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Gene: Ctnnb1 (catenin (cadherin associated protein), beta 1) Mus musculus
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Symbol: Ctnnb1
Name: catenin (cadherin associated protein), beta 1
Description: This gene encodes not only an important cytoplasmic component of the classical cadherin adhesion complex that forms the adherens junction in epithelia and mediates cell-cell adhesion in many other tissues but also a key signaling molecule in the canonical Wnt signaling pathway that controls cell growth and differentiation during both normal development and tumorigenesis. The gene product contains a central armadillo-repeat containing domain through which it binds the cytoplasmic tail of classical cadherins; meanwhile, it also binds alpha-catenin, which further links the cadherin complex to the actin cytoskeleton either directly or indirectly. Beta-catenin is therefore necessary for the adhesive function of classical cadherins. Another key function of this protein is to mediate the canonical Wnt signaling pathway and regulate gene transcription. Without Wnt signal, cytoplasmic beta-catenin that is not associated with the cadherin complex is quickly phosphorylated at the N-terminal Ser/Thr residues by the so called degradation complex containing axin, adenomatous polyposis coli (APC), casein kinase I, and GSK3B, then ubiquitylated by beta-TrCP, and degraded by the proteasome. However, in the presence of Wnt signal, the degradation complex is disrupted and the stabilized cytoplasmic beta-catenin translocates into the nucleus, where it binds various transcription factors and, together with these factors, regulates the transcription of many downstream genes. Mutations of this gene have been linked with various types of tumors. Alternatively spliced variants have been found for this gene. [provided by RefSeq, Sep 2009]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: beta-catenin; Bfc; catenin beta-1; Catnb; Mesc
Orthologs:
Homo sapiens (human) : CTNNB1 (catenin beta 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ctnnb1 (catenin beta 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ctnnb1 (catenin beta 1)
Pan paniscus (bonobo/pygmy chimpanzee) : CTNNB1 (catenin beta 1)
Canis lupus familiaris (dog) : CTNNB1 (catenin beta 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ctnnb1 (catenin beta 1)
Sus scrofa (pig) : CTNNB1 (catenin beta 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm389120,933,400 - 120,960,507 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv379120,842,518 - 120,869,625 (+)NCBIGRCm37mm9NCBIm37
MGSCv369120,782,173 - 120,809,205 (+)NCBImm8
Celera9121,404,098 - 121,431,499 (+)NCBICelera
Cytogenetic Map9 F4NCBI
cM Map972.19NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations