains
DSL   EGF-like   Notch ligand N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61483-F1-model_v2 AlphaFold Q61483 1-722 view protein structure

Promoters
RGD ID:6828007
Promoter ID:MM_KWN:22219
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:OTTMUST00000049751
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361715,505,871 - 15,506,371 (-)MPROMDB
RGD ID:6828008
Promoter ID:MM_KWN:22221
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:OTTMUST00000049749
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361715,511,376 - 15,511,876 (-)MPROMDB
RGD ID:6828005
Promoter ID:MM_KWN:22222
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   Spleen
Transcripts:OTTMUST00000049746,   OTTMUST00000049748
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361715,512,236 - 15,513,392 (-)MPROMDB
RGD ID:6828006
Promoter ID:MM_KWN:22223
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:OTTMUST00000049747
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361715,513,516 - 15,514,016 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104659 AgrOrtholog
Ensembl Genes ENSMUSG00000014773 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000014917 ENTREZGENE
  ENSMUST00000014917.8 UniProtKB/Swiss-Prot
  ENSMUST00000143460.2 UniProtKB/TrEMBL
Gene3D-CATH 2.10.25.140 UniProtKB/Swiss-Prot
  2.60.40.3510 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot
InterPro DSL UniProtKB/Swiss-Prot
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  Notch_Cell-Fate_Det UniProtKB/Swiss-Prot
  Notch_ligand_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13388 UniProtKB/Swiss-Prot
MGD MGI:104659 ENTREZGENE
NCBI Gene 13388 ENTREZGENE
PANTHER CRUMBS FAMILY MEMBER UniProtKB/Swiss-Prot
  NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1 UniProtKB/Swiss-Prot
Pfam DL-JAG_EGF-like UniProtKB/Swiss-Prot
  DSL UniProtKB/Swiss-Prot
  EGF UniProtKB/Swiss-Prot
  MNNL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dll1 PhenoGen
PRINTS EGFBLOOD UniProtKB/Swiss-Prot
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot
  DSL UniProtKB/Swiss-Prot
  EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
SMART DSL UniProtKB/Swiss-Prot
  EGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot
  SSF57184 UniProtKB/Swiss-Prot
UniProt A0A338P7A6_MOUSE UniProtKB/TrEMBL
  DLL1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q6PFV7 ENTREZGENE
  Q99N81_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q6PFV7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-31 Dll1  delta like canonical Notch ligand 1    delta-like 1 (Drosophila)  Symbol and/or name change 5135510 APPROVED