Dll1 (delta like canonical Notch ligand 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Dll1 (delta like canonical Notch ligand 1) Heterocephalus glaber
Analyze
Symbol: Dll1
Name: delta like canonical Notch ligand 1
RGD ID: 18903676
Description: ENCODES a protein that exhibits Notch binding (ortholog); receptor ligand activity (ortholog); scaffold protein binding (ortholog); INVOLVED IN astrocyte development (ortholog); cell-cell signaling (ortholog); cerebellar molecular layer formation (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH Brain Neoplasms (ortholog); Breast Neoplasms (ortholog); Chronic Pancreatitis (ortholog); FOUND IN adherens junction (ortholog); apical plasma membrane (ortholog); cytoplasmic vesicle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: delta-like protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248506,134,908 - 6,143,404 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248506,135,214 - 6,142,975 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
astrocyte development  (ISO)
cell communication  (IEA)
cell differentiation  (IEA)
cell-cell signaling  (ISO)
cerebellar molecular layer formation  (ISO)
cerebellar Purkinje cell layer structural organization  (ISO)
clathrin-dependent endocytosis  (ISO)
compartment pattern specification  (ISO)
determination of left/right symmetry  (ISO)
endothelial tip cell fate specification  (ISO)
energy homeostasis  (ISO)
heart looping  (ISO)
inhibition of neuroepithelial cell differentiation  (ISO)
inner ear auditory receptor cell differentiation  (ISO)
inner ear development  (ISO)
lateral inhibition  (ISO)
left/right axis specification  (ISO)
loop of Henle development  (ISO)
marginal zone B cell differentiation  (ISO)
myeloid cell differentiation  (ISO)
negative regulation of cardiac muscle cell differentiation  (ISO)
negative regulation of cell differentiation  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of epidermal cell differentiation  (ISO)
negative regulation of epithelial cell differentiation  (ISO)
negative regulation of glial cell apoptotic process  (ISO)
negative regulation of inner ear auditory receptor cell differentiation  (ISO)
negative regulation of interleukin-10 production  (ISO)
negative regulation of myeloid cell differentiation  (ISO)
negative regulation of myoblast differentiation  (ISO)
negative regulation of neuron differentiation  (ISO)
nephron development  (ISO)
neuroepithelial cell differentiation  (ISO)
neuron differentiation  (ISO)
neuron fate specification  (ISO)
neuronal stem cell population maintenance  (ISO)
Notch signaling pathway  (IEA)
Notch signaling pathway involved in arterial endothelial cell fate commitment  (ISO)
organ growth  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of endocytosis  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of Notch signaling pathway  (ISO)
positive regulation of skeletal muscle tissue growth  (ISO)
positive regulation of sprouting angiogenesis  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
proximal tubule development  (ISO)
proximal/distal pattern formation  (ISO)
regulation of blood pressure  (ISO)
regulation of cell adhesion  (ISO)
regulation of cell division  (ISO)
regulation of growth  (ISO)
regulation of neurogenesis  (ISO)
regulation of skeletal muscle tissue growth  (ISO)
regulation of somitogenesis  (ISO)
regulation of vascular endothelial growth factor receptor signaling pathway  (ISO)
regulation of vascular endothelial growth factor signaling pathway  (ISO)
retina development in camera-type eye  (ISO)
retina morphogenesis in camera-type eye  (ISO)
skeletal muscle tissue growth  (ISO)
skin epidermis development  (ISO)
somite specification  (ISO)
somitogenesis  (ISO)
spinal cord development  (ISO)
type B pancreatic cell development  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Dll1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248506,134,908 - 6,143,404 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248506,135,214 - 6,142,975 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
DLL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386170,282,206 - 170,291,078 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6170,282,206 - 170,306,565 (-)EnsemblGRCh38hg38GRCh38
GRCh376170,591,294 - 170,600,166 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366170,433,219 - 170,441,622 (-)NCBINCBI36Build 36hg18NCBI36
Build 346170,508,932 - 170,517,112NCBI
Celera6171,388,861 - 171,397,261 (-)NCBICelera
Cytogenetic Map6q27NCBI
HuRef6168,098,039 - 168,106,439 (-)NCBIHuRef
CHM1_16170,851,870 - 170,860,273 (-)NCBICHM1_1
T2T-CHM13v2.06171,640,900 - 171,649,769 (-)NCBIT2T-CHM13v2.0
Dll1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391715,587,616 - 15,597,275 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1715,587,616 - 15,597,134 (-)EnsemblGRCm39 Ensembl
GRCm381715,367,354 - 15,376,932 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1715,367,354 - 15,376,872 (-)EnsemblGRCm38mm10GRCm38
MGSCv371715,504,318 - 15,512,787 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361715,072,317 - 15,080,550 (-)NCBIMGSCv36mm8
Celera1716,154,981 - 16,163,462 (-)NCBICelera
Cytogenetic Map17A2NCBI
cM Map178.95NCBI
Dll1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8164,985,161 - 64,993,274 (-)NCBIGRCr8
mRatBN7.2156,312,062 - 56,320,177 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl156,312,066 - 56,320,179 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx161,164,063 - 61,172,170 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0169,827,568 - 69,835,693 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0163,074,034 - 63,082,141 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0157,318,621 - 57,326,732 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl157,318,708 - 57,327,379 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01242,107,684 - 242,115,795 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4154,240,395 - 54,248,183 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1154,243,339 - 54,251,125 (-)NCBI
Celera152,521,212 - 52,529,325 (-)NCBICelera
Cytogenetic Map1q12NCBI
Dll1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554113,478,033 - 3,486,604 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554113,478,943 - 3,486,541 (+)NCBIChiLan1.0ChiLan1.0
DLL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25190,554,039 - 190,562,923 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16188,458,574 - 188,466,578 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06168,440,192 - 168,449,071 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16173,535,941 - 173,545,362 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6173,534,292 - 173,544,759 (-)Ensemblpanpan1.1panPan2
DLL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11272,265,078 - 72,272,347 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1272,265,682 - 72,272,348 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1272,029,118 - 72,036,680 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01273,251,013 - 73,258,571 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11272,524,902 - 72,532,408 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01272,346,638 - 72,354,211 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01272,737,393 - 72,744,967 (-)NCBIUU_Cfam_GSD_1.0
Dll1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946151,369,680 - 151,377,618 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004937098213,227 - 220,427 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004937098212,704 - 220,589 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DLL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1199,358 - 211,346 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11198,815 - 211,346 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21280,640 - 291,729 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DLL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11397,928,480 - 97,936,594 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1397,928,634 - 97,936,589 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604069,934,302 - 69,943,226 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000003643   ⟹   ENSHGLP00000003588
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248506,134,908 - 6,143,404 (-)Ensembl
RefSeq Acc Id: XM_004868848   ⟹   XP_004868905
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248506,135,216 - 6,142,975 (-)NCBI
RefSeq Acc Id: XM_004868849   ⟹   XP_004868906
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248506,135,214 - 6,142,975 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004868905 (Get FASTA)   NCBI Sequence Viewer  
  XP_004868906 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000003588
GenBank Protein JAN98958 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004868906   ⟸   XM_004868849
- Peptide Label: isoform X2
- UniProtKB: G5C7R7 (UniProtKB/TrEMBL),   A0AAX6Q7H1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004868905   ⟸   XM_004868848
- Peptide Label: isoform X1
- UniProtKB: A0A0P6JED8 (UniProtKB/TrEMBL),   G5C7R7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000003588   ⟸   ENSHGLT00000003643


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000002650 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000003643 ENTREZGENE
Gene3D-CATH 2.10.25.140 UniProtKB/TrEMBL
  2.60.40.3510 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro DSL UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_CS UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  Notch_ligand_N UniProtKB/TrEMBL
  Notch_signaling UniProtKB/TrEMBL
KEGG Report hgl:101698853 UniProtKB/TrEMBL
NCBI Gene Dll1 ENTREZGENE
PANTHER DELTA-LIKE PROTEIN 1 UniProtKB/TrEMBL
  NOTCH LIGAND FAMILY MEMBER UniProtKB/TrEMBL
Pfam DL-JAG_EGF-like UniProtKB/TrEMBL
  DSL UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  hEGF UniProtKB/TrEMBL
  MNNL UniProtKB/TrEMBL
PRINTS EGFBLOOD UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  DSL UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
SMART DSL UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
UniProt A0A0P6JED8 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6Q7H1 ENTREZGENE, UniProtKB/TrEMBL
  G5C7R7 ENTREZGENE, UniProtKB/TrEMBL