Slc9a7 (solute carrier family 9 (sodium/hydrogen exchanger), member 7) - Rat Genome Database

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Gene: Slc9a7 (solute carrier family 9 (sodium/hydrogen exchanger), member 7) Mus musculus
Analyze
Symbol: Slc9a7
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 7
RGD ID: 1557845
MGI Page MGI
Description: Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; regulation of Golgi lumen acidification; and sodium ion import across plasma membrane. Predicted to act upstream of or within potassium ion transport and sodium ion transport. Predicted to be located in recycling endosome membrane and trans-Golgi network. Predicted to be active in plasma membrane and recycling endosome. Human ortholog(s) of this gene implicated in X-linked intellectual developmental disorder 108. Orthologous to human SLC9A7 (solute carrier family 9 member A7).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 6330509M05R; 6330509M05Rik; A530087D17Rik; AI450287; hypothetical protein LOC102913; Na(+)/H(+) exchanger 7; NHE; NHE-7; NHE7; RIKEN cDNA 6330509M05 gene; sodium/hydrogen exchanger 7; solute carrier family 9 (sodium/hydrogen exchanger), isoform 7; solute carrier family 9 member 7; uncharacterized protein LOC102913
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X19,965,090 - 20,158,274 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX19,971,993 - 20,158,046 (-)EnsemblGRCm39 Ensembl
GRCm38X20,098,851 - 20,292,035 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX20,105,754 - 20,291,807 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X19,682,881 - 19,868,890 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X19,262,714 - 19,448,723 (-)NCBIMGSCv36mm8
CeleraX18,234,853 - 18,421,077 (-)NCBICelera
Cytogenetic MapXA1.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:14610273   PMID:15489334   PMID:15522866   PMID:16141072   PMID:16141073   PMID:19521566   PMID:21267068  
PMID:21677750   PMID:21873635   PMID:32325033   PMID:38152992  


Genomics

Comparative Map Data
Slc9a7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X19,965,090 - 20,158,274 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX19,971,993 - 20,158,046 (-)EnsemblGRCm39 Ensembl
GRCm38X20,098,851 - 20,292,035 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX20,105,754 - 20,291,807 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X19,682,881 - 19,868,890 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X19,262,714 - 19,448,723 (-)NCBIMGSCv36mm8
CeleraX18,234,853 - 18,421,077 (-)NCBICelera
Cytogenetic MapXA1.3NCBI
SLC9A7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X46,599,251 - 46,759,118 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX46,599,251 - 46,759,118 (-)EnsemblGRCh38hg38GRCh38
GRCh37X46,458,686 - 46,618,553 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X46,351,317 - 46,503,416 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X46,222,626 - 46,374,726NCBI
CeleraX50,658,215 - 50,810,335 (-)NCBICelera
Cytogenetic MapXp11.3NCBI
HuRefX44,170,288 - 44,254,619 (-)NCBIHuRef
CHM1_1X46,490,827 - 46,650,713 (-)NCBICHM1_1
T2T-CHM13v2.0X46,006,221 - 46,166,134 (-)NCBIT2T-CHM13v2.0
Slc9a7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X4,767,578 - 4,948,602 (+)NCBIGRCr8
mRatBN7.2X2,214,064 - 2,395,052 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX2,214,441 - 2,388,012 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX2,247,588 - 2,428,241 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X5,723,322 - 5,903,992 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X2,033,698 - 2,214,361 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X2,434,918 - 2,615,936 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX2,435,305 - 2,614,770 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X3,226,147 - 3,409,761 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X13,633,105 - 13,808,939 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX2,743,256 - 2,912,530 (+)NCBICelera
Cytogenetic MapXq11NCBI
Slc9a7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555161,286,070 - 1,428,789 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555161,286,070 - 1,428,789 (+)NCBIChiLan1.0ChiLan1.0
SLC9A7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X48,227,846 - 48,387,778 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X48,231,436 - 48,391,151 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X39,037,499 - 39,197,421 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X46,898,953 - 47,057,674 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX46,906,644 - 47,057,705 (-)Ensemblpanpan1.1panPan2
SLC9A7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X40,240,169 - 40,389,167 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX40,245,654 - 40,389,423 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX14,616,012 - 14,764,673 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X40,378,163 - 40,523,311 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX40,379,864 - 40,523,703 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X40,363,040 - 40,511,661 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X40,350,111 - 40,499,013 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X40,443,100 - 40,592,043 (-)NCBIUU_Cfam_GSD_1.0
Slc9a7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X32,605,876 - 32,746,453 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650212,452,720 - 12,587,192 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650212,450,702 - 12,587,196 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC9A7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX41,236,246 - 41,398,999 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X41,233,308 - 41,399,032 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X46,076,182 - 46,199,212 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC9A7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X43,806,085 - 43,958,985 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX43,806,349 - 43,958,959 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660769,060,922 - 9,208,835 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc9a7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248873,408,109 - 3,563,639 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248873,403,764 - 3,563,699 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc9a7
4694 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:552
Count of miRNA genes:373
Interacting mature miRNAs:438
Transcripts:ENSMUST00000072451, ENSMUST00000115393, ENSMUST00000130938, ENSMUST00000151845
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302195Pbwg10_mpostnatal body weight growth 10 (mouse)Not determinedX126202173Mouse
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse
1301551Spha1_msperm head anomaly 1 (mouse)Not determinedX1026622539921652Mouse
13208553Wght11_mweight 11 (mouse)X1186623959045360Mouse
13208557Lgth13_mbody length 13 (mouse)X1186623959045360Mouse

Markers in Region
px-24d2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X20,159,938 - 20,160,075UniSTSGRCm38
MGSCv37X19,737,064 - 19,737,201UniSTSGRCm37
CeleraX18,288,804 - 18,288,941UniSTS
Cytogenetic MapXA1.3UniSTS
px-62b5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X20,178,183 - 20,178,412UniSTSGRCm38
MGSCv37X19,755,309 - 19,755,538UniSTSGRCm37
CeleraX18,307,125 - 18,307,354UniSTS
Cytogenetic MapXA1.3UniSTS
Slc9a7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXA1.3UniSTS
cM MapX15.55UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000072451   ⟹   ENSMUSP00000072274
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX19,971,994 - 20,158,046 (-)Ensembl
GRCm38.p6 EnsemblX20,105,755 - 20,291,807 (-)Ensembl
RefSeq Acc Id: ENSMUST00000115393   ⟹   ENSMUSP00000111051
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX20,018,691 - 20,158,009 (-)Ensembl
GRCm38.p6 EnsemblX20,152,452 - 20,291,770 (-)Ensembl
RefSeq Acc Id: ENSMUST00000130938
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX20,030,755 - 20,158,046 (-)Ensembl
GRCm38.p6 EnsemblX20,164,516 - 20,291,807 (-)Ensembl
RefSeq Acc Id: ENSMUST00000151845
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX19,986,316 - 20,158,025 (-)Ensembl
GRCm38.p6 EnsemblX20,120,077 - 20,291,786 (-)Ensembl
RefSeq Acc Id: ENSMUST00000224372   ⟹   ENSMUSP00000153063
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX19,971,993 - 20,028,439 (-)Ensembl
GRCm38.p6 EnsemblX20,105,754 - 20,162,200 (-)Ensembl
RefSeq Acc Id: NM_177353   ⟹   NP_796327
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X19,965,090 - 20,158,066 (-)NCBI
GRCm38X20,098,851 - 20,291,827 (-)NCBI
MGSCv37X19,682,881 - 19,868,890 (-)RGD
CeleraX18,234,853 - 18,421,077 (-)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006527616   ⟹   XP_006527679
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X19,965,090 - 20,158,269 (-)NCBI
GRCm38X20,098,851 - 20,292,030 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006527617   ⟹   XP_006527680
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X19,965,090 - 20,158,274 (-)NCBI
GRCm38X20,098,851 - 20,292,035 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030251315   ⟹   XP_030107175
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X19,968,154 - 20,158,269 (-)NCBI
GRCm38X20,101,915 - 20,292,030 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_796327   ⟸   NM_177353
- Peptide Label: precursor
- UniProtKB: A2ACD5 (UniProtKB/Swiss-Prot),   A2ACD6 (UniProtKB/Swiss-Prot),   Q8BLV3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006527679   ⟸   XM_006527616
- Peptide Label: isoform X1
- UniProtKB: A2ACD5 (UniProtKB/Swiss-Prot),   A2ACD6 (UniProtKB/Swiss-Prot),   Q8BLV3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006527680   ⟸   XM_006527617
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_030107175   ⟸   XM_030251315
- Peptide Label: isoform X2
RefSeq Acc Id: ENSMUSP00000072274   ⟸   ENSMUST00000072451
RefSeq Acc Id: ENSMUSP00000153063   ⟸   ENSMUST00000224372
RefSeq Acc Id: ENSMUSP00000111051   ⟸   ENSMUST00000115393
Protein Domains
Cation/H+ exchanger

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BLV3-F1-model_v2 AlphaFold Q8BLV3 1-726 view protein structure

Promoters
RGD ID:6846387
Promoter ID:MM_KWN:59719
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Liver,   Spleen
Transcripts:OTTMUST00000041314,   OTTMUST00000041315,   OTTMUST00000041316,   OTTMUST00000041317
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X19,868,606 - 19,869,106 (-)MPROMDB
RGD ID:13680172
Promoter ID:EPDNEW_M24235
Type:initiation region
Name:Slc9a7_1
Description:Mus musculus solute carrier family 9 (sodium/hydrogen exchanger),member 7 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X20,291,760 - 20,291,820EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2444530 AgrOrtholog
Ensembl Genes ENSMUSG00000037341 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000072451 ENTREZGENE
  ENSMUST00000072451.11 UniProtKB/Swiss-Prot
  ENSMUST00000115393.3 UniProtKB/Swiss-Prot
  ENSMUST00000224372.2 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.1330 UniProtKB/Swiss-Prot
InterPro Cation/H_exchanger UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cation/H_exchanger_CPA1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na/H_exchanger_6 UniProtKB/Swiss-Prot
  NaH_exchanger UniProtKB/Swiss-Prot
KEGG Report mmu:236727 UniProtKB/Swiss-Prot
MGD MGI:2444530 ENTREZGENE
NCBI Gene 236727 ENTREZGENE
PANTHER PTHR10110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SODIUM/HYDROGEN EXCHANGER 7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Na_H_Exchanger UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc9a7 PhenoGen
PRINTS NAHEXCHNGR UniProtKB/Swiss-Prot
  NAHEXCHNGR6 UniProtKB/Swiss-Prot
UniProt A0A286YD31_MOUSE UniProtKB/TrEMBL
  A2ACD5 ENTREZGENE
  A2ACD6 ENTREZGENE
  Q8BLV3 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A2ACD5 UniProtKB/Swiss-Prot
  A2ACD6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-08-01 Slc9a7  solute carrier family 9 (sodium/hydrogen exchanger), member 7  6330509M05Rik  RIKEN cDNA 6330509M05 gene  Data merged from RGD:1612472 737654 PROVISIONAL