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Gene: Smc3 (structural maintenance of chromosomes 3) Mus musculus
Symbol: Smc3
Name: structural maintenance of chromosomes 3
Description: Exhibits chromatin binding activity and mediator complex binding activity. Involved in meiotic cell cycle and stem cell population maintenance. Localizes to lateral element and nuclear meiotic cohesin complex. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and respiratory system. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 3. Orthologous to human SMC3 (structural maintenance of chromosomes 3); PARTICIPATES IN cell cycle pathway, mitotic; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene; cisplatin.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Bamacan; basement membrane-associated chondroitin proteoglycan; chondroitin sulfate proteoglycan 6; chromosome segregation protein SmcD; Cspg6; HCAP; mad member-interacting protein 1; Mmip1; SMC protein 3; SMC-3; SmcD; structural maintenace of chromosomes 3; structural maintenance of chromosomes protein 3
Homo sapiens (human) : SMC3 (structural maintenance of chromosomes 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Smc3 (structural maintenance of chromosomes 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Smc3 (structural maintenance of chromosomes 3)
Pan paniscus (bonobo/pygmy chimpanzee) : SMC3 (structural maintenance of chromosomes 3)
Canis lupus familiaris (dog) : SMC3 (structural maintenance of chromosomes 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Smc3 (structural maintenance of chromosomes 3)
Sus scrofa (pig) : SMC3 (structural maintenance of chromosomes 3)
Chlorocebus sabaeus (African green monkey) : SMC3 (structural maintenance of chromosomes 3)
Heterocephalus glaber (naked mole-rat) : Smc3 (structural maintenance of chromosomes 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1953,600,398 - 53,645,833 (+)EnsemblGRCm38mm10GRCm38
GRCm381953,600,396 - 53,645,831 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371953,674,886 - 53,720,321 (+)NCBIGRCm37mm9NCBIm37
MGSCv361953,653,759 - 53,698,460 (+)NCBImm8
Celera1955,793,196 - 55,838,677 (+)NCBICelera
Cytogenetic Map19D2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Smc3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 62298
Created: 2001-04-11
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.