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[Beta-catenin and its mRNA in renal cell carcinoma]

Authors: Zang, T  Zhuang, L  Zhang, Z  Xin, D  Guo, Y 
Citation: Zang T, etal., Zhonghua Wai Ke Za Zhi. 2000 Jan;38(1):37-9.
Pubmed: (View Article at PubMed) PMID:11831984

OBJECTIVES: To investigate the role of beta-catenin in renal cell carcinoma. METHODS: The expression of beta-catenin in 26 cases of renal cell carcinoma was studied by LSAB immunohistochemistry, Western blotting and RT-PCR. RESULTS: The expression of beta-catenin was higher in cancer tissues than in normal kidney tissues in 25 cases and the level of beta-catenin was associated with tumor stage. The expression was obviously higher in pT3 and pT4 than in pT1 and pT2 (P < 0.01). The expression of its mRNA was not higher in tumor cells than in normal cells. Beta-catenin was expressed mainly in cytoplasm. CONCLUSIONS: Beta-catenin might be related to the occurrence and development of kidney tumor.


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RGD Object Information
RGD ID: 2289835
Created: 2008-02-13
Species: All species
Last Modified: 2008-02-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.