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Gene: Amfr (autocrine motility factor receptor) Mus musculus
Symbol: Amfr
Name: autocrine motility factor receptor
RGD ID: 1323069
Description: Predicted to have several functions, including BAT3 complex binding activity; chaperone binding activity; and ubiquitin-specific protease binding activity. Involved in negative regulation of canonical Wnt signaling pathway and regulation of SREBP signaling pathway. Predicted to localize to several cellular components, including endoplasmic reticulum membrane; growth cone; and neuronal cell body. Is expressed in several structures, including central nervous system; genitourinary system; integumental system; liver; and retina nuclear layer. Orthologous to human AMFR (autocrine motility factor receptor); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (S)-amphetamine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AMF receptor; E3 ubiquitin-protein ligase AMFR; gp7; gp78; RING-type E3 ubiquitin transferase AMFR
Homo sapiens (human) : AMFR (autocrine motility factor receptor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Amfr (autocrine motility factor receptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Amfr (autocrine motility factor receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : AMFR (autocrine motility factor receptor)
Canis lupus familiaris (dog) : AMFR (autocrine motility factor receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Amfr (autocrine motility factor receptor)
Sus scrofa (pig) : AMFR (autocrine motility factor receptor)
Chlorocebus sabaeus (African green monkey) : AMFR (autocrine motility factor receptor)
Heterocephalus glaber (naked mole-rat) : Amfr (autocrine motility factor receptor)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39894,698,216 - 94,739,268 (-)NCBI
GRCm38893,971,588 - 94,012,640 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl893,971,588 - 94,012,842 (-)EnsemblGRCm38mm10GRCm38
MGSCv37896,495,488 - 96,536,540 (-)NCBIGRCm37mm9NCBIm37
MGSCv36896,861,055 - 96,901,971 (-)NCBImm8
Celera898,301,641 - 98,335,290 (-)NCBICelera
Cytogenetic Map8C5NCBI
cM Map845.96NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Amfr
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1323069
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-11-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.