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GENE - TERM ANNOTATION REPORT

RGD ID: 1550466
Species: Mus musculus
RGD Object: Gene
Symbol: Ctnnb1
Name: catenin (cadherin associated protein), beta 1
Acc ID: DOID:3948
Term: adrenocortical carcinoma
Definition: A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.
Definition Source(s): MESH:D018268, http://cancergenome.nih.gov/cancersselected/AdrenocorticalCarcinoma, http://www.cancer.gov/cancertopics/types/adrenocortical
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: Adrenocortical carcinoma

PMID:10027390, PMID:10435629, PMID:11351304, PMID:11930117, PMID:11950921, PMID:12124804, PMID:15133491, PMID:24788118, PMID:25157968, PMID:26619011, PMID:26822237, PMID:9065403
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: Adrenocortical Carcinoma

PMID:10027390, PMID:10435629, PMID:11351304, PMID:11930117, PMID:11950921, PMID:12124804, PMID:15133491, PMID:24788118, PMID:25157968, PMID:26619011, PMID:9065403
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: Adrenocortical Carcinoma

PMID:10027390, PMID:11351304, PMID:11930117, PMID:11950921, PMID:12124804, PMID:15133491, PMID:25157968, PMID:26619011, PMID:9065403
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: Adrenocortical carcinoma

PMID:10192393, PMID:25157968, PMID:26619011, PMID:26822237
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: Adrenocortical Carcinoma

PMID:10192393, PMID:26619011
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: Adrenocortical carcinoma

PMID:10398436, PMID:10435629, PMID:10655994, PMID:26619011, PMID:26822237, PMID:9500465, PMID:9927029
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: Adrenocortical Carcinoma

PMID:23265383, PMID:25157968, PMID:26619011, PMID:9927029
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: Adrenocortical Carcinoma

PMID:25157968, PMID:26619011
 ISORGD:7337058554872ClinVarClinVar Annotator: match by term: Adrenocortical Carcinoma

PMID:26619011
 ISORGD:73370511554173CTDCTD Direct Evidence: marker/mechanism

PMID:24747642
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.