Pcsk9 (proprotein convertase subtilisin/kexin type 9) - Rat Genome Database

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Gene: Pcsk9 (proprotein convertase subtilisin/kexin type 9) Mus musculus
Analyze
Symbol: Pcsk9
Name: proprotein convertase subtilisin/kexin type 9
RGD ID: 731024
MGI Page MGI
Description: Enables apolipoprotein binding activity; lipoprotein particle binding activity; and low-density lipoprotein particle receptor binding activity. Involved in several processes, including cellular response to insulin stimulus; cellular response to starvation; and regulation of neuron apoptotic process. Acts upstream of or within several processes, including low-density lipoprotein receptor particle metabolic process; regulation of low-density lipoprotein particle receptor catabolic process; and triglyceride metabolic process. Located in COPII-coated ER to Golgi transport vesicle; endoplasmic reticulum; and extracellular space. Is expressed in several structures, including alimentary system; cerebellum; genitourinary system; liver; and telencephalon. Human ortholog(s) of this gene implicated in familial hypercholesterolemia and hypobetalipoproteinemia. Orthologous to human PCSK9 (proprotein convertase subtilisin/kexin type 9); INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI415265; AI747682; convertase subtilisin; FH3; HCHOLA3; MGC47409; Na; NARC-1; Narc1; neural apoptosis regulated convertase 1; neural apoptosis-regulated convertase 1; PC9; proprotein convertase 9; proprotein convertase PC9; subtilisin/kexin-like protease PC9
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394106,299,531 - 106,321,522 (-)NCBIGRCm39mm39
GRCm39 Ensembl4106,299,526 - 106,321,526 (-)Ensembl
GRCm384106,442,334 - 106,464,325 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4106,442,329 - 106,464,329 (-)EnsemblGRCm38mm10GRCm38
MGSCv374106,114,939 - 106,136,930 (-)NCBIGRCm37mm9NCBIm37
MGSCv364105,940,274 - 105,974,961 (-)NCBImm8
Celera4104,803,009 - 104,824,874 (-)NCBICelera
Cytogenetic Map4C7NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1-(3-(trifluoromethyl)phenyl)piperazine  (ISO)
1-benzylpiperazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
6-propyl-2-thiouracil  (ISO)
acetaldehyde  (EXP)
acetamide  (ISO)
acetohydrazide  (EXP)
Actein  (ISO)
aflatoxin B1  (ISO)
aldrin  (EXP)
amiodarone  (ISO)
arsenous acid  (ISO)
avobenzone  (ISO)
belinostat  (ISO)
benzalkonium chloride  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (EXP,ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (ISO)
butan-1-ol  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP,ISO)
chloroethene  (EXP)
ciguatoxin CTX1B  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP,ISO)
curcumin  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diclofenac  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
ethanol  (EXP)
ezetimibe  (ISO)
fenofibrate  (ISO)
flusilazole  (ISO)
fluvastatin  (ISO)
Ganoderic acid A  (ISO)
gemcitabine  (ISO)
genistein  (EXP)
glafenine  (ISO)
glutathione  (ISO)
hydrazine  (EXP)
indometacin  (ISO)
ketoconazole  (ISO)
L-ascorbic acid  (EXP,ISO)
lipopolysaccharide  (EXP)
manganese(II) chloride  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
methylmercury chloride  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
O-methyleugenol  (ISO)
orphenadrine  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP)
pentachlorophenol  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
pioglitazone  (EXP,ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sulindac sulfide  (ISO)
tamoxifen  (EXP)
testosterone  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (EXP,ISO)
Yessotoxin  (ISO)
zaragozic acid A  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA)
cellular response to insulin stimulus  (IDA,ISO)
cellular response to starvation  (IDA,ISO)
cholesterol homeostasis  (ISO,ISS)
cholesterol metabolic process  (IDA)
kidney development  (IEP,ISO)
lipid metabolic process  (IEA)
lipoprotein metabolic process  (IDA)
liver development  (IEP,ISO)
low-density lipoprotein particle receptor catabolic process  (ISO,ISS)
low-density lipoprotein receptor particle metabolic process  (IDA)
lysosomal transport  (ISO)
negative regulation of low-density lipoprotein particle clearance  (ISO)
negative regulation of low-density lipoprotein particle receptor binding  (ISO)
negative regulation of low-density lipoprotein receptor activity  (ISO)
negative regulation of receptor recycling  (ISO)
negative regulation of receptor-mediated endocytosis involved in cholesterol transport  (ISO)
negative regulation of sodium ion transmembrane transporter activity  (ISO)
neurogenesis  (IEP,ISO)
neuron differentiation  (IDA,IMP)
phospholipid metabolic process  (IDA)
positive regulation of low-density lipoprotein particle receptor catabolic process  (ISO)
positive regulation of neuron apoptotic process  (ISO,ISS)
positive regulation of receptor internalization  (ISO)
protein autoprocessing  (ISO,ISS)
protein processing  (ISO)
proteolysis  (IEA)
regulation of low-density lipoprotein particle receptor catabolic process  (IMP)
regulation of neuron apoptotic process  (IMP)
regulation of signaling receptor activity  (ISO)
steroid metabolic process  (IEA)
triglyceride metabolic process  (IDA)

References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12897189   PMID:14622975   PMID:15178557   PMID:15358785   PMID:15385538   PMID:15489334  
PMID:15677715   PMID:15741654   PMID:15805190   PMID:16141072   PMID:16141073   PMID:16407292   PMID:16537572   PMID:16602821   PMID:16794006   PMID:16893422   PMID:17080197   PMID:17242417  
PMID:18039650   PMID:18039658   PMID:18280815   PMID:18287559   PMID:18354138   PMID:18378686   PMID:18638454   PMID:18660751   PMID:18666258   PMID:18675252   PMID:18799458   PMID:19265033  
PMID:19443683   PMID:19501082   PMID:19635789   PMID:19878649   PMID:20026049   PMID:20080679   PMID:20453200   PMID:20498851   PMID:20562239   PMID:20566868   PMID:20826464   PMID:21147780  
PMID:21262787   PMID:21267068   PMID:21273557   PMID:21491542   PMID:21518694   PMID:21873635   PMID:22261195   PMID:22426206   PMID:22481440   PMID:22580899   PMID:22593575   PMID:22611251  
PMID:22848640   PMID:23135270   PMID:23362348   PMID:23559630   PMID:23580231   PMID:23614904   PMID:23623011   PMID:23675525   PMID:23690465   PMID:23775089   PMID:23883163   PMID:23974119  
PMID:24006456   PMID:24506872   PMID:24675665   PMID:24808179   PMID:24916110   PMID:25070550   PMID:25320235   PMID:25446528   PMID:25490141   PMID:25613181   PMID:25621930   PMID:25652089  
PMID:25682035   PMID:26092101   PMID:26323289   PMID:26494228   PMID:26508642   PMID:26547624   PMID:26628375   PMID:26824363   PMID:26833058   PMID:26980204   PMID:27146480   PMID:27197615  
PMID:27279328   PMID:27284008   PMID:27358438   PMID:27470509   PMID:27477186   PMID:27909053   PMID:28495363   PMID:28504688   PMID:28515357   PMID:28535426   PMID:28546220   PMID:28600283  
PMID:28656218   PMID:28750079   PMID:28751571   PMID:28758421   PMID:28894089   PMID:28970592   PMID:29084995   PMID:29180444   PMID:29197601   PMID:29396908   PMID:29438441   PMID:29548750  
PMID:29593095   PMID:29617722   PMID:29800228   PMID:29845234   PMID:30044755   PMID:30066942   PMID:30297903   PMID:30395847   PMID:30582457   PMID:30592271   PMID:30768966   PMID:30831144  
PMID:30844857   PMID:31004037   PMID:31317882   PMID:31332258   PMID:31366894   PMID:31419281   PMID:31553664   PMID:31731717   PMID:31776890   PMID:32100557   PMID:32244519   PMID:32423823  
PMID:32615123   PMID:32641981   PMID:32673528   PMID:32750454   PMID:32862122   PMID:32913121   PMID:33020528   PMID:33070710   PMID:33211673   PMID:33606190   PMID:33972728   PMID:33992809  
PMID:34252181  


Genomics

Comparative Map Data
Pcsk9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394106,299,531 - 106,321,522 (-)NCBIGRCm39mm39
GRCm39 Ensembl4106,299,526 - 106,321,526 (-)Ensembl
GRCm384106,442,334 - 106,464,325 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4106,442,329 - 106,464,329 (-)EnsemblGRCm38mm10GRCm38
MGSCv374106,114,939 - 106,136,930 (-)NCBIGRCm37mm9NCBIm37
MGSCv364105,940,274 - 105,974,961 (-)NCBImm8
Celera4104,803,009 - 104,824,874 (-)NCBICelera
Cytogenetic Map4C7NCBI
PCSK9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl155,039,447 - 55,064,852 (+)EnsemblGRCh38hg38GRCh38
GRCh38155,039,548 - 55,064,852 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37155,505,221 - 55,530,525 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36155,277,808 - 55,303,111 (+)NCBINCBI36hg18NCBI36
Build 34155,217,240 - 55,242,544NCBI
Celera153,792,769 - 53,818,130 (+)NCBI
Cytogenetic Map1p32.3NCBI
HuRef153,618,200 - 53,643,557 (+)NCBIHuRef
CHM1_1155,621,314 - 55,646,685 (+)NCBICHM1_1
Pcsk9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25121,211,278 - 121,233,688 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl5121,211,278 - 121,233,688 (-)Ensembl
Rnor_6.05126,031,368 - 126,053,726 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5126,031,368 - 126,053,726 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05129,878,797 - 129,900,625 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45127,501,476 - 127,524,289 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15127,507,768 - 127,529,490 (-)NCBI
Celera5119,960,965 - 119,983,199 (-)NCBICelera
Cytogenetic Map5q34NCBI
Pcsk9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554644,425,435 - 4,439,842 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554644,424,583 - 4,439,805 (-)NCBIChiLan1.0ChiLan1.0
PCSK9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1155,911,016 - 55,943,404 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl155,911,016 - 55,936,456 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0154,323,036 - 54,355,397 (+)NCBIMhudiblu_PPA_v0panPan3
PCSK9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1554,197,211 - 54,210,724 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha554,264,679 - 54,280,339 (-)NCBI
ROS_Cfam_1.0554,383,361 - 54,399,016 (-)NCBI
UMICH_Zoey_3.1554,380,525 - 54,396,181 (-)NCBI
UNSW_CanFamBas_1.0554,270,491 - 54,282,704 (-)NCBI
UU_Cfam_GSD_1.0554,658,929 - 54,672,888 (-)NCBI
Pcsk9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505869,116,048 - 69,144,955 (+)NCBI
SpeTri2.0NW_0049365226,271,339 - 6,300,202 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PCSK9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6157,388,372 - 157,409,604 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16157,388,370 - 157,409,620 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26145,451,983 - 145,473,336 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PCSK9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12077,893,574 - 77,921,076 (-)NCBI
ChlSab1.1 Ensembl2077,893,590 - 77,918,613 (-)Ensembl
Vero_WHO_p1.0NW_02366603339,376,139 - 39,401,572 (+)NCBI
Pcsk9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248624,873,457 - 4,895,836 (-)NCBI

Position Markers
AI747682  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384106,442,570 - 106,442,685UniSTSGRCm38
MGSCv374106,115,175 - 106,115,290UniSTSGRCm37
Celera4104,803,245 - 104,803,360UniSTS
Cytogenetic Map4C7UniSTS
Whitehead/MRC_RH41487.19UniSTS
AI415265  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384106,442,420 - 106,442,545UniSTSGRCm38
MGSCv374106,115,025 - 106,115,150UniSTSGRCm37
Celera4104,803,095 - 104,803,220UniSTS
Cytogenetic Map4C7UniSTS
Whitehead/MRC_RH41475.09UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
15039382Ltgq7_mliver triglyceride QTL 7 (mouse)4105812001139812001Mouse
15039377Bw45_mbody weight QTL 45 (mouse)4105812001139812001Mouse
11039517Ltpr4_mLeishmania tropica response 4 (mouse)479477514113477630Mouse
27226746Metcl8_mmetatarsal-calcaneal length 8, 10 week (mouse)487600000107300000Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined489063832151570093Mouse
1301930Papg1_mpulmonary adenoma progression 1 (mouse)Not determined485923970119924082Mouse
12910808Pwbwq9_mpost-weaning body weight QTL 9 (mouse)4105978113141706527Mouse
27095927Pglq7_mpelvic girdle length QTL 7, 10 week (mouse)488200000108500000Mouse
27095939Ulnl9_mulna length 9, 16 week (mouse)465400000119000000Mouse
15039368Nmrs19_mNAFLD-associated magnetic resonance shift 19 (mouse)491025583125025583Mouse
1300689Dob1_mDietary obesity 1 (mouse)Body weight4101717404123233418Mouse
11532705Sluc43b_msusceptibility to lung cancer 43b (mouse)474556462108556746Mouse
13208562Wght7_mweight 7 (mouse)491000000148000000Mouse
15039378Adip30_madiposity 30 (mouse)4105812001139812001Mouse
11532700Sluc43d_msusceptibility to lung cancer 43d (mouse)474556462108556746Mouse
4141900Skts-fp1_mskin tumor susceptibility in FVB and PWK 1 (mouse)Not determined453550839124161387Mouse
1301545Gauc_mglucose area under curve (mouse)Not determined476874870110875068Mouse
11532714Sluc43_msusceptibility to lung cancer 43 (mouse)446642108123233418Mouse
4141093W3q17_mweight 3 weeks QTL 17 (mouse)Not determined89063832140740892Mouse
1300697Sle2_msystemic lupus erythmatosus susceptibility 2 (mouse)Not determined478069342112069538Mouse
12904933Edlmmq3_mextensor digitorum longus muscle mass QTL 3 (mouse)481325754115325754Mouse
27226766Tibl17_mtibia length 17, 16 week (mouse)488600000108600000Mouse
1301597Anxty_manxiety (mouse)Not determined474219337128115487Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155600000Mouse
11532701Sluc43e_msusceptibility to lung cancer 43e (mouse)474556462108556746Mouse
27226782Tibl2_mtibia length 2, 5 week (mouse)491000000111400000Mouse
14696689Gdq2_mgrooming duration QTL 2, females (mouse)4101000000125000000Mouse
10412193Plep_mplasma lepin levels (mouse)Not determined474556462108556746Mouse
1301556Cd4vts1_mCD4 virgin T cell subset 1 (mouse)Not determined485571641119571840Mouse
27095905Scvln3_msacral vertebrae length 2, 5 week (mouse)455600000129100000Mouse
1301731Cafq2_mcaffeine metabolism QTL 2 (mouse)Not determined494875058128875257Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468100000150800000Mouse
1301233Sbw2_msplenomegaly-NZB x NZW 2 (mouse)Not determined495069342128115487Mouse
1301106Skts7_mskin tumor susceptibility 7 (mouse)Not determined4100214774134215009Mouse
1300918Stheal4_msoft tissue heal 4 (mouse)Not determined490112430124112550Mouse
27095917Scvln14_msacral vertebrae length 2, 16 week (mouse)468100000130500000Mouse
26884449Sklq2_mskull length QTL 2, 5 week (mouse)436700000129100000Mouse
11532707Sluc43h_msusceptibility to lung cancer 43h (mouse)474556462108556746Mouse
4141549W10q10_mweight 10 weeks QTL 10 (mouse)Not determined89063832140740892Mouse
1301118Bbaa23_mB.burgdorferi-associated arthritis 23 (mouse)Not determined485923970119924082Mouse
11532702Sluc43f_msusceptibility to lung cancer 43f (mouse)474556462108556746Mouse
13824982Svwq1_mseminal vesicle weight QTL 1 (mouse)490000000119000000Mouse
1301847Fecq2_mfecundity QTL 2 (mouse)Not determined4100214774134215009Mouse
1357895Ctrcts_mcataract severity (mouse)Not determined445709925138615442Mouse
1300580Lbw2_mlupus NZB x NZW 2 (mouse)Not determined498657302128115487Mouse
1357529Lvrq8_mliver weight QTL 8 (mouse)Not determined489063832140740892Mouse
14696687Gdq1_mgrooming duration QTL 1, males (mouse)497000000112000000Mouse
11039504Ltpr4a_mLeishmania tropica response 4a (mouse)479477514113477630Mouse
1301867Idd11_minsulin dependent diabetes susceptibility 11 (mouse)Not determined483747673117747809Mouse
25314312Syncl2_msynaptonemal complex length 2 (mouse)465800000146500000Mouse
4141623W6q13_mweight 6 weeks QTL 13 (mouse)Not determined89063832140740892Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined495069342150592401Mouse
27095921Pglq12_mpelvic girdle length QTL 12, 16 week (mouse)483200000108500000Mouse
12910813Pwbwq4_mpre-weaning body weight QTL 4 (mouse)4105978113141706527Mouse
1302031Bulb1_mbulb size 1 (mouse)Not determined474145650108145792Mouse
11532708Sluc43i_msusceptibility to lung cancer 43i (mouse)474556462108556746Mouse
11532738Abd1_mautoimmune biliary disease 1 (mouse)489063832116413923Mouse
27226787Feml14_mfemur length 14, 10 week (mouse)485000000107300000Mouse
27095900Scvln9_msacral vertebrae length 2, 10 week (mouse)468100000107300000Mouse
1302204Spm1_msplenomegaly modifier (mouse)Not determined482356158116356345Mouse
11039505Ltpr4c_mLeishmania tropica response 4c (mouse)479477514113477630Mouse
12904002Opfaq9_mopen field activity QTL 9 (mouse)493118593127118593Mouse
11553870Cmmm_mcarcinoma modifier of MSM (mouse)490733471124733584Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156183778Mouse
12910797Pwgrq4_mpre-weaning growth rate QTL 4 (mouse)4105978113141706527Mouse
27226770Tibl11_mtibia length 11, 10 week (mouse)488600000108500000Mouse
12880433Fgf23lq1_mFGF23 serum level QTL 1 (mouse)4101300000135300000Mouse
27095924Pglq2_mpelvic girdle length QTL 2, 5 week (mouse)469200000131000000Mouse
39128212Lwq21_mliver weight QTL 21 (mouse)489063832140740892Mouse
12910794Pwbwq8_mpost-weaning body weight QTL 8 (mouse)4105978113141706527Mouse
11532703Sluc43g_msusceptibility to lung cancer 43g (mouse)474556462108556746Mouse
27226724Tibw2_mtibia width 2, proximal, 10 week (mouse)443000000108500000Mouse
27226716Metcl2_mmetatarsal-calcaneal length 2, 5 week (mouse)488200000118700000Mouse
26884431Zlq8_mzygomatic length QTL 8, 16 week (mouse)474800000108500000Mouse
1357726Lnopy1_mlens opacity 1 (mouse)Not determined485571641119571840Mouse
11039506Ltpr4b_mLeishmania tropica response 4b (mouse)479477514113477630Mouse
11532704Sluc43a_msusceptibility to lung cancer 43a (mouse)474556462108556746Mouse
4142047Mvwf3_mmodifier of von Willebrand factor 3 (mouse)Not determined14010457117215009Mouse
27226739Metcl14_mmetatarsal-calcaneal length 14, 16 week (mouse)487600000108500000Mouse
27226760Feml19_mfemur length 19, 16 week (mouse)491000000108600000Mouse
11532706Sluc43c_msusceptibility to lung cancer 43c (mouse)474556462108556746Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:322
Count of miRNA genes:261
Interacting mature miRNAs:283
Transcripts:ENSMUST00000049507
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000049507   ⟹   ENSMUSP00000055757
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4106,299,526 - 106,321,526 (-)Ensembl
GRCm38.p6 Ensembl4106,442,329 - 106,464,329 (-)Ensembl
RefSeq Acc Id: NM_153565   ⟹   NP_705793
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394106,299,531 - 106,321,522 (-)NCBI
GRCm384106,442,334 - 106,464,325 (-)ENTREZGENE
MGSCv374106,114,939 - 106,136,930 (-)RGD
Celera4104,803,009 - 104,824,874 (-)RGD
cM Map4 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_705793   ⟸   NM_153565
- Peptide Label: precursor
- UniProtKB: Q80W65 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000055757   ⟸   ENSMUST00000049507
Protein Domains
Peptidase S8

Promoters
RGD ID:6835825
Promoter ID:MM_KWN:38774
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:OTTMUST00000018618
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364106,136,471 - 106,136,971 (-)MPROMDB
RGD ID:6884040
Promoter ID:EPDNEW_M5471
Type:multiple initiation site
Name:Pcsk9_1
Description:Mus musculus proprotein convertase subtilisin/kexin type 9 ,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384106,464,091 - 106,464,151EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2140260 AgrOrtholog
Ensembl Genes ENSMUSG00000044254 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000055757 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000049507 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.80 UniProtKB/Swiss-Prot
  3.40.50.200 UniProtKB/Swiss-Prot
InterPro PCSK9_C UniProtKB/Swiss-Prot
  PCSK9_C2 UniProtKB/Swiss-Prot
  PCSK9_C3 UniProtKB/Swiss-Prot
  PCSK9_ProteinaseK-like UniProtKB/Swiss-Prot
  Peptidase_S8/S53_dom UniProtKB/Swiss-Prot
  Peptidase_S8/S53_dom_sf UniProtKB/Swiss-Prot
  Peptidase_S8_subtilisin-rel UniProtKB/Swiss-Prot
  S8pro/Inhibitor_I9_sf UniProtKB/Swiss-Prot
KEGG Report mmu:100102 UniProtKB/Swiss-Prot
MGD MGI:2140260 ENTREZGENE
NCBI Gene 100102 ENTREZGENE
Pfam PCSK9_C1 UniProtKB/Swiss-Prot
  PCSK9_C2 UniProtKB/Swiss-Prot
  PCSK9_C3 UniProtKB/Swiss-Prot
  Peptidase_S8 UniProtKB/Swiss-Prot
PharmGKB PCSK9 RGD
PhenoGen Pcsk9 PhenoGen
PRINTS SUBTILISIN UniProtKB/Swiss-Prot
PROSITE SUBTILASE UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52743 UniProtKB/Swiss-Prot
UniProt PCSK9_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B1AZI4 UniProtKB/Swiss-Prot
  Q3UEH7 UniProtKB/Swiss-Prot
  Q8BXW9 UniProtKB/Swiss-Prot
  Q8CFT6 UniProtKB/Swiss-Prot