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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550466
Species: Mus musculus
RGD Object: Gene
Symbol: Ctnnb1
Name: catenin (cadherin associated protein), beta 1
Acc ID: CHEBI:73755
Term: 1,2-dimethylhydrazine
Definition: A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
Chemical ID: MESH:D019813
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:704876480464CTD1, 2-Dimethylhydrazine results in increased expression of CTNNB1 protein

PMID:29031619, PMID:29999212
increases mutagenesisISORGD:704876480464CTD1, 2-Dimethylhydrazine results in increased mutagenesis of CTNNB1 gene

PMID:12628520
multiple interactionsISORGD:704876480464CTD[chlorophyllin affects the reaction [1, 2-Dimethylhydrazine results in increased mutagenesis of CTNNB1 gene]] inhibits the reaction [GSK3B protein results in increased phosphorylation of and results in increased ubiquitination of CTNNB1 protein], Artesunate inhibits the reaction [1, 2-Dimethylhydrazine results in increased expression of CTNNB1 protein], chlorophyllin affects the reaction [1, 2-Dimethylhydrazine results in increased mutagenesis of CTNNB1 gene], epigallocatechin gallate promotes the reaction [Sulindac inhibits the reaction [1, 2-Dimethylhydrazine results in increased expression of CTNNB1 protein]], kaempferol promotes the reaction [Sulindac inhibits the reaction [1, 2-Dimethylhydrazine results in increased expression of CTNNB1 protein]], Sulindac inhibits the reaction [1, 2-Dimethylhydrazine results in increased expression of CTNNB1 protein]

PMID:12628520, PMID:29031619, PMID:29999212
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.