Cstb (cystatin B) - Rat Genome Database
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Gene: Cstb (cystatin B) Mus musculus
Analyze
Symbol: Cstb
Name: cystatin B
RGD ID: 10417
MGI Page MGI
Description: Predicted to have cysteine-type endopeptidase inhibitor activity and protease binding activity. Involved in adult locomotory behavior. Localizes to collagen-containing extracellular matrix. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study Unverricht-Lundborg syndrome. Human ortholog(s) of this gene implicated in Unverricht-Lundborg syndrome and progressive myoclonus epilepsy 1A. Orthologous to human CSTB (cystatin B); INTERACTS WITH 1,1-dichloroethene; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AA960480; cystatin-B; stefin-B; Stf; Stfb
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391078,261,504 - 78,263,456 (+)NCBIGRCm39mm39
GRCm381078,425,670 - 78,427,622 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1078,425,669 - 78,427,622 (+)EnsemblGRCm38mm10GRCm38
MGSCv371077,888,415 - 77,890,367 (+)NCBIGRCm37mm9NCBIm37
MGSCv361077,828,799 - 77,830,751 (+)NCBImm8
Celera1079,447,767 - 79,449,719 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,6-dinitrotoluene  (ISO)
2-nitrofluorene  (ISO)
3',5'-cyclic AMP  (ISO)
3,4-dichloroaniline  (ISO)
3-chloropropane-1,2-diol  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
arsenous acid  (ISO)
ATP  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (EXP)
bisphenol A  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (EXP)
chloropicrin  (ISO)
choline  (EXP)
ciglitazone  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenzo[a,l]pyrene  (EXP)
dieldrin  (ISO)
diethylstilbestrol  (EXP,ISO)
dioxygen  (EXP)
diuron  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP)
fenamidone  (EXP)
folic acid  (EXP)
formaldehyde  (ISO)
fumonisin B1  (EXP)
genistein  (EXP)
gentamycin  (ISO)
griseofulvin  (EXP)
isotretinoin  (ISO)
L-methionine  (EXP)
lipopolysaccharide  (EXP)
methamphetamine  (ISO)
methapyrilene  (ISO)
microcystin-LR  (EXP)
morphine  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (ISO)
nickel atom  (EXP)
nickel dichloride  (ISO)
paracetamol  (EXP)
phenobarbital  (EXP)
phosgene  (EXP)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (EXP)
rotenone  (ISO)
sarin  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP,ISO)
tetrachloromethane  (EXP)
tetrahydropalmatine  (ISO)
titanium dioxide  (EXP)
tolcapone  (ISO)
trichostatin A  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:8938434   PMID:9878246   PMID:10051316   PMID:10349636   PMID:10613844   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11114168   PMID:11535822   PMID:11555622   PMID:12477932  
PMID:12484571   PMID:12934064   PMID:14610273   PMID:14681479   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16602821   PMID:17188503   PMID:17319918   PMID:17655504   PMID:18757940  
PMID:19420257   PMID:20075068   PMID:20889561   PMID:21047530   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22140471   PMID:22157618   PMID:23955077   PMID:24462687   PMID:24586687  
PMID:24603771   PMID:25047918   PMID:25288807   PMID:25327891   PMID:26370502   PMID:26908626   PMID:27355630   PMID:27894304   PMID:28071719   PMID:32325033   PMID:32378798  


Genomics

Comparative Map Data
Cstb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391078,261,504 - 78,263,456 (+)NCBIGRCm39mm39
GRCm381078,425,670 - 78,427,622 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1078,425,669 - 78,427,622 (+)EnsemblGRCm38mm10GRCm38
MGSCv371077,888,415 - 77,890,367 (+)NCBIGRCm37mm9NCBIm37
MGSCv361077,828,799 - 77,830,751 (+)NCBImm8
Celera1079,447,767 - 79,449,719 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
CSTB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2143,772,511 - 43,776,318 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl2143,772,511 - 43,776,445 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl2143,772,511 - 43,776,330 (-)EnsemblGRCh38hg38GRCh38
GRCh382143,773,950 - 43,776,308 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372145,193,831 - 45,196,189 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh372145,193,546 - 45,196,256 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362144,018,259 - 44,020,687 (-)NCBINCBI36hg18NCBI36
Build 342144,018,259 - 44,020,687NCBI
Celera2130,299,423 - 30,301,851 (-)NCBI
Cytogenetic Map21q22.3NCBI
HuRef2130,561,944 - 30,564,654 (-)NCBIHuRef
CHM1_12144,754,030 - 44,756,740 (-)NCBICHM1_1
Cstb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22010,245,462 - 10,247,505 (-)NCBI
Rnor_6.0 Ensembl2010,966,331 - 10,968,432 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02010,966,357 - 10,968,399 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02013,137,896 - 13,139,938 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42010,576,664 - 10,578,706 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12010,576,891 - 10,578,923 (-)NCBI
Celera2011,756,111 - 11,758,153 (-)NCBICelera
Cytogenetic Map20p12NCBI
Cstb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540741,475,533 - 41,479,150 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540741,475,533 - 41,478,943 (+)NCBIChiLan1.0ChiLan1.0
CSTB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12143,329,002 - 43,343,874 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v02130,030,359 - 30,032,899 (-)NCBIMhudiblu_PPA_v0panPan3
CSTB
(Canis lupus familiaris - dog)
No map positions available.
Cstb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936500502,444 - 503,307 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CSTB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13206,706,063 - 206,710,646 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113206,706,060 - 206,710,598 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CSTB
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1287,551,341 - 87,555,145 (-)NCBI
Cstb
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474530,152,988 - 30,155,704 (+)NCBI

Position Markers
U59807  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381078,425,971 - 78,426,073UniSTSGRCm38
MGSCv371077,888,716 - 77,888,818UniSTSGRCm37
Celera1079,448,068 - 79,448,170UniSTS
Cytogenetic Map10C1UniSTS
cM Map1042.0UniSTS
Whitehead/MRC_RH10885.53UniSTS
AA960480  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381078,427,307 - 78,427,477UniSTSGRCm38
MGSCv371077,890,052 - 77,890,222UniSTSGRCm37
Celera1079,449,404 - 79,449,574UniSTS
Cytogenetic Map10C1UniSTS
cM Map1042.0UniSTS
Whitehead/MRC_RH10884.62UniSTS
Cstb  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381078,426,932 - 78,427,421UniSTSGRCm38
MGSCv371077,889,677 - 77,890,166UniSTSGRCm37
Celera1079,449,029 - 79,449,518UniSTS
Cytogenetic Map10C1UniSTS
cM Map1042.0UniSTS
cM Map1042.0UniSTS
cM Map1042.0UniSTS
Cstb  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381078,425,837 - 78,427,378UniSTSGRCm38
MGSCv371077,888,582 - 77,890,123UniSTSGRCm37
Celera1079,447,934 - 79,449,475UniSTS
Cytogenetic Map10C1UniSTS
cM Map1042.0UniSTS
Cstb  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10C1UniSTS
cM Map1042.0UniSTS
Cstb  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381078,426,930 - 78,427,429UniSTSGRCm38
MGSCv371077,889,675 - 77,890,174UniSTSGRCm37
Celera1079,449,027 - 79,449,526UniSTS
Cytogenetic Map10C1UniSTS
Cstb  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10C1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357740Obsty3_mobesity 3 (mouse)Not determined108359714116355075Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101023252187565233Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101282830784243920Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101282830784243920Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101282830784243920Mouse
1357893Lvrq4_mliver weight QTL 4 (mouse)Not determined101282830784243920Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1282830784243920Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1282830784243920Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1282830784243920Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1282830784243920Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101282830784243920Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018383585125739363Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1019000000129800000Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021532255114381325Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102300000091200000Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024800000121200000Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039300000129800000Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039300000129800000Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1045000000116100000Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045600000120800000Mouse
4142313Angvq1_mangiogenesis by VEGF QTL 1 (mouse)Not determined4684430782655287Mouse
1302150Bbaa18_mB.burgdorferi-associated arthritis 18 (mouse)Not determined104950223383502378Mouse
4142169Pbwg16_mpostnatal body weight growth 16 (mouse)Not determined105001240884012633Mouse
1300597Skull14_mskull morphology 14 (mouse)Not determined105001240884012633Mouse
10045641Jckm3_mjuvenile cystic kidney modifier 3 (mouse)Not determined105001240884012633Mouse
1301966Lifespan2_mlife span 2 (mouse)Not determined105001244384012618Mouse
1357737Hpcr2_mhepatocarcinogen resistance 2 (mouse)Not determined105001244384012618Mouse
1300882Ath17_matherosclerosis 17 (mouse)Not determined105125566085255809Mouse
1301502Eae17_msusceptibility to experimental allergic encephalomyelitis 17 (mouse)Not determined105125566085255809Mouse
1301380Cia8_mcollagen induced arthritis QTL 8 (mouse)Not determined105161730482655287Mouse
14746991Manh68_mmandible shape 68 (mouse)105244466786444667Mouse
1301787Bsc1_mbrain size control 1 (mouse)Not determined105868113592681262Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059500000122500000Mouse
13208560Wght9_mweight 9 (mouse)1060000000121000000Mouse
26884424Zlq9_mzygomatic length QTL 9, 16 week (mouse)1064100000116100000Mouse
1302060El3_mepilepsy 3 (mouse)Not determined106565510499655287Mouse
1300533Aem3_manti-erythrocyte autoantibody modifier 3 (mouse)Not determined106565510499655287Mouse
1301737Insq9_minsulin QTL 9 (mouse)Not determined106565510499655287Mouse
1302035Lmb4_mlupus in MRL and B6 F2 cross (mouse)Not determined106701240892422811Mouse
26884447Sklq9_mskull length QTL 9, 10 week (mouse)1067500000111900000Mouse
26884430Zlq5_mzygomatic length QTL 5, 10 week (mouse)1068000000125000000Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069900000132500000Mouse
11039497Ltpr5a_mLeishmania tropica response 5a (mouse)1073671039107671185Mouse
4142107Obrq12_mobesity resistance QTL 12 (mouse)Not determined7415138482655287Mouse
11353832Pcholq4_mplasma cholesterol QTL 4 (mouse)1074151384125680038Mouse
11353843Gluq1_mblood glucose QTL 1 (mouse)1074151384125680038Mouse
1300975Fembrs3_mfemur breaking strength 3 (mouse)Not determined1075502706109502905Mouse
4142137Femwf3_mfemur work to failure 3 (mouse)Not determined75502706109502905Mouse
1357632Vtbt9_mvertebral trabecular bone trait 9 (mouse)Not determined1075502706109502905Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:109
Count of miRNA genes:108
Interacting mature miRNAs:109
Transcripts:ENSMUST00000005185
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000005185   ⟹   ENSMUSP00000005185
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1078,425,669 - 78,427,622 (+)Ensembl
RefSeq Acc Id: NM_007793   ⟹   NP_031819
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391078,261,504 - 78,263,456 (+)NCBI
GRCm381078,425,670 - 78,427,622 (+)ENTREZGENE
MGSCv371077,888,415 - 77,890,367 (+)RGD
Celera1079,447,767 - 79,449,719 (+)RGD
cM Map10 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_031819   ⟸   NM_007793
- UniProtKB: Q62426 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000005185   ⟸   ENSMUST00000005185

Promoters
RGD ID:6819143
Promoter ID:MM_KWN:4729
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_007793
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361077,888,171 - 77,888,671 (+)MPROMDB
RGD ID:6848562
Promoter ID:MM_TRO:1047
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour
Transcripts:MTR009499.10.1323.3
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361077,888,959 - 77,889,459 (+)MPROMDB
RGD ID:8672492
Promoter ID:EPDNEW_M14277
Type:initiation region
Name:Cstb_1
Description:Mus musculus cystatin B , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381078,425,741 - 78,425,801EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109514 AgrOrtholog
Ensembl Genes ENSMUSG00000005054 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000005185 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000005185 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Cystatin_dom UniProtKB/Swiss-Prot
  Prot_inh_cystat_CS UniProtKB/Swiss-Prot
  Prot_inh_stefin UniProtKB/Swiss-Prot
KEGG Report mmu:13014 UniProtKB/Swiss-Prot
MGD MGI:109514 ENTREZGENE
NCBI Gene 13014 ENTREZGENE
PANTHER PTHR11414 UniProtKB/Swiss-Prot
Pfam Cystatin UniProtKB/Swiss-Prot
PhenoGen Cstb PhenoGen
PRINTS STEFINA UniProtKB/Swiss-Prot
PROSITE CYSTATIN UniProtKB/Swiss-Prot
SMART SM00043 UniProtKB/Swiss-Prot
UniProt CYTB_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q3UAW2 UniProtKB/Swiss-Prot