Kremen1 (kringle containing transmembrane protein 1) - Rat Genome Database

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Gene: Kremen1 (kringle containing transmembrane protein 1) Mus musculus
Analyze
Symbol: Kremen1
Name: kringle containing transmembrane protein 1
RGD ID: 1553545
MGI Page MGI
Description: Involved in several processes, including negative regulation of axon regeneration; negative regulation of canonical Wnt signaling pathway; and negative regulation of ossification. Located in neuronal cell body. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb ectoderm; and sensory organ. Human ortholog(s) of this gene implicated in ectodermal dysplasia 13. Orthologous to human KREMEN1 (kringle containing transmembrane protein 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AV002070; dickkopf receptor; Kremen; kremen protein 1; kringle domain-containing transmembrane protein 1; kringle-coding gene marking the eye and the nose; kringle-containing protein marking the eye and the nose; Krm; Krm1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39115,141,551 - 5,212,220 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl115,141,552 - 5,211,558 (-)EnsemblGRCm39 Ensembl
GRCm38115,191,551 - 5,261,713 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl115,191,552 - 5,261,558 (-)EnsemblGRCm38mm10GRCm38
MGSCv37115,091,555 - 5,161,613 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36115,091,555 - 5,161,613 (-)NCBIMGSCv36mm8
Celera115,691,158 - 5,761,052 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map113.36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Molecular cloning and characterization of Kremen, a novel kringle-containing transmembrane protein. Nakamura T, etal., Biochim Biophys Acta 2001 Mar 19;1518(1-2):63-72.
3. Function and biological roles of the Dickkopf family of Wnt modulators. Niehrs C Oncogene. 2006 Dec 4;25(57):7469-81.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12050670   PMID:12421700   PMID:12466851   PMID:12477932   PMID:14610273   PMID:14681479  
PMID:15342465   PMID:15617677   PMID:16141072   PMID:16141073   PMID:18068158   PMID:18346943   PMID:18502762   PMID:18505822   PMID:19515997   PMID:21267068   PMID:21677750   PMID:21873635  
PMID:21905163   PMID:23293290   PMID:24167472   PMID:24952961   PMID:25910078   PMID:26206087   PMID:26288816   PMID:26859490   PMID:27550540   PMID:29681460   PMID:35333176  


Genomics

Comparative Map Data
Kremen1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39115,141,551 - 5,212,220 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl115,141,552 - 5,211,558 (-)EnsemblGRCm39 Ensembl
GRCm38115,191,551 - 5,261,713 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl115,191,552 - 5,261,558 (-)EnsemblGRCm38mm10GRCm38
MGSCv37115,091,555 - 5,161,613 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36115,091,555 - 5,161,613 (-)NCBIMGSCv36mm8
Celera115,691,158 - 5,761,052 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map113.36NCBI
KREMEN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382229,073,035 - 29,168,333 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2229,073,035 - 29,168,333 (+)EnsemblGRCh38hg38GRCh38
GRCh372229,469,023 - 29,564,321 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362227,799,106 - 27,872,808 (+)NCBINCBI36Build 36hg18NCBI36
Build 342227,793,659 - 27,863,040NCBI
Celera2213,268,961 - 13,364,205 (+)NCBICelera
Cytogenetic Map22q12.1NCBI
HuRef2212,431,878 - 12,528,398 (+)NCBIHuRef
CHM1_12229,428,225 - 29,523,454 (+)NCBICHM1_1
T2T-CHM13v2.02229,534,263 - 29,631,831 (+)NCBIT2T-CHM13v2.0
Kremen1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81484,295,931 - 84,361,534 (-)NCBIGRCr8
mRatBN7.21480,081,870 - 80,147,489 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1480,084,403 - 80,147,516 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1484,486,512 - 84,548,999 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01485,726,601 - 85,789,092 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01482,175,948 - 82,238,427 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01485,441,209 - 85,503,661 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1485,438,707 - 85,484,275 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01486,114,543 - 86,175,894 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41485,845,443 - 85,909,575 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11485,864,587 - 85,928,720 (-)NCBI
Celera1478,972,429 - 79,034,890 (-)NCBICelera
Cytogenetic Map14q21NCBI
Kremen1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554553,320,346 - 3,368,690 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554553,308,740 - 3,368,690 (+)NCBIChiLan1.0ChiLan1.0
KREMEN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22339,057,120 - 39,131,287 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12241,756,654 - 41,835,774 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02210,128,326 - 10,202,548 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12227,828,014 - 28,007,213 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2227,828,011 - 28,031,917 (+)Ensemblpanpan1.1panPan2
KREMEN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12622,408,397 - 22,481,646 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2622,407,506 - 22,480,384 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2622,280,486 - 22,353,730 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02622,783,070 - 22,856,290 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2622,782,815 - 22,851,716 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12622,492,122 - 22,565,437 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02622,756,210 - 22,829,458 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02622,819,719 - 22,893,111 (+)NCBIUU_Cfam_GSD_1.0
Kremen1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118112,667,995 - 112,715,143 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366573,155,958 - 3,202,658 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366573,155,564 - 3,206,385 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KREMEN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1446,254,326 - 46,323,354 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11446,254,248 - 46,323,355 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21449,218,268 - 49,287,935 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KREMEN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11911,943,787 - 12,056,706 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1911,943,835 - 12,014,759 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045114,122,710 - 114,206,650 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kremen1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247475,377,996 - 5,445,504 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247475,377,996 - 5,449,203 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kremen1
2278 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2504
Count of miRNA genes:872
Interacting mature miRNAs:1168
Transcripts:ENSMUST00000020662, ENSMUST00000151978
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357722Vtbt11_mvertebral trabecular bone trait 11 (mouse)Not determined11123880487Mouse
1300768Tshp9_mtooth shape 9 (mouse)Not determined11125976374Mouse
1301765Skull15_mskull morphology 15 (mouse)Not determined11125976374Mouse
1300661Lmr6_mleishmaniasis resistance 6 (mouse)Not determined11125976374Mouse
10044008Hbnr15_mHeligmosomoides bakeri nematode resistance 15 (mouse)Not determined1122705234227232Mouse
1300599Cocrb11_mcocaine related behavior 11 (mouse)Not determined11267035536671472Mouse
27095914Pglq16_mpelvic girdle length QTL 16, 16 week (mouse)11325000018150000Mouse
27095919Pglq10_mpelvic girdle length QTL 10, 10 week (mouse)11325000018450000Mouse
27095925Pglq5_mpelvic girdle length QTL 5, 5 week (mouse)11325000019750000Mouse
27095904Scvln12_msacral vertebrae length 2, 10 week (mouse)11325000034495048Mouse
27095909Scvln6_msacral vertebrae length 2, 5 week (mouse)11325000044090827Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
10053676Eae44a_mexperimental allergic encephalomyelitis susceptibility 44a (mouse)Not determined11450789621379532Mouse
27226741Metcl5_mmetatarsal-calcaneal length 5, 5 week (mouse)11465000046290827Mouse

Markers in Region
AV002070  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38115,191,807 - 5,191,909UniSTSGRCm38
MGSCv37115,091,810 - 5,091,912UniSTSGRCm37
Celera115,691,413 - 5,691,515UniSTS
Cytogenetic Map11A1UniSTS
Whitehead/MRC_RH1122.11UniSTS
Kremen1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38115,194,297 - 5,195,109UniSTSGRCm38
MGSCv37115,094,300 - 5,095,112UniSTSGRCm37
Celera115,693,903 - 5,694,715UniSTS
Cytogenetic Map11A1UniSTS
cM Map11 UniSTS
Ins1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381952,264,471 - 52,264,845UniSTSGRCm38
GRCm38115,207,570 - 5,208,085UniSTSGRCm38
MGSCv37115,107,573 - 5,108,088UniSTSGRCm37
MGSCv371952,338,961 - 52,339,335UniSTSGRCm37
Celera1954,451,640 - 54,452,014UniSTS
Celera115,707,168 - 5,707,683UniSTS
Cytogenetic Map19D2UniSTS
Cytogenetic Map11A1UniSTS
cM Map1949.0UniSTS
cM Map1949.0UniSTS
cM Map769.1UniSTS
UniSTS:236506  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38115,191,775 - 5,191,923UniSTSGRCm38
MGSCv37115,091,778 - 5,091,926UniSTSGRCm37
Celera115,691,381 - 5,691,529UniSTS
Cytogenetic Map11A1UniSTS
Kremen1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11A1UniSTS
cM Map11 UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000020662   ⟹   ENSMUSP00000020662
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl115,141,552 - 5,211,558 (-)Ensembl
GRCm38.p6 Ensembl115,191,552 - 5,261,558 (-)Ensembl
RefSeq Acc Id: ENSMUST00000151978   ⟹   ENSMUSP00000121252
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl115,154,833 - 5,188,448 (-)Ensembl
GRCm38.p6 Ensembl115,204,833 - 5,238,448 (-)Ensembl
RefSeq Acc Id: NM_032396   ⟹   NP_115772
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39115,141,552 - 5,211,610 (-)NCBI
GRCm38115,191,552 - 5,261,610 (-)NCBI
MGSCv37115,091,555 - 5,161,613 (-)RGD
Celera115,691,158 - 5,761,052 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006514912   ⟹   XP_006514975
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39115,141,551 - 5,211,713 (-)NCBI
GRCm38115,191,551 - 5,261,713 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006514913   ⟹   XP_006514976
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39115,158,473 - 5,211,663 (-)NCBI
GRCm38115,208,473 - 5,261,663 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036157108   ⟹   XP_036013001
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39115,141,551 - 5,212,220 (-)NCBI
Sequence:
RefSeq Acc Id: NP_115772   ⟸   NM_032396
- Peptide Label: precursor
- UniProtKB: Q640Q6 (UniProtKB/Swiss-Prot),   Q99N43 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006514975   ⟸   XM_006514912
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006514976   ⟸   XM_006514913
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSMUSP00000020662   ⟸   ENSMUST00000020662
RefSeq Acc Id: ENSMUSP00000121252   ⟸   ENSMUST00000151978
RefSeq Acc Id: XP_036013001   ⟸   XM_036157108
- Peptide Label: isoform X2
Protein Domains
CUB   Kringle   WSC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99N43-F1-model_v2 AlphaFold Q99N43 1-473 view protein structure

Promoters
RGD ID:6821152
Promoter ID:MM_KWN:6287
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Lung
Transcripts:ENSMUST00000072714,   OTTMUST00000011369
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36115,161,451 - 5,162,077 (-)MPROMDB
RGD ID:8673836
Promoter ID:EPDNEW_M14949
Type:initiation region
Name:Kremen1_1
Description:Mus musculus kringle containing transmembrane protein 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38115,261,608 - 5,261,668EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1933988 AgrOrtholog
Ensembl Genes ENSMUSG00000020393 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000020662 ENTREZGENE
  ENSMUST00000020662.15 UniProtKB/Swiss-Prot
  ENSMUST00000151978.2 UniProtKB/TrEMBL
Gene3D-CATH 2.40.20.10 UniProtKB/Swiss-Prot
  2.60.120.290 UniProtKB/Swiss-Prot
InterPro CUB_dom UniProtKB/Swiss-Prot
  Kremen UniProtKB/Swiss-Prot
  Kringle UniProtKB/Swiss-Prot
  Kringle-like UniProtKB/Swiss-Prot
  Kringle_CS UniProtKB/Swiss-Prot
  Kringle_sf UniProtKB/Swiss-Prot
  Sperma_CUB_dom_sf UniProtKB/Swiss-Prot
  WSC_carb-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:84035 UniProtKB/Swiss-Prot
MGD MGI:1933988 ENTREZGENE
NCBI Gene 84035 ENTREZGENE
PANTHER KREMEN PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KREMEN PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CUB UniProtKB/Swiss-Prot
  Kringle UniProtKB/Swiss-Prot
  WSC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kremen1 PhenoGen
PIRSF Kremen UniProtKB/Swiss-Prot
PRINTS KRINGLE UniProtKB/Swiss-Prot
PROSITE CUB UniProtKB/Swiss-Prot
  KRINGLE_1 UniProtKB/Swiss-Prot
  KRINGLE_2 UniProtKB/Swiss-Prot
  WSC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CUB UniProtKB/Swiss-Prot
  SM00130 UniProtKB/Swiss-Prot
  WSC UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49854 UniProtKB/Swiss-Prot
  SSF57440 UniProtKB/Swiss-Prot
UniProt F6S1T7_MOUSE UniProtKB/TrEMBL
  KREM1_MOUSE UniProtKB/Swiss-Prot
  Q640Q6 ENTREZGENE
  Q8BNJ0_MOUSE UniProtKB/TrEMBL
  Q99N43 ENTREZGENE
UniProt Secondary Q640Q6 UniProtKB/Swiss-Prot