Aif1 (allograft inflammatory factor 1) - Rat Genome Database

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Gene: Aif1 (allograft inflammatory factor 1) Mus musculus
Analyze
Symbol: Aif1
Name: allograft inflammatory factor 1
RGD ID: 62217
MGI Page MGI
Description: Exhibits actin filament binding activity and calcium ion binding activity. Involved in several processes, including Rac protein signal transduction; actin filament organization; and ruffle assembly. Localizes to several cellular components, including actin filament; phagocytic cup; and ruffle membrane. Is expressed in adrenal cortex; central nervous system; embryo mesenchyme; and retina. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human AIF1 (allograft inflammatory factor 1); INTERACTS WITH 1,1-dichloroethene; 1,2-dimethylhydrazine; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI607846; AIF-1; D17H6S50; D17H6S50E; G1; Ib; Iba1; ionized calcium binding adapter molecule 1; ionized calcium-binding adapter molecule 1; testis specific
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,389,962 - 35,395,050 (-)NCBIGRCm39mm39
GRCm39 Ensembl1735,389,967 - 35,395,044 (-)Ensembl
GRCm381735,170,986 - 35,176,083 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1735,170,991 - 35,176,068 (-)EnsemblGRCm38mm10GRCm38
MGSCv371735,307,937 - 35,312,946 (-)NCBIGRCm37mm9NCBIm37
MGSCv361734,779,048 - 34,784,057 (-)NCBImm8
Celera1738,267,928 - 38,272,936 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.59NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(S)-colchicine  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,5-hexanedione  (ISO)
2-nitrofluorene  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3'-diindolylmethane  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
8-OH-DPAT  (EXP)
acetamide  (ISO)
aconitine  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allyl isothiocyanate  (ISO)
alpha-D-galactose  (EXP)
amentoflavone  (EXP)
aminoguanidine  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
antirheumatic drug  (ISO)
apocynin  (EXP)
arsenous acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
Benzo[k]fluoranthene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
buspirone  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (EXP)
chloroprene  (EXP)
chlorpyrifos  (ISO)
chrysene  (EXP)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyprodinil  (EXP,ISO)
dabigatran  (EXP)
decabromodiphenyl ether  (ISO)
diarsenic trioxide  (ISO)
diisopropyl fluorophosphate  (ISO)
diuron  (ISO)
doxorubicin  (EXP)
entinostat  (ISO)
ethanol  (ISO)
ethylmalonic acid  (ISO)
flavonoids  (ISO)
flutamide  (ISO)
folic acid  (EXP)
galactose  (EXP)
gentamycin  (ISO)
ginsenoside Re  (EXP)
glyburide  (EXP,ISO)
hexachlorobenzene  (ISO)
Ibudilast  (ISO)
isoprenaline  (EXP)
kainic acid  (ISO)
lead diacetate  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lycopene  (EXP)
Magnolol  (EXP)
maneb  (EXP)
manganese(II) chloride  (EXP)
medroxyprogesterone acetate  (ISO)
mepanipyrim  (EXP,ISO)
methamphetamine  (EXP)
methylmalonic acid  (ISO)
methylmercury chloride  (EXP)
minocycline  (EXP)
morphine  (ISO)
mycophenolic acid  (ISO)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (EXP)
N-butylbenzenesulfonamide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodimethylamine  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
nevirapine  (ISO)
nickel atom  (ISO)
nimesulide  (ISO)
Nonylphenol  (ISO)
Norbinaltorphimine  (EXP)
oxaliplatin  (ISO)
oxybenzone  (ISO)
p-menthan-3-ol  (ISO)
paraquat  (EXP)
permethrin  (EXP)
pirinixic acid  (ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
Pyridostigmine bromide  (EXP)
pyrimethanil  (EXP,ISO)
quercetin  (ISO)
quinoline  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
rottlerin  (EXP)
SCH 23390  (EXP)
silicon dioxide  (EXP)
sodium arsenite  (EXP)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP)
sulpiride  (EXP)
tacrolimus hydrate  (EXP)
tadalafil  (EXP)
tamibarotene  (ISO)
Tesaglitazar  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
thioacetamide  (EXP,ISO)
titanium dioxide  (EXP)
tolcapone  (ISO)
toluene  (EXP,ISO)
topotecan  (ISO)
tributylstannane  (ISO)
trimethyltin  (EXP)
valproic acid  (EXP)
vincaleukoblastine  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin crosslink formation  (IMP)
actin filament bundle assembly  (IBA,IDA,ISO)
actin filament polymerization  (ISO)
cellular response to extracellular stimulus  (ISO)
cellular response to hormone stimulus  (ISO)
cellular response to hydroperoxide  (ISO)
cellular response to interferon-gamma  (ISO)
cellular response to morphine  (ISO)
cellular response to oxidative stress  (ISO)
cerebellum development  (ISO)
inflammatory response  (ISO)
microglial cell activation  (NAS)
negative regulation of apoptotic process  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of smooth muscle cell chemotaxis  (ISO)
negative regulation of smooth muscle cell proliferation  (ISO)
parallel actin filament bundle assembly  (IDA)
phagocytosis, engulfment  (IMP)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of chemokine production  (ISO)
positive regulation of chemotaxis  (ISO)
positive regulation of fibroblast growth factor production  (ISO)
positive regulation of G1/S transition of mitotic cell cycle  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of monocyte chemotaxis  (ISO)
positive regulation of mononuclear cell migration  (ISO)
positive regulation of muscle hyperplasia  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of smooth muscle cell chemotaxis  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of T cell migration  (ISO)
positive regulation of T cell proliferation  (ISO)
Rac protein signal transduction  (IMP)
response to axon injury  (ISO)
response to cytokine  (ISO)
response to electrical stimulus  (ISO)
response to glucocorticoid  (ISO)
ruffle assembly  (IBA,IMP,NAS)

Cellular Component
actin filament  (IBA,IDA,ISO)
cell projection  (ISO)
cytoplasm  (IDA,ISO)
cytoskeleton  (IEA)
cytosol  (ISO)
lamellipodium  (IDA,ISO)
membrane  (IEA)
nucleus  (IDA,ISO)
perikaryon  (ISO)
perinuclear region of cytoplasm  (ISO)
phagocytic cup  (IDA)
plasma membrane  (IEA)
ruffle  (IDA)
ruffle membrane  (IBA,IDA,ISO)

Molecular Function

References

References - curated
1. Almolda B, etal., J Neuroimmunol. 2009 Apr 30;209(1-2):65-80. Epub 2009 Feb 26.
2. Beiter T, etal., J Neuroimmunol. 2005 Mar;160(1-2):25-31. Epub 2004 Dec 15.
3. Chen ZW, etal., Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13879-84.
4. Eike MC, etal., Genes Immun. 2009 Mar;10(2):141-50. Epub 2008 Nov 6.
5. Girard S, etal., Neuroscience. 2009 Jan 23;158(2):673-82. Epub 2008 Oct 30.
6. Herden C, etal., Neuropathol Appl Neurobiol. 2005 Oct;31(5):512-21.
7. Hirsch J, etal., Mol Cell Proteomics. 2006 Jun;5(6):979-86. Epub 2006 Feb 24.
8. Jakubs K, etal., J Neurosci. 2008 Nov 19;28(47):12477-88.
9. Jakubs K, etal., Neuron. 2006 Dec 21;52(6):1047-59.
10. Kalm M, etal., J Neuroimmunol. 2009 Jan 3;206(1-2):70-5. Epub 2008 Dec 13.
11. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
12. Lee JK, etal., Neurosci Lett. 2009 Jan 30;450(2):136-41. Epub 2008 Dec 6.
13. Lepore AC, etal., Nat Neurosci. 2008 Nov;11(11):1294-301. Epub 2008 Oct 19.
14. Lund T, etal., Diabetologia 1993 Aug;36(8):727-33.
15. MGD and Homologene mouse data transfer
16. MGD data from the GO Consortium
17. Mishima T, etal., Int J Mol Med. 2008 Feb;21(2):181-7.
18. Nakano T, etal., Neurosci Lett. 2009 Sep 18;461(2):110-5. Epub 2009 Jun 9.
19. Narita M, etal., Neurosci Lett. 2007 Feb 27;414(1):21-5. Epub 2006 Dec 15.
20. Nixon K, etal., Neurobiol Dis. 2008 Aug;31(2):218-29. Epub 2008 May 3.
21. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
22. Postler E, etal., J Neuroimmunol. 2000 Apr 3;104(1):85-91.
23. Rappold PM, etal., Brain Res. 2006 May 17;1089(1):171-8. Epub 2006 Apr 25.
24. RGD automated import pipeline
25. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. RGD automated import pipeline for gene-chemical interactions
27. Rivera EJ, etal., J Alzheimers Dis. 2005 Dec;8(3):247-68.
28. Sakuma M, etal., J Neural Transm. 2008;115(3):413-22. Epub 2008 Feb 26.
29. Tanaka S, etal., J Neurosci 1998 Aug 15;18(16):6358-69.
30. Thored P, etal., Glia. 2009 Jun;57(8):835-49.
31. Tsubata Y, etal., Kidney Int. 2006 Dec;70(11):1948-54. Epub 2006 Oct 11.
32. Tsuda M, etal., Glia. 2008 Mar;56(4):378-86.
33. Vega-Avelaira D, etal., Brain Behav Immun. 2007 Jul;21(5):617-23. Epub 2006 Dec 8.
34. Wixey JA, etal., J Neuroimmunol. 2009 Jul 25;212(1-2):35-43. Epub 2009 May 17.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10469308   PMID:10871872   PMID:10934045   PMID:11042159   PMID:11076861   PMID:11500035   PMID:11722645   PMID:11861656   PMID:11943136   PMID:11976791  
PMID:12477932   PMID:14506935   PMID:14610273   PMID:14656967   PMID:14756805   PMID:15489334   PMID:15601948   PMID:15748167   PMID:16141072   PMID:16141073   PMID:16160063   PMID:16291819  
PMID:16868985   PMID:17011575   PMID:17515609   PMID:17874251   PMID:17991871   PMID:18001291   PMID:18366138   PMID:18398829   PMID:18680569   PMID:18786355   PMID:19373938   PMID:19570515  
PMID:19838178   PMID:20404134   PMID:20737593   PMID:20889973   PMID:20966214   PMID:21040744   PMID:21085684   PMID:21623369   PMID:21677750   PMID:21862018   PMID:21873635   PMID:22046273  
PMID:22056141   PMID:22079990   PMID:22150368   PMID:22173850   PMID:22337526   PMID:22398208   PMID:22442384   PMID:22525427   PMID:22529212   PMID:22542597   PMID:22666322   PMID:22666391  
PMID:22806269   PMID:22859373   PMID:22884324   PMID:22895712   PMID:22915101   PMID:23022189   PMID:23332759   PMID:23334579   PMID:23525041   PMID:23744272   PMID:23929822   PMID:24507192  
PMID:24512632   PMID:24741061   PMID:24766809   PMID:24857653   PMID:24912173   PMID:24952082   PMID:24990151   PMID:25044744   PMID:25285789   PMID:25425146   PMID:25574476   PMID:25653379  
PMID:25741723   PMID:26044557   PMID:26063905   PMID:26367446   PMID:26604141   PMID:26758845   PMID:26848828   PMID:26869039   PMID:26911661   PMID:26961959   PMID:26964679   PMID:27008858  
PMID:27135602   PMID:27199256   PMID:27418600   PMID:27626380   PMID:27798843   PMID:27860408   PMID:27878595   PMID:28009292   PMID:28224999   PMID:28284905   PMID:28322231   PMID:28368047  
PMID:28373281   PMID:28472653   PMID:28513333   PMID:28570266   PMID:28836308   PMID:28892060   PMID:28929580   PMID:28964716   PMID:29187321   PMID:29203794   PMID:29225172   PMID:29361054  
PMID:29483282   PMID:29548672   PMID:29588831   PMID:29666241   PMID:29704636   PMID:29744881   PMID:29749461   PMID:29788012   PMID:29789531   PMID:29920279   PMID:29973370   PMID:30026565  
PMID:30111840   PMID:30258231   PMID:30282965   PMID:30512224   PMID:30538199   PMID:30606613   PMID:30647151   PMID:30699346   PMID:30760929   PMID:30800127   PMID:30938680   PMID:31002029  
PMID:31081019   PMID:31197172   PMID:31200100   PMID:31271872   PMID:31439353   PMID:31442405   PMID:31505254   PMID:31543758   PMID:31696965   PMID:31712428   PMID:31729371   PMID:31731293  
PMID:31754024   PMID:31861806   PMID:31950314   PMID:32123192   PMID:32135084   PMID:32150249   PMID:32242005   PMID:32259484   PMID:32294451   PMID:32369453   PMID:32450295   PMID:32525278  
PMID:32553121   PMID:32579270   PMID:32659913   PMID:32797202   PMID:32895288   PMID:33082323   PMID:33116204   PMID:33165593  


Genomics

Comparative Map Data
Aif1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,389,962 - 35,395,050 (-)NCBIGRCm39mm39
GRCm39 Ensembl1735,389,967 - 35,395,044 (-)Ensembl
GRCm381735,170,986 - 35,176,083 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1735,170,991 - 35,176,068 (-)EnsemblGRCm38mm10GRCm38
MGSCv371735,307,937 - 35,312,946 (-)NCBIGRCm37mm9NCBIm37
MGSCv361734,779,048 - 34,784,057 (-)NCBImm8
Celera1738,267,928 - 38,272,936 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.59NCBI
AIF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl631,615,217 - 31,617,021 (+)EnsemblGRCh38hg38GRCh38
GRCh38631,615,212 - 31,617,015 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37631,583,011 - 31,584,792 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,691,012 - 31,692,777 (+)NCBINCBI36hg18NCBI36
Build 34631,691,767 - 31,692,777NCBI
Celera633,181,222 - 33,183,026 (+)NCBI
Cytogenetic Map6p21.33NCBI
HuRef631,369,335 - 31,370,975 (+)NCBIHuRef
CHM1_1631,585,122 - 31,586,938 (+)NCBICHM1_1
Aif1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2203,646,784 - 3,652,670 (+)NCBI
Rnor_6.0 Ensembl205,161,333 - 5,166,448 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0205,161,350 - 5,167,176 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0207,234,609 - 7,240,454 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,714,428 - 3,716,327 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1203,714,654 - 3,716,552NCBI
Celera204,373,127 - 4,375,026 (-)NCBICelera
Cytogenetic Map20p12NCBI
Aif1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955437157,509 - 158,919 (+)NCBIChiLan1.0ChiLan1.0
AIF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1632,166,301 - 32,168,125 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl632,166,301 - 32,168,125 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0631,276,215 - 31,278,051 (+)NCBIMhudiblu_PPA_v0panPan3
AIF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,104,350 - 1,106,179 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl121,104,394 - 1,106,177 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha121,240,799 - 1,242,629 (+)NCBI
ROS_Cfam_1.0121,249,600 - 1,251,430 (+)NCBI
UMICH_Zoey_3.1121,108,905 - 1,110,735 (+)NCBI
UNSW_CanFamBas_1.0121,176,225 - 1,178,056 (+)NCBI
UU_Cfam_GSD_1.0121,243,086 - 1,244,917 (+)NCBI
Aif1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494635,651,964 - 35,653,851 (+)NCBI
SpeTri2.0NW_0049367271,907,493 - 1,909,350 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AIF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl723,711,722 - 23,731,671 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1723,711,752 - 23,731,191 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2727,520,797 - 27,540,237 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AIF1
(Chlorocebus sabaeus - African green monkey)
No map positions available.
Aif1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475424,590,071 - 24,591,913 (-)NCBI

Position Markers
AI607846  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381735,171,519 - 35,171,825UniSTSGRCm38
MGSCv371735,308,464 - 35,308,770UniSTSGRCm37
Celera1738,268,455 - 38,268,761UniSTS
Cytogenetic Map17B1UniSTS
cM Map1719.05UniSTS
Whitehead/MRC_RH17479.08UniSTS
Aif1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381735,171,544 - 35,172,337UniSTSGRCm38
MGSCv371735,308,489 - 35,309,282UniSTSGRCm37
Celera1738,268,480 - 38,269,273UniSTS
Cytogenetic Map17B1UniSTS
cM Map1719.05UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10412276Leci2_mleukocyte endothelial cell interactions 2 (mouse)Not determined17312791337128037Mouse
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17392461548559063Mouse
4141215Mnic1_mmacronutrient intake, carbohydrate 1 (mouse)Not determined480447745359340Mouse
1300706Alan1_malloantigen response 1 (mouse)Not determined17480447746158776Mouse
1357789Kdnw3_mkidney weight 3 (mouse)Not determined17480447747574740Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined480447765330362Mouse
10043949Pbft7_mpercent body fat 7 (mouse)Not determined17667496240674962Mouse
1301935Skull24_mskull morphology 24 (mouse)Not determined17836594042366175Mouse
1300787Cd8mts5_mCD8 memory T cell subset 5 (mouse)Not determined17836594042366175Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined17986241186688972Mouse
1302028Asbb3_mautoimmune susceptibility in C57BL/6J and BALB/c 3 (mouse)Not determined171065914544659245Mouse
4142342Lfnq4_mlung function QTL 4 (mouse)Not determined1098759739053168Mouse
4141067Hbnr2_mHeligmosomoides bakeri nematode resistance 2 (mouse)Not determined1166699745667145Mouse
14747010Mancz14_mmandible centroid size 14 (mouse)171177921045779210Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171206732483054339Mouse
12904946Tammq8_mtibialis anterior muscle mass QTL 8 (mouse)171223281346232813Mouse
13524847Asrq8a_macoustic startle response 8a (mouse)171242798746427987Mouse
11081168Tir7_mtrypanosome infection response 7 (mouse)171390439847904522Mouse
1300914Pcir4_mperiosteal circumference 4 (mouse)Not determined171484267848842786Mouse
1558886Lgth9_mbody length 9 (mouse)Not determined171484267848842786Mouse
1302070Tbbmd7_mtotal body bone mineral density 7 (mouse)Not determined171484267848842786Mouse
1300995Fembrs4_mfemur breaking strength 4 (mouse)Not determined171484267848842786Mouse
1302140Wta4_mweight adult 4 (mouse)Not determined171660074750600869Mouse
1302152Skull25_mskull morphology 25 (mouse)Not determined171660074750600869Mouse
1301505Tir1_mtrypanosome infection response 1 (mouse)Not determined171660074750600869Mouse
10412083Sm2_msusceptibility to Schistosoma mansoni infection 2 (mouse)Not determined171681096950811104Mouse
1302042Acsns3_mAngiostrongylus costaricensis nematode susceptibility 3 (mouse)Not determined171724323451243371Mouse
1300535Char3_mP. chabaudi malaria resistance QTL 3 (mouse)Not determined171724323451243371Mouse
10412214Sxbq3_mSGC/Knj cross B6 QTL 3 (mouse)Not determined171724323451243371Mouse
13452396Leusq3_mleucocytosis susceptibility QTL 3 (mouse)171724323451243371Mouse
13452399Leusq6_mleucocytosis susceptibility QTL 6 (mouse)171724323451243371Mouse
1301840Ssial4_msusceptibility to sialadenitiss 4 (mouse)Not determined171795643651959238Mouse
1301331Lbw1_mlupus NZB x NZW 1 (mouse)Not determined171819938152202007Mouse
1301056Pas2_mpulmonary adenoma susceptibility 2 (mouse)Not determined171820316552205351Mouse
15039354Nmrs36_mNAFLD-associated magnetic resonance shift 36 (mouse)171883413352834133Mouse
1301454Eae5_msusceptibility to experimental allergic encephalomyelitis 5 (mouse)Not determined172430185958301973Mouse
10412198Sst5_msusceptibility to tuberculosis 5 (mouse)Not determined172485760955405969Mouse
10412196Bbaa28_mB.burgdorferi-associated arthritis 28 (mouse)Not determined172536594043665344Mouse
10412204Bbaa29_mB.burgdorferi-associated arthritis 29 (mouse)Not determined172574029459740461Mouse
1558758Kcal2_mkilocalorie 2 (mouse)Not determined172618203852604676Mouse
1300602Eye2_meye weight 2 (mouse)Not determined172628636340794146Mouse
1302005Loco2_mlocomotor activity 2 (mouse)Not determined172657408160574223Mouse
11075105Modc1_mmodifier of Odc1 (mouse)172749681845311728Mouse
15039348Nmrs37_mNAFLD-associated magnetic resonance shift 37 (mouse)172750432261504322Mouse
10045977Tir9_mtrypanosome infection response 9 (mouse)Not determined172765914543574223Mouse
1300703Uvbi2_mUVB induced immunosuppression 2 (mouse)Not determined172831148062311728Mouse
1300589Myaa2_mmodifier of Yaa 2 (mouse)Not determined172982162963821740Mouse
4140955Plgr1_mplague resistance locus 1 (mouse)Not determined3072257564722705Mouse
4141357Mrdq1_mmodifier of retinal degeneration QTL 1 (mouse)Not determined3076892947728778Mouse
1300692Blmpf1_mbleomycin-induced pulmonary fibrosis 1 (mouse)Not determined173184267837333884Mouse
25394538Skmw84_mskeletal muscle weight 84, TA (mouse)173244145235301060Mouse
26884379Skwq5_mskull length QTL 5, 5 week (mouse)173290000053800000Mouse
1302189Dps3_mdelta power in slow-wave sleep 3 (mouse)Not determined173360074735939288Mouse
1300885Mbis4_mMycobacterium bovis-induced systemic lupus erythematosus 4 (mouse)Not determined173495684169858931Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1711
Count of miRNA genes:581
Interacting mature miRNAs:694
Transcripts:ENSMUST00000025257, ENSMUST00000172679, ENSMUST00000172693, ENSMUST00000173106, ENSMUST00000173281, ENSMUST00000173324, ENSMUST00000174044
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001361501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001361502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_019467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006523503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB013745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB036423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF074959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF109719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ560664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ560665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK006184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK006562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC021539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE947563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR974444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU406961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU466548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D86382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF101555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U82792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000025257   ⟹   ENSMUSP00000025257
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1735,170,994 - 35,173,278 (-)Ensembl
RefSeq Acc Id: ENSMUST00000172679
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1735,170,996 - 35,176,068 (-)Ensembl
RefSeq Acc Id: ENSMUST00000172693   ⟹   ENSMUSP00000134214
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1735,170,991 - 35,172,819 (-)Ensembl
RefSeq Acc Id: ENSMUST00000173106   ⟹   ENSMUSP00000134107
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1735,171,523 - 35,172,631 (-)Ensembl
RefSeq Acc Id: ENSMUST00000173281
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1735,170,991 - 35,171,858 (-)Ensembl
RefSeq Acc Id: ENSMUST00000173324   ⟹   ENSMUSP00000133709
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1735,170,992 - 35,176,001 (-)Ensembl
RefSeq Acc Id: ENSMUST00000174044
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1735,172,530 - 35,176,001 (-)Ensembl
RefSeq Acc Id: NM_001361501   ⟹   NP_001348430
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391735,389,962 - 35,395,028 (-)NCBI
GRCm381735,170,986 - 35,176,052 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001361502   ⟹   NP_001348431
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391735,389,962 - 35,395,028 (-)NCBI
GRCm381735,170,986 - 35,176,052 (-)NCBI
Sequence:
RefSeq Acc Id: NM_019467   ⟹   NP_062340
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391735,389,962 - 35,395,028 (-)NCBI
GRCm381735,170,986 - 35,176,052 (-)NCBI
MGSCv371735,307,937 - 35,312,946 (-)RGD
Celera1738,267,928 - 38,272,936 (-)RGD
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006523503   ⟹   XP_006523566
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391735,389,967 - 35,395,050 (-)NCBI
GRCm381735,170,991 - 35,176,083 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_062340   ⟸   NM_019467
- Peptide Label: isoform a
- UniProtKB: O70200 (UniProtKB/Swiss-Prot),   Q4FJL9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006523566   ⟸   XM_006523503
- Peptide Label: isoform X1
- UniProtKB: O70200 (UniProtKB/Swiss-Prot),   Q4FJL9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001348431   ⟸   NM_001361502
- Peptide Label: isoform b
RefSeq Acc Id: NP_001348430   ⟸   NM_001361501
- Peptide Label: isoform a
RefSeq Acc Id: ENSMUSP00000134214   ⟸   ENSMUST00000172693
RefSeq Acc Id: ENSMUSP00000133709   ⟸   ENSMUST00000173324
RefSeq Acc Id: ENSMUSP00000134107   ⟸   ENSMUST00000173106
RefSeq Acc Id: ENSMUSP00000025257   ⟸   ENSMUST00000025257
Protein Domains
EF-hand

Promoters
RGD ID:13675834
Promoter ID:EPDNEW_M22066
Type:initiation region
Name:Aif1_1
Description:Mus musculus allograft inflammatory factor 1 , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M22067  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381735,172,617 - 35,172,677EPDNEW
RGD ID:13675836
Promoter ID:EPDNEW_M22067
Type:initiation region
Name:Aif1_2
Description:Mus musculus allograft inflammatory factor 1 , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M22066  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381735,176,001 - 35,176,061EPDNEW
RGD ID:6827770
Promoter ID:MM_KWN:23283
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung,   Spleen
Transcripts:ENSMUST00000025257,   UC008CGL.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361735,309,491 - 35,310,542 (-)MPROMDB
RGD ID:6827769
Promoter ID:MM_KWN:23284
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:NM_019467
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361735,312,531 - 35,313,031 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1343098 AgrOrtholog
Ensembl Genes ENSMUSG00000024397 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000025257 UniProtKB/Swiss-Prot
  ENSMUSP00000133709 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000134107 UniProtKB/TrEMBL
  ENSMUSP00000134214 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000025257 UniProtKB/Swiss-Prot
  ENSMUST00000172679 ENTREZGENE
  ENSMUST00000172693 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000173106 UniProtKB/TrEMBL
  ENSMUST00000173324 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro AIF1/AIF1L UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11629 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1343098 ENTREZGENE
NCBI Gene 11629 ENTREZGENE
PANTHER PTHR10356 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Aif1 PhenoGen
PROSITE EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A1E2H8_MOUSE UniProtKB/TrEMBL
  AIF1_MOUSE UniProtKB/Swiss-Prot
  G3UYJ2_MOUSE UniProtKB/TrEMBL
  O70200 ENTREZGENE
  Q4FJL9 ENTREZGENE, UniProtKB/TrEMBL