Lmod2 (leiomodin 2 (cardiac)) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Lmod2 (leiomodin 2 (cardiac)) Mus musculus
Analyze
Symbol: Lmod2
Name: leiomodin 2 (cardiac)
RGD ID: 1557393
MGI Page MGI
Description: Predicted to enable actin monomer binding activity and tropomyosin binding activity. Involved in actin filament polymerization and sarcomere organization. Predicted to be located in actin filament; cardiac myofibril; and sarcomere. Predicted to be active in striated muscle thin filament. Predicted to colocalize with M band. Is expressed in several structures, including aorta; central nervous system; foregut; heart; and skeletal musculature. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 2G. Orthologous to human LMOD2 (leiomodin 2).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: C-Lm; C-Lmod; cardiac leiomodin; leiomodin; leiomodin-2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39624,597,770 - 24,605,413 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl624,597,761 - 24,605,413 (+)EnsemblGRCm39 Ensembl
GRCm38624,597,771 - 24,605,414 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl624,597,762 - 24,605,414 (+)EnsemblGRCm38mm10GRCm38
MGSCv37624,547,771 - 24,555,414 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36624,547,781 - 24,555,424 (+)NCBIMGSCv36mm8
Celera624,608,808 - 24,616,451 (+)NCBICelera
Cytogenetic Map6A3.1NCBI
cM Map611.28NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Mouse MP Annotation Import Pipeline RGD automated import pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11318603   PMID:12466851   PMID:16096065   PMID:16141072   PMID:16141073   PMID:17904117   PMID:21267068   PMID:21873635  
PMID:22157009   PMID:26487682   PMID:27274810   PMID:28292896   PMID:29078393   PMID:29101288   PMID:30102883   PMID:31517052   PMID:37126682   PMID:38478604  


Genomics

Comparative Map Data
Lmod2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39624,597,770 - 24,605,413 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl624,597,761 - 24,605,413 (+)EnsemblGRCm39 Ensembl
GRCm38624,597,771 - 24,605,414 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl624,597,762 - 24,605,414 (+)EnsemblGRCm38mm10GRCm38
MGSCv37624,547,771 - 24,555,414 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36624,547,781 - 24,555,424 (+)NCBIMGSCv36mm8
Celera624,608,808 - 24,616,451 (+)NCBICelera
Cytogenetic Map6A3.1NCBI
cM Map611.28NCBI
LMOD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387123,655,866 - 123,664,290 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7123,655,866 - 123,664,290 (+)EnsemblGRCh38hg38GRCh38
GRCh377123,295,920 - 123,304,344 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367123,083,097 - 123,091,383 (+)NCBINCBI36Build 36hg18NCBI36
Celera7118,099,608 - 118,107,893 (+)NCBICelera
Cytogenetic Map7q31.32NCBI
HuRef7117,659,008 - 117,667,293 (+)NCBIHuRef
CHM1_17123,229,166 - 123,237,469 (+)NCBICHM1_1
T2T-CHM13v2.07124,972,622 - 124,981,048 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27122,684,489 - 122,692,776 (+)NCBI
Lmod2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8454,032,974 - 54,040,670 (+)NCBIGRCr8
mRatBN7.2453,067,428 - 53,075,124 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl453,067,428 - 53,075,120 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx458,054,273 - 58,061,969 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0453,961,154 - 53,968,857 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0452,395,647 - 52,403,354 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0451,553,439 - 51,561,135 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl451,553,454 - 51,561,174 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0451,329,520 - 51,337,216 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera448,233,305 - 48,241,001 (+)NCBICelera
Cytogenetic Map4q22NCBI
Lmod2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554795,142,609 - 5,150,656 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554795,143,430 - 5,151,096 (+)NCBIChiLan1.0ChiLan1.0
LMOD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26160,511,342 - 160,535,107 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1712,521,591 - 12,538,672 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07115,649,102 - 115,657,174 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17128,331,803 - 128,340,268 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7128,331,803 - 128,340,263 (+)Ensemblpanpan1.1panPan2
LMOD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11411,916,842 - 11,924,616 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1411,917,878 - 11,924,438 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1411,600,923 - 11,609,013 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01411,694,569 - 11,702,674 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1411,694,565 - 11,702,599 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11411,884,086 - 11,892,192 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01411,622,032 - 11,630,112 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01411,862,637 - 11,870,749 (-)NCBIUU_Cfam_GSD_1.0
Lmod2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511850,365,568 - 50,373,525 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366051,830,405 - 1,838,400 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366051,829,187 - 1,838,385 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LMOD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1823,803,682 - 23,812,479 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11823,803,927 - 23,815,772 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21825,400,944 - 25,409,479 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LMOD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12192,454,067 - 92,462,904 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2192,454,438 - 92,462,958 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604210,986,877 - 11,010,665 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lmod2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478312,336,535 - 12,345,781 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478312,337,554 - 12,345,712 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:66
Count of miRNA genes:60
Interacting mature miRNAs:63
Transcripts:ENSMUST00000031694
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396633110Mouse
11353836Bmiq1_mbody mass index QTL 1 (mouse)6450382329751333Mouse
4140989Spqq2_msperm quality QTL 2 (mouse)Not determined1771159851711719Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080576983Mouse
1357520Axtq2_manxiety QTL 2 (mouse)Not determined6450382348703611Mouse
10043869Cia6a_mcollagen induced arthritis QTL 6a (mouse)Not determined61211797146118069Mouse
1301850Fglu_mfasting glucose (mouse)Not determined61771159851711719Mouse
4141749Obrq2_mobesity resistance QTL 2 (mouse)Not determined1275122146751333Mouse
1301724Pcd4ts1_mp-glycoprotein positive CD4 T cell subset 1 (mouse)Not determined61771159851711719Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396633110Mouse
10412107Desp4_mdespair 4 (mouse)Not determined62004983054049830Mouse
1357442Dbts1_mdiabetes 1 (mouse)Not determined61823414773364675Mouse
1301131Chol2_mcholesterol 2 (mouse)Not determined6132144495Mouse
1302024Skull7_mskull morphology 7 (mouse)Not determined6132144495Mouse
11353841Bmiq3_mbody mass index QTL 3 (mouse)6450382348703611Mouse
11353840Bmiq2_mbody mass index QTL 2 (mouse)6450382345291115Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487403016Mouse
12904934Edlmmq4_mextensor digitorum longus muscle mass QTL 4 (mouse)6125514064Mouse
5491191Mobq2_mmultigenic obesity QTL 2 (mouse)Not determined6132144495Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396633110Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396633110Mouse
1300731Smdq3_msegregation of mitochondrial DNA QTL 3 (mouse)Not determined6424920638249325Mouse
12904940Edlmmq5_mextensor digitorum longus muscle mass QTL 5 (mouse)61961634653616346Mouse
15039372Nmrs22_mNAFLD-associated magnetic resonance shift 22 (mouse)6147633435476334Mouse
12904942Tammq3_mtibialis anterior muscle mass QTL 3 (mouse)6125514064Mouse
12904943Tammq4_mtibialis anterior muscle mass QTL 4 (mouse)61961634653616346Mouse
10412213Sxbq2_mSGC/Knj cross B6 QTL 2 (mouse)Not determined61991268571299759Mouse
1302051Sluc7_msusceptibility to lung cancer 7 (mouse)Not determined6929707443297168Mouse
14700690Ccs6_mcolon cancer susceptibility 6 (mouse)62377693457776934Mouse
27226726Tibmd7_mtibia midshaft diameter 7, 16 week (mouse)61769999953476985Mouse
12904952Gmmq4_mgastrocnemius muscle mass QTL 4 (mouse)61961634653616346Mouse
1357481Aaj2_manxiety in A/J 2 (mouse)Not determined6450382348703611Mouse
1301998Bts2_mbladder tumor susceptibility 2 (mouse)Not determined61275122146751333Mouse
12904955Gmmq3_mgastrocnemius muscle mass QTL 3 (mouse)6125514064Mouse

Markers in Region
Lmod2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38624,603,730 - 24,603,845UniSTSGRCm38
MGSCv37624,553,730 - 24,553,845UniSTSGRCm37
Celera624,614,767 - 24,614,882UniSTS
Cytogenetic Map6A3UniSTS
cM Map6 UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000031694   ⟹   ENSMUSP00000031694
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl624,597,761 - 24,605,413 (+)Ensembl
GRCm38.p6 Ensembl624,597,762 - 24,605,414 (+)Ensembl
RefSeq Acc Id: NM_053098   ⟹   NP_444328
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39624,597,770 - 24,605,413 (+)NCBI
GRCm38624,597,771 - 24,605,414 (+)ENTREZGENE
MGSCv37624,547,771 - 24,555,414 (+)RGD
Celera624,608,808 - 24,616,451 (+)RGD
cM Map6 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_444328 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK00789 (Get FASTA)   NCBI Sequence Viewer  
  BAE27711 (Get FASTA)   NCBI Sequence Viewer  
  EDL13820 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000031694
  ENSMUSP00000031694.7
GenBank Protein Q3UHZ5 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_444328   ⟸   NM_053098
- UniProtKB: Q99PM7 (UniProtKB/Swiss-Prot),   Q3UHZ5 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000031694   ⟸   ENSMUST00000031694
Protein Domains
WH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3UHZ5-F1-model_v2 AlphaFold Q3UHZ5 1-550 view protein structure

Promoters
RGD ID:6889114
Promoter ID:EPDNEW_M8008
Type:initiation region
Name:Lmod2_1
Description:Mus musculus leiomodin 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38624,597,772 - 24,597,832EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2135672 AgrOrtholog
Ensembl Genes ENSMUSG00000029683 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000031694 ENTREZGENE
  ENSMUST00000031694.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot
InterPro LRR_dom_sf UniProtKB/Swiss-Prot
  TMOD UniProtKB/Swiss-Prot
KEGG Report mmu:93677 UniProtKB/Swiss-Prot
MGD MGI:2135672 ENTREZGENE
NCBI Gene 93677 ENTREZGENE
PANTHER PTHR10901 UniProtKB/Swiss-Prot
  PTHR10901:SF12 UniProtKB/Swiss-Prot
Pfam Tropomodulin UniProtKB/Swiss-Prot
PhenoGen Lmod2 PhenoGen
Superfamily-SCOP RNI-like UniProtKB/Swiss-Prot
UniProt LMOD2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q99PM7 ENTREZGENE
UniProt Secondary Q99PM7 UniProtKB/Swiss-Prot