Slc9a7 (solute carrier family 9 member A7) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Slc9a7 (solute carrier family 9 member A7) Rattus norvegicus
Analyze
Symbol: Slc9a7
Name: solute carrier family 9 member A7
RGD ID: 1561385
Description: Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in regulation of Golgi lumen acidification. Predicted to be located in plasma membrane; recycling endosome membrane; and trans-Golgi network. Human ortholog(s) of this gene implicated in X-linked intellectual developmental disorder 108. Orthologous to human SLC9A7 (solute carrier family 9 member A7); INTERACTS WITH 17alpha-ethynylestradiol; 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Nhe7; sodium/hydrogen exchanger 7; solute carrier family 9 (sodium/hydrogen exchanger), isoform 7; solute carrier family 9 (sodium/hydrogen exchanger), member 7; solute carrier family 9, member 7; solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X2,214,064 - 2,395,052 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX2,214,441 - 2,388,012 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX2,247,588 - 2,428,241 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X5,723,322 - 5,903,992 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X2,033,698 - 2,214,361 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X2,434,918 - 2,615,936 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX2,435,305 - 2,614,770 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X3,226,147 - 3,409,761 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X13,633,105 - 13,808,939 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX2,743,256 - 2,912,530 (+)NCBICelera
Cytogenetic MapXq11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11279194   PMID:15840657   PMID:30335141  


Genomics

Comparative Map Data
Slc9a7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X2,214,064 - 2,395,052 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX2,214,441 - 2,388,012 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX2,247,588 - 2,428,241 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X5,723,322 - 5,903,992 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X2,033,698 - 2,214,361 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X2,434,918 - 2,615,936 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX2,435,305 - 2,614,770 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X3,226,147 - 3,409,761 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X13,633,105 - 13,808,939 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX2,743,256 - 2,912,530 (+)NCBICelera
Cytogenetic MapXq11NCBI
SLC9A7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X46,599,251 - 46,759,118 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX46,599,251 - 46,759,118 (-)EnsemblGRCh38hg38GRCh38
GRCh37X46,458,686 - 46,618,553 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X46,351,317 - 46,503,416 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X46,222,626 - 46,374,726NCBI
CeleraX50,658,215 - 50,810,335 (-)NCBICelera
Cytogenetic MapXp11.3NCBI
HuRefX44,170,288 - 44,254,619 (-)NCBIHuRef
CHM1_1X46,490,827 - 46,650,713 (-)NCBICHM1_1
T2T-CHM13v2.0X46,006,221 - 46,166,134 (-)NCBIT2T-CHM13v2.0
Slc9a7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X19,965,090 - 20,158,274 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX19,971,993 - 20,158,046 (-)EnsemblGRCm39 Ensembl
GRCm38X20,098,851 - 20,292,035 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX20,105,754 - 20,291,807 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X19,682,881 - 19,868,890 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X19,262,714 - 19,448,723 (-)NCBIMGSCv36mm8
CeleraX18,234,853 - 18,421,077 (-)NCBICelera
Cytogenetic MapXA1.3NCBI
Slc9a7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555161,286,070 - 1,428,789 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555161,286,070 - 1,428,789 (+)NCBIChiLan1.0ChiLan1.0
SLC9A7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1X48,231,436 - 48,391,151 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X39,037,499 - 39,197,421 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X46,898,953 - 47,057,674 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX46,906,644 - 47,057,705 (-)Ensemblpanpan1.1panPan2
SLC9A7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X40,240,169 - 40,389,167 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX40,245,654 - 40,389,423 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX14,616,012 - 14,764,673 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X40,378,163 - 40,523,311 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX40,379,864 - 40,523,703 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X40,363,040 - 40,511,661 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X40,350,111 - 40,499,013 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X40,443,100 - 40,592,043 (-)NCBIUU_Cfam_GSD_1.0
Slc9a7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X32,605,876 - 32,746,453 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650212,452,720 - 12,587,192 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650212,450,702 - 12,587,196 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC9A7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX41,236,246 - 41,398,999 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X41,233,308 - 41,399,032 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X46,076,182 - 46,199,212 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC9A7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X43,806,085 - 43,958,985 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX43,806,349 - 43,958,959 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660769,060,922 - 9,208,835 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc9a7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248873,408,109 - 3,563,639 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248873,403,764 - 3,563,699 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc9a7
357 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:157
Count of miRNA genes:121
Interacting mature miRNAs:132
Transcripts:ENSRNOT00000005623
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
70166Bp65Blood pressure QTL 655.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144797211374346Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat

Markers in Region
PMC152551P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X2,281,592 - 2,281,856 (+)MAPPERmRatBN7.2
mRatBN7.2X2,480,869 - 2,481,133 (-)MAPPERmRatBN7.2
mRatBN7.21211,665,050 - 11,665,317 (+)MAPPERmRatBN7.2
Rnor_6.0X2,509,978 - 2,510,240NCBIRnor6.0
Rnor_6.01213,717,782 - 13,718,048NCBIRnor6.0
Rnor_5.01215,747,795 - 15,748,061UniSTSRnor5.0
Rnor_5.0X3,300,207 - 3,300,469UniSTSRnor5.0
Celera1213,454,382 - 13,454,648UniSTS
CeleraX3,004,715 - 3,004,978UniSTS
Cytogenetic MapXq12UniSTS
Cytogenetic Map12p11UniSTS
PMC275467P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X2,281,592 - 2,281,843 (+)MAPPERmRatBN7.2
mRatBN7.2X2,480,882 - 2,481,133 (-)MAPPERmRatBN7.2
mRatBN7.21211,665,063 - 11,665,317 (+)MAPPERmRatBN7.2
Rnor_6.0X2,509,978 - 2,510,227NCBIRnor6.0
Rnor_6.01213,717,795 - 13,718,048NCBIRnor6.0
Rnor_5.01215,747,808 - 15,748,061UniSTSRnor5.0
Rnor_5.0X3,300,207 - 3,300,456UniSTSRnor5.0
Celera1213,454,395 - 13,454,648UniSTS
CeleraX3,004,728 - 3,004,978UniSTS
Cytogenetic MapXq12UniSTS
Cytogenetic Map12p11UniSTS
PMC150974P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21211,665,202 - 11,666,036 (+)MAPPERmRatBN7.2
Rnor_6.01213,717,934 - 13,718,767NCBIRnor6.0
Rnor_5.01215,747,947 - 15,748,780UniSTSRnor5.0
RGSC_v3.41212,049,161 - 12,049,994UniSTSRGSC3.4
RGSC_v3.4X13,700,285 - 13,700,891UniSTSRGSC3.4
Celera1213,454,534 - 13,455,367UniSTS
Cytogenetic Map12p11UniSTS
Cytogenetic MapXq12UniSTS
RH138299  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X2,332,855 - 2,332,978 (+)MAPPERmRatBN7.2
Rnor_6.0X2,559,083 - 2,559,205NCBIRnor6.0
Rnor_5.0X3,349,312 - 3,349,434UniSTSRnor5.0
RGSC_v3.4X13,753,169 - 13,753,291UniSTSRGSC3.4
CeleraX2,857,748 - 2,857,870UniSTS
Cytogenetic MapXq12UniSTS
Actb  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X2,281,288 - 2,281,798 (+)MAPPERmRatBN7.2
mRatBN7.2X2,480,927 - 2,481,437 (-)MAPPERmRatBN7.2
Rnor_6.0X2,509,674 - 2,510,182NCBIRnor6.0
Rnor_5.0X3,299,903 - 3,300,411UniSTSRnor5.0
RGSC_v3.4X13,700,476 - 13,700,985UniSTSRGSC3.4
Celera1213,453,754 - 13,454,454UniSTS
Cytogenetic MapXq12UniSTS
Cytogenetic Map12p11UniSTS
PMC85795P4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X2,281,589 - 2,282,085 (+)MAPPERmRatBN7.2
mRatBN7.2X2,480,640 - 2,481,136 (-)MAPPERmRatBN7.2
mRatBN7.21211,664,354 - 11,665,320 (+)MAPPERmRatBN7.2
Rnor_6.01213,717,086 - 13,718,051NCBIRnor6.0
Rnor_6.0X2,509,975 - 2,510,469NCBIRnor6.0
Rnor_5.0X3,300,204 - 3,300,698UniSTSRnor5.0
Rnor_5.01215,747,099 - 15,748,064UniSTSRnor5.0
Celera1213,453,686 - 13,454,651UniSTS
CeleraX3,004,486 - 3,004,981UniSTS
Cytogenetic Map12p11UniSTS
Cytogenetic MapXq12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 14 50
Low 2 24 32 19 5 19 8 11 24 32 35 11 8
Below cutoff 1 18 22 22 22 3 5

Sequence


RefSeq Acc Id: ENSRNOT00000005623   ⟹   ENSRNOP00000005623
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX2,214,441 - 2,388,012 (+)Ensembl
Rnor_6.0 EnsemblX2,435,305 - 2,614,770 (+)Ensembl
RefSeq Acc Id: NM_001401002   ⟹   NP_001387931
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X2,214,401 - 2,395,052 (+)NCBI
RefSeq Acc Id: XM_006256637   ⟹   XP_006256699
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X2,214,064 - 2,395,052 (+)NCBI
Rnor_6.0X2,434,919 - 2,615,936 (+)NCBI
Rnor_5.0X3,226,147 - 3,409,761 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001387931 (Get FASTA)   NCBI Sequence Viewer  
  XP_006256699 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL97690 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005623
  ENSRNOP00000005623.7
RefSeq Acc Id: XP_006256699   ⟸   XM_006256637
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000005623   ⟸   ENSRNOT00000005623
RefSeq Acc Id: NP_001387931   ⟸   NM_001401002
- UniProtKB: D3ZCI2 (UniProtKB/TrEMBL)
Protein Domains
Cation/H+ exchanger

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZCI2-F1-model_v2 AlphaFold D3ZCI2 1-359 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701700
Promoter ID:EPDNEW_R12224
Type:single initiation site
Name:Slc9a7_1
Description:solute carrier family 9 member A7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X2,435,264 - 2,435,324EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561385 AgrOrtholog
BioCyc Gene G2FUF-3172 BioCyc
Ensembl Genes ENSRNOG00000004150 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005623 ENTREZGENE
  ENSRNOT00000005623.7 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.1330 UniProtKB/TrEMBL
InterPro Cation/H_exchanger UniProtKB/TrEMBL
  Cation/H_exchanger_cons-reg UniProtKB/TrEMBL
  NaH_exchanger UniProtKB/TrEMBL
  NHE-6/7/9 UniProtKB/TrEMBL
NCBI Gene 317170 ENTREZGENE
PANTHER Cation/H_exchanger_cons-reg UniProtKB/TrEMBL
  SODIUM/HYDROGEN EXCHANGER 7 UniProtKB/TrEMBL
Pfam Na_H_Exchanger UniProtKB/TrEMBL
PhenoGen Slc9a7 PhenoGen
PRINTS NAHEXCHNGR UniProtKB/TrEMBL
  NAHEXCHNGR6 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004150 RatGTEx
UniProt D3ZCI2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-01 Slc9a7  solute carrier family 9 member A7  Slc9a7  solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Slc9a7  solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7  Slc9a7  solute carrier family 9 (sodium/hydrogen exchanger), member 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-02 Slc9a7  solute carrier family 9 (sodium/hydrogen exchanger), member 7  Slc9a7  solute carrier family 9 (sodium/hydrogen exchanger), isoform 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Slc9a7  solute carrier family 9 (sodium/hydrogen exchanger), isoform 7  Slc9a7_predicted  solute carrier family 9 (sodium/hydrogen exchanger), member 7 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Slc9a7_predicted  solute carrier family 9 (sodium/hydrogen exchanger), member 7 (predicted)    solute carrier family 9, member 7 (predicted)  Name updated 1299863 APPROVED
2006-03-07 Slc9a7_predicted  solute carrier family 9, member 7 (predicted)  Slc9a7  solute carrier family 9, member 7  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 Slc9a7  solute carrier family 9, member 7      Symbol and Name status set to provisional 70820 PROVISIONAL